LOCUS       NM_001282970            2233 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 14 open reading frame 93 (C14orf93),
            transcript variant 7, mRNA.
ACCESSION   NM_001282970 XM_005267974
VERSION     NM_001282970.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Yu,Y., Liu,C., Zhang,J., Zhang,M., Wen,W., Ruan,X., Li,D.,
            Zhang,S., Gao,M. and Chen,L.
  TITLE     Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and
            in vivo Thyroid Function
  JOURNAL   Sci Rep 7, 43396 (2017)
   PUBMED   28230092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Liu,C., Yu,Y., Yin,G., Zhang,J., Wen,W., Ruan,X., Li,D., Zhang,S.,
            Cai,W., Gao,M. and Chen,L.
  TITLE     C14orf93 (RTFC) is identified as a novel susceptibility gene for
            familial nonmedullary thyroid cancer
  JOURNAL   Biochem Biophys Res Commun 482 (4), 590-596 (2017)
   PUBMED   27864143
  REMARK    GeneRIF: RTFC promotes thyroid cancer cell survival under starving
            conditions, and thyroid cancer cell migration. The R115Q, V205M and
            G209D RTFC mutants enhance the colony forming capacity of thyroid
            cancer cells, and are able to transform normal thyroid cells. In
            summary, our data suggest the roles of RTFC in thyroid
            carcinogenesis.
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Fatemifar,G., Hoggart,C.J., Paternoster,L., Kemp,J.P.,
            Prokopenko,I., Horikoshi,M., Wright,V.J., Tobias,J.H., Richmond,S.,
            Zhurov,A.I., Toma,A.M., Pouta,A., Taanila,A., Sipila,K.,
            Lahdesmaki,R., Pillas,D., Geller,F., Feenstra,B., Melbye,M.,
            Nohr,E.A., Ring,S.M., St Pourcain,B., Timpson,N.J., Davey Smith,G.,
            Jarvelin,M.R. and Evans,D.M.
  TITLE     Genome-wide association study of primary tooth eruption identifies
            pleiotropic loci associated with height and craniofacial distances
  JOURNAL   Hum Mol Genet 22 (18), 3807-3817 (2013)
   PUBMED   23704328
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA891690.1, BC014299.2, BX161383.1 and CN309429.1.
            
            On May 31, 2019 this sequence version replaced NM_001282970.1.
            
            Transcript Variant: This variant (7) uses an alternate exon
            structure in the 3' coding region, compared to variant 1. The
            encoded isoform (c) is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014299.2 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA891690.1         59-81
            24-1602             BC014299.2         1-1579
            1603-1734           BX161383.1         1598-1729
            1735-2028           CN309429.1         284-577
            2029-2233           BC014299.2         2006-2210
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2233
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="chromosome 14 open reading frame 93"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
     exon            1..43
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            44..1019
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1919
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="isoform c is encoded by transcript variant 7;
                     uncharacterized protein C14orf93; regulator of thyroid
                     function and cancer"
                     /codon_start=1
                     /product="uncharacterized protein C14orf93 isoform c"
                     /protein_id="NP_001269899.1"
                     /db_xref="CCDS:CCDS61400.1"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
                     /translation="MSFSATILFSPPSGSEARCCCCACKSETNGGNTGSQGGNPPPST
                     PITVTGHGLAVQSSEQLLHVIYQRVDKAVGLAEAALGLARANNELLKRLQEEVGDLRQ
                     GKVSIPDEDGESRAHSSPPEEPGPLKESPGEAFKALSAVEEECDSVGSGVQVVIEELR
                     QLGAASVGPGPLGFPATQRDMRLPGCTLAASEAAPLLNPLVDDYVASEGAVQRVLVPA
                     YAKQLSPATQLAIQRATPETGPENGTKLPPPRPEDMLNAAAALDSALEESGPGSTGEL
                     RHSLGLTVSPCRTRGSGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNI
                     SVVKFLLEKLKQELVTSPHNYTDKELKGACVAYFLTKRREYRNSLNPFKGLKEKEEKK
                     LRSRRYRLFANRSSIMRHFGPEDQRLWNDVTEELMSDEEDSLNEPDRLPSAEAQLLPP
                     ELYNPNFQEEEDEGGDENAPGSPSFDQPHKTCCPDLNSFIEIKVEKDE"
     exon            1020..1340
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1402
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1506
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1619
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1734
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..2233
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AATAAA"
     polyA_site      1938
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="major polyA site"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AATAAT"
     polyA_site      2030
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
     regulatory      2208..2213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AAGAAA"
     polyA_site      2233
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
ORIGIN      
        1 ctttttgcac acacacgaat acaaagagcc atacgacctt cggatgccgg aaggtccttc
       61 tgaatccctt ccctgttcct taggttgcac tagtcggggg ttccatgctg gggggcagaa
      121 ggaatgctct ctaccgtctg aaaccgttca tcaggaaggc cttgatttgt gatgtgctag
      181 gagagcacag gatctgcaaa tagaaggcac ctgtctccct tctgcaggcc gaggagaggc
      241 cgccatggac tgtgtgcttc ttcatggctt gtttactctt ctttcacaga ccctacagct
      301 tggggcctgg gctcctctga ccatcctcat tgagaaagga aagtgagtcc agagaagttg
      361 atgcttccta cctgttggag cggcccagca gtgtaagcgt ggttgttact gccccatccg
      421 ccatgtcctt cagtgccacc attctcttct cccctcccag tggcagcgag gccagatgct
      481 gctgctgcgc ctgtaagagt gagactaatg gaggcaacac aggctcccag ggtgggaatc
      541 ctcctcccag cacccccatc acagtgactg gacatggctt ggctgttcag agctcagagc
      601 agctcctgca tgttatctac cagcgggtcg ataaggcagt gggtttggct gaagctgctc
      661 tgggtcttgc cagggccaac aatgagttgt taaaacgtct ccaggaggaa gtgggtgacc
      721 tgaggcaagg gaaagtgtcc atccctgatg aagatgggga aagccgggca catagttccc
      781 cacctgagga gcctgggcct ctcaaggaaa gtcccgggga agcctttaag gctctgtctg
      841 ccgtggaaga ggagtgtgac agcgtgggca gcggcgtgca ggtggtgatt gaggagctgc
      901 ggcagctggg agcagcctca gtggggcctg ggcctttggg cttcccagca actcagaggg
      961 acatgcggct cccagggtgc acgctggctg ccagcgaggc ggcccccctg ctcaatcctc
     1021 tggtggatga ttacgtggcc tctgagggtg cagtacagcg agttctggtc cctgcttatg
     1081 ccaagcaact ctcaccagcc acacaactgg caatccagcg ggcaacccca gagacaggac
     1141 cagaaaatgg aaccaagctg ccaccacccc gccctgagga catgctcaat gccgctgctg
     1201 cgctggacag tgccttggaa gagtcaggcc ctgggagcac tggggagctg agacactctc
     1261 tagggctgac cgtttcccca tgcaggacca gaggaagtgg gcagaagaac tccaggcgca
     1321 agcgggatct tgtactctct aaactggtcc acaatgtgca taaccacatc accaatgaca
     1381 agagattcaa tgggtctgaa agcatcaagt cctcttggaa tatttcagta gtgaagtttc
     1441 ttctggaaaa gctcaagcaa gagctggtga ccagtcccca caattacact gataaggagc
     1501 taaaaggagc ctgtgtggcc tacttcctta ctaagaggcg tgagtaccgc aactccctga
     1561 acccctttaa aggcctgaag gaaaaagagg agaagaaact tcgaagtcgc cgatatcggc
     1621 tttttgccaa ccgatccagt atcatgaggc attttggacc tgaggaccaa cgtctgtgga
     1681 atgatgtgac agaggaactg atgtcagatg aagaggacag tcttaacgag ccagacagac
     1741 tgccttctgc tgaagcccag ctccttccac cagaacttta caatcctaat ttccaagaag
     1801 aggaagatga gggaggggat gagaatgcac ctggctcccc atcttttgac caaccccaca
     1861 aaacctgctg tcctgacttg aactcattca ttgaaatcaa ggtggaaaag gatgaataaa
     1921 atctacagcc aagaataact ctggcttccg ccatgcccca tgtctcagaa ataggtggcc
     1981 atggggcttc acaaaataat gagatgctct gtgcagtctg agaaagcaaa tttgcctctt
     2041 ttcttaacac agtctctact ggggaagcag aacactggtg ggataaaaac ttatctagaa
     2101 ggggagaaac tccctccact gtgaacagta agccagaata tgcttattcc tcagcataaa
     2161 cagtatctcg gagaagcctg ggatgagaaa atgaggagga tgggtccaag aaacatgagg
     2221 ccttcttgac ata
//
