LOCUS       NM_001286400            2597 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 14 open reading frame 180 (C14orf180),
            transcript variant 3, mRNA.
ACCESSION   NM_001286400 XM_005267639
VERSION     NM_001286400.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2597)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2597)
  AUTHORS   Zhang,R., Yao,F., Gao,F. and Abou-Samra,A.B.
  TITLE     Nrac, a novel nutritionally-regulated adipose and cardiac-enriched
            gene
  JOURNAL   PLoS One 7 (9), e46254 (2012)
   PUBMED   23029450
  REMARK    GeneRIF: Nrac is a nutritionally-regulated adipose and
            cardiac-enriched gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX161457.1, AW451284.1 and BX927359.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001286400.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate splice site in the 3' coding region, which results in
            a frameshift, compared to variant 1. The encoded isoform (b) has a
            distinct C-terminus and is shorter than isoform a. Variants 2 and 3
            encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX161457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1890              BX161457.1         120-2009
            1891-1929           AW451284.1         17-55               c
            1930-2597           BX927359.1         140609-141276
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2597
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="chromosome 14 open reading frame 180"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
     exon            1..366
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            367..493
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..865
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="isoform b is encoded by transcript variant 3;
                     transmembrane protein C14orf180; nutritionally-regulated
                     adipose and cardiac enriched protein homolog"
                     /codon_start=1
                     /product="nutritionally-regulated adipose and cardiac
                     enriched protein homolog isoform b"
                     /protein_id="NP_001273329.1"
                     /db_xref="CCDS:CCDS32166.1"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
                     /translation="MRTAAGAVSPDSRPETRRQTRKNEEAAWGPRVCRAEREDNRKCP
                     PSILKRSRPEHHRPEAKPQRTSRRVWFREPPAVTVHYIADKNATATVRVPGRPRPHGG
                     SLLLQLCVCVLLVLALGLYCGRAKPVATALEDLRARLLGLVLHLRHVALTCWRGLLRL
                     "
     exon            494..623
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            624..659
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            660..2597
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="hexamer: ATTAAA"
     polyA_site      1929
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="major polyA site"
ORIGIN      
        1 cccagtcttc ttccaccgga agaaggcaca acctgcatct gcagccccag ggccattggg
       61 ttaggcctgt ggccaaacta ctaaggtgct gggagactga ggaggcccag ctcctcctgg
      121 ggccaccaag cccgtggttg acggcctccc catggaccgg gctgtcccga gagcagcaag
      181 tcagccgggg ccctcagggc cgctgaggcc actgctcagt gtcgccgtaa tggaaacttc
      241 tcagctggtt gtgagccgca acagctctgg ttcacaccct gcgacagcga ggctgtgacc
      301 gccagtggat ctcggggctg atcaggcctg agccaccccg gaggtacagc accagcagga
      361 gcccaggacc atgttccagt aaatgaggac tgcagcagga gccgtgagcc ctgactcccg
      421 gccagagaca cgacgtcaga ccagaaagaa tgaggaggcc gcgtggggcc cgcgggtgtg
      481 cagggcagag agggaggaca acaggaagtg ccccccctcc atcctgaaac ggagccggcc
      541 ggagcaccac cgcccagagg ccaagcccca gaggacctcg aggcgcgtgt ggttccgaga
      601 acccccagcg gtgaccgtcc actacattgc tgacaagaac gccacagcca ctgtcagggt
      661 gcccggccgg cccaggccac acggcggctc cctgctcctg cagctgtgtg tgtgcgtcct
      721 gctcgtgctg gccctgggcc tatactgcgg ccgggccaag cccgtggcaa cggcactgga
      781 ggacctgcgg gcccggctcc tcggccttgt cctgcacctg cggcacgtgg ccctcacctg
      841 ctggcgcggc ctcctgcggc tctgacgggc aggacgggca ggacgggcag ggcttccagg
      901 agagctcaag cactccgggg gctccgagac agcctgagcc ctggccctgc tgcttggtga
      961 atcatggggg ccaaaagggg ctgctgcctg agggctaact aggaaaaggg ggaccccgtg
     1021 gcgtgagatc ggacatgggg ggcacagcag gcggccccgc cacactagtc agcacagccc
     1081 tcctgtctcc tgtgttgggt ccatgtgaga ttttattaga aagaggattc gactgctaac
     1141 agttgaggct ccccaggctc acccaaagac ccctccctcg tcccagcagg aactcctgct
     1201 gctgctaggg cctggcccgg ccatcaccgt gtgcaccctc ttgaggaggg ggacacactg
     1261 cccgtgttca aggggctgct cggaggaggc aaacccagcc ttttgcgatt atggcttgtg
     1321 gggaatccag acctcgaaac cccacgggga gggaagggtc tggttgtcaa ggtgggtccc
     1381 tttgatgtga ggtgccatcc tctgagccca ggtctgaccc ccctacccag ccccgtgagt
     1441 ctggagaggc cccagggaag gacccctcat caggggcggc ttcaggtgta gaagccgagg
     1501 ggacagcaag gggcccagac acccccgacc ttcagaacag ccatctgtgc ccagctctgc
     1561 aggccaggca cacccagctg agcccggggc cagccagcac cacccaccag ctggggcctg
     1621 tgggtcccgg agaccgtctg tggttgtggc tttgtcgccg gattgcagag ctgaagggag
     1681 ccctgtggat gacaaacacc aggggcctct ccagacccta cgtgggggga gggctgaaca
     1741 aagcagggag gcccacggtt agacaccagg cagaactgcc caggagagac acagggacaa
     1801 tcagaccagc gtcctcgagg ttagcctgag gcgggtgggc acggccgacc atccacccgg
     1861 tggttcctgt ttgtcccacc acttaactgg gagacactgt tttattaaaa cacaccgtgg
     1921 cttccttcag tcttggtgtt tttatagaaa tgagagaaac cagaaccgat ttgctaagga
     1981 atcggcctca gtggccaaag cggatgtcct gggcgcctgg aacctcccca tctcctgcag
     2041 gcctgggagt ggatgtgtcc actcgggcag gggctgacca agcccctggg tcttgaggga
     2101 tgcccggccg gctccctttg ccctgcagtc agggtgtgtc cctgcaactc caggtgccag
     2161 ggaacaggtg aagtggtctc cagggtcact tccagctttg gaatccaggg agcccagagt
     2221 tgcgggtgga ggtaacaaaa ggggctgttt ccagaagtgg cccagaaggg accatggtgg
     2281 gggctccccc ggggaccctc cagcatctct ccccaggccc agcccatccc accccacccc
     2341 aggaaggagg atgggcaggt tcctgcccca tattctggat gcagaagcag cggctcccag
     2401 aggttgggtc tctcagagca gtcacaggcc caggctcagc cctgtgtgct tgggacaccc
     2461 ctccagcccc ggttctgacg ggggacaccg cacaggccga tctcccccag ccgctgctgt
     2521 ctgtccactg caaaggcaac gcaaggacgt gcctggcttt gcggggtccc acgctacgac
     2581 ctcaggtgtt ttcgaat
//
