LOCUS       NM_206967                911 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens chromosome 16 open reading frame 74 (C16orf74),
            transcript variant 1, mRNA.
ACCESSION   NM_206967
VERSION     NM_206967.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Huang,L., Liu,P., Du,Y., Bazan,J.F., Pan,D., Chen,Q., Lee,A.,
            Kola,V.S.R., Wolfe,S.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine, ASRA, is a leptin receptor
            antagonist that stimulates appetite
  JOURNAL   bioRxiv (2024)
   PUBMED   37745491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Gong,J., Fan,H., Deng,J. and Zhang,Q.
  TITLE     LncRNA HAND2-AS1 represses cervical cancer progression by
            interaction with transcription factor E2F4 at the promoter of
            C16orf74
  JOURNAL   J Cell Mol Med 24 (11), 6015-6027 (2020)
   PUBMED   32314545
  REMARK    GeneRIF: LncRNA HAND2-AS1 represses cervical cancer progression by
            interaction with transcription factor E2F4 at the promoter of
            C16orf74.
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Kushibiki,T., Nakamura,T., Tsuda,M., Tsuchikawa,T., Hontani,K.,
            Inoko,K., Takahashi,M., Asano,T., Okamura,K., Murakami,S.,
            Kurashima,Y., Ebihara,Y., Noji,T., Nakanishi,Y., Tanaka,K.,
            Maishi,N., Sasaki,K., Park,W.R., Shichinohe,T., Hida,K., Tanaka,S.
            and Hirano,S.
  TITLE     Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel
            Therapeutic Target
  JOURNAL   Mol Cancer Ther 19 (1), 187-198 (2020)
   PUBMED   31597713
  REMARK    GeneRIF: Role of Dimerized C16orf74 in Aggressive Pancreatic
            Cancer: A Novel Therapeutic Target.
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Sato,S., Nakamura,T., Katagiri,T., Tsuchikawa,T., Kushibiki,T.,
            Hontani,K., Takahashi,M., Inoko,K., Takano,H., Abe,H., Takeuchi,S.,
            Ono,M., Kuwabara,S., Umemoto,K., Suzuki,T., Sato,O., Nakamura,Y.
            and Hirano,S.
  TITLE     Molecular targeting of cell-permeable peptide inhibits pancreatic
            ductal adenocarcinoma cell proliferation
  JOURNAL   Oncotarget 8 (69), 113662-113672 (2017)
   PUBMED   29371937
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Nakamura,T., Katagiri,T., Sato,S., Kushibiki,T., Hontani,K.,
            Tsuchikawa,T., Hirano,S. and Nakamura,Y.
  TITLE     Overexpression of C16orf74 is involved in aggressive pancreatic
            cancers
  JOURNAL   Oncotarget 8 (31), 50460-50475 (2016)
   PUBMED   28881575
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Quemener-Redon,S., Benech,C., Audebert-Bellanger,S., Friocourt,G.,
            Planes,M., Parent,P. and Ferec,C.
  TITLE     A small de novo 16q24.1 duplication in a woman with severe clinical
            features
  JOURNAL   Eur J Med Genet 56 (4), 211-215 (2013)
   PUBMED   23333879
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Kim,W.T., Yun,S.J., Park,C., Kim,I.Y., Moon,S.K., Kwon,T.G.,
            Choi,Y.H. and Kim,W.J.
  TITLE     Identification of C16orf74 as a marker of progression in primary
            non-muscle invasive bladder cancer
  JOURNAL   PLoS One 5 (12), e15260 (2010)
   PUBMED   21203532
  REMARK    GeneRIF: C16orf74 expression level represents a potentially useful
            marker for predicting progression in primary non-muscle invasive
            bladder cancer patients
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018695.6, CD674248.1 and AW072412.1.
            
            On Nov 23, 2018 this sequence version replaced NM_206967.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB115764.1, SRR1163655.251942.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284245.9/ ENSP00000284245.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC018695.6         60976-60988         c
            14-460              CD674248.1         1-447
            461-911             AW072412.1         2-452               c
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..911
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /note="chromosome 16 open reading frame 74"
                     /db_xref="GeneID:404550"
                     /db_xref="HGNC:HGNC:23362"
     exon            1..171
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /inference="alignment:Splign:2.1.0"
     exon            172..217
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..420
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /note="hypothetical protein 1; hypothetical protein 2;
                     hypothetical protein 3; adipose-secreted regulator of
                     appetite"
                     /codon_start=1
                     /product="uncharacterized protein C16orf74"
                     /protein_id="NP_996850.1"
                     /db_xref="CCDS:CCDS45540.1"
                     /db_xref="GeneID:404550"
                     /db_xref="HGNC:HGNC:23362"
                     /translation="MGLKMSCLKGFQMCVSSSSSSHDEAPVLNDKHLDVPDIIITPPT
                     PTGMMLPRDLGSTVWLDETGSCPDDGEIDPEA"
     exon            218..361
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /inference="alignment:Splign:2.1.0"
     exon            362..911
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      890..895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /note="hexamer: AATAAA"
     polyA_site      911
                     /gene="C16orf74"
                     /gene_synonym="ASRA"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgcgg ctgcccgagc gccggccggg ccatgacccc cgctgctctg tcttgcaggc
       61 tcgtcgccgc ggccccccga gcccgaccgc cgccgccacc accaccagcg cccgggcggg
      121 cctcgcgcgc ctcgggcgcg gctccgcagt gagcccacca agaaggaagc ggcctgcaga
      181 ggtgccgaca tggggcttaa gatgtcctgc ctgaaaggct ttcaaatgtg tgtcagcagc
      241 agcagcagca gccacgacga ggcccccgtc ctgaacgaca agcacctgga cgtgcccgac
      301 atcatcatca cgccccccac ccccacgggc atgatgctgc cgagggactt ggggagcaca
      361 gtctggctgg atgagacagg gtcgtgccca gatgatggag aaatcgaccc agaagcctga
      421 ggaggtgtcc tgggtttggc tggctggctc ctgctccagc ggcccggctt caggtgtccg
      481 ggggcgtggc tgcctggagc aggtgtgctg aataccctgg atgggaactg agcgaacccg
      541 ggcctccgct cagagagacg tggcaggacc agcgaggaat ccagcctgtc cacttccaga
      601 acagtgtttc ccaggccccg ctgagtggac cggacctctg acacctccag gttcttgctg
      661 actccggcct ggtgaaaggg agcgccatgg tcctggctgt tggggtccca gggagaggct
      721 ctcttctgga caaacacacc ctcccagccc ccagggctgt gcaaacacat gcccctgcca
      781 taagcaccaa caagaacttc ttgcaggtgg agtggctgtt ttttataagt tgttttacag
      841 atacggaaac agtccaaaat gggatttata atttcttttt tgcattataa ataaagatcc
      901 tctgtaacaa a
//
