LOCUS       NM_001282968            3048 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 14 open reading frame 93 (C14orf93),
            transcript variant 5, mRNA.
ACCESSION   NM_001282968 XM_005267975
VERSION     NM_001282968.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3048)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3048)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3048)
  AUTHORS   Yu,Y., Liu,C., Zhang,J., Zhang,M., Wen,W., Ruan,X., Li,D.,
            Zhang,S., Gao,M. and Chen,L.
  TITLE     Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and
            in vivo Thyroid Function
  JOURNAL   Sci Rep 7, 43396 (2017)
   PUBMED   28230092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3048)
  AUTHORS   Liu,C., Yu,Y., Yin,G., Zhang,J., Wen,W., Ruan,X., Li,D., Zhang,S.,
            Cai,W., Gao,M. and Chen,L.
  TITLE     C14orf93 (RTFC) is identified as a novel susceptibility gene for
            familial nonmedullary thyroid cancer
  JOURNAL   Biochem Biophys Res Commun 482 (4), 590-596 (2017)
   PUBMED   27864143
  REMARK    GeneRIF: RTFC promotes thyroid cancer cell survival under starving
            conditions, and thyroid cancer cell migration. The R115Q, V205M and
            G209D RTFC mutants enhance the colony forming capacity of thyroid
            cancer cells, and are able to transform normal thyroid cells. In
            summary, our data suggest the roles of RTFC in thyroid
            carcinogenesis.
REFERENCE   5  (bases 1 to 3048)
  AUTHORS   Fatemifar,G., Hoggart,C.J., Paternoster,L., Kemp,J.P.,
            Prokopenko,I., Horikoshi,M., Wright,V.J., Tobias,J.H., Richmond,S.,
            Zhurov,A.I., Toma,A.M., Pouta,A., Taanila,A., Sipila,K.,
            Lahdesmaki,R., Pillas,D., Geller,F., Feenstra,B., Melbye,M.,
            Nohr,E.A., Ring,S.M., St Pourcain,B., Timpson,N.J., Davey Smith,G.,
            Jarvelin,M.R. and Evans,D.M.
  TITLE     Genome-wide association study of primary tooth eruption identifies
            pleiotropic loci associated with height and craniofacial distances
  JOURNAL   Hum Mol Genet 22 (18), 3807-3817 (2013)
   PUBMED   23704328
REFERENCE   6  (bases 1 to 3048)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA891690.1, BX161507.1, CN309429.1, BC014299.2 and AL132780.5.
            
            On May 31, 2019 this sequence version replaced NM_001282968.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus than isoform a. Variants 5 and
            6 encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX161507.1, SRR1803616.260738.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA891690.1         59-79
            22-1797             BX161507.1         1-1776
            1798-1836           CN309429.1         539-577
            1837-2041           BC014299.2         2006-2210
            2042-3048           AL132780.5         89691-90697         c
FEATURES             Location/Qualifiers
     source          1..3048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3048
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="chromosome 14 open reading frame 93"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
     exon            1..43
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            44..392
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            393..707
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     CDS             651..1727
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="isoform b is encoded by transcript variant 5;
                     uncharacterized protein C14orf93; regulator of thyroid
                     function and cancer"
                     /codon_start=1
                     /product="uncharacterized protein C14orf93 isoform b"
                     /protein_id="NP_001269897.1"
                     /db_xref="CCDS:CCDS61399.1"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
                     /translation="MRLPGCTLAASEAAPLLNPLVDDYVASEGAVQRVLVPAYAKQLS
                     PATQLAIQRATPETGPENGTKLPPPRPEDMLNAAAALDSALEESGPGSTGELRHSLGL
                     TVSPCRTRGSGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNISVVKFL
                     LEKLKQELVTSPHNYTDKELKGACVAYFLTKRREYRNSLNPFKGLKEKEEKKLRSRRY
                     RLFANRSSIMRHFGPEDQRLWNDVTEELMSDEEDSLNEPGVWVARPPRFRAQRLTELC
                     YHLDANSKHGTKANRVYGPPSDRLPSAEAQLLPPELYNPNFQEEEDEGGDENAPGSPS
                     FDQPHKTCCPDLNSFIEIKVEKDE"
     exon            708..1028
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1090
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1194
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1307
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..3048
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AATAAA"
     polyA_site      1746
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="major polyA site"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AATAAT"
     polyA_site      1838
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AAGAAA"
     polyA_site      2041
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
     polyA_site      2189
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /note="hexamer: AATAAA"
     polyA_site      3043
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
ORIGIN      
        1 ctttttgcac acacacgaat acaaagagcc atacgacctt cggatgccgg aaggtccttc
       61 tgaatccctt ccctgttcct taggttgcac tagtcggggg ttccatgctg gggggcagaa
      121 ggaatgctct ctaccgtctg aaaccgttca tcaggaaggc cttgatttgt gatgtgctag
      181 gagagcacag gatctgcaaa tagaaggcac ctgtctccct tctgcaggcc gaggagaggc
      241 cgccatggac tgtgtgcttc ttcatggctt gtttactctt ctttcacaga ccctacagct
      301 tggggcctgg gctcctctga ccatcctcat tgagaaagga aagtgagtcc agagaagttg
      361 atgcttccta cctgttggag cggcccagca gtgaggaagt gggtgacctg aggcaaggga
      421 aagtgtccat ccctgatgaa gatggggaaa gccgggcaca tagttcccca cctgaggagc
      481 ctgggcctct caaggaaagt cccggggaag cctttaaggc tctgtctgcc gtggaagagg
      541 agtgtgacag cgtgggcagc ggcgtgcagg tggtgattga ggagctgcgg cagctgggag
      601 cagcctcagt ggggcctggg cctttgggct tcccagcaac tcagagggac atgcggctcc
      661 cagggtgcac gctggctgcc agcgaggcgg cccccctgct caatcctctg gtggatgatt
      721 acgtggcctc tgagggtgca gtacagcgag ttctggtccc tgcttatgcc aagcaactct
      781 caccagccac acaactggca atccagcggg caaccccaga gacaggacca gaaaatggaa
      841 ccaagctgcc accaccccgc cctgaggaca tgctcaatgc cgctgctgcg ctggacagtg
      901 ccttggaaga gtcaggccct gggagcactg gggagctgag acactctcta gggctgaccg
      961 tttccccatg caggaccaga ggaagtgggc agaagaactc caggcgcaag cgggatcttg
     1021 tactctctaa actggtccac aatgtgcata accacatcac caatgacaag agattcaatg
     1081 ggtctgaaag catcaagtcc tcttggaata tttcagtagt gaagtttctt ctggaaaagc
     1141 tcaagcaaga gctggtgacc agtccccaca attacactga taaggagcta aaaggagcct
     1201 gtgtggccta cttccttact aagaggcgtg agtaccgcaa ctccctgaac ccctttaaag
     1261 gcctgaagga aaaagaggag aagaaacttc gaagtcgccg atatcggctt tttgccaacc
     1321 gatccagtat catgaggcat tttggacctg aggaccaacg tctgtggaat gatgtgacag
     1381 aggaactgat gtcagatgaa gaggacagtc ttaacgagcc aggtgtgtgg gtggcccgcc
     1441 ctccccgttt ccgggcccag cgcctcacag agctctgcta ccacctggat gctaactcta
     1501 agcatggcac caaagccaac cgtgtgtatg ggcctccctc agacagactg ccttctgctg
     1561 aagcccagct ccttccacca gaactttaca atcctaattt ccaagaagag gaagatgagg
     1621 gaggggatga gaatgcacct ggctccccat cttttgacca accccacaaa acctgctgtc
     1681 ctgacttgaa ctcattcatt gaaatcaagg tggaaaagga tgaataaaat ctacagccaa
     1741 gaataactct ggcttccgcc atgccccatg tctcagaaat aggtggccat ggggcttcac
     1801 aaaataatga gatgctctgt gcagtctgag aaagcaaatt tgcctctttt cttaacacag
     1861 tctctactgg ggaagcagaa cactggtggg ataaaaactt atctagaagg ggagaaactc
     1921 cctccactgt gaacagtaag ccagaatatg cttattcctc agcataaaca gtatctcgga
     1981 gaagcctggg atgagaaaat gaggaggatg ggtccaagaa acatgaggcc ttcttgacat
     2041 atgccctgtc tctgagttgt ttctgcccct gcccagttcc acccaaagct ctgaggaagc
     2101 agcccaggtt gtaccttttg cttccctgtg actacttgtc ttgctctgca gtggaaaccg
     2161 aacatgacca gtgcaggtta ataccgccac ctggtgggca gtttcagtca tgagcttgag
     2221 tcttctgacc aagggaacac aagttctatc actattgggg aattgggttc ctgatataat
     2281 agctattgtt tattgaatta catgaggaaa attttactat tcctatctta cagatgagga
     2341 aattaaggct taaagagttc ccgtgtctca ccggcagcct ctctctcact atgtgaccaa
     2401 gcaaaataca cagctttgta gctgtttctt ggtcctgtca gccaagctgt attttgagga
     2461 aggggtgtgc attttggatg gattgaaaag caaaaatggc tttacattta ttcagtctta
     2521 taacaaacat tgatcgcttt actaggtgtc aggtactgtg ctatggatac attgttgata
     2581 aggttggatg ctgttcagag atttttttag tttagtcagg aagccaggca gtggagtagg
     2641 caatgaaatg aactgtgata agggtgacca tggtggagtg tagtgcacta tggcaatata
     2701 cagcaggggt agctaaccta ctcttgcagt ctggaaaggc ttcttctgag agggtgtaat
     2761 gtctaaactg gggaagagtt aaccagaagg aaaggggagg ctaagagagt gttccaaaca
     2821 gggaactgca ggtacaaaag tccaggggca agagagagta cagacaaggt ccagttctac
     2881 tgcagacttt tggggaaggg ataatgctag aggagaggct ggagagtgag acagacctca
     2941 taatacagag tacagacttc aacccaaggg cagtgagaaa tcattgaaag tttgttttag
     3001 cagggaaata aaacgacagg ttttgcctac aggcagtccc caactcaa
//
