LOCUS       NM_152589               1711 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 12 open reading frame 50 (C12orf50),
            transcript variant 1, mRNA.
ACCESSION   NM_152589
VERSION     NM_152589.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091516.8, AK093140.1 and AC090060.15.
            
            On Nov 23, 2018 this sequence version replaced NM_152589.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298699.7/ ENSP00000298699.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC091516.8         141048-141049
            3-1707              AK093140.1         1-1705
            1708-1711           AC090060.15        125715-125718       c
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.32"
     gene            1..1711
                     /gene="C12orf50"
                     /note="chromosome 12 open reading frame 50"
                     /db_xref="GeneID:160419"
                     /db_xref="HGNC:HGNC:26665"
     exon            1..62
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            63..182
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1415
                     /gene="C12orf50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C12orf50"
                     /codon_start=1
                     /product="uncharacterized protein C12orf50 isoform 1"
                     /protein_id="NP_689802.1"
                     /db_xref="CCDS:CCDS9031.1"
                     /db_xref="GeneID:160419"
                     /db_xref="HGNC:HGNC:26665"
                     /translation="MEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSS
                     NITLQKEIQEGIPLQSQSQEPLKPQENISRPIHHPLVLKTNFEEEEEVDEQNDASSLW
                     TKTPEEIEEKRAIKEMCYKSGEYYRFHTPPDILSSKSMTPTAEKQLEKPLENGSELQE
                     GDSLTVPTKLSQYERQGEIKTSLHGKPKTDIAAFENGGGDCYVPQRVIFLGVDESEAL
                     TEEKEITISKCSNTKDNKDSPHPKHSLTTRLVPTTHVLNATENISMKCREDPSSMNDV
                     QPVKKPHFKGVKKRKWIYDEPQNFPNSGMQRAVQAPRPQNKMSYHRNNKNRNAENASY
                     IHVQRDAVRTVALNAPSRSRPTHGSYNKVHANREPKPNLSPDKYTSTSYNDSAWRKRI
                     PFSKTYSKSEKIYPEPRRNGSK"
     exon            183..303
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            304..459
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            460..537
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            538..651
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            652..762
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            763..870
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            871..987
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1092
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1296
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1389
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1711
                     /gene="C12orf50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C12orf50"
                     /note="hexamer: AATAAA"
     polyA_site      1711
                     /gene="C12orf50"
                     /note="major polyA site"
ORIGIN      
        1 agaagtttga gtttgtgtgc ttactagcaa ccactttcag cgtttctgca aagctagaga
       61 agggttccca gtgccgattc cgacactgtg aagaggccct tggcagtgac actgtgtgct
      121 cattatggag agagaggaaa tgtttagatc cactttgcag atttagacac atggaaatgc
      181 agcaaaactg cagcatttca tgcttctggg aaactcagcc tcttggttgt gtgaagatca
      241 gctgtatctt ttatcacagc aaacctcgaa atatcaatgg attatttttg ccaccaagta
      301 gcaatatcac actacagaaa gaaattcagg aaggaattcc actccagtcc cagagtcaag
      361 aacctctgaa acctcaggaa aatatatcac gacccatcca ccatccttta gttttaaaaa
      421 ctaattttga ggaagaagag gaagtagatg aacaaaatga tgcttctagt ttatggacaa
      481 agacccctga agaaattgaa gaaaaaagag caataaagga gatgtgttat aaatctgggg
      541 aatactacag atttcatact cctccagata ttttgtcatc aaaaagcatg acacctacag
      601 cagaaaaaca gttagaaaag cctttggaaa atggcagtga attgcaagaa ggagatagtc
      661 ttacagttcc gacaaaactt agccaatatg aaaggcaagg tgaaataaaa acatcattgc
      721 atgggaaacc aaagactgac attgctgctt ttgaaaatgg aggaggtgac tgttatgttc
      781 cacagagggt catatttctt ggagtcgatg aaagtgaagc tttaactgaa gagaaagaaa
      841 tcaccatatc aaaatgttca aatactaaag ataacaagga cagtcctcat ccaaagcatt
      901 ccctaactac ccgactagta cctacaacgc atgtattaaa tgctactgag aatatcagta
      961 tgaagtgcag agaggacccc tcttcaatga atgatgtcca gccagtgaag aagcctcatt
     1021 ttaaaggtgt gaagaaaaga aaatggattt atgatgaacc acagaacttt cctaactctg
     1081 gaatgcagag agcagtacag gccccaagac cccaaaataa aatgagttat caccgcaata
     1141 ataaaaatcg aaatgcggag aatgcatcct atatccacgt tcaaagagat gctgtcagga
     1201 ctgtcgcgtt gaatgcacct tcccgcagca ggcccacgca tgggtcctac aataaagtcc
     1261 atgctaacag ggaacccaaa cccaacctca gtccagacaa atatacgtca acatcatata
     1321 atgattcagc ctggcgaaaa cgaattcctt tttcaaaaac atattcaaaa agtgaaaaga
     1381 tatatccaga gccaagaaga aatgggagca agtaaacctg gaggttgaga gagagaaaaa
     1441 tgagaaaaaa ttgccagaca tcatctgatt tacaatcaaa aatgaaaatt caaagaatga
     1501 gatactcaag tactccatgt tatgtagtgg atagccaaag atgataaaaa tgcaaattct
     1561 gaaaataaga tgcaggaagt acattgtgct ctttcaaaac tgataaaaat gcaaattacc
     1621 aacagctgcc agtgtattta tgtaggtctg gaattcattc cgtgcattac tccaaacatt
     1681 ttaataaaat ttaaaagttt gacaattaaa a
//
