LOCUS       NM_001286086             646 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens chromosome 11 open reading frame 98 (C11orf98),
            transcript variant 1, mRNA.
ACCESSION   NM_001286086
VERSION     NM_001286086.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 646)
  AUTHORS   Zhang,Y., Liang,X., Luo,S., Chen,Y., Li,Y., Ma,C., Li,N. and Gao,N.
  TITLE     Visualizing the nucleoplasmic maturation of human pre-60S ribosomal
            particles
  JOURNAL   Cell Res 33 (11), 867-878 (2023)
   PUBMED   37491604
REFERENCE   2  (bases 1 to 646)
  AUTHORS   Chu,Q., Rathore,A., Diedrich,J.K., Donaldson,C.J., Yates,J.R. 3rd
            and Saghatelian,A.
  TITLE     Identification of Microprotein-Protein Interactions via APEX
            Tagging
  JOURNAL   Biochemistry 56 (26), 3299-3306 (2017)
   PUBMED   28589727
  REMARK    GeneRIF: Data suggest that C11orf98 microprotein, NPM1, and
            nucleolin interact and colocalize in the cell nucleolus. (C11orf98
            = chromosome 11 open reading frame 98 protein; NPM1 = nucleophosmin
            1)
REFERENCE   3  (bases 1 to 646)
  AUTHORS   Michel,A.M., Choudhury,K.R., Firth,A.E., Ingolia,N.T., Atkins,J.F.
            and Baranov,P.V.
  TITLE     Observation of dually decoded regions of the human genome using
            ribosome profiling data
  JOURNAL   Genome Res 22 (11), 2219-2229 (2012)
   PUBMED   22593554
REFERENCE   4  (bases 1 to 646)
  AUTHORS   Oyama,M., Kozuka-Hata,H., Suzuki,Y., Semba,K., Yamamoto,T. and
            Sugano,S.
  TITLE     Diversity of translation start sites may define increased
            complexity of the human short ORFeome
  JOURNAL   Mol Cell Proteomics 6 (6), 1000-1006 (2007)
   PUBMED   17317662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN256679.1 and BX107288.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001286086.1.
            
            Summary: This gene shares three exons in common with another gene,
            LBH domain containing 1 (GeneID:79081), but the encoded protein
            uses a reading frame that is different from that of the LBH domain
            containing 1 gene. [provided by RefSeq, Nov 2017].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM670731.1, BI550350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524958.6/ ENSP00000432523.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                CN256679.1         7-92
            87-646              BX107288.1         65-624
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..646
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /note="chromosome 11 open reading frame 98"
                     /db_xref="GeneID:102288414"
                     /db_xref="HGNC:HGNC:51238"
     exon            1..80
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..413
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /codon_start=1
                     /product="uncharacterized protein C11orf98"
                     /protein_id="NP_001273015.1"
                     /db_xref="CCDS:CCDS73306.1"
                     /db_xref="GeneID:102288414"
                     /db_xref="HGNC:HGNC:51238"
                     /translation="MGAPGGKINRPRTELKKKLFKRRRVLNRERRLRHRVVGAVIDQG
                     LITRHHLKKRASSARANITLSGKKRRKLLQQIRLAQKEKTAMEVEAPSKPARTSEPQL
                     KRQKKTKAPQDVEMKDLEDES"
     exon            81..205
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            206..303
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            304..646
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      626..631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /note="hexamer: AATAAA"
     polyA_site      646
                     /gene="C11orf98"
                     /gene_synonym="C11orf48"
                     /note="major polyA site"
ORIGIN      
        1 gagcggaagt acggaccgtg aactggagtg gaatcgcgac tatgggagct ccggggggaa
       61 agatcaaccg gccccgaacg gagctgaaga agaagctgtt caaacgccgg cgggtgttga
      121 atcgggagcg gcgtctgagg caccgggtgg tcggggctgt gatagaccaa gggctgatca
      181 cgcggcacca cctcaagaag cgggcgtcca gtgcacgtgc caacattaca ctgtcaggga
      241 agaagcgcag aaaactcctc cagcagatcc ggcttgccca gaaagagaag acagccatgg
      301 aagtggaagc cccttcaaag ccagccagga ctagtgaacc acagctcaaa aggcaaaaga
      361 agacaaaagc cccccaggat gtagaaatga aggaccttga agatgagagc taaacctctt
      421 ccactagaag attctcaact ggagccagcc ttcagactca gtggttgttt cagaggactt
      481 tgacaaaagc aaggcccctt ttcactctcc agatttcctc ctacctaatg gcctactgac
      541 ctcccctaga gggatgtctt tgggagggaa gaaggtacag aagaaagatt ggagaagggc
      601 ctctctagca gtcaactcca tttgtaataa agccctagca ctctga
//
