LOCUS       NM_001001436            6845 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 16 open reading frame 87 (C16orf87),
            transcript variant 1, mRNA.
ACCESSION   NM_001001436
VERSION     NM_001001436.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6845)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6845)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 6845)
  AUTHORS   Joshi,P., Greco,T.M., Guise,A.J., Luo,Y., Yu,F., Nesvizhskii,A.I.
            and Cristea,I.M.
  TITLE     The functional interactome landscape of the human histone
            deacetylase family
  JOURNAL   Mol Syst Biol 9, 672 (2013)
   PUBMED   23752268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007225.2, BC056676.1 and BX647945.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001001436.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.300646.1,
                                           SRR1660805.58567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMN03267769
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285697.9/ ENSP00000285697.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC007225.2         54331-54348
            19-1401             BC056676.1         5-1387
            1402-6180           AC007225.2         83465-88243
            6181-6841           BX647945.1         5978-6638
            6842-6845           AC007225.2         88905-88908
FEATURES             Location/Qualifiers
     source          1..6845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q11.2"
     gene            1..6845
                     /gene="C16orf87"
                     /note="chromosome 16 open reading frame 87"
                     /db_xref="GeneID:388272"
                     /db_xref="HGNC:HGNC:33754"
     exon            1..97
                     /gene="C16orf87"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..496
                     /gene="C16orf87"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0547 protein C16orf87"
                     /codon_start=1
                     /product="UPF0547 protein C16orf87 isoform 1"
                     /protein_id="NP_001001436.1"
                     /db_xref="CCDS:CCDS10724.1"
                     /db_xref="GeneID:388272"
                     /db_xref="HGNC:HGNC:33754"
                     /translation="MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNA
                     KHSEKSPPSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGR
                     PKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL"
     exon            98..194
                     /gene="C16orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            195..377
                     /gene="C16orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            378..6845
                     /gene="C16orf87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf87"
                     /note="hexamer: AATAAA"
     polyA_site      1404
                     /gene="C16orf87"
                     /note="major polyA site"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf87"
                     /note="hexamer: ATTAAA"
     polyA_site      1427
                     /gene="C16orf87"
     regulatory      6740..6745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf87"
                     /note="hexamer: AATAAA"
     polyA_site      6763
                     /gene="C16orf87"
     regulatory      6823..6828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf87"
                     /note="hexamer: AGTAAA"
     polyA_site      6845
                     /gene="C16orf87"
ORIGIN      
        1 gtcgctgctg ccgccgctaa gggagaggag catgtctgca actcgagcca agaaagtgaa
       61 gatggccacc aaatcatgcc ccgagtgcga ccaacaggtt cctgttgcat gtaaatcatg
      121 tccttgtggt tacatattta ttagcagaaa acttttaaat gcaaaacact cagagaaatc
      181 accaccttct acagaaaaca agcatgaggc caagaggagg cgaacagaga gagttaggag
      241 agagaagata aattctacag taaataaaga tttagaaaac agaaagaggt ctcgaagtaa
      301 cagccattca gatcatatca gacgaggaag aggaagacct aaaagtgcat ctgccaaaaa
      361 acatgaggaa gaaagagaga aacaggaaaa ggaaattgac atctatgcta acctgtctga
      421 tgaaaaggct ttcgtgtttt cagtcgcctt ggcagaaata aatagaaaaa ttatcaatca
      481 aagacttatt ctctgatact tgtttgcaaa atctgctgaa acttctgtca ggataacatc
      541 agcaaattct caaacagtta tggactctca ggagcattct gactgcatca ataagggcca
      601 tcgattgttt ctttctcgcc tgtcgtttag cctgtgccac acttcgggag caaagctgtg
      661 taggcttgga ctgttctggg atttccttgt ttaccaagga gtattgtcag tgttttgtgt
      721 ttgggatata agtaagtgta tttgccaaca acaaaaaaaa accaacaaaa atgctggatg
      781 gatgttaaag gataaaaagt gatggggtat ggggtaggta tgaaaactag ggtaataaga
      841 tgcttgattg ttttcaggtt tgccaccaga gatgcaatat tttaaatact gtcagaaaga
      901 gtgattttta aaaatatata tttcagattt tcagtgctaa cagattgcat atatacagtt
      961 catttacttt tattaaattg gcaatcgata ttttattgaa tggggaatta agaatataaa
     1021 ctgtaaattt tgtcttaaat tgattttttt tcttggcctt tatttttatt acttaaggta
     1081 tgagttatat tttaggagat actttctaga cagtttgaag tttgggtgct atatgaagaa
     1141 aaacatttaa tgatatactc agatataaac accttgtttt cttgaatgta atttatttat
     1201 tagctaaaaa aaaaaaacaa actgctctca agatggtgcc tgttaaccta aacatgaaat
     1261 atatttatta catgcaaaat atttcttagc cacttttaag cagtaatgtt ttatctgaat
     1321 ggatatttgt ttctatatcc tgataattat ttaaattgtt actttcaatc tggaagaaaa
     1381 aataaacctt aatattgaaa ctaagtagat taaatagtgt gataaaagtt ttttgttctg
     1441 gtgaagtttg tgaaatatat ttaaattctt aatttttcta gtgttaagtc ataatcgttt
     1501 atagttgatt tatattaaat gcttttgcat tttggcatat caatttaatg attaacatat
     1561 tcaaacttgg taatcactcc ccttattttc agtcgctctt cccccaatct gtttagaaat
     1621 ccttttaaag ccttcttaca gaagatagtc atcagttaga tttagccccc ttttaagaga
     1681 atctcccttt caattttagc cgtaacatta tcaatttcag acttcatcct gcatctccca
     1741 tcacctcctc aaagaaaaaa ggtcaacatt ttttcctact ttatttaaat ggtaaccagc
     1801 agagggagct taagaggtac tctagatagg ataaagaatt ttcctaagga ttccttttcc
     1861 tttaatccct gtatctatct gcaggtacta ctgcaactat tttgtatgca ttttatttat
     1921 ttatttagga gacagagtct tgctcggtcg cccaggctgg agtgcagtgg cactgtctca
     1981 gctcactgca acctctgcct cctgggttca agtgattctt atgcctcagc ctcctgagta
     2041 gctgtgacta gaggcgtgcg ccaccacgcc tggctgtttt tttttttgta ttttttagta
     2101 cagatggggt ctcagcatgt tggccaggct ggtctcaaat tcctggcctt aggtgatctg
     2161 cccgccttgg cctcccaaag tgctgggatt acaggcatga gccactgcac tcagccttgt
     2221 gtgcgtttta gagtcttaac tagtagtttc cccaataatg taatgtgatt ttatctttga
     2281 aacatactgt aaggaaactt ttgattttaa gtaaaaaagc ttaaaaatga ttaatatcta
     2341 aaaatgcttg tatacatata tatgtcctca gaaaaagcaa gaacagcttg tggaataagc
     2401 acgtctttaa ggaattatcg atgtcagagt ctatccattt aaagctgaag accattacag
     2461 gaaagtcatg ttaaaatatt cattggatat ggtaaaggag gtactggtgg ctgggctgga
     2521 gcttgccgta tagaaaagta attacttcag atctcataat gttaaattat tggcttattt
     2581 aaaaatttcc gtggcagaga ggcaaattag gtttcctctg tgacataacc tatttaacca
     2641 atttttcaaa aaattgtact ctatgagctt tcttgttata aagctaaaaa atttaatttg
     2701 tctaggcatg ttgtaatggt cccagaaaat attactttgt cactggtgtc agagaaacct
     2761 ctgtcatcag cagatgtcct aagagtataa ttatagttct ttacttaatc caaaatttgt
     2821 tctgctctga tatctataaa tgatatgatt attcaaaata ccttgaaatg attccacaat
     2881 tagattaggt ctgttgaaga taacttattc ttaaatatga gtaagattaa ataaaagtag
     2941 tttgagagtt gttactccct gcctcaactc catggtattc caaaatgttt ttgtgggcac
     3001 tttaatactt gtagtttgat tttgtttgtt agttttagaa atgaacattt cttagatttt
     3061 catgggtatt ttttggctgt atttaaatgt aaatgatata aaagtaaggg aaattgtgca
     3121 aattatttct tgtgtagtaa tcagtggaag tgatcaaaca gcttgaagca gtttatgatg
     3181 agaaaattta aaattgcaaa tgacctgaaa atttagccag tctattctta tttctttaaa
     3241 tttcagaaat acttaagaaa aaaaaaaaaa aggtcagtat gacctctgag ttgcttccta
     3301 aaagtaatca gatagtgttc tccctcagat aagatttcaa attgaaaagt atttgacttc
     3361 tttaactcta gtaattgcac ttgattctct aattctgatc attaaaatga cttggcaata
     3421 tttaattttg gcttgccttt caatctgcat gtttgtctta aatttagaaa aattaagctc
     3481 tttacttact tttatataaa gtattaattg gccaggcatg gtggcttaca cctgtaatcc
     3541 caacactttg ggaggccaag gcaggagagt tgtttgaagc caggagtttg agaccagcct
     3601 gggcaacatg atgagaccgc gtctctacaa aaagtaaaat tagctgggtg tggtgcttcc
     3661 agctactagg cagctgaggc taaaggatca cttgagccca ggagttcgag gctgcagtga
     3721 gtgatgatct tgccactgca ctccagcctg ggaggcagag caagaaacac cctgtgtgaa
     3781 aaaagtattg aatttgtttg attccacttt caaaatatgc tctagataca ggtagtcatt
     3841 ctgccaaatt gtgttcttct ctaaaacatt ttgtccgtca ttctttgaaa ctcattctta
     3901 attatttcca ctttaccttc tagtttggtt tgatgcctta tattcttgct agttaaaagc
     3961 attttttccc tagtattttc tgtctttcta gcctttaagg catattgttg ttaacaaatc
     4021 tcttatttaa gttaattaaa gttttttctg tgcagctggg ttttttcttt tactacatga
     4081 caagcttcat ttttacattt ggaagtacat gtatatatgt ttatatattt ttattctcag
     4141 gatctatttt ctagggaact atttttttaa attattcttt tgtgctgcct taacccattt
     4201 attatagttt gaatattagt agtacttact actcaaagat tacaactata ctaataacta
     4261 tcctaacata caaagcagac tctccaggat taaaagtatg agacatataa cagagtctgg
     4321 aatagaataa ttctttttac cccagtcaag tatttgcctt ttgcattatt aaggaatctg
     4381 ttttgttctt ttattgataa tttctatatt tttttctttg ccttattgca ctggttggga
     4441 ctttttgcct tgatccagtt gtagggggga aacattcagt cattaagcat taaataactt
     4501 tgttgttgtt gtgggcttga aaaaataccc tttagtagat tgagggtaga ctcttttatt
     4561 tctgcttgtt ggaagttttc tgtcaggaac agatgttgaa ttttgtcaga tgctttttct
     4621 gcataattga taggaccttt tttctcccct ttagaatgtt catatggtga aacatactga
     4681 tagcttttct tttctttttt ttttgacacg gagtctcact ctgtcaccca ggctggagtg
     4741 caatggtgcg atcttggctc actgcaccct ctgcctcttg ggttcaagct tccctcacca
     4801 gcctcccaag tacctgggta tacaggtgtg catcaccatg cccggctaat ttttgaattt
     4861 ttagtagaga taggttttta ccatgttggc caggctggtc ttcaactcct gactcagcct
     4921 cccaaagtgt tgggattaca gtctcgctct gtcgcccagg ctggagggca gtggtgtgat
     4981 cttggctcaa tgcaaccttg caacctctgc ctcccgagtt caagcgattc tcctgcctta
     5041 gcctcctgag tagctggaat tacaggcgca cgccactaca cccagcttct ttttgtattt
     5101 ttagtagaga tggagtttca ccatgttggc caagctggtc tcgaactcct gagctccggt
     5161 gatccacccg cctttacagg catgagccac cgtgcccggc tgcatttctc ttttgtaaga
     5221 acctgctctg gtttattgat attttgctgt ttttctgttt taagtttcat taatttctga
     5281 tctttagtat tttctccttt ctttgctttg ggcttatttg ctcccttttc tagcttattg
     5341 tggcggaagc tcagatcatt gattttaaaa tttacttatt tatttattta tttatttaat
     5401 tcaacactga tcagaaggct ttttgtgctt ttctaaaaaa agcatttaat gctataaatt
     5461 tcccatttgc tttatctcac aaattttatt gtgttgtaat tttgtgttca atttagaata
     5521 ttctgatttt tcttggtatt actataattt tcaaatattt agagtttttt tcagttatct
     5581 ttctgttact gattgtaatt tattgttttt taaaattata gttctttgaa tagttttgca
     5641 gtatttgctc tagggattac tataaacata cttcactttt tacagttcac ttagaagtca
     5701 atattttacc agttcaagtg gaatgtagaa aaatcttacc actgtttaca ttcctttacc
     5761 ctctcccctt tatgttataa ttttcttata aatcataaga cttggctggg cacagtggct
     5821 cacctgtaat cccaggactg ggaggccgag gcgagcagat tgcttaagtc caggagttcg
     5881 agaccagcct ggacaatgtg gtgaaacccc aactctacaa aaaatacaca aaattagcta
     5941 ggcgtggtag catgttcctg tagtcccagc tactcaggag gctgaagtgg gaggattact
     6001 tgagcccagg aggcagaggt tgcagtgagc caagatcact ccactccact ccagcctgag
     6061 tgacagagct agacactgtg tctcaaaaaa taaaaataaa aaataagact catcagataa
     6121 tgtatttttt ccttacaact atcatagata tttttaagaa cccaagagga aaacagtcta
     6181 tcacatttac cacaatattt atcatttgta ttaatcttcc ttaattcttg atgttccaag
     6241 tttacatagg tatcagtcct tttcatctgg aaaatttctt ttagtgcagg tctgttgaca
     6301 tttaattctc ttattttttc ttcatctgag aatgtcttta ttttgcctta attcatgaaa
     6361 gatatttttg ctggatataa actactgtgt tgacagttct ttcagcctcc atggtttctg
     6421 atgagaaatg tgcagccatt aaagtaatat ttcccctgta tgaaacatgt tatttttctc
     6481 tgagtatttt caggaatctt tgtctttggt ttttattggt ttgattatga tgtgcccggg
     6541 tgtttgaatt tattctcttt gggatttgtt gagcttaaat gtgtaagttt atgcctttca
     6601 tcagattatg taaagtttta aaccattcag atattttctg ctctactttc tcctccctct
     6661 taggctccag tgatgcaagt gttagactct ttggtattat ctcacagatc tcagaacctc
     6721 tgttcattta ttttatttta ataaatcatt tcagttaaca aaatcatata ttgtatgcag
     6781 catgatgttt caatatgtat gttcacattg taggatgtct aaagtaaaga taatgaacat
     6841 atgca
//
