LOCUS       NM_175900               2569 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 16 open reading frame 54 (C16orf54), mRNA.
ACCESSION   NM_175900 XM_001128758
VERSION     NM_175900.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Du,X., Xia,W., Fan,W., Shen,X., Wu,H. and Zhang,H.
  TITLE     Integrated Analysis of C16orf54 as a Potential Prognostic,
            Diagnostic, and Immune Marker across Pan-Cancer
  JOURNAL   Dis Markers 2022, 9365046 (2022)
   PUBMED   36118669
  REMARK    GeneRIF: Integrated Analysis of C16orf54 as a Potential Prognostic,
            Diagnostic, and Immune Marker across Pan-Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Kim,S.Y., Theunissen,J.W., Balibalos,J., Liao-Chan,S.,
            Babcock,M.C., Wong,T., Cairns,B., Gonzalez,D., van der Horst,E.H.,
            Perez,M., Levashova,Z., Chinn,L., D'Alessio,J.A., Flory,M.,
            Bermudez,A., Jackson,D.Y., Ha,E., Monteon,J., Bruhns,M.F., Chen,G.
            and Migone,T.S.
  TITLE     A novel antibody-drug conjugate targeting SAIL for the treatment of
            hematologic malignancies
  JOURNAL   Blood Cancer J 5 (5), e316 (2015)
   PUBMED   26024286
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA427069.1, BC104466.2, BC025741.1 and AC009133.7.
            
            On Nov 22, 2018 this sequence version replaced NM_175900.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025741.1, AK093000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329410.4/ ENSP00000327506.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA427069.1         30-31
            3-1287              BC104466.2         1-1285
            1288-1782           BC025741.1         1260-1754
            1783-2055           BC025741.1         1756-2028
            2056-2056           AC009133.7         122413-122413
            2057-2569           BC025741.1         2030-2542
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2569
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /note="chromosome 16 open reading frame 54"
                     /db_xref="GeneID:283897"
                     /db_xref="HGNC:HGNC:26649"
     exon            1..80
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            81..2569
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..755
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /note="Surface Antigen In Leukemia"
                     /codon_start=1
                     /product="transmembrane protein C16orf54"
                     /protein_id="NP_787096.2"
                     /db_xref="CCDS:CCDS10652.1"
                     /db_xref="GeneID:283897"
                     /db_xref="HGNC:HGNC:26649"
                     /translation="MPLTPEPPSGRVEGPPAWEAAPWPSLPCGPCIPIMLVLATLAAL
                     FILTTAVLAERLFRRALRPDPSHRAPTLVWRPGGELWIEPMGTARERSEDWYGSAVPL
                     LTDRAPEPPTQVGTLEARATAPPAPSAPNSAPSNLGPQTVLEVPARSTFWGPQPWEGR
                     PPATGLVSWAEPEQRPEASVQFGSPQARRQRPGSPDPEWGLQPRVTLEQISAFWKREG
                     RTSVGF"
     regulatory      2552..2557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /note="hexamer: AATACA"
     polyA_site      2569
                     /gene="C16orf54"
                     /gene_synonym="SAIL"
                     /note="major polyA site"
ORIGIN      
        1 accctccaag cctgcacctc ttagtccagc accaggaaga gtggctctag gagggagagg
       61 agcccaggga ctgacccaag atgccgttga ctccagagcc gccctctggg cgcgtggagg
      121 ggccccccgc atgggaagca gccccatggc cctcactgcc ctgtgggccc tgcatcccca
      181 tcatgctggt cctggccacc ctggctgcgc tcttcatcct caccaccgct gtgttggctg
      241 aacgcctgtt ccgccgtgct ctccgcccag accccagcca ccgtgcaccc accctggtgt
      301 ggcgcccagg aggagagctg tggattgagc ccatgggcac cgcccgagag cgctctgagg
      361 actggtatgg ctctgcggtc cccctgctga cagatcgggc ccctgagcct cccacccagg
      421 tgggcacttt ggaggcccga gcaacagccc cacctgcccc ctcagcccca aattctgctc
      481 ccagcaactt gggcccccag accgtactgg aggtcccagc ccggagcacc ttctgggggc
      541 cccagccctg ggaggggagg ccccccgcca caggcctggt gagctgggct gaacccgagc
      601 agaggccaga ggccagcgtc cagtttggga gcccccaggc caggaggcag cggccaggga
      661 gcccggatcc tgagtggggc ctccagccac gggtcacctt ggagcagatc tcagctttct
      721 ggaagcgtga aggccggacc agtgtggggt tctgaatccc cagggttccc cagagatccc
      781 cgaggcaggc cttgcctcag tgggaccggg gaccccagga tccagcatta ggattgagac
      841 tgccccagcg aagatgccct tcccaggctc cttccacctg gagtccccct ccccgggtct
      901 gggtggtggc caggctatgt ggactagggg aagcccagca gtgcctctgc tcagctacct
      961 gggctgtggc tcagagacct gggggtggag ccaatgccag gccagaagcc ttcaagatcg
     1021 catccagatg aagaacccaa ggtactagat agtcaggaaa tggcatcgac cagccacctc
     1081 caccttcttt cagtgtttac cgaagccacc aataccaaag agaacgggtc ctgcggtgct
     1141 gaacagcctc ggtgtggcga tgacagctgg caggagatga caggaatcca gtttcccaga
     1201 gccacaaatc ctgttctcct tggccactca cccactgtga ggtcctctag gaaaatacac
     1261 aaagagagga ccagaccagg cagaggaaca ttttgtttca tatgaactgt ggctttgacc
     1321 cccaaactgc aaggaggaac ttgctgggcc aagctgcagc ggcgctgtct tgctggagtg
     1381 gggacctaga gtcagagaaa acccacaggc tcctctgccc attctcctcc atctgcacac
     1441 gtctcagcct cggaccctca ccactccatg gtgaggaagg ccatggccag gggaaactga
     1501 gtttcatcca atgtggagag gagcgttgtc ctagagcagg gcaactccca aactgtgacc
     1561 tctgatcatc gtcccttcca gcttgctgga gtgtccagag agacagattt gccacaagct
     1621 aggcttactt ataatgctcc accctacaga aatgggaccc caagtaccca atcttccctt
     1681 taggagaggc aggcaggtgg gtgagcagca gatgtagttt ccatttccct gggggtttaa
     1741 ttttccaaac tttgtctttt tttttttttt tttttttttt ttgagacaga atctcaactc
     1801 tgtcacccag actggagtgc agtggcacaa tctcaactca ctacagcctc gaactcctag
     1861 gctcaagcga tcctcccacc tcaacctcta gaatagctgg gactgcaggt gcataccacc
     1921 acgcccagct aatttttgta ttttttttgt agagacacgg tctcaccata ctgcctgggc
     1981 aggtttccaa ctcctgggct caagtgatcc agcagcctta gcctcccaaa atgctgggat
     2041 tacaggtatg agcactgcac ccggccactt ttttttgttt ttgaaacagg gtctcactct
     2101 gttgcccagg ctggactaca gtggcacaat ctcagctcac tgcggccttg aactcctggg
     2161 cttaagtgat cctcccacct cagtctccct agtaggtgga actacaggca tgtaccacca
     2221 cacctggcta tttttttttt ttagagacag ggtcttgcta tgttgcccag gctggtcttt
     2281 aattcctggg ctcgagagag ccactcatcc ccatctctca gagtgttggg attacagcca
     2341 tgagccacca tgcccggcca aacttcagcc ttgaatatta gtgattttgc catattagtt
     2401 taccatctgt acaattattt gctttatatt tttctttaaa ttggctcatt attcacttaa
     2461 tgaaattatt gcaacaggaa tcttttgtat cacttctgta aatggaaaac cagtctcatt
     2521 tgccatcaat agaaggtaaa acatgaaaat aaatacaatg taaacaaaa
//
