LOCUS       NM_001143936            4193 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 15 open reading frame 61 (C15orf61), mRNA.
ACCESSION   NM_001143936 XM_001718659 XM_096885 XM_940644
VERSION     NM_001143936.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   McLaughlin,K.L., Kew,K.A., McClung,J.M. and Fisher-Wellman,K.H.
  TITLE     Subcellular proteomics combined with bioenergetic phenotyping
            reveals protein biomarkers of respiratory insufficiency in the
            setting of proofreading-deficient mitochondrial polymerase
  JOURNAL   Sci Rep 10 (1), 3603 (2020)
   PUBMED   32107436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016355.8, CK903599.1, AK294012.1 and BM664696.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143936.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.210071.1,
                                           SRR1803614.201597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342683.6/ ENSP00000342254.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC016355.8         67250-67302         c
            54-118              CK903599.1         1-65
            119-823             AK294012.1         1-705
            824-1341            AC016355.8         61139-61656         c
            1342-1350           BM664696.1         17-25               c
            1351-4193           AC016355.8         58287-61129         c
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..4193
                     /gene="C15orf61"
                     /note="chromosome 15 open reading frame 61"
                     /db_xref="GeneID:145853"
                     /db_xref="HGNC:HGNC:34453"
     exon            1..464
                     /gene="C15orf61"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..592
                     /gene="C15orf61"
                     /note="uncharacterized protein C15orf61"
                     /codon_start=1
                     /product="uncharacterized protein C15orf61 precursor"
                     /protein_id="NP_001137408.1"
                     /db_xref="CCDS:CCDS45289.1"
                     /db_xref="GeneID:145853"
                     /db_xref="HGNC:HGNC:34453"
                     /translation="MEALRRAHEVALRLLLCRPWASRAAARPKPSASEVLTRHLLQRR
                     LPHWTSFCVPYSAVRNDQFGLSHFNWPVQGANYHVLRTGCFPFIKYHCSKAPWQDLAR
                     QNRFFTALKVVNLGIPTLLYGLGSWLFARVTETVHTSYGPITVYFLNKEDEGAMY"
     exon            465..4193
                     /gene="C15orf61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      669..674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C15orf61"
                     /note="hexamer: AATAAA"
     polyA_site      687
                     /gene="C15orf61"
                     /note="major polyA site"
     regulatory      3169..3174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C15orf61"
                     /note="hexamer: AATAAA"
     polyA_site      3194
                     /gene="C15orf61"
     regulatory      4173..4178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C15orf61"
                     /note="hexamer: AATAAA"
     polyA_site      4193
                     /gene="C15orf61"
ORIGIN      
        1 acaccggggg ctctcgggca cccgcgcggc gccggttggc cttcccggcg ctcgcccggg
       61 ggcgcgcttg cgcgccagcg gctgcggaca ccagcctgcg tccccggcgc ggcgggccat
      121 ggaggccctg aggagggccc acgaggtcgc gctccgcctg ctgctgtgta ggccgtgggc
      181 ctcgcgcgcc gccgcccgcc ccaagcccag cgcctcggag gtgctgacgc ggcatctgct
      241 gcagcggcgc ctgccgcact ggacctcctt ctgcgtgccc tacagcgccg tccgcaacga
      301 ccagttcggc ctctcgcact tcaactggcc ggtgcagggc gccaactacc acgtcctgcg
      361 caccggctgc ttccccttca tcaagtacca ctgctccaag gctccctggc aggacctggc
      421 ccggcagaac cgcttcttca cggcgctcaa ggtcgtcaac ctcggtattc caactttatt
      481 atatggactt ggctcctggt tatttgccag agtcacagag actgtgcata ccagttatgg
      541 acccataaca gtttattttc tcaataaaga agatgaaggt gccatgtatt gaaagtgtgc
      601 gtcaaagaac ataaatatca gtggattttc tctgtgtata tgtgcagtat ttatttttga
      661 tcctttaaaa taaaactttt gcaaatactt ttttctttct acagtatctg cttctttaag
      721 atgaatcatt gccctcaaga ggtgaagctt tttatacatc gttatatatt acatactctg
      781 tttagctgat gtgaactaca aacacatgaa gcttcacacc attttttccc tagaactagg
      841 ttaacctaca gataaaaaat gattacaatg taatagattc tatagttaat taacaattta
      901 aatcaactct gaagagaaaa tatagatgcc cacacaaaag agaagggggg aaaatctttt
      961 atgtaacaat ggaaaaagaa gtagaagaca ttaggatgta tgatggaaat attacatcat
     1021 tggcaaatcc aaaattgatg agaatctaat tgtaatctca agtctaaacc attcagctgc
     1081 caggattgta aatagaaacg ttttaaaggc cttgtgccat ttacctggag gaggggttgg
     1141 agtgtaatgt tgaaacttct tgttgcttaa agagtccaaa accatatcgt ttgtaaaatg
     1201 taataataac tggttaatat aagtgtagca aggtgaatga aactcagact tattaaaagt
     1261 taaaacagct ttcctataaa gctgtaagaa caattaagat cttctagaaa gatgcagaaa
     1321 aataaatttg gtaactgttt ataaaagcaa ttaactgaaa tggtacatat ccatagactt
     1381 attggcaata aggagtgggc tgaaatttta aagacctaat ggcacttttg catttgaatt
     1441 ttattaactt aattgcattt ttgaaagcca agtcatttaa aaaaatgtat ccttggggta
     1501 gtcacaaaat acccagatga atggtaaatt tcagacattt ggagtaattt agggagaact
     1561 aagtagaact atttaatttc taaaccaatg ggtgtttaag atttatgatc tctcccataa
     1621 ttacaaacat acattatata tcattttatg ttaatgtgtt gctgatactc tgcaacactt
     1681 acacattttt gtagcaaaac attttataaa attcaacatt tggatgctta tgtcaagtca
     1741 gtagagaaag tgagtggaag tgactgaggt gaaggcacca gaataatgaa gtaatacaaa
     1801 ctagcttcgt taaaggtagt cattttaaat gatctacaga gtgaactgtt cttcaaatat
     1861 atgtggtgtt cacttgtcta aaagcaattc taagtaacac tttaatcaaa gaagtactta
     1921 tgccaatata tttagtccag aagaatatac ttgacactag ttaaatgaat ggcttacaca
     1981 aaggagatag tgttacatta agcttcatta ataataaaac aactggctat tagcattttg
     2041 cagggaaggc tagaactgat ttcctctgta atgggcaaag ttaaataact atagctcata
     2101 agttttaagt caaatactgc tcattcattg ctgctggtct tgtcaatagt ggctgtaaag
     2161 gtttggtccc aacacaaggc tgataaaatg gtctttaatt accagactat aaatacagct
     2221 tttcagtaga gttgcacctc ttttcacact ggcctgtttg atttctgata atttgtactg
     2281 ctgactctgc ttacctgttt ttcaatagct atagtcagtg tgacttcttg cccatatgtg
     2341 ataggtaagt gtccttggag aacatctttg acaaactacc ctattgatct ctgtaattct
     2401 ctgctgcttg cagcattaaa cagggccttg atttcttgtc tgatgtgctc actgtataac
     2461 aagtaaatgt aatattttct tgtattacat gaaaatcaat agacctcttg ctcttacgga
     2521 gttgatcatg gtgaaggatg aactaactca acaatgggta aaggcgtggt ttaaaaattt
     2581 aaatatcatt cattggattt attaagtctt gtaaacttgt agtctgaaaa caatacttcc
     2641 cattgaacag caatggttta agttttttct ttaaagctgc atattacacc aaagtattat
     2701 ggcctgaaag ggagaaagta taaatgtgta agtcaggaga ctgagtctat ttttagtatt
     2761 ggtgctgtct tactttttga cctcaggcta ataactctcc tcctttgtgt cttggttttt
     2821 ccacctgtaa tctgagaaga acgaaacaag agacatttct acccgaaaat gtacatcaat
     2881 tttacttttg tctctgcaaa agctctgttt ttataatcca cattcttctg ctccattata
     2941 cttaaaggac ttcattaatt aaaaaatttc aaaaataagg tgatggagaa agaaggagag
     3001 atgcattgat agcacatgcc cactaaccct gaagtggcat gtggggagct gaagaggccc
     3061 ttctcttctg catatcagta gttttcttaa ttggtgaaac cactgattag cttttctgtc
     3121 atatttcttt gacaggattt ttatctttaa tccaaccaaa actgttttaa taaaggtgta
     3181 cttttagtac aaaaccttgc atctcttcta ttgttatttc tatacaaatg aattatcacg
     3241 tattggaata aatttctagg caaattccta ggcaaaattc ttagttcctg tgtaagttgt
     3301 gagccactat aaagatgcag taacctattt gggagcgtga gagaggctgc taatacaaaa
     3361 atctctattt tcttagtgtt gatgtcctaa aatgccaaat tgtagaaaca gttatagttt
     3421 accacacatt ttggggcatt aatatttttc taacgttgac ttccgtaaaa attcaaactt
     3481 ttctttttga gaaggagttt cagtcttgtt gtctaggctg gagtgcaatg gtgcgacctt
     3541 ggctcactgc aacctccacc tcccaggtcc aagcgattct cctgtctcag cctcctgagt
     3601 agctgggatt acaggtatgc accaccacgc cggctaattt tgtattttct gtacagacgg
     3661 tttcaccatg ttggtcaggc tggtcttgaa ctcctgatct caggtgatct gccggcctcg
     3721 gcctcccaaa gtgctgggat tacaggcatg agccaccagg cctagctgaa acatttgtaa
     3781 ttattaaaac cgtgtatctt ttaaagtaca ttttacttca tgtcatttat attcacccaa
     3841 aactgtaagc atagaacatc tatagttctt catgaaatat cttttaactc tgttaaagaa
     3901 tgatgtttga ataagtggga tgacataaaa ggcaaagatc ttggtttcac tgcactgaaa
     3961 agctaatgca gataacagaa accttatcct aaagctagtg gattaagtat ctactgttac
     4021 tcaaacaata atgacatttg ggggcatctt aacctaaaca agtacttagc attacatctc
     4081 acctgggtca acagtctaga gtatcagagt taaactctgt tactgtaaat taatggaaaa
     4141 tgtaactgca ctttgctgaa agatcaatgt ccaataaagg ctgcacgatc aaa
//
