LOCUS       NM_174978               2780 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens chromosome 14 open reading frame 39 (C14orf39), mRNA.
ACCESSION   NM_174978
VERSION     NM_174978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Ali,H., Unar,A., Zubair,M., Dil,S., Ullah,F., Khan,I., Hussain,A.
            and Shi,Q.
  TITLE     In silico analysis of a novel pathogenic variant c.7G > A in
            C14orf39 gene identified by WES in a Pakistani family with
            azoospermia
  JOURNAL   Mol Genet Genomics 297 (3), 719-730 (2022)
   PUBMED   35305148
  REMARK    GeneRIF: In silico analysis of a novel pathogenic variant c.7G > A
            in C14orf39 gene identified by WES in a Pakistani family with
            azoospermia.
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Hou,D., Yao,C., Xu,B., Luo,W., Ke,H., Li,Z., Qin,Y. and Guo,T.
  TITLE     Variations of C14ORF39 and SYCE1 Identified in Idiopathic Premature
            Ovarian Insufficiency and Nonobstructive Azoospermia
  JOURNAL   J Clin Endocrinol Metab 107 (3), 724-734 (2022)
   PUBMED   34718620
  REMARK    GeneRIF: Variations of C14ORF39 and SYCE1 Identified in Idiopathic
            Premature Ovarian Insufficiency and Nonobstructive Azoospermia.
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Fan,S., Jiao,Y., Khan,R., Jiang,X., Javed,A.R., Ali,A., Zhang,H.,
            Zhou,J., Naeem,M., Murtaza,G., Li,Y., Yang,G., Zaman,Q., Zubair,M.,
            Guan,H., Zhang,X., Ma,H., Jiang,H., Ali,H., Dil,S., Shah,W.,
            Ahmad,N., Zhang,Y. and Shi,Q.
  TITLE     Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Am J Hum Genet 108 (2), 324-336 (2021)
   PUBMED   33508233
  REMARK    GeneRIF: Homozygous mutations in C14orf39/SIX6OS1 cause
            non-obstructive azoospermia and premature ovarian insufficiency in
            humans.
            Erratum:[Am J Hum Genet. 2022 Jul 7;109(7):1343. doi:
            10.1016/j.ajhg.2022.06.006.. PMID: 35803236]
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Gomez-H,L., Felipe-Medina,N., Sanchez-Martin,M., Davies,O.R.,
            Ramos,I., Garcia-Tunon,I., de Rooij,D.G., Dereli,I., Toth,A.,
            Barbero,J.L., Benavente,R., Llano,E. and Pendas,A.M.
  TITLE     C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and
            is essential for mouse fertility
  JOURNAL   Nat Commun 7, 13298 (2016)
   PUBMED   27796301
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Verhoeven,V.J., Hysi,P.G., Wojciechowski,R., Fan,Q.,
            Guggenheim,J.A., Hohn,R., MacGregor,S., Hewitt,A.W., Nag,A.,
            Cheng,C.Y., Yonova-Doing,E., Zhou,X., Ikram,M.K., Buitendijk,G.H.,
            McMahon,G., Kemp,J.P., Pourcain,B.S., Simpson,C.L., Makela,K.M.,
            Lehtimaki,T., Kahonen,M., Paterson,A.D., Hosseini,S.M., Wong,H.S.,
            Xu,L., Jonas,J.B., Parssinen,O., Wedenoja,J., Yip,S.P., Ho,D.W.,
            Pang,C.P., Chen,L.J., Burdon,K.P., Craig,J.E., Klein,B.E.,
            Klein,R., Haller,T., Metspalu,A., Khor,C.C., Tai,E.S., Aung,T.,
            Vithana,E., Tay,W.T., Barathi,V.A., Chen,P., Li,R., Liao,J.,
            Zheng,Y., Ong,R.T., Doring,A., Evans,D.M., Timpson,N.J.,
            Verkerk,A.J., Meitinger,T., Raitakari,O., Hawthorne,F.,
            Spector,T.D., Karssen,L.C., Pirastu,M., Murgia,F., Ang,W.,
            Mishra,A., Montgomery,G.W., Pennell,C.E., Cumberland,P.M.,
            Cotlarciuc,I., Mitchell,P., Wang,J.J., Schache,M.,
            Janmahasatian,S., Igo,R.P. Jr., Lass,J.H., Chew,E., Iyengar,S.K.,
            Gorgels,T.G., Rudan,I., Hayward,C., Wright,A.F., Polasek,O.,
            Vatavuk,Z., Wilson,J.F., Fleck,B., Zeller,T., Mirshahi,A.,
            Muller,C., Uitterlinden,A.G., Rivadeneira,F., Vingerling,J.R.,
            Hofman,A., Oostra,B.A., Amin,N., Bergen,A.A., Teo,Y.Y., Rahi,J.S.,
            Vitart,V., Williams,C., Baird,P.N., Wong,T.Y., Oexle,K.,
            Pfeiffer,N., Mackey,D.A., Young,T.L., van Duijn,C.M., Saw,S.M.,
            Bailey-Wilson,J.E., Stambolian,D., Klaver,C.C. and Hammond,C.J.
  CONSRTM   Consortium for Refractive Error and Myopia (CREAM); Diabetes
            Control and Complications Trial/Epidemiology of Diabetes
            Interventions and Complications (DCCT/EDIC) Research Group;
            Wellcome Trust Case Control Consortium 2 (WTCCC2); Fuchs' Genetics
            Multi-Center Study Group
  TITLE     Genome-wide meta-analyses of multiancestry cohorts identify
            multiple new susceptibility loci for refractive error and myopia
  JOURNAL   Nat Genet 45 (3), 314-318 (2013)
   PUBMED   23396134
  REMARK    Erratum:[Nat Genet. 2013 Jun;45(2):712. Janmahasathian, Sarayut
            [corrected to Sarayut Janmahasatian]]
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Alfano,G., Vitiello,C., Caccioppoli,C., Caramico,T., Carola,A.,
            Szego,M.J., McInnes,R.R., Auricchio,A. and Banfi,S.
  TITLE     Natural antisense transcripts associated with genes involved in eye
            development
  JOURNAL   Hum Mol Genet 14 (7), 913-923 (2005)
   PUBMED   15703187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL122057.4 and AL132778.6.
            
            On Nov 23, 2018 this sequence version replaced NM_174978.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832219.1, AK098187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321731.8/ ENSP00000324920.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL122057.4         135930-136048       c
            120-176             AL122057.4         135015-135071       c
            177-233             AL122057.4         134866-134922       c
            234-360             AL122057.4         133676-133802       c
            361-450             AL122057.4         128285-128374       c
            451-638             AL122057.4         121537-121724       c
            639-681             AL122057.4         121402-121444       c
            682-802             AL122057.4         119518-119638       c
            803-894             AL122057.4         118430-118521       c
            895-1022            AL122057.4         116902-117029       c
            1023-1099           AL122057.4         115964-116040       c
            1100-1185           AL122057.4         111493-111578       c
            1186-1244           AL122057.4         111339-111397       c
            1245-1306           AL122057.4         108663-108724       c
            1307-1485           AL122057.4         106902-107080       c
            1486-1630           AL132778.6         168980-169124       c
            1631-1688           AL132778.6         156053-156110       c
            1689-2780           AL132778.6         149935-151026       c
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..2780
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /note="chromosome 14 open reading frame 39"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
     exon            1..119
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            120..176
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1891
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /note="six6 opposite strand transcript 1"
                     /codon_start=1
                     /product="protein SIX6OS1"
                     /protein_id="NP_777638.3"
                     /db_xref="CCDS:CCDS9746.1"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
                     /translation="MNDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKEN
                     KVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQG
                     TVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLK
                     MNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEI
                     EINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLF
                     LPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNH
                     SKCSHITTITSSQKFMQVRLLTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTS
                     QAIYTEHFGKSVENDSDEVEERAENFPRTSEIPIFLGTPKAVKAPESLEKIKFPKTPP
                     FEINRNRNAVPEVQTEKESPGLSFLMSYTSRSPGLNLFDSSVFDTEISSDQFNEHYSA
                     RNLNPLSSEQEIGNLLEKPEGEDGFTFSFPSDTSTHTFGAGKDDFSFPFSFGQGQNSI
                     PSSSLKGFSSSSQNTTQFTFF"
     exon            177..233
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            234..360
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            361..450
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            451..638
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            639..681
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            682..802
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            803..894
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1022
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1099
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1185
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1244
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1306
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1485
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1630
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1688
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..2780
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /note="hexamer: AATAAA"
     polyA_site      2780
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /note="major polyA site"
ORIGIN      
        1 gagtccagcc cagggctccg gggaccgttt gtagttagga tccgctgtgg cgtcctgagt
       61 ggagtttggg accccaggga gggagggtgt gggcgttcgg gtccagagga gctgtttagt
      121 atccaagatg aatgacagcc tgtttgtcag tttggacaga cttttgctag aatttgtctt
      181 ccagtatgag caagacataa gtactaaaga agagatgatt caaagaatta ataaatgctg
      241 tgaagatatt aaggaaaaca aagtaactat ttgtaggata cacgaaacta taaatgcaac
      301 agatgaggaa attgatcatt actgtaaaca tagtgaggag attaaagaca actgtagaaa
      361 ctggaagcca acatgtgatg tttttcgtaa acatgaagat tatatgcagg accaatttac
      421 tgtttatcaa ggaactgttg aaaaagacaa agaaatgtat catgattata tatgtcagta
      481 taaagaagtt ttgaagcagt accaactaaa atactcagaa acaccctttt cacgtgaata
      541 ttatgagaag aaaagagaac atgaagaaat tcaaagcaga gtgttggcat gtactgaaca
      601 attaaaaatg aatgaaacaa tttttatgaa atttcgagtg cctgctccct ttccatcact
      661 tactaaatgg actttaaaca ttgttaattt gagatgtgaa acacaagata ttcttaaaca
      721 tgccagcaat cttaccaaaa gttcatccga attgaagaaa gaagtagatg aaatggaaat
      781 agaaattaat tatttaaacc agcagatatc taggcataat gaaactaagg ctctttcaga
      841 aactctggaa gaaaagaaca aaaatacaga aaacagaaaa gaactgaaag aaagaatttt
      901 tggaaaagat gagcatgtac ttacattgaa taaaactcaa agcagtcaat tatttcttcc
      961 ttatgaatct cagaaattag taagaccaat aaagatgcat tcttcagaac caagagttgc
     1021 agatataaaa gaagaaagtt ctgcgaagca gtcaaagctt gccaatattg actttagaca
     1081 aaaagaaaat gatacacaga tatttaatga ctctgctgtg gataaccatt caaaatgttc
     1141 acatattacg actatcacaa gttcacaaaa gtttatgcaa gtcagattgt taaccccaca
     1201 gaaacaatca aattccaatc agtggtcgga aaaaggggat aaagatgctg agtatggaga
     1261 taaagggaca gtaagacaag taagagaatc aaaatgtact tcacaagcta tatatactga
     1321 acattttggg aagtcagtag aaaatgatag tgatgaagta gaagagagag ctgagaattt
     1381 tccacgaacg tctgaaattc ctatattttt aggaactccc aaagctgtga aagcacctga
     1441 gtcattggag aaaataaaat tccctaaaac ccccccgttc gaaattaaca gaaatagaaa
     1501 tgcagtacct gaagttcaaa cagaaaagga atcccctgga ctttcttttc ttatgagtta
     1561 tacttctaga tcacctggat tgaatttatt tgattcttct gtatttgata cagaaatctc
     1621 atcagatcag tttaatgaac attattctgc aagaaatcta aatcctctgt catcagagca
     1681 agagattgga aacttacttg agaagccaga aggagaagat ggctttacat tttcttttcc
     1741 atcagacact tcaactcata catttggagc tggaaaagat gattttagtt ttccattttc
     1801 atttggacag ggtcaaaatt caataccttc ttcttcttta aaaggttttt catcttcctc
     1861 acaaaataca acacagttta cttttttttg agctagtcat taattcctta aattatttta
     1921 ctgttctgtg ttcatgaggg cataaattta cattattgct taaaacatga agactgcttt
     1981 cttttattga ttaaagcagt aatgtttaca ttatttgatt atatttattg aaatattgaa
     2041 atactgaata ttttgggttt tgtgtgtgct attaactaat cattatttat tttggttttg
     2101 attttgcgag ccgtggtcag gtagaacttt tattaatctt aatagaattt gatgcttttt
     2161 tcattactct ttatttaaat attaagcctg cttctccttg gaacctaagg tttttttctg
     2221 gaagtattgt tggtactttg ataagaacaa gaactgcagt agtaactcca gagttagtgc
     2281 tgaagcgtac tttagctact aaaaatttct attaaaatta ttgggtttca cttctgcttc
     2341 actatgtagt atacagagtg gtactgtaat aataatttca aataatttat gttaataaca
     2401 aaatctgtgt tattttcttc taatataaca catggtacaa ttctaatttt atgagttatg
     2461 ctaatgcttt caatggctaa aaattaaatg taaagggcaa gagtaatttc tgaaaattgg
     2521 attgttgtat cagtggtgat cctgttaata ttcttttttg cttaaatatt ttttgaagaa
     2581 catttacaat tttgtctcct tcaataacaa aaatttcttc tttatgtttt gtgttcagta
     2641 tttgtcaatt aattatatag cttaagtgaa gatatttaag atttgatgaa cttctgtaaa
     2701 cattttgctc aatatcattg tattttgtgc tttgtaaatt agctgtactg agttaccaag
     2761 taataaaggg tttgactcca
//
