LOCUS       NM_014267               3920 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 58 (C11orf58), mRNA.
ACCESSION   NM_014267
VERSION     NM_014267.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Shilenok,I., Kobzeva,K., Soldatov,V., Deykin,A. and Bushueva,O.
  TITLE     C11orf58 (Hero20) Gene Polymorphism: Contribution to Ischemic
            Stroke Risk and Interactions with Other Heat-Resistant Obscure
            Chaperones
  JOURNAL   Biomedicines 12 (11), 2603 (2024)
   PUBMED   39595169
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Gong,T.W., Hegeman,A.D., Shin,J.J., Lindberg,K.H., Barald,K.F. and
            Lomax,M.I.
  TITLE     Novel genes expressed in the chick otocyst during development:
            identification using differential display of RNA
  JOURNAL   Int J Dev Neurosci 15 (4-5), 585-594 (1997)
   PUBMED   9263035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026639.6.
            
            On Nov 23, 2018 this sequence version replaced NM_014267.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007103.1, SRR3476690.1034924.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228136.9/ ENSP00000228136.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC026639.6         89854-90048
            196-279             AC026639.6         95808-95891
            280-340             AC026639.6         99304-99364
            341-450             AC026639.6         103992-104101
            451-3920            AC026639.6         106078-109547
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..3920
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="chromosome 11 open reading frame 58"
                     /db_xref="GeneID:10944"
                     /db_xref="HGNC:HGNC:16990"
                     /db_xref="MIM:619625"
     exon            1..195
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..684
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /codon_start=1
                     /product="small acidic protein"
                     /protein_id="NP_055082.1"
                     /db_xref="CCDS:CCDS7822.1"
                     /db_xref="GeneID:10944"
                     /db_xref="HGNC:HGNC:16990"
                     /db_xref="MIM:619625"
                     /translation="MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRL
                     MGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGL
                     GFSEVEDHDGEGDVAGDDDDDDDDSPDPESPDDSESDSESEKEESAEELQAAEHPDEV
                     EDPKNKKDAKSNYKMMFVKSSGS"
     exon            196..279
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            280..340
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            341..450
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            451..3920
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="hexamer: AATAAA"
     polyA_site      927
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="major polyA site"
     regulatory      2698..2703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="hexamer: AATACA"
     polyA_site      2721
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
     regulatory      3899..3904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
                     /note="hexamer: AGTAAA"
     polyA_site      3920
                     /gene="C11orf58"
                     /gene_synonym="Hero20; IMAGE145052; SMAP"
ORIGIN      
        1 agagaaggcc cggaggggct ctgcgttctg tagtggcgct gcttgggccc ttggcggatt
       61 gtaagctgct ggttttgcgg ctgggaagag cggcgagagg gttcggcatt tttcgtcggg
      121 atccccgcaa ggatgagtgc tgccagagag tctcacccgc atggggtgaa gcgttcagcc
      181 tccccagacg acgatctggg atctagcaat tgggaggcag cagacttggg taatgaagag
      241 agaaaacaaa agttcttgag acttatgggt gcaggaaaga aagaacatac tggtcgtctt
      301 gttataggag atcacaaatc aacatctcac ttccgaaccg gggaagaaga caagaaaatt
      361 aatgaagaac tggagtctca atatcagcaa agtatggaca gtaaattatc aggaagatat
      421 cggcgacatt gtggacttgg cttcagtgag gtagaagacc atgatggaga aggtgatgtg
      481 gctggagatg atgatgatga cgatgatgat tcacctgatc ctgaaagtcc agatgattct
      541 gaaagcgatt cagagtcaga gaaagaagaa tctgctgaag aactccaagc tgctgagcac
      601 cctgatgaag tggaggatcc caaaaacaaa aaagatgcaa aaagcaatta taaaatgatg
      661 tttgttaaat ccagtggttc ataactccca aacgcttagt ctttgtatta aaagtaagcc
      721 ttattgttac aatgcacagt ggaggactgc ttatagagca cagacctttg tattataatt
      781 tttaaaaagg cccttttaaa taattacaaa gagtgtttgc tttcaaatgc catgggttac
      841 acttttatgg gcatgactat aaccattttt gtaaagagta agagttgtat aaaataagaa
      901 ataaatacag tactcaactt cctttcatat tagcatcatc aaccctctaa ttcaccttat
      961 gggggaaatg cttctttttg tttgtgatag ctattttatc atttccttca tatttttctc
     1021 ttataaaaat gtatttgata ctgtgatatg ttcacgaaaa gtattcttta attattcttt
     1081 gttatagtag agctgttcat tatggatatt tctgctgcca gtcacaatct aaattaattt
     1141 tggcaaaaga ttgggtactt agtttcctgt tactgagtta gctctactct tttggaccaa
     1201 agcaacatga gagcaagtac ttttcacact tgttaagatg gagttataac tgtcatacat
     1261 ttggaatatt atgatcccaa gtagtctttt tataatttgg attgtatcgt atgttagatt
     1321 tttgataaaa tttggccaat ttttacagaa gaaattctct gatcatttag ttctgtctat
     1381 ttagaaatat gtaaaactgg attttttttt aagtaatatg tgaccaaagt taattttgtc
     1441 ccaaaggtct aaataaagag cagtttccca tatttggctg tgataccttt atcctcatta
     1501 tctacaaatg aggaacaggc ttactgataa gaagctgaaa caagaaattc tcttcatttt
     1561 atcccagtgc tattttattg attaattact aaaaagtatt actttctaat tttattgctg
     1621 tttctgttgg tgtgagatta gaatcatctg actgctatta ggtggttgat ttgtatagct
     1681 gattaacaca aattgcatta tgagctagta aatggatctt tggataatgg ggtccaaatt
     1741 cttaatgttt ataagtaaca agttcaaagg ctttagtcac acctgtttgt gagctgagct
     1801 attatacatc tacatactta aaggatgtat ttggagtgtt ggattttttt tttttttttt
     1861 tttttttgag acggagtctc attctgtcgc ccaggctgga gtgcagtggc gcgatctcag
     1921 ctaactgcaa cctctgcctc ccaggttcaa gcgattctcc tgcctcagcc tcccaagtag
     1981 ttgggactac agtcatgtgc cactactcct ggctaatttt ttgtattttt agtagagttg
     2041 gggtttcacg gtgttagcca ggatcgtctc gatctcctga cctcgtgatc cacccacctt
     2101 ggcctcccaa agtgctggga ttacaggcgt gagccaccac gcccagcctt ggagtgttgg
     2161 aatttttaaa aattattctt atgtcacttt gaaatgtaga acgtgttgcc atgtgcggtg
     2221 gctcacacct ataatcccag cactttggga ggccgaggtg gctggatcac ctgaagtcag
     2281 gagtttgaga ccagcctgac caacatggag aaaccccatc tctactaaaa atacaaaatt
     2341 agctgggcgt ggtggtgcat gcctgtaatc ccagctactc aggaggctga ggcaggagaa
     2401 tcacttgaac ccaggaagcg gaggttgcag tgagccaaga tcaccccatt gcactccagc
     2461 ctgggcaaca agagcaaaac tccatctcaa aaaaaaaaaa aaaaaaaatt tagaatgtgt
     2521 tagagaaatt taacaagtag aacaggtgat ttctggttga tagactctat cttgcagtat
     2581 atttatttca tgtatcagac cccaaagttg ttgccttgtt atttttttaa tttctcacat
     2641 ttttgaaaaa tagatgctat cctctatagt aaaatattga atcactttat agtagacaat
     2701 acatatgaca tttaacaaat acttggtttg aaaaagtttg gctttattca acaattttag
     2761 tttgcccact gattttcaaa tgtctgtggg attgcttata actaagtaga aagtgaagac
     2821 tgatttttac ttaagaatgg gatagagatg agttttatgg tttttaaaag tattttcagt
     2881 tcattattta aatgttgggt tgttgatatg gtcttgtttc tgataaggaa ataggagcaa
     2941 cttgttttaa aataactaca ctaaaagact ttcttcatct ccgtatagag aaatccagat
     3001 ttcaattaat tcatttattg ggtgctaaca aaattcaggg ttagagtaaa tttaggtctg
     3061 ttggtccatg tggcctggtt tcctagcacc cattaaacat aatgctatct tttaagcctg
     3121 aacatgtggg ttttttaaat caaattggaa aaaaattaga caactgatgt catgctgtct
     3181 tggtatccat actaaaaaag tatcaggaaa atagattatt tttgtgctgt gaaacactat
     3241 tcagtggaaa gtttagtggc aacttttcca tatcattcat gacttaatac ctgaaatgca
     3301 cttttaaatg tttgccttat atccaagtgt ttacttgtat ccatgaccta accgtctatt
     3361 gaaaagaatg tttgcagatg cagattgcaa tgttgtttgt attcataggc aaaagtcctc
     3421 ttctctagta taatttttta aatctgagag aattgaaggt acagaaaaaa attctggagt
     3481 gcctgaacca cagtttgaga gcacaaaggt cacattcttt cagtaaattt gggggaaata
     3541 aatttcagct acctggttag cttcagtgac tacttacaca cagggctttg gttccattac
     3601 ttgtttccac cacagccaca tcctaaatac ttggaatatc cgaaaacaac ttctaaaatc
     3661 actcaataaa agtattcact tctaaccaac tcctcctcct ttatacctgc tctgtgttag
     3721 ggcgtagtct gtttccacct ctgtaagtcc tatctaggct tcctgatcta tcaattcagt
     3781 atcatgattg ttaacccaaa cgacttcctg gaaaattccc agccctagat gtatccaagc
     3841 cctcctaccc tcaccagtta tttctggaga aagatcacca aatgtataaa tccgtattag
     3901 taaaaattgg ttttaactga
//
