LOCUS       NM_001145199            1311 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.
ACCESSION   NM_001145199 XR_040442 XR_040443 XR_040444
VERSION     NM_001145199.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Zhang,X., Tao,X. and Feng,F.
  TITLE     Downregulation of C12orf75 gene inhibits migration and invasion of
            liver cancer cell via suppressing the Wnt/beta-catenin signaling
            pathway in vitro
  JOURNAL   Biochem Biophys Res Commun 614, 92-99 (2022)
   PUBMED   35576683
  REMARK    GeneRIF: Downregulation of C12orf75 gene inhibits migration and
            invasion of liver cancer cell via suppressing the Wnt/beta-catenin
            signaling pathway in vitro.
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Yousefi,F., Najafi,H., Behmanesh,M. and Soltani,B.M.
  TITLE     OCC-1D regulates Wnt signaling pathway: potential role of long
            noncoding RNA in colorectal cancer
  JOURNAL   Mol Biol Rep 49 (5), 3377-3387 (2022)
   PUBMED   35397713
  REMARK    GeneRIF: OCC-1D regulates Wnt signaling pathway: potential role of
            long noncoding RNA in colorectal cancer.
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Cai,G., Jin,G., Liang,J., Li,G., Chen,X., Liang,H. and Ding,Z.
  TITLE     Pan-cancer analysis of the prognostic value of C12orf75 based on
            data mining
  JOURNAL   Aging (Albany NY) 13 (11), 15214-15239 (2021)
   PUBMED   34074799
  REMARK    GeneRIF: Pan-cancer analysis of the prognostic value of C12orf75
            based on data mining.
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Ghalaei,A., Kay,M., Zarrinfam,S., Hoseinpour,P., Behmanesh,M. and
            Soltani,B.M.
  TITLE     Overexpressed in colorectal carcinoma gene (OCC-1) upregulation and
            APPL2 gene downregulation in breast cancer specimens
  JOURNAL   Mol Biol Rep 45 (6), 1889-1895 (2018)
   PUBMED   30218350
  REMARK    GeneRIF: OCC-1D overexpression resulted in increased sub-G1 cell
            population in MCF7 cells, detected by flow cytometry. Results
            suggest that OCC1-D variant have an inhibitory effect on APPL2
            expression and may regulate the cell cycle status.
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Najafi,H., Soltani,B.M., Dokanehiifard,S., Nasiri,S. and Mowla,S.J.
  TITLE     Alternative splicing of the OCC-1 gene generates three splice
            variants and a novel exonic microRNA, which regulate the Wnt
            signaling pathway
  JOURNAL   RNA 23 (1), 70-85 (2017)
   PUBMED   27986894
  REMARK    GeneRIF: Study identified three novel transcripts of the OCC-1
            gene; two of them, including a novel miRNA, are shown to be
            associated with the Wnt signaling pathway. Also, OCC-1 was found to
            affect the transcription level of its neighboring gene APPL2.
REFERENCE   6  (bases 1 to 1311)
  AUTHORS   Cobb,J., Cule,E., Moncrieffe,H., Hinks,A., Ursu,S., Patrick,F.,
            Kassoumeri,L., Flynn,E., Bulatovic,M., Wulffraat,N., van Zelst,B.,
            de Jonge,R., Bohm,M., Dolezalova,P., Hirani,S., Newman,S.,
            Whitworth,P., Southwood,T.R., De Iorio,M., Wedderburn,L.R. and
            Thomson,W.
  CONSRTM   Childhood Arthritis Response to Medication Study (CHARMS);
            Childhood Arthritis Prospective Study (CAPS); BSPAR study group
  TITLE     Genome-wide data reveal novel genes for methotrexate response in a
            large cohort of juvenile idiopathic arthritis cases
  JOURNAL   Pharmacogenomics J 14 (4), 356-364 (2014)
   PUBMED   24709693
REFERENCE   7  (bases 1 to 1311)
  AUTHORS   Ramanan,V.K., Risacher,S.L., Nho,K., Kim,S., Swaminathan,S.,
            Shen,L., Foroud,T.M., Hakonarson,H., Huentelman,M.J., Aisen,P.S.,
            Petersen,R.C., Green,R.C., Jack,C.R., Koeppe,R.A., Jagust,W.J.,
            Weiner,M.W. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     APOE and BCHE as modulators of cerebral amyloid deposition: a
            florbetapir PET genome-wide association study
  JOURNAL   Mol Psychiatry 19 (3), 351-357 (2014)
   PUBMED   23419831
REFERENCE   8  (bases 1 to 1311)
  AUTHORS   Chai,B., Li,J.Y., Fritze,D., Zhang,W., Xia,Z. and Mulholland,M.W.
  TITLE     A novel transcript is up-regulated by fasting in the hypothalamus
            and enhances insulin signalling
  JOURNAL   J Neuroendocrinol 25 (3), 292-301 (2013)
   PUBMED   22935015
REFERENCE   9  (bases 1 to 1311)
  AUTHORS   Kikuchi,K., Fukuda,M., Ito,T., Inoue,M., Yokoi,T., Chiku,S.,
            Mitsuyama,T., Asai,K., Hirose,T. and Aizawa,Y.
  TITLE     Transcripts of unknown function in multiple-signaling pathways
            involved in human stem cell differentiation
  JOURNAL   Nucleic Acids Res 37 (15), 4987-5000 (2009)
   PUBMED   19531736
REFERENCE   10 (bases 1 to 1311)
  AUTHORS   Pibouin,L., Villaudy,J., Ferbus,D., Muleris,M., Prosperi,M.T.,
            Remvikos,Y. and Goubin,G.
  TITLE     Cloning of the mRNA of overexpression in colon carcinoma-1: a
            sequence overexpressed in a subset of colon carcinomas
  JOURNAL   Cancer Genet Cytogenet 133 (1), 55-60 (2002)
   PUBMED   11890990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013920.1 and BQ021766.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001145199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013920.1, SRR1163657.293945.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443585.6/ ENSP00000448536.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1310              BC013920.1         58-1367
            1311-1311           BQ021766.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..1311
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="chromosome 12 open reading frame 75"
                     /db_xref="GeneID:387882"
                     /db_xref="HGNC:HGNC:35164"
     exon            1..247
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..393
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="overexpressed in colon carcinoma-1; adipogenesis
                     down-regulated 3"
                     /codon_start=1
                     /product="overexpressed in colon carcinoma 1 protein"
                     /protein_id="NP_001138671.1"
                     /db_xref="CCDS:CCDS55879.1"
                     /db_xref="GeneID:387882"
                     /db_xref="HGNC:HGNC:35164"
                     /translation="MGCGNSTATSAGAGQGPAGAAKDVTEESVTEDDKRRNYGGVYVG
                     LPSEAVNMVSSQTKTVRKN"
     exon            248..272
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..308
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..388
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..426
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1311
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="hexamer: AATAAA"
     polyA_site      1046
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="major polyA site"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1311
                     /gene="C12orf75"
                     /gene_synonym="AGD3; OCC-1; OCC1"
                     /note="major polyA site"
ORIGIN      
        1 ggtttccgcc cggcagcccg cagcccgctg cgccccgggc cgcgtctccc ggcggtggga
       61 gggggcggcc cccactcggt tcctggcccc tcgcggcccc gtcagcctcc cgctcggggt
      121 gcgccgccct tcgtctgggt ctccgccccc aggacccgcg gccgagagct ccggagcgcg
      181 gcttccccgg ccggctgcgc gatgggctgc gggaactcca ccgccaccag cgcgggcgcg
      241 ggccaaggcc ctgcaggagc agccaaagat gtaacagaag aatccgtaac agaagatgac
      301 aagaggagaa actatggagg agtatatgtt ggcctaccat ctgaagctgt caatatggtg
      361 tccagtcaaa caaagacggt tcggaaaaat tagaagaaaa taacatcatg actcaagaat
      421 caagagcttg ctcatcagtt tggaaggaat ttggctccgt gggacgttgt aatgtgcaca
      481 gacatttcca aggaaattct aaacagtcac ccttcccttt tgcattcccc caaatcttaa
      541 gtgtatacat aaaaccctgg gtacatattg ttgtggtaat agaagggaat tggttaaaca
      601 gtacacttgt ttatggaact ttctgtggcc acctacgaaa gacaagttaa caaactgtca
      661 tggaggctgt tgttgcccag ccagggccgc tgcattttga caacatttcc accctggcca
      721 ctcagcacat ttcatggagg tcatgtcttt tcactgatac ttttttgata gtttttatat
      781 aacaaaatcc ttattctatt tataacttaa gatgataagg cactataaat taatgaccta
      841 aaataatata tttgtctgtt atcttttgct atttctactt cactttaatt tttagctgta
      901 aaattggtaa atggattctt acaactatct ctttccattt cttactattt ggttttcaaa
      961 tttcatttaa atgtcagaat ttcctttttt aggaacaatg tgtatttcat tgcactattt
     1021 aaaaataaac tcaaatttgc atgccatatg cacattttga ttacattttt attttctttc
     1081 gtgaaaggca tgtgcaacta caaatacttc atagctgttt gggttgctca ttctacatca
     1141 cgacaatctc atcatattat ttctataact tttcaaggac ttgcgatgga tggttagtgg
     1201 gatatctgga aattaatttg ataatgactt gtgtatctac ttagtattgc aatgtaagtt
     1261 actcaattca ccaatgtatt tcaacaatta aaacattttt atccctcttc a
//
