LOCUS       NM_001382359            2105 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens chromosome 17 open reading frame 58 (C17orf58),
            transcript variant 3, mRNA.
ACCESSION   NM_001382359
VERSION     NM_001382359.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134407.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352441.79145.1,
                                           ERR4368409.117294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580729.3/ ENSP00000489720.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AC134407.6         127253-127599       c
            348-908             AC134407.6         124554-125114       c
            909-1100            AC134407.6         124174-124365       c
            1101-2105           AC134407.6         122229-123233       c
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..2105
                     /gene="C17orf58"
                     /note="chromosome 17 open reading frame 58"
                     /db_xref="GeneID:284018"
                     /db_xref="HGNC:HGNC:27568"
     exon            1..347
                     /gene="C17orf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1291
                     /gene="C17orf58"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; UPF0450 protein C17orf58"
                     /codon_start=1
                     /product="UPF0450 protein C17orf58 isoform c precursor"
                     /protein_id="NP_001369288.1"
                     /db_xref="CCDS:CCDS92385.1"
                     /db_xref="GeneID:284018"
                     /db_xref="HGNC:HGNC:27568"
                     /translation="MTARAFWLLCLIVGSSPEAPVAERKTSPPHSRKPDSRGCPSAEE
                     TPGPRAQPLLEAPQRPRAAEVAPAARAWPDPRRRKPPPPADNQASFREAARAPAGPPG
                     PRLAQAENRASPRREPASEDAPRRARSRALRFPAARPPALATEGSAGHAHPNRPRAAA
                     LAPGPAPAPPPRFSLSFGLSPPQRDAEPGAEPCARACRSDLDEREAFCESEFAVNGIV
                     HDVDVLGAGIRLVTLLVDRDGLYKMNRLYLTPDGFFFRVHMLALDSSSCNKPCPEFKP
                     GSRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAI
                     HTQCI"
     exon            348..908
                     /gene="C17orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1100
                     /gene="C17orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..2105
                     /gene="C17orf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C17orf58"
                     /note="hexamer: AATAAA"
     polyA_site      2105
                     /gene="C17orf58"
                     /note="major polyA site"
ORIGIN      
        1 gtgatgctct cctcgcccgc agatcacagg acagacattc ccggggacaa ctttgcaagg
       61 ccatgtgctc gtcctcctta ggaaggaaga gggagaaatc cctgcggctc ggttttgttc
      121 caatggtctg ctcagcgagt gattcccgtt tccccaaagg ctgcccctca ttagcatgaa
      181 cgggggtggg ggtgtggaga aggggttggg ggagagaaag caagcaaaag accaggctca
      241 cttttagagc ctgggaaccc tgtctgcaaa aatgacagct agagctttct ggctcctctg
      301 tttgatcgtc ggatcatccc ccgaagcacc ggtggcggag agaaaaacct cgccgccgca
      361 cagcagaaag ccggactccc gcggctgccc gagcgcggag gagacaccgg ggccccgcgc
      421 gcagccactc cttgaggccc cgcagcggcc gcgcgcggcc gaggtcgctc ccgccgcccg
      481 cgcctggcct gacccgcgcc gccggaagcc cccaccgccg gccgacaacc aggccagctt
      541 ccgggaggcc gcacgcgcgc ccgctggccc gccgggcccg cgcctggcgc aagccgagaa
      601 ccgcgcgtcg ccgcgccgcg agcccgcgtc ggaggacgcc ccgcgacgcg cgcgctcacg
      661 ggccctgcgc ttccccgccg cccggccgcc cgcgctcgcc accgagggct ccgccggcca
      721 cgcccacccc aaccggccgc gcgccgccgc gctggccccg ggacccgcgc ccgcgccgcc
      781 gccgcgcttc agcctcagct tcggcctcag cccgccgcag agggacgcgg agcccggcgc
      841 tgagccctgc gcgcgcgcct gccggtccga tctggacgaa cgcgaggcgt tctgcgagag
      901 cgaattcgcg gtgaacggga tcgtgcacga tgtggacgtg ctgggcgcgg gcatccggct
      961 ggtgaccctg ctggtggatc gggacgggct gtacaagatg aaccgcctgt acctcacccc
     1021 cgacggcttc ttcttccgag tccacatgtt agccctggac tcctccagct gcaataagcc
     1081 gtgtccagag tttaaacctg gcagcaggta tattgtgatg ggccacatct accataagag
     1141 acggcagctc cctacagctc tgctccaggt cctgagaggc cgcctccgtc caggggatgg
     1201 actgctaagg agcagcagca gctatgtgaa aaggtttaat cgaaaaaggg aagggcagat
     1261 tcaaggtgca attcataccc aatgcatttg aaacaaccat cctggcattt ctggaccgca
     1321 agagacttgg acgtcggcaa caagacatga aaggtctacc ttcatgtaat gggtcctcct
     1381 tcagaagaga gccctcagct actctgtgaa tgacttgcat agctgcaact gtaatctcga
     1441 aggtgtcact ttgttattta caagatgctt cttaaatggg ctgctcctga gctcagtgtc
     1501 aaggtgattc aactgtagtg ccagacaatg atttacacag ctcagataat tgacctgtcc
     1561 agttaacaga tcattgcttc ataagttttt aaattatttt aatttaatat tctttagtag
     1621 aaatagtcca caaaaacatt ttcttgaatt taaatataca acttttatat catgtatcaa
     1681 accagatttt atattcaaac gatcacattt taaattctgt acataacagt aagcgcacta
     1741 gtcaaaagac atttatgttt gaaatgtcat ttagatcaaa cacaagggtc aaagcccagg
     1801 acaagtatta aagttttata cttaaagagt actaaagggc cagtgtgcag atgggtggat
     1861 taaaaaaata aataaaataa aaaatagtac taaagggctt acttcaggca aaagtgttcc
     1921 tgacgtacca aaaagtaaga tatagtttat tttcatgcct ccctgctcct agtaatgtat
     1981 gttttgtgct gaactggcag ctatcccaat gtgaaatgta ttttggatgt atctggtgtc
     2041 atttttctat taagaccaag tataatgttt gtttgtaaag caataaatct tgacttgaaa
     2101 tcaga
//
