LOCUS       NM_175874               1586 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 12 open reading frame 60 (C12orf60), mRNA.
ACCESSION   NM_175874
VERSION     NM_175874.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Cousminer,D.L., Berry,D.J., Timpson,N.J., Ang,W., Thiering,E.,
            Byrne,E.M., Taal,H.R., Huikari,V., Bradfield,J.P., Kerkhof,M.,
            Groen-Blokhuis,M.M., Kreiner-Moller,E., Marinelli,M., Holst,C.,
            Leinonen,J.T., Perry,J.R., Surakka,I., Pietilainen,O., Kettunen,J.,
            Anttila,V., Kaakinen,M., Sovio,U., Pouta,A., Das,S., Lagou,V.,
            Power,C., Prokopenko,I., Evans,D.M., Kemp,J.P., St Pourcain,B.,
            Ring,S., Palotie,A., Kajantie,E., Osmond,C., Lehtimaki,T.,
            Viikari,J.S., Kahonen,M., Warrington,N.M., Lye,S.J., Palmer,L.J.,
            Tiesler,C.M., Flexeder,C., Montgomery,G.W., Medland,S.E.,
            Hofman,A., Hakonarson,H., Guxens,M., Bartels,M., Salomaa,V.,
            Murabito,J.M., Kaprio,J., Sorensen,T.I., Ballester,F., Bisgaard,H.,
            Boomsma,D.I., Koppelman,G.H., Grant,S.F., Jaddoe,V.W., Martin,N.G.,
            Heinrich,J., Pennell,C.E., Raitakari,O.T., Eriksson,J.G.,
            Smith,G.D., Hypponen,E., Jarvelin,M.R., McCarthy,M.I., Ripatti,S.
            and Widen,E.
  CONSRTM   ReproGen Consortium; Early Growth Genetics (EGG) Consortium
  TITLE     Genome-wide association and longitudinal analyses reveal genetic
            loci linking pubertal height growth, pubertal timing and childhood
            adiposity
  JOURNAL   Hum Mol Genet 22 (13), 2735-2747 (2013)
   PUBMED   23449627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038836.1, BC015546.1 and AC007655.1.
            
            On May 17, 2019 this sequence version replaced NM_175874.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289942.1, SRR1803615.191792.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330828.3/ ENSP00000331691.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BC038836.1         99-128
            31-1029             BC015546.1         1-999
            1030-1586           AC007655.1         34584-35140
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..1586
                     /gene="C12orf60"
                     /note="chromosome 12 open reading frame 60"
                     /db_xref="GeneID:144608"
                     /db_xref="HGNC:HGNC:28726"
     exon            1..82
                     /gene="C12orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            83..1586
                     /gene="C12orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..844
                     /gene="C12orf60"
                     /codon_start=1
                     /product="uncharacterized protein C12orf60"
                     /protein_id="NP_787070.2"
                     /db_xref="CCDS:CCDS8667.1"
                     /db_xref="GeneID:144608"
                     /db_xref="HGNC:HGNC:28726"
                     /translation="MSSESEKDKERLIQAAKMFFFHVQDLASVINTLTELFSRSMNTQ
                     ILLMAVKNNSYIKDFFEQMLKIFKEMQSVVDARHDKIQKESLCSKVAMAMCSVVQKST
                     NVEELHQSAKEVFKSAHTPVIISVLNSSNILGSLESSLSHLMKFPIMNLQLSDFYTED
                     TKEQSDVTTSERTRSPPGSSKTTMIDTLKKLQDVLKTEDSKNPTKSAADLLEQIVKAM
                     GPILEILQKAIKTMEMNISVFKKASDK"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf60"
                     /note="hexamer: AAGAAA"
     polyA_site      1029
                     /gene="C12orf60"
                     /note="major polyA site"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf60"
                     /note="hexamer: ATTAAA"
     polyA_site      1155
                     /gene="C12orf60"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf60"
                     /note="hexamer: AATAAA"
     polyA_site      1271
                     /gene="C12orf60"
ORIGIN      
        1 agaagaagat agctgctaac tgagtggctg acggtcctgt ctctcgagtt ggaggcatct
       61 tgacttagtt gctgggagcc tgtgttggaa cttatttgtt ggagaaatgt cttcagagtc
      121 agaaaaggat aaagagagac tgattcaagc tgccaaaatg ttcttctttc atgtacaaga
      181 tcttgcttct gtcataaaca cactgactga attgtttagc cgcagtatga atactcaaat
      241 ccttttgatg gctgtgaaaa acaatagtta cattaaggat ttttttgagc aaatgctcaa
      301 aatttttaag gagatgcaat ctgtagtgga tgcaagacat gacaaaattc aaaaggagtc
      361 tttatgttcc aaggttgcaa tggccatgtg ctctgtggtt cagaagagta ccaatgtaga
      421 ggagttgcat cagtcagcta aagaagtatt caaaagtgcc catacgccag tcatcatctc
      481 tgtgctaaac agcagtaaca tccttgggag tctggaatct tctctttcac acttgatgaa
      541 attccccatc atgaatcttc aattaagtga cttctataca gaagacacca aagagcaatc
      601 agatgtcacc acatctgaga gaaccagaag tcctccaggt tcttccaaaa ccactatgat
      661 agacaccttg aaaaaactgc aggatgtact aaaaactgag gattccaaaa atcccacaaa
      721 gtcagcagca gatttgttgg aacaaattgt caaggctatg ggaccaatct tagagatcct
      781 ccaaaaagcg ataaagacta tggaaatgaa tatttctgtg tttaagaaag ccagtgacaa
      841 gtagggatgc aacagaaatg ttcatttctg tcagaaaact acttaaaatc ttatggtttt
      901 tcatagtagt ttctaagatc ttttggtgcc aaacatgtgc tatgttagaa cataagtaca
      961 caaaagtcat ctggcaaaac atttacctgt agttttgctt tattaaaata aaaagaaata
     1021 attaagaaag cctgtttgaa atgtcagtca ctaagaagaa tatattgttg aaaaaaacaa
     1081 agtggtatta catttgagga tgtttctaaa tattgtgttt catcttaaag cataattaaa
     1141 acaaccctaa agtagttccc actcttaact attctatttc cagtgagaaa tccaggtaaa
     1201 ctgtaaatat tatcattaga tagaaaatct aggcctggga aacaaaataa actccatttt
     1261 tgtcactcat ataccaattt ctatatactt cagtaccttg acgatcagaa gccatcacta
     1321 aatattttaa atatgattca taagtaagtg agaacagtga atgagcaata atagactttt
     1381 cttgcttatg tgagtaagac cagaacagat agttcattct cacttgtctc ctgaggtctt
     1441 atgattagaa aatactagag gtggaaaaat ggaagtactc tagcctttca caaagaaaag
     1501 actttcacaa ggaaaacact tgcagaagta ggatatctga gatgtgcttt atttaaagaa
     1561 atgagatagg gcagtctctt tgtcta
//
