LOCUS       NP_001091984             361 aa            linear   PRI 28-MAR-2025
DEFINITION  UPF0764 protein C16orf89 isoform 2 precursor [Homo sapiens].
ACCESSION   NP_001091984
VERSION     NP_001091984.2
DBSOURCE    REFSEQ: accession NM_001098514.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 361)
  AUTHORS   Afink,G.B., Veenboer,G., de Randamie,J., Keijser,R., Meischl,C.,
            Niessen,H. and Ris-Stalpers,C.
  TITLE     Initial characterization of C16orf89, a novel thyroid-specific gene
  JOURNAL   Thyroid 20 (7), 811-821 (2010)
   PUBMED   20578903
  REMARK    GeneRIF: characterization of C16orf89; mRNA and translated protein
            sequences (signal peptide, O-glycosylation sites); mRNA expression
            in various tissues primarily thyroid
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026458.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 24, 2010 this sequence version replaced NP_001091984.1.
            
            Summary: This gene is expressed predominantly in the thyroid. Based
            on expression patterns similar to thyroid transcription factors and
            proteins, this gene may function in the development and function of
            the thyroid. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2011].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site at the 3' terminal exon compared to variant 1. This
            results in a frame-shift and a shorter isoform (2) with a distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033681.1, AK300708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:20578903)
            MANE Ensembl match               :: ENST00000472572.8/
                                                ENSP00000420566.2
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     Protein         1..361
                     /product="UPF0764 protein C16orf89 isoform 2 precursor"
                     /note="UPF0764 protein C16orf89"
                     /calculated_mol_wt=38495
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2136
     Region          60..340
                     /region_name="DUF4735"
                     /note="Domain of unknown function (DUF4735); pfam15882"
                     /db_xref="CDD:464922"
     CDS             1..361
                     /gene="C16orf89"
                     /coded_by="NM_001098514.3:49..1134"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS45404.2"
                     /db_xref="GeneID:146556"
                     /db_xref="HGNC:HGNC:28687"
                     /db_xref="MIM:621148"
ORIGIN      
        1 maslglllll lltalpplws sslpgldtae skatiadlil saleratvfl eqrlpeinld
       61 gmvgvrvlee qlksvrekwa qepllqplsl rvgmlgekle aaiqrslhyl klsdpkylre
      121 fqltlqpgfw klphawihtd aslvyptfgp qdsfseersd vclvqllgtg tdssepcgls
      181 dlcrslmtkp gcsgyclshq llfflwarmr gctqgplqqs qdyinlfcan mmdlnrraea
      241 igyayptrdi fmenimfcgm ggfsdfyklr wleailswqk qqegcfgepd aedeelskai
      301 qyqqhfsrrv krrekqfpdg csshntatav aalggflyil aeyppanrep hpstppppss
      361 r
//
