LOCUS       NM_174893                850 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens BPTF associated chromatin complex component 1 (BACC1),
            transcript variant 2, mRNA.
ACCESSION   NM_174893 XM_371010
VERSION     NM_174893.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Liu,W., Wang,S., Lin,L., Zou,R., Sun,H., Zeng,K., Wu,Y., Li,Y.,
            Shigeaki,K., Wang,X., Wang,C. and Zhao,Y.
  TITLE     BAP18 acting as a novel peroxisome proliferator-activated receptor
            alpha co-regulator contributes to hepatocellular carcinoma
            progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166974 (2024)
   PUBMED   38042310
  REMARK    GeneRIF: BAP18 acting as a novel peroxisome proliferator-activated
            receptor alpha co-regulator contributes to hepatocellular carcinoma
            progression.
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Sun,G., Wei,Y., Zhou,B., Wang,M., Luan,R., Bai,Y., Li,H., Wang,S.,
            Zheng,D., Wang,C., Wang,S., Zeng,K., Liu,S., Lin,L., He,M.,
            Zhang,Q. and Zhao,Y.
  TITLE     BAP18 facilitates CTCF-mediated chromatin accessible to regulate
            enhancer activity in breast cancer
  JOURNAL   Cell Death Differ 30 (5), 1260-1278 (2023)
   PUBMED   36828916
  REMARK    GeneRIF: BAP18 facilitates CTCF-mediated chromatin accessible to
            regulate enhancer activity in breast cancer.
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Wei,S.J., Li,J., Wang,J.Y., Zhang,L.X., Zhang,H.B., Du,D.J. and
            Li,Q.X.
  TITLE     BAP18 induces growth of non-small-cell lung carcinoma through
            upregulating transcriptional level of CCND1/2
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (9), 3074-3082 (2022)
   PUBMED   35587057
  REMARK    GeneRIF: BAP18 induces growth of non-small-cell lung carcinoma
            through upregulating transcriptional level of CCND1/2.
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 850)
  AUTHORS   Sun,G., Wang,C., Wang,S., Sun,H., Zeng,K., Zou,R., Lin,L., Liu,W.,
            Sun,N., Song,H., Liu,W., Zhou,T., Jin,F., Shan,Z. and Zhao,Y.
  TITLE     An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core
            subunits co-activates ERalpha action and associates with the
            sensitivity of antiestrogen in breast cancer
  JOURNAL   Nucleic Acids Res 48 (19), 10768-10784 (2020)
   PUBMED   32986841
  REMARK    GeneRIF: An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like
            core subunits co-activates ERalpha action and associates with the
            sensitivity of antiestrogen in breast cancer.
REFERENCE   6  (bases 1 to 850)
  AUTHORS   Jiang,H., Lu,X., Shimada,M., Dou,Y., Tang,Z. and Roeder,R.G.
  TITLE     Regulation of transcription by the MLL2 complex and MLL
            complex-associated AKAP95
  JOURNAL   Nat Struct Mol Biol 20 (10), 1156-1163 (2013)
   PUBMED   23995757
REFERENCE   7  (bases 1 to 850)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   8  (bases 1 to 850)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 850)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 850)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM011108.1 and BC040036.1.
            
            On Jun 2, 2019 this sequence version replaced NM_174893.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            that causes a frameshift in the 3' coding region, compared to
            variant 1. The resulting isoform (2) has a distinct and shorter
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.211489.1,
                                           SRR5189667.302063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439424.6/ ENSP00000411851.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               BM011108.1         9-201
            194-850             BC040036.1         171-827
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..850
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /note="BPTF associated chromatin complex component 1"
                     /db_xref="GeneID:124944"
                     /db_xref="HGNC:HGNC:28737"
                     /db_xref="MIM:617215"
     exon            1..97
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..595
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /note="isoform 2 is encoded by transcript variant 2;
                     MLL1/MLL complex subunit C17orf49; chromatin complexes
                     subunit BAP18; BPTF-associated protein of 18 kDa; human
                     embryo lung cellular protein interacting with SARS-CoV
                     nsp-10"
                     /codon_start=1
                     /product="BPTF-associated chromatin complex component 1
                     isoform 2"
                     /protein_id="NP_777553.1"
                     /db_xref="CCDS:CCDS32542.1"
                     /db_xref="GeneID:124944"
                     /db_xref="HGNC:HGNC:28737"
                     /db_xref="MIM:617215"
                     /translation="MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTE
                     TEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPAESPKKGPK
                     KVASGVLSPPPAAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDVVDIEGLGE
                     TPPAKKLNFDQA"
     exon            98..192
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     exon            193..294
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     exon            295..485
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     exon            486..590
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     exon            591..850
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /note="hexamer: AATAAA"
     polyA_site      850
                     /gene="BACC1"
                     /gene_synonym="BAP18; C17orf49; HEPIS"
                     /note="major polyA site"
ORIGIN      
        1 agtctccctg ctctccgtgg tcccggctcg cgtgtagcgg cggcggcggc gtctccgtga
       61 ggaggcgcgc ggggccatga cgtcagcgtc cacaaaggtc ggagagatct tctcggcggc
      121 cggcgccgcc ttcacgaagc tcggggagct gacgatgcag ctgcatcccg tggccgactc
      181 ttctcctgcg ggtgcgaagt ggacggagac ggaaatagag atgctgaggg ctgctgtgaa
      241 gcgatttggg gacgatctta atcacatcag ctgtgtcatc aaggaacgga cagtggccca
      301 gataaaggcc actgtgaaac gcaaggtata tgaagattct ggcatccccc ttccagctga
      361 gtcacccaag aaagggccca agaaggtggc atctggtgtc ttgtcacctc ctccagctgc
      421 ccctcctccc agcagctcca gtgtccctga ggccgggggt ccccccataa agaaacagaa
      481 ggctgatgtg acactcagtg ctctgaacga ctccgatgcc aacagtgacg tggtggatat
      541 tgaagggcta ggagaaactc ctccagctaa gaaactcaac ttcgaccagg cctgaccctg
      601 gattctggcc ttctcatgac ctctgctgat cctcctctcc tctcctgctg agccttccac
      661 ctctgacctc tcactgttca tgccggacct gtggatctcc tgggactccg agcaaggcct
      721 gcacgagaga gggctgaaag gctgctgggg ctgccacctc gctattcccg cataagcatc
      781 tgcccccaac ccctttgacc ttcatctgat ggacattttt atacagaaaa caataaagat
      841 ttccctctca
//
