LOCUS       NM_001351993            3861 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 54 (C11orf54),
            transcript variant 15, mRNA.
ACCESSION   NM_001351993 XM_017017619
VERSION     NM_001351993.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3861)
  AUTHORS   Tan,J., Wang,W., Liu,X., Xu,J., Che,Y., Liu,Y., Hu,J., Hu,L., Li,J.
            and Zhou,Q.
  TITLE     C11orf54 promotes DNA repair via blocking CMA-mediated degradation
            of HIF1A
  JOURNAL   Commun Biol 6 (1), 606 (2023)
   PUBMED   37277441
  REMARK    GeneRIF: C11orf54 promotes DNA repair via blocking CMA-mediated
            degradation of HIF1A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3861)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3861)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3861)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 3861)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3861)
  AUTHORS   Manjasetty,B.A., Bussow,K., Fieber-Erdmann,M., Roske,Y., Gobom,J.,
            Scheich,C., Gotz,F., Niesen,F.H. and Heinemann,U.
  TITLE     Crystal structure of Homo sapiens PTD012 reveals a zinc-containing
            hydrolase fold
  JOURNAL   Protein Sci 15 (4), 914-920 (2006)
   PUBMED   16522806
REFERENCE   7  (bases 1 to 3861)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001273.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001351993.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1621283.1,
                                           SRR14372080.1755607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AP001273.4         14000-14056
            58-156              AP001273.4         22674-22772
            157-230             AP001273.4         26010-26083
            231-332             AP001273.4         26264-26365
            333-509             AP001273.4         27538-27714
            510-626             AP001273.4         32070-32186
            627-3861            AP001273.4         33843-37077
FEATURES             Location/Qualifiers
     source          1..3861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3861
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="chromosome 11 open reading frame 54"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
     exon            1..57
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            58..156
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..800
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="isoform e is encoded by transcript variant 15;
                     ester hydrolase C11orf54; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="ester hydrolase C11orf54 isoform e"
                     /protein_id="NP_001338922.1"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
                     /translation="MQKGLKDNFADVQVSVVDCPDLTKEPFTFPVKGICGKTRIAEVG
                     GVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPVIQTESEH
                     KPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANLFASEGQPGKPAEFSSCPLN
                     SDEEVNKWLHFYEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEGGHYHYDTTPDI
                     VEYLGYFLPAEFLYRIDQPKETHSIGRD"
     exon            157..230
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            231..332
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            333..509
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            510..626
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3861
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: ATTAAA"
     polyA_site      825
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     polyA_site      3566
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
ORIGIN      
        1 ggggttggcc taggcgaaga tccggactct gggtgttttg ctaccgtgac cgtttagtta
       61 tgcagaaggg gttaaaagat aactttgctg atgtccaggt ctctgtagtt gattgccctg
      121 atttgactaa ggaacccttt acctttcctg taaaaggcat ctgtgggaaa actagaattg
      181 cagaagttgg aggtgtgcct tacttattgc ctcttgtaaa ccaaaaaaaa gtttatgatc
      241 tgaataaaat tgcaaaagaa atcaagctgc ctggagcctt tattcttgga gcaggagcag
      301 gtccatttca gactctcggg ttcaattctg agtttatgcc agttattcag acagaaagtg
      361 aacacaagcc tcctgtaaat ggaagttact ttgcccatgt gaaccctgca gatggagggt
      421 gcctactgga gaaatacagt gagaaatgtc atgattttca gtgtgcatta ctggctaatc
      481 tttttgccag tgaaggccaa cctggcaagc ctgcagaatt ttcttcctgc cccttgaact
      541 ctgatgaaga agtgaataaa tggttgcatt tttatgaaat gaaagctcct ttggtttgtc
      601 taccagtttt tgtctccaga gacccagggt ttgatttgcg actggagcac actcattttt
      661 ttagtcgtca tggagaaggt ggacactacc attatgacac tactccagat atagtggaat
      721 atcttggata cttcttacct gcagagtttc tctatcgcat tgatcaacca aaagagacgc
      781 attcaattgg gcgagattaa atcagctgat acttatttag aaaaagaaat aattaaggtt
      841 aattaattga ttgacttatt aattaatact gatataaaac caatagaaat gatcccacag
      901 gccaggcaca atggctcatg cctataatcc cagcactttg ggaggctgag gcaggaagca
      961 cactggagcc caggagtttg agaccagctt gggcaacata gcaagaccct gtctattttt
     1021 ttaaaaaagt aaaaaataga aattatctca ctacttaaat cccatttttt tcacttcata
     1081 tgaaagaaca tattgatagt atattctata ttatttcata gatctgtctg aaagagattg
     1141 ggaacaaaaa tatctaattg agatattctt taatttttta catagcagct ttattttttt
     1201 tattctgtag tatcagcgaa atcagtcatg tttatacctt gaatataaat atcaggaatc
     1261 atgcaattat ttctactatg tatttagtag tatcttatat ttgtataaca ttattacatt
     1321 ttgcaaatta gtatcacaac tgctaagtag atgtttctga gtattagaaa aatcagtgtt
     1381 attacctgca ggatattaaa aaacatttga aaaagagaaa aagaaaaatc agtgtttaga
     1441 aatgttgata gttattgaat ctttgaattg aattttaaaa atccattcta gtaatcagag
     1501 tatacttttt ttatagaaca aggtggcagg tggggagccc tttacccttc tggtgaagtt
     1561 aaaccataga agtttacaat ttgcctttca caaacattag cagtccgggc atggtggctg
     1621 aagcctgtga tcccagcatg ttgggaggcc gagtgggagg attgcctgag cctaggagtt
     1681 taaaccagcc tgggcaccat ggtgagaccc catctctatt atttaaaatg tttcttaaat
     1741 aaaaaaaaca caaacattag caactagttg gctagccata attcctccct tgtttcgatt
     1801 gccagttaga agcaattttt atttcactgg ttatttgcaa gagaaggggt aaaaaaacag
     1861 catcagagtg caacactgaa gtgagcttac tttaatttgt aagtgaagct gttgctgaac
     1921 atgaccacta tcgttgctga aatataaaat tatactcact gattgtaatg gttgaaattt
     1981 tcctgaataa tcattagcca aagatcaact ctctaatggt gctaatggca atctagctaa
     2041 tgtgcaaatt taggaagtct tcagtactaa gtacataatt ttcaaataat attttttaat
     2101 tgtctacttt ggatgttagc tatgtcttgt gagtataaat tccaatttta agcactattt
     2161 tgatgcaaaa aaatgaataa aaaatttaat ttatgatatg tttgtaatat cttacctcca
     2221 gacaaaataa tattaatagt ctatcattta acaaatatgt attgaacacc tacccttctc
     2281 tctggagtgt acacttcatg tgggcaaggg ccttgttcac gactgtagca ctagtgcctt
     2341 taactgctag caaagtagcc actcggatga ttataccaaa cactttacta aagctgggga
     2401 tctgtctagt ggggaagaca aacaataaat atataatatg tcaggtggta ttaaatgcta
     2461 tgaaaagaaa ggagtagatg gactgtaaag gaggatgcta tttttttgtg gccatcccgc
     2521 actgagacag gatgcattcc acactcaaaa tttggttcac atgtccagac tgatagccaa
     2581 gttcagtggc tcacgcctgt aatcctagta cttagggaga ccaaggcagg aggatcactt
     2641 gaggccagga gttcaaggcc agcctgggca acagagagag acccccatct ctgcaaaaaa
     2701 agaaaaaaaa ttttttaatt atctgggcat ggttgtgcac acctgttgtc ccagctgctc
     2761 aggaggctga ggcacgagaa tcacttgagc ccagaagttg gaggctacag tgagctatga
     2821 ttgtttcatt gcactgtagc ctgggcaaca cagtgagacc ctgtctcaaa aagaaaaaaa
     2881 aaatgactga tgaagccaca cacacaccaa cagagtatga aagggttgtt actcacataa
     2941 tgaagctttc tggggaaagc agggcagctc ctaagcagga tttgacaaca gggaaggaga
     3001 ctgacttgga gttttttggt ggttagggag tagggccaga gtgatgtttc ttgcatgtgg
     3061 tttgaatttc ccactggtat caaagaagga aacacccagg cttgcttgct ttattttttt
     3121 aaagagatgg tgtctcacta tgttgcccag gctgggctca agtcatcttc ctgcctcggc
     3181 ctcccaaagt gctgggatta caggcatggg ccaccatgtc tggcgagcac ccaggctttc
     3241 ttagcttgcc agaggtgtag ggcataaggg gacgaggggt gggataaggc ttaaaagcca
     3301 ccagcagtca aacataaatt aagtcagatt cttaattaca gatttcagat ctgatttcag
     3361 atcagagctt atttcaggtc agattccagg tgtagagatc atctgaagca gtcctgggcc
     3421 tcttcacact acagatacca acactgcctt tactcttcca ttagtgtcct ccaaaatggg
     3481 gtgcatggac agcaggtaca catgaccttc caaggggtgt gggaatatta gaacatctat
     3541 ttatatattt tatttcgtcc ttttaagttt ctgtggtttt gtgtacattt cttacgttag
     3601 ggatttcagt tcaaaattgt attgctgata gacacaattc aaaaagcttg gagaccaggt
     3661 acattcacac catctaatag agatggggga aaagatcaaa atgcttttct ttttaaattt
     3721 tttcttagtt ttctttcttt atagagacag agtttcgccg tgttggccag gctgttctcg
     3781 aactcctggc ctcaagtgat ctgcccgtct cagcctctca aattgctggg attacaggca
     3841 tgaggcactg cacctcaccc a
//
