LOCUS       NP_001129107             293 aa            linear   PRI 28-APR-2025
DEFINITION  UPF0696 protein C11orf68 isoform 1 [Homo sapiens].
ACCESSION   NP_001129107
VERSION     NP_001129107.1
DBSOURCE    REFSEQ: accession NM_001135635.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 293)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 293)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 293)
  AUTHORS   Khater,S. and Mohanty,D.
  TITLE     Genome-wide search for eliminylating domains reveals novel function
            for BLES03-like proteins
  JOURNAL   Genome Biol Evol 6 (8), 2017-2033 (2014)
   PUBMED   25062915
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 293)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 293)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (residues 1 to 293)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (residues 1 to 293)
  AUTHORS   Bitto,E., Bingman,C.A., Robinson,H., Allard,S.T., Wesenberg,G.E.
            and Phillips,G.N. Jr.
  TITLE     The structure at 2.5 A resolution of human basophilic
            leukemia-expressed protein BLES03
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 61 (Pt 9), 812-817
            (2005)
   PUBMED   16511166
  REMARK    GeneRIF: crystal structure of the human basophilic
            leukemia-expressed protein (BLES03, p5326, Hs.433573) was
            determined by single-wavelength anomalous diffraction and refined
            to an R factor of 18.8% (Rfree = 24.5%) at 2.5 A resolution
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006287.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.262008.1,
                                           SRR1163655.469864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438576.3/ ENSP00000398350.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     Protein         1..293
                     /product="UPF0696 protein C11orf68 isoform 1"
                     /note="basophilic leukemia expressed protein BLES03;
                     protein p5326; basophilic leukemia-expressed protein
                     Bles03; UPF0696 protein C11orf68"
                     /calculated_mol_wt=31386
     Site            29
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9H3H3.3)"
     Region          <157..254
                     /region_name="DUF1917"
                     /note="Domain of unknown function (DUF1917); pfam08939"
                     /db_xref="CDD:401038"
     CDS             1..293
                     /gene="C11orf68"
                     /gene_synonym="BLES03; P5326"
                     /coded_by="NM_001135635.2:32..913"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS44652.1"
                     /db_xref="GeneID:83638"
                     /db_xref="HGNC:HGNC:28801"
ORIGIN      
        1 maaaaaaava gvgrggggae prqersrarg wagversegr srmepgeele eegspggred
       61 gftaehlaae amaadmdpwl vfdarttpat eldawlakyp psqvtrygdp gspnsepvgw
      121 iavygqgysp nsgdvqglqa awealqtsgr pitpgtlrql aithhvlsgk wlmhlapgfk
      181 ldhawagiar avvegqlqva kvsprakegg rqvicvytdd ftdrlgvlea dsairaagik
      241 clltykpdvy tylgiyranr whlcptlyes rfqlggsarg srvldrannv elt
//
