LOCUS       NM_015492               4425 bp    mRNA    linear   PRI 04-JUL-2024
DEFINITION  Homo sapiens chromosome 15 open reading frame 39 (C15orf39), mRNA.
ACCESSION   NM_015492 XM_370875
VERSION     NM_015492.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4425)
  AUTHORS   Zhang,M., Xu,Y., Zhu,G., Zeng,Q., Gao,R., Qiu,J., Su,W. and Wang,R.
  TITLE     Human C15orf39 Inhibits Inflammatory Response via PRMT2 in Human
            Microglial HMC3 Cell Line
  JOURNAL   Int J Mol Sci 25 (11), 6025 (2024)
   PUBMED   38892217
  REMARK    GeneRIF: Human C15orf39 Inhibits Inflammatory Response via PRMT2 in
            Human Microglial HMC3 Cell Line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4425)
  AUTHORS   Zhang,T., Fassl,A., Vaites,L.P., Fu,S., Sicinski,P., Paulo,J.A. and
            Gygi,S.P.
  TITLE     Interrogating Kinase-Substrate Relationships with Proximity
            Labeling and Phosphorylation Enrichment
  JOURNAL   J Proteome Res 21 (2), 494-506 (2022)
   PUBMED   35044772
REFERENCE   3  (bases 1 to 4425)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113208.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015492.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110367.1, AK125604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394987.5/ ENSP00000378438.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC113208.5         36032-36209         c
            179-3004            AC113208.5         29267-32092         c
            3005-4425           AC113208.5         25922-27342         c
FEATURES             Location/Qualifiers
     source          1..4425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..4425
                     /gene="C15orf39"
                     /note="chromosome 15 open reading frame 39"
                     /db_xref="GeneID:56905"
                     /db_xref="HGNC:HGNC:24497"
     exon            1..178
                     /gene="C15orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            179..3004
                     /gene="C15orf39"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..3372
                     /gene="C15orf39"
                     /codon_start=1
                     /product="uncharacterized protein C15orf39"
                     /protein_id="NP_056307.3"
                     /db_xref="CCDS:CCDS10276.1"
                     /db_xref="GeneID:56905"
                     /db_xref="HGNC:HGNC:24497"
                     /translation="MAEKRPLRTLGPVMYGKLPRLETDSGLEHSLPHSVGNQDPCTYK
                     GSYFSCPMAGTPKAESEQLASWTPYPPLYSTGMAGPPLQADNLLTNCLFYRSPAEGPE
                     KMQDSSPVELLPFSPQAHSYPGPPLAAPKPVYRNPLCYGLSTCLGEGAVKRPLDVDWT
                     LATGPLLPSADPPCSLAPAPSKGQTLDGTFLRGVPAEGSSKDSSGSFSPCQPFLEKYQ
                     TIHSTGFLASRYTGPYPRNSKQAMSEGPSSPWTQLAQPLGPPCQDTGPTHYPPPHHPP
                     PHPPQALPCPPACRHPEKQGSYSPALPLQPLGGHKGTGYQAGGLGSPYLRQQAAQAPY
                     IPPLGLDAYPYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLSFPYARDDLSLYGASP
                     GLGGTPPSQNNVRAVPQPGAFQRACQPLPASQPCSEPVRPAQEAEEKTWLPSCRKEKL
                     QPRLSEHSGPPIVIRDSPVPCTPPALPPCARECQSLPQKEGARPPSSPPMPVIDNVFS
                     LAPYRDYLDVPAPEATTEPDSATAEPDSAPATSEGQDKGCRGTLPAQEGPSGSKPLRG
                     SLKEEVALDLSVRKPTAEASPVKASRSVEHAKPTAAMDVPDVGNMVSDLPGLKKIDTE
                     APGLPGVPVTTDAMPRTNFHSSVAFMFRKFKILRPAPLPAAVVPSTPTSAPAPTQPAP
                     TPTSGPIGLRILAQQPLSVTCFSLALPSPPAVAVASPAPAPAPSPAPARAQAPASARD
                     PAPAPAPVAGPAPASTSAPGDSLEQHFTGLHASLCDAISGSVAHSPPEKLREWLETAG
                     PWGQAAWQDCQGVQGLLAKLLSQLQRFDRTHRCPFPHVVRAGAIFVPIHLVKERLFPR
                     LPPASVDHVLQEHRVELRPTTLSEERALRELALPGCTSRMLKLLALRQLPDIYPDLLG
                     LQWRDCVRRQLGDFDTEAGAVSSSEPTVARGEPESLALAQKSPAPKVRKPGRKPPTPG
                     PEKAEAAAGEESCGASPTPATSASPPGPTLKARFRSLLETAWLNGLALPTWGHKSSRP
                     DQPSPCPQLLDSQSHHL"
     exon            3005..4425
                     /gene="C15orf39"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3777
                     /gene="C15orf39"
                     /note="major polyA site"
     regulatory      4399..4404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C15orf39"
                     /note="hexamer: ATTAAA"
     polyA_site      4425
                     /gene="C15orf39"
                     /note="major polyA site"
ORIGIN      
        1 agacggcgcc cagcggcggc gcgaacggca gctaggaggg ttgctccggg cttggtgctc
       61 actgcgactt cccgcgcagg gcccggtcgg actaggaccc gcggcctgag agacgctgga
      121 ggatgcggac gcggaggccg cctggggtag cggcggcggg agtcctggcg ctctgcaggt
      181 cagaagttga gtagcagggg cctaggaggg ctcgaagcct tcacagcgat ggcagagaag
      241 cgacccctga gaaccctggg gcctgtgatg tatggcaagc tgccccgctt agagacagac
      301 tccgggctcg agcacagcct gccccactct gttggtaacc aggatccctg cacctacaag
      361 gggtcctact tctcctgccc catggcaggt actcctaagg ccgagtctga gcagttggcg
      421 tcctggaccc catacccacc cttgtactct accggtatgg caggaccccc acttcaggca
      481 gacaacctgc tgaccaactg cctgttctac cgctcgccag cagaaggccc tgagaagatg
      541 caggactcca gccctgttga gctcctgccc ttcagtcccc aggctcactc ctacccaggc
      601 ccaccactgg cagcacccaa acctgtctac cgcaaccctc tgtgctatgg gctctcaact
      661 tgtctggggg aaggagcagt gaagaggcca ctggatgttg actggactct ggcgactggg
      721 cccctgttgc cctcagctga cccaccctgc tctctggccc cagctcctag caagggccag
      781 actctggatg gcaccttctt gcggggggtg ccagctgagg ggtccagtaa agactcctca
      841 gggagcttct ccccatgcca gcccttcctg gagaaatatc agaccatcca cagcacgggc
      901 ttcctggcct ccaggtacac aggtccttac cctaggaact ccaagcaagc aatgtctgag
      961 gggccctcaa gtccttggac ccagctggcc cagcccctgg ggccaccctg tcaggacacc
     1021 gggcccaccc actacccacc accccaccac ccaccacccc accctccaca ggccctgcct
     1081 tgccctccag cctgtcgcca cccagagaag cagggcagct acagcccagc actcccactg
     1141 cagcctctgg ggggccacaa ggggaccggg taccaggctg gtgggctggg cagcccctac
     1201 ctgaggcagc aggcagccca ggcaccttac attcccccac tggggctgga cgcttacccc
     1261 tacccctctg cccctctccc agcaccctct ccaggcctca agctggagcc gcctctcact
     1321 ccacggtgcc cattggactt tgccccccag acactgagtt ttccttatgc ccgggatgac
     1381 ctctctctct atggagcatc ccctgggctt ggagggacac caccttccca gaacaatgtg
     1441 cgggctgtgc cacagcctgg tgccttccag agggcatgcc agcctttgcc agcgagccag
     1501 ccctgctcag agcctgtgag gcctgcacag gaagccgaag agaagacctg gctgcccagc
     1561 tgcaggaaag agaagctcca gccccggctc agtgagcact ctgggccgcc catcgtcatc
     1621 cgagacagtc cagttccctg taccccccca gcactgcccc cctgtgcccg ggagtgccag
     1681 tctcttccac agaaggaggg cgcaaggcca cccagctctc caccaatgcc tgtcattgac
     1741 aatgtcttca gcctggcccc ctaccgtgac tatctggatg tgccggcacc cgaggccaca
     1801 actgagcctg actctgccac agctgagcct gactcagccc cagccaccag tgaaggtcag
     1861 gacaaaggct gcagggggac cctgcctgcc caggagggcc cctcagggag taaaccccta
     1921 aggggctcac ttaaggagga ggtagccctg gatttgagtg tgaggaagcc cacagcagag
     1981 gcctcccctg tcaaggcttc ccgttctgtg gagcatgcca agcctactgc agccatggat
     2041 gtgccagatg tgggcaacat ggtgtcagat ctgccaggcc tgaaaaagat agacacagaa
     2101 gcaccaggct tgcctggggt gccagtgacc acagatgcca tgccaaggac caacttccac
     2161 agctctgtgg ccttcatgtt ccgaaagttc aagatcctcc gtccggcacc tttgcctgca
     2221 gccgtggtcc cgtccacgcc cacctcagct cctgctccca cacagcctgc acccaccccc
     2281 acatctgggc ccattggact gcggattctc gctcaacagc ccttgtctgt gacctgcttc
     2341 agcctggcac tgcccagccc tccagccgta gctgtggcct cccctgcccc tgctccagct
     2401 ccatcccctg ctccggctcg agctcaggct ccagcttcag cccgggatcc agctccagct
     2461 ccagctccag ttgcaggccc tgctccagca tctacttcag ccccagggga ctccctggag
     2521 cagcatttta caggactaca tgcgtccctg tgtgatgcta tttctggctc cgtcgcccac
     2581 tctcctccag agaagcttcg cgagtggcta gagacggctg ggccctgggg ccaggctgcg
     2641 tggcaggact gccagggtgt gcaggggctg ctggccaagc tgctgtctca gctgcagcgc
     2701 ttcgatcgca cccaccggtg ccccttcccc catgtggtgc gagctggcgc catcttcgtg
     2761 cccattcacc tggtgaagga gcggctcttc cctcggctgc cacccgcttc tgtggaccat
     2821 gtgctgcagg agcatcgtgt ggagctgcgg cccaccacgc tgtcggagga gcgggcactg
     2881 cgggagctcg ccctgccagg ctgcacctca cgcatgctga agttactggc gctgcgccag
     2941 ctgccggaca tttaccccga ccttctcggc ctgcagtggc gcgactgtgt acgccgccag
     3001 ctgggtgact ttgacactga ggctggagct gtgtcctcct cagagcccac tgtggccaga
     3061 ggtgagccag agagcctagc cctggctcag aagtcaccgg cccccaaggt caggaagcca
     3121 ggcaggaagc caccaacccc tggcccggag aaagcagagg cagctgctgg ggaagagtcc
     3181 tgtggtgcct cccctacccc tgctaccagt gccagcccac ctggccccac actgaaggcc
     3241 cgcttccgca gtctgctgga gaccgcctgg ctcaatggcc tggctctgcc cacctggggc
     3301 cacaagtcct caagaccaga ccagccctca ccctgcccac agctgctgga cagccagagc
     3361 catcacctgt agcactggtt gccagtgctg tgtgtatagc agtcactctc cacccttccc
     3421 ttctgcctgc ccagctgccc cggggccacg agtggatgct ggggctgtgg ctgctcccct
     3481 ggaggggttc catctctgac cctgtggccc attcagggtg ggctgaagag cccctgagct
     3541 tttaacgtga gggtctttat tggataggac tactccctat ttcttgccta gagaacacac
     3601 atgggctttg gagcccgaca gacctgggct tgaatcccgg ctcgtgttct tgctgcagga
     3661 cctgggcaag aaacttcacc tctgctgagc cctcattccc catgtgtaaa atgggacaac
     3721 gcaacctacc tcacagggtt gttgtgggga tgctgcctga tacataccct gtcaccattt
     3781 ggtctctgct tcctctctgg gacagggcct agaattggag gcagagaacc ttcctataga
     3841 aagtcttcgt gtgtcctagg acttggctat cgtagagtgg taccttaggc agtggatgtg
     3901 actcacactt tcaggagtca ccccccagca tttggggttg ggttggccct actccagcct
     3961 ggagctccct gagggagcct gcactccctg ctcccaatcc ccgctactgg tgcagggatg
     4021 cagcctggag ctggcgtcct tgttctgggc ctgctgctgc cgccacccca ggaggcccca
     4081 ggcctgtcct gaattgacat cagtgcttcc ctgaactgcc tcccccaccc ctggcattat
     4141 cccaggaaac ttatgttttc tagaagctaa gcagctgctg ggactcaggg actggtgcag
     4201 gtaggctgag tggcagctca gtcctagaag gtctctgaag atctggactg aggaccctgc
     4261 tgctccccaa gccagagccc atcagccagg cctgctgtga gccacctgcc tgtggagtgc
     4321 tgagctcaac caaaggctgg caagctctgg gcctcattta agggattctg atgagccgat
     4381 gggccctgga ggcagcccat taaagcatct ggctcgtttt tggaa
//
