LOCUS       NM_001008404            2471 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 14 open reading frame 180 (C14orf180),
            transcript variant 2, mRNA.
ACCESSION   NM_001008404 XM_375108
VERSION     NM_001008404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   Zhang,R., Yao,F., Gao,F. and Abou-Samra,A.B.
  TITLE     Nrac, a novel nutritionally-regulated adipose and cardiac-enriched
            gene
  JOURNAL   PLoS One 7 (9), e46254 (2012)
   PUBMED   23029450
  REMARK    GeneRIF: Nrac is a nutritionally-regulated adipose and
            cardiac-enriched gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095913.1, BX161457.1, AW451284.1 and BX927359.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001008404.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a. Variants 2 and 3 encode the same isoform
            (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095913.1, BC041103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557649.6/ ENSP00000452502.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               AK095913.1         46-967
            923-1764            BX161457.1         1168-2009
            1765-1803           AW451284.1         17-55               c
            1804-2471           BX927359.1         140609-141276
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2471
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="chromosome 14 open reading frame 180"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
     exon            1..240
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            241..367
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..739
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="isoform b is encoded by transcript variant 2;
                     transmembrane protein C14orf180; nutritionally-regulated
                     adipose and cardiac enriched protein homolog"
                     /codon_start=1
                     /product="nutritionally-regulated adipose and cardiac
                     enriched protein homolog isoform b"
                     /protein_id="NP_001008404.1"
                     /db_xref="CCDS:CCDS32166.1"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
                     /translation="MRTAAGAVSPDSRPETRRQTRKNEEAAWGPRVCRAEREDNRKCP
                     PSILKRSRPEHHRPEAKPQRTSRRVWFREPPAVTVHYIADKNATATVRVPGRPRPHGG
                     SLLLQLCVCVLLVLALGLYCGRAKPVATALEDLRARLLGLVLHLRHVALTCWRGLLRL
                     "
     exon            368..497
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            498..533
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     exon            534..2471
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="hexamer: ATTAAA"
     polyA_site      1803
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /note="major polyA site"
ORIGIN      
        1 acaacagacc cggccctgcc agcgggcggt ggcgcctcca gatcagagcc ctcgggaagg
       61 aggcctgggc gggcctggcc cgttcacctg tgtgccctgc agttctgccc gaggctcaac
      121 tctcaagggc ctgggagggg tgctgccggc caagagggtc caggacctca ctggactgtg
      181 ccccacaggg agatcccgaa gagcctgttt ctgtccctcg gggagccagg agggaaccag
      241 gaccatgttc cagtaaatga ggactgcagc aggagccgtg agccctgact cccggccaga
      301 gacacgacgt cagaccagaa agaatgagga ggccgcgtgg ggcccgcggg tgtgcagggc
      361 agagagggag gacaacagga agtgcccccc ctccatcctg aaacggagcc ggccggagca
      421 ccaccgccca gaggccaagc cccagaggac ctcgaggcgc gtgtggttcc gagaaccccc
      481 agcggtgacc gtccactaca ttgctgacaa gaacgccaca gccactgtca gggtgcccgg
      541 ccggcccagg ccacacggcg gctccctgct cctgcagctg tgtgtgtgcg tcctgctcgt
      601 gctggccctg ggcctatact gcggccgggc caagcccgtg gcaacggcac tggaggacct
      661 gcgggcccgg ctcctcggcc ttgtcctgca cctgcggcac gtggccctca cctgctggcg
      721 cggcctcctg cggctctgac gggcaggacg ggcaggacgg gcagggcttc caggagagct
      781 caagcactcc gggggctccg agacagcctg agccctggcc ctgctgcttg gtgaatcatg
      841 ggggccaaaa ggggctgctg cctgagggct aactaggaaa agggggaccc cgtggcgtga
      901 gatcggacat ggggggcaca gcaggcggcc ccgccacact agtcagcaca gccctcctgt
      961 ctcctgtgtt gggtccatgt gagattttat tagaaagagg attcgactgc taacagttga
     1021 ggctccccag gctcacccaa agacccctcc ctcgtcccag caggaactcc tgctgctgct
     1081 agggcctggc ccggccatca ccgtgtgcac cctcttgagg agggggacac actgcccgtg
     1141 ttcaaggggc tgctcggagg aggcaaaccc agccttttgc gattatggct tgtggggaat
     1201 ccagacctcg aaaccccacg gggagggaag ggtctggttg tcaaggtggg tccctttgat
     1261 gtgaggtgcc atcctctgag cccaggtctg acccccctac ccagccccgt gagtctggag
     1321 aggccccagg gaaggacccc tcatcagggg cggcttcagg tgtagaagcc gaggggacag
     1381 caaggggccc agacaccccc gaccttcaga acagccatct gtgcccagct ctgcaggcca
     1441 ggcacaccca gctgagcccg gggccagcca gcaccaccca ccagctgggg cctgtgggtc
     1501 ccggagaccg tctgtggttg tggctttgtc gccggattgc agagctgaag ggagccctgt
     1561 ggatgacaaa caccaggggc ctctccagac cctacgtggg gggagggctg aacaaagcag
     1621 ggaggcccac ggttagacac caggcagaac tgcccaggag agacacaggg acaatcagac
     1681 cagcgtcctc gaggttagcc tgaggcgggt gggcacggcc gaccatccac ccggtggttc
     1741 ctgtttgtcc caccacttaa ctgggagaca ctgttttatt aaaacacacc gtggcttcct
     1801 tcagtcttgg tgtttttata gaaatgagag aaaccagaac cgatttgcta aggaatcggc
     1861 ctcagtggcc aaagcggatg tcctgggcgc ctggaacctc cccatctcct gcaggcctgg
     1921 gagtggatgt gtccactcgg gcaggggctg accaagcccc tgggtcttga gggatgcccg
     1981 gccggctccc tttgccctgc agtcagggtg tgtccctgca actccaggtg ccagggaaca
     2041 ggtgaagtgg tctccagggt cacttccagc tttggaatcc agggagccca gagttgcggg
     2101 tggaggtaac aaaaggggct gtttccagaa gtggcccaga agggaccatg gtgggggctc
     2161 ccccggggac cctccagcat ctctccccag gcccagccca tcccacccca ccccaggaag
     2221 gaggatgggc aggttcctgc cccatattct ggatgcagaa gcagcggctc ccagaggttg
     2281 ggtctctcag agcagtcaca ggcccaggct cagccctgtg tgcttgggac acccctccag
     2341 ccccggttct gacgggggac accgcacagg ccgatctccc ccagccgctg ctgtctgtcc
     2401 actgcaaagg caacgcaagg acgtgcctgg ctttgcgggg tcccacgcta cgacctcagg
     2461 tgttttcgaa t
//
