LOCUS       NM_001109659             953 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens chromosome 16 open reading frame 92 (C16orf92),
            transcript variant 1, mRNA.
ACCESSION   NM_001109659 XM_001134319 XM_001134320
VERSION     NM_001109659.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Fujihara,Y., Lu,Y., Noda,T., Oji,A., Larasati,T., Kojima-Kita,K.,
            Yu,Z., Matzuk,R.M., Matzuk,M.M. and Ikawa,M.
  TITLE     Spermatozoa lacking Fertilization Influencing Membrane Protein
            (FIMP) fail to fuse with oocytes in mice
  JOURNAL   Proc Natl Acad Sci U S A 117 (17), 9393-9400 (2020)
   PUBMED   32295885
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 953)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093512.2.
            
            On Jun 16, 2020 this sequence version replaced NM_001109659.1.
            
            Transcript Variant: This variant (1) uses an alternate splice
            acceptor site for exon 2; the N-terminus of the predicted protein
            is distinct compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000681219.1/
                                                ENSP00000506393.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC093512.2         91248-91454
            208-366             AC093512.2         91777-91935
            367-454             AC093512.2         92049-92136
            455-953             AC093512.2         92256-92754
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..953
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /note="chromosome 16 open reading frame 92"
                     /db_xref="GeneID:146378"
                     /db_xref="HGNC:HGNC:26346"
                     /db_xref="MIM:618911"
     exon            1..207
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..476
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C16orf92;
                     fertilization-influencing membrane protein"
                     /codon_start=1
                     /product="fertilization-influencing membrane protein
                     isoform 1 precursor"
                     /protein_id="NP_001103129.1"
                     /db_xref="CCDS:CCDS92135.1"
                     /db_xref="GeneID:146378"
                     /db_xref="HGNC:HGNC:26346"
                     /db_xref="MIM:618911"
                     /translation="MRLWPWVLVWVWLAALGAIETAPRPKRATASALGTESPRFLDRP
                     DFFDYPDSDQARLLAVAQFIGEKPIVFINSGSSPGLFHHILVGLLVVAFFFLLFQFCT
                     HINFQKGA"
     exon            208..366
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            367..454
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            455..953
                     /gene="C16orf92"
                     /gene_synonym="FIMP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcttctc ctctcctctt ctgatgagag tgagggatgg gggaggggtc ccagctccta
       61 gcactttctc ccctcacccc aaagtgccat cagaacagct ctgggctgtg acatcacaga
      121 gcccccacct catgatagga gtcatgaggc tgtggccatg ggtgctggtg tgggtgtggc
      181 tggctgcact aggggccata gaaactgcac ccagacccaa gcgtgccacg gcgtcagccc
      241 tggggacaga gtctccgcgc ttcttagaca gacctgactt cttcgattat ccggactcag
      301 accaagccag gctgctggct gtggcccagt ttattggaga gaaacccatc gtgttcatta
      361 actcaggttc cagccccggg ctcttccatc acatcctggt gggcttgctg gtggtggcgt
      421 tcttctttct ccttttccag ttctgcaccc acataaactt ccagaaaggg gcctaaagag
      481 ccggacaagg gctctggact caacctgagc acccacaccc acctcctctc ctgttgatga
      541 gcaaaagttc cctgctttcc tcctccctga ctgcccagcg agcagctggg gatcctgtcc
      601 cctctgtttc ccatggccca agccccccac ctcctccctt cccagcccca aagaacttgg
      661 tggcaagggc cttggtggcg ttcacgcaga tcgtctttta ttagcggtct gtaaagcacc
      721 tcccagggtc ccccgacccc agattggagg aagccttgag aggtcagtag caccagggac
      781 atggcagggc ccgagggcgc gatgtgcagc cgatggtgag ggactgggcg ccctcgcctg
      841 cccccggggt tgtcagcact gggaaggctt gggggtagca gccacctcct tcccccaacc
      901 caacagacta gttcaaattt gggtaaataa ataaaataaa taagattcct caa
//
