LOCUS       NM_001130448            2470 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 15 open reading frame 62 (C15orf62), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001130448 XR_041736 XR_041737 XR_041738
VERSION     NM_001130448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027487.1, AK291344.1, BM706032.1 and CN478592.1.
            
            On May 17, 2019 this sequence version replaced NM_001130448.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC027487.1, SRR7346977.991542.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344320.8/ ENSP00000341178.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               BC027487.1         1-744
            745-1066            AK291344.1         646-967
            1067-1338           BC027487.1         1067-1338
            1339-1695           BM706032.1         27-383
            1696-2283           BC027487.1         1677-2264
            2284-2470           CN478592.1         15-201              c
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2470
                     /gene="C15orf62"
                     /note="chromosome 15 open reading frame 62"
                     /db_xref="GeneID:643338"
                     /db_xref="HGNC:HGNC:34489"
     exon            1..2470
                     /gene="C15orf62"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..1044
                     /gene="C15orf62"
                     /note="uncharacterized protein C15orf62, mitochondrial"
                     /codon_start=1
                     /product="uncharacterized protein C15orf62, mitochondrial
                     precursor"
                     /protein_id="NP_001123920.1"
                     /db_xref="CCDS:CCDS45229.1"
                     /db_xref="GeneID:643338"
                     /db_xref="HGNC:HGNC:34489"
                     /translation="METWRKGSFRNASFFKQLSLGRPRRLRRQSSVLSQASTAGGDHE
                     EYSNREVIRELQGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESSSCPNILEPPPAY
                     TAAYSATLPSALSLSSALHQHSEKGLVDTPCFQRTPTPDLSDPFLSFKVDLGISLLEE
                     VLQMLREQFPSEPSF"
     regulatory      2453..2458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C15orf62"
                     /note="hexamer: AATAAA"
     polyA_site      2470
                     /gene="C15orf62"
                     /note="major polyA site"
ORIGIN      
        1 agccaggcca ctcatcagag tccgggagcc actggcagag agggcacggc cccacactgc
       61 cccagagaca tataggagcc aggcaaacac cagggcgagt gagctcgggc catctgctgc
      121 ctgcctgtgg aaggagcgct cgccagcctc acccagcccg agaaggtcca cctctgcctc
      181 cgccggagct gccctcattc tggctccagt aagtgctgct tcttcctcct gggttttttt
      241 ccactaccct attcagtaac caggccactc ctgtccctgt gggaaactct tgctgccagg
      301 aactcccagc tgtctgctct cctgggcaaa aaagttcctt cttcctgagc cctcctctca
      361 ccatccaaga tgtggtcaaa ggtctgtgct gagtggaaac cctgaggcct ctgctcctag
      421 gggagcctcc ccagctgctg gcactcactg ccccagcagg gaccacatgc accctggctg
      481 ctcctgaaca cctgtctgct ggctcccctg ggccccatgg agacctggcg gaaaggctcc
      541 ttccgcaacg cctccttctt caagcagctg agcctggggc ggccacggcg gctccggcga
      601 cagagtagtg tgcttagcca ggccagcaca gcaggtgggg accacgagga gtacagcaac
      661 cgagaagtca tccgggagct acaagggagg ccagatggcc ggcgcctgcc actgtggggg
      721 gacgagcagc cccgggccac cctgctggcc ccacccaagc ccccacgcct ctaccgagag
      781 agctcaagct gccccaacat cctggagccc ccacctgcct acacagcagc ctactctgcc
      841 accctgccat cggcgctctc tctgtcgagt gccctccacc agcactcaga gaagggcctt
      901 gtggacactc cctgcttcca gaggacacct accccagacc tcagtgatcc cttcctctcc
      961 ttcaaagtgg acctggggat ttcacttctt gaggaagttc tgcagatgct aagggagcag
     1021 tttcctagcg agcccagctt ctaaatgggg tgagggtggg caaagccggg gtgactggaa
     1081 gatccagagg ctggggatta aggaaaggac agggacagga ctccaggccc atcgctggag
     1141 ggttcaggca ggcagagctt cttcatcctg ggggaggatt ccaggatagg aatccagggc
     1201 tctgcctgct ctctgggtcc tggacagtcc ttccaggcac cccagagtgg agggacagag
     1261 gcaatctgga aatgttgggg gggcggccct tcctggcagg accctgaaga aagctggcta
     1321 tgccgggaaa gggaggctgt gccgggaaag ggaggctctg tgcggcacta caggaaccag
     1381 gtagaggctg gcagagccag aaggtggcac ggggtcagat cagggagtgg gaggacacag
     1441 actgagcaga agagatgagt gccccatgcc agcctctttg gaagccactg tcaacagaga
     1501 gaggtcacag gacaagcttg ggtaaaggca gtccaaccca ggcagaagag gaaagtggga
     1561 aggcccagga agaaagggga gaaggcctga ccctgtctaa tctggtggcc actcactgca
     1621 tgacactgaa ttgaaataaa taaaattaac agttcagttc ctcagctgca ccgttattcc
     1681 agattccaca ttccaaatgc ccggtggcca cacatgatta atggctacca cactggtcag
     1741 tgcagaatgg acgtaaacat cgctgcacaa agttctaatg gacagcgctg tctagaccat
     1801 ggcctggagc caccagcaaa ggggaggcgc atacaggggc tggccacata ggaagagata
     1861 ggtagagata gagtataact caggaaaaag accaggcaaa tccttagcag aaatgaggac
     1921 gtggctcagt ctgccaacac agctacccgg agcaatccct ggtgaaggaa ggcagctcta
     1981 gagaatgcca gccacaggca cgcgcacggc ttgcaaaggg gtactttggg gaattcccag
     2041 aattactagt gatgggagcc ctggcaggtt tccttcctcg aagagaggag aactggatcc
     2101 agggatgggc attcaacagc gaagcggcac agctggtttc cagaaccgtc tcccgggatt
     2161 agacagttct gccgcctgaa ccctccgacg atgggcctgc caaccaggcc aagcccactg
     2221 ggtcaaagcc acaggctgtg ctacggcccc accccatggc ctcaccagaa cacagaaacc
     2281 agagcccagc agcactggct gggccatgtg ttggtggccc cccgggactc gctaagagta
     2341 gcaaagggga gagggaagct ctgacacaca ccatttctac gacctaaatc agtggcctcc
     2401 ctctttcctc ctcttgtgta taggtaccga gctgtggata caggagagaa tgaataaaat
     2461 tctaacacaa
//
