LOCUS       NM_152337               1599 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens chromosome 16 open reading frame 46 (C16orf46),
            transcript variant 2, mRNA.
ACCESSION   NM_152337
VERSION     NM_152337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA525473.1, AK057264.1, AC092718.3, BC064143.1 and AA905107.1.
            
            On Feb 27, 2020 this sequence version replaced NM_152337.2.
            
            Transcript Variant: This variant (2) lacks differs in the 5' UTR
            and in the 3' UTR and coding region compared to variant 1. The
            resulting isoform (2) has a shorter and distinct C-terminus
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057264.1, BX460147.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299578.10/ ENSP00000299578.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA525473.1         30-68
            40-820              AK057264.1         1-781
            821-821             AC092718.3         121075-121075
            822-879             AK057264.1         783-840
            880-880             BC064143.1         766-766
            881-1423            AK057264.1         842-1384
            1424-1424           AC092718.3         121678-121678
            1425-1569           AK057264.1         1386-1530
            1570-1599           AA905107.1         13-42               c
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..1599
                     /gene="C16orf46"
                     /note="chromosome 16 open reading frame 46"
                     /db_xref="GeneID:123775"
                     /db_xref="HGNC:HGNC:26525"
     exon            1..103
                     /gene="C16orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            104..192
                     /gene="C16orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            193..440
                     /gene="C16orf46"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1418
                     /gene="C16orf46"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C16orf46"
                     /codon_start=1
                     /product="uncharacterized protein C16orf46 isoform 2"
                     /protein_id="NP_689550.2"
                     /db_xref="CCDS:CCDS10932.1"
                     /db_xref="GeneID:123775"
                     /db_xref="HGNC:HGNC:26525"
                     /translation="MDLCQKNETDLENAENNEIQFTEETEPTYTCPDGKSEKNHVYCL
                     LDVSDITLEQDEKAKEFIIGTGWEEAVQGWGRTSPAACIWPRKIPKKARVGEGACSDC
                     LVCVNLSHWSLQTKPPTEGGPEKDQSSPSQTQAAPQGPSTASRAISDICFPTYFRAEK
                     KSLQIKEFIWCNKDWAIPGTNRGKASGNPSGGAHRGLSIPGPLTSRALLVLPPLKASL
                     SNALDVLGKKSKNSFLQSEEKVLDVEKDGCVAYAYGLKTADGKGEKRASELAKHPMVN
                     DTPSSPSPAAQISLLTDPEQRCLHWSLLSEKNLACPPDPSNVRYLAALQLLQKRGVQS
                     YKSKFKAKEPRSPVITRKHVLPKAKQENRPQMLETKVFPRPVLPSLTVSRVIIPVSTH
                     RIL"
     exon            441..1599
                     /gene="C16orf46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgtaaccc aaggcaacgg cccatccggc agcgacctga gtagctcttg ccagtaggcc
       61 gggactagct gtctcggggc cttccatccg cttggcccca caggaaaaga ccccaatatt
      121 ctcttttagt agcggagcgt gttgatcctg cctgaagtac accagtgttc cgaaggtgca
      181 tctggtgatc tgcaagaaga tgttaaaaac tttaagcaag catcacagta atggatctct
      241 gtcagaaaaa tgagactgac ttagaaaatg ctgaaaataa tgaaattcag ttcacagaag
      301 aaacagaacc aacctatact tgtccagatg gaaaaagtga aaaaaatcat gtttattgtc
      361 ttctcgatgt cagtgacatt acgcttgaac aagatgaaaa agccaaagag tttattattg
      421 gaactggatg ggaagaggca gtccaagggt ggggaaggac ttctccagct gcctgcatct
      481 ggccgaggaa gataccaaaa aaggcgaggg taggggaagg tgcctgcagc gactgcttgg
      541 tgtgtgttaa cctctcccac tggagcctcc agaccaagcc tcctactgag gggggcccag
      601 agaaggatca gagcagcccc tcccagactc aggcagcccc ccagggcccc agcactgctt
      661 ccagggcaat tagcgacatc tgctttccca cctactttcg agcagagaaa aaaagtctgc
      721 aaatcaagga gtttatttgg tgcaacaaag actgggccat ccccggcact aataggggca
      781 aggcctctgg gaatcccagt ggaggggccc acagagggct gtccatccca ggccccctga
      841 cttccagggc cctcctagtt ctgcctcccc tgaaggcttc actttcaaat gctttggatg
      901 ttctgggtaa gaagagtaag aactctttct tgcagtcaga agagaaggtg ctggatgtgg
      961 aaaaggatgg gtgtgtggct tatgcatatg gcttgaaaac agcagatggg aaaggtgaaa
     1021 aaagagccag tgagctggcc aaacacccta tggtcaacga cacgccatcc tccccttccc
     1081 cagcggccca gatatccctg ctgaccgatc cggagcagcg ctgcctgcat tggtccctcc
     1141 tgtctgagaa aaacctggcg tgccctccag accccagcaa cgttcgctac cttgctgcct
     1201 tgcagcttct gcagaaacgg ggagtgcaaa gctacaaatc caaattcaaa gccaaggagc
     1261 caagatctcc tgtgatcacc cgaaagcatg ttctcccaaa ggccaagcag gaaaacaggc
     1321 cccaaatgct ggagaccaaa gttttcccaa gacctgtctt gccgtctctc acagtgagca
     1381 gagttatcat tcctgtctct acccacagga tcctctgagc ggttgcggta gaacccctgg
     1441 gaataagcac cgtttgagat gcagccatcc tttctctttc ttctctctca tttcccaccc
     1501 accccccact ctctctttct ctcctccccg tcagtctgtc tttactcttc ttttcctcca
     1561 tttttttttt gtagtacaac tgaagaaaac tgaacctca
//
