LOCUS       NM_001135635            1562 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 68 (C11orf68),
            transcript variant 1, mRNA.
ACCESSION   NM_001135635
VERSION     NM_001135635.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1562)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1562)
  AUTHORS   Khater,S. and Mohanty,D.
  TITLE     Genome-wide search for eliminylating domains reveals novel function
            for BLES03-like proteins
  JOURNAL   Genome Biol Evol 6 (8), 2017-2033 (2014)
   PUBMED   25062915
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1562)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1562)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1562)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1562)
  AUTHORS   Bitto,E., Bingman,C.A., Robinson,H., Allard,S.T., Wesenberg,G.E.
            and Phillips,G.N. Jr.
  TITLE     The structure at 2.5 A resolution of human basophilic
            leukemia-expressed protein BLES03
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 61 (Pt 9), 812-817
            (2005)
   PUBMED   16511166
  REMARK    GeneRIF: crystal structure of the human basophilic
            leukemia-expressed protein (BLES03, p5326, Hs.433573) was
            determined by single-wavelength anomalous diffraction and refined
            to an R factor of 18.8% (Rfree = 24.5%) at 2.5 A resolution
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006287.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001135635.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.262008.1,
                                           SRR1163655.469864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438576.3/ ENSP00000398350.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AP006287.2         34161-34313         c
            154-1562            AP006287.2         32061-33469         c
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1562
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /note="chromosome 11 open reading frame 68"
                     /db_xref="GeneID:83638"
                     /db_xref="HGNC:HGNC:28801"
     exon            1..153
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..913
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /note="isoform 1 is encoded by transcript variant 1;
                     basophilic leukemia expressed protein BLES03; protein
                     p5326; basophilic leukemia-expressed protein Bles03;
                     UPF0696 protein C11orf68"
                     /codon_start=1
                     /product="UPF0696 protein C11orf68 isoform 1"
                     /protein_id="NP_001129107.1"
                     /db_xref="CCDS:CCDS44652.1"
                     /db_xref="GeneID:83638"
                     /db_xref="HGNC:HGNC:28801"
                     /translation="MAAAAAAAVAGVGRGGGGAEPRQERSRARGWAGVERSEGRSRME
                     PGEELEEEGSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPS
                     QVTRYGDPGSPNSEPVGWIAVYGQGYSPNSGDVQGLQAAWEALQTSGRPITPGTLRQL
                     AITHHVLSGKWLMHLAPGFKLDHAWAGIARAVVEGQLQVAKVSPRAKEGGRQVICVYT
                     DDFTDRLGVLEADSAIRAAGIKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGG
                     SARGSRVLDRANNVELT"
     exon            154..1562
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /note="hexamer: AATAAA"
     polyA_site      1562
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /note="major polyA site"
ORIGIN      
        1 aaagttgttg ttgaggtggc gcggcgctaa gatggcggcg gcggcggcgg cggccgtggc
       61 gggggtgggg cgcggtggcg gtggcgcgga gccacggcag gagcggagcc gggcccgggg
      121 ctgggccggc gtcgaacgca gcgaaggccg gagcaggatg gaaccaggtg aggagctgga
      181 agaggagggc tctccaggtg gccgtgagga tggcttcacc gccgagcacc tggctgcaga
      241 ggccatggca gctgacatgg acccctggct agtgtttgat gcccgcacaa cgcctgccac
      301 tgagctggat gcctggctgg ccaagtaccc accatcccaa gttacccgct atggggaccc
      361 cggttcaccc aactcagagc ctgtgggctg gattgcagtg tatgggcagg gctacagccc
      421 caactccggg gacgtgcagg gcctgcaggc agcctgggaa gctctgcaga ccagtgggcg
      481 gcccatcaca ccgggtaccc tgcgccagct cgccatcacc caccacgtgc tctcgggcaa
      541 gtggcttatg catctggcac cgggcttcaa gctggaccac gcctgggctg gcattgcccg
      601 ggccgtggtt gaaggccagc ttcaggtggc caaggtgagc ccacgtgcca aggagggtgg
      661 gcgccaggtc atctgtgttt acacggacga cttcacggac cgcttgggtg tactggaggc
      721 ggattcagcc atccgtgcag cgggcattaa gtgcctgctc acctacaagc ctgatgtcta
      781 cacctacctg ggcatctacc gggccaatcg ctggcacctc tgccccactc tctatgagag
      841 ccgtttccag cttgggggta gtgcccgtgg ctcccgagtg cttgaccgtg ccaacaacgt
      901 ggaactgacc taggggggcc aaattgggga gactgcccac tcccccctcc atgctggggt
      961 tggatcctcc tgtcttcctc cttgtcctat gaaggccaca ccccccagct ctggggactc
     1021 ctaggtcact tgggaactac ctgcatcttc agtccccttg aacttctgcc ctctgttcag
     1081 ggctgacaca agccccacag gctggggggc tccggttccc tgagggatga gccttcagcc
     1141 tccctttgta atgctgctcc tctccactgc ccagcaccat gagttgggtg cagacaccta
     1201 gaaggagaga cttcttggaa cgctcatccc ccgctatacc tccccttcct cctgcatctc
     1261 cccttctttc cttccccctc aggagagaga aaacttagtg cttccagccc ttcttggagc
     1321 cttcatggtc caggggtagg ggccccactg gcctgagcat gccattttga ggggagggta
     1381 gttgtgccta cttatcccct ggcagagggg atgccaggac catggacatg aggcttgccc
     1441 atccctgcca acttacacag cctgtaccac tgtcccccct tccttggcta ctttgacatg
     1501 tgcctgctcc tggcatttca ataaaacccg gcttgggtct gtgtcttgag tgttttttaa
     1561 aa
//
