LOCUS       NM_001351987            4906 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 54 (C11orf54),
            transcript variant 9, mRNA.
ACCESSION   NM_001351987 XM_017017615
VERSION     NM_001351987.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4906)
  AUTHORS   Tan,J., Wang,W., Liu,X., Xu,J., Che,Y., Liu,Y., Hu,J., Hu,L., Li,J.
            and Zhou,Q.
  TITLE     C11orf54 promotes DNA repair via blocking CMA-mediated degradation
            of HIF1A
  JOURNAL   Commun Biol 6 (1), 606 (2023)
   PUBMED   37277441
  REMARK    GeneRIF: C11orf54 promotes DNA repair via blocking CMA-mediated
            degradation of HIF1A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4906)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4906)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4906)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 4906)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 4906)
  AUTHORS   Manjasetty,B.A., Bussow,K., Fieber-Erdmann,M., Roske,Y., Gobom,J.,
            Scheich,C., Gotz,F., Niesen,F.H. and Heinemann,U.
  TITLE     Crystal structure of Homo sapiens PTD012 reveals a zinc-containing
            hydrolase fold
  JOURNAL   Protein Sci 15 (4), 914-920 (2006)
   PUBMED   16522806
REFERENCE   7  (bases 1 to 4906)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001273.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001351987.1.
            
            Transcript Variant: This variant (9), as well as variants 1-3, 7,
            8, 10 and 11, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.205739.1,
                                           SRR1803612.42906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AP001273.4         14000-14056
            58-805              AP001273.4         15346-16093
            806-952             AP001273.4         19630-19776
            953-1051            AP001273.4         22674-22772
            1052-1125           AP001273.4         26010-26083
            1126-1227           AP001273.4         26264-26365
            1228-1404           AP001273.4         27538-27714
            1405-1554           AP001273.4         29644-29793
            1555-1671           AP001273.4         32070-32186
            1672-4906           AP001273.4         33843-37077
FEATURES             Location/Qualifiers
     source          1..4906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4906
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="chromosome 11 open reading frame 54"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
     exon            1..57
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            58..805
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            806..952
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     CDS             898..1845
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="isoform a is encoded by transcript variant 9; ester
                     hydrolase C11orf54; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="ester hydrolase C11orf54 isoform a"
                     /protein_id="NP_001338916.1"
                     /db_xref="CCDS:CCDS66204.1"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
                     /translation="MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKE
                     PFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPF
                     QTLGFNSEFMPVIQTESEHKPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANL
                     FASEGQPGKVIEVKAKRRTGPLNFVTCMRETLEKHYGNKPIGMGGTFIIQKGKVKSHI
                     MPAEFSSCPLNSDEEVNKWLHFYEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEG
                     GHYHYDTTPDIVEYLGYFLPAEFLYRIDQPKETHSIGRD"
     exon            953..1051
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1125
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1227
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1404
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1554
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1671
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..4906
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: ATTAAA"
     polyA_site      1870
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     regulatory      3221..3226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: AATAAA"
     polyA_site      3241
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     polyA_site      4611
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
ORIGIN      
        1 ggggttggcc taggcgaaga tccggactct gggtgttttg ctaccgtgac cgtttagaaa
       61 cagagtctcg ctctgtcgcc caggctggag tgcagtgtgg cccgatctca gctcactgca
      121 acccccacct cccgggctca agagatccac ccacctcagc ttcccaagta gctgggacta
      181 cacgcgcccg ccaccacaac cggctaattt ttgtactttt agtagagacc aggtttcacc
      241 atgttggcca ggcaggtctc gaactcttga cctcaagtga tccgtctgcc tcggcctccc
      301 aaagtgctgg gagtacaggc gtgaatcacc gcgcccggcc acatttggta tttctctgtt
      361 tgtgttatag agacagggtc ttgctctgcc acccaggctg gagtgcagtt gaagcaggat
      421 attcctctga ccccttcgtg ggtcttgcgg ctgcggtgcc tcacttactt agcccacggc
      481 tctcaactcc tcgcgggagg gggggcgcga gtgaatgagg cgggaactgg agtgctggaa
      541 gccacgaact ccagtcaccc aggcctgctg cgctccaccc tttatgggag ggtgcgtggg
      601 ggtgagcaga tgctggagcc ggagcgagcg cttttggtcg ccggtaggag cgaactccat
      661 gcaggccctg cggctgtgtc taggggatgc ccgcgacccc tgaagaccca cagcctgtct
      721 tacaacctgt catggttgtg aaaagttttg agagaacgtc tgcacagtgt ctaacggtgt
      781 ctggtatata gtgtgcactc aaatgaaact gttcatactt ggtgcgctgt ggactcttgt
      841 gataattaac caagagtagc tctatttgtc caacctcaca cctaaagaag aaagaaaatg
      901 gcttgtgctg agttttcttt tcatgtacca agtcttgaag agcttgctgg agttatgcag
      961 aaggggttaa aagataactt tgctgatgtc caggtctctg tagttgattg ccctgatttg
     1021 actaaggaac cctttacctt tcctgtaaaa ggcatctgtg ggaaaactag aattgcagaa
     1081 gttggaggtg tgccttactt attgcctctt gtaaaccaaa aaaaagttta tgatctgaat
     1141 aaaattgcaa aagaaatcaa gctgcctgga gcctttattc ttggagcagg agcaggtcca
     1201 tttcagactc tcgggttcaa ttctgagttt atgccagtta ttcagacaga aagtgaacac
     1261 aagcctcctg taaatggaag ttactttgcc catgtgaacc ctgcagatgg agggtgccta
     1321 ctggagaaat acagtgagaa atgtcatgat tttcagtgtg cattactggc taatcttttt
     1381 gccagtgaag gccaacctgg caaggtaatt gaggtgaaag ccaaaagaag aactggacca
     1441 cttaactttg tgacttgtat gagagagacc ctggaaaaac attatggaaa taagcctata
     1501 ggaatgggag gtactttcat aattcagaag ggaaaagtga agtctcacat tatgcctgca
     1561 gaattttctt cctgcccctt gaactctgat gaagaagtga ataaatggtt gcatttttat
     1621 gaaatgaaag ctcctttggt ttgtctacca gtttttgtct ccagagaccc agggtttgat
     1681 ttgcgactgg agcacactca tttttttagt cgtcatggag aaggtggaca ctaccattat
     1741 gacactactc cagatatagt ggaatatctt ggatacttct tacctgcaga gtttctctat
     1801 cgcattgatc aaccaaaaga gacgcattca attgggcgag attaaatcag ctgatactta
     1861 tttagaaaaa gaaataatta aggttaatta attgattgac ttattaatta atactgatat
     1921 aaaaccaata gaaatgatcc cacaggccag gcacaatggc tcatgcctat aatcccagca
     1981 ctttgggagg ctgaggcagg aagcacactg gagcccagga gtttgagacc agcttgggca
     2041 acatagcaag accctgtcta tttttttaaa aaagtaaaaa atagaaatta tctcactact
     2101 taaatcccat ttttttcact tcatatgaaa gaacatattg atagtatatt ctatattatt
     2161 tcatagatct gtctgaaaga gattgggaac aaaaatatct aattgagata ttctttaatt
     2221 ttttacatag cagctttatt ttttttattc tgtagtatca gcgaaatcag tcatgtttat
     2281 accttgaata taaatatcag gaatcatgca attatttcta ctatgtattt agtagtatct
     2341 tatatttgta taacattatt acattttgca aattagtatc acaactgcta agtagatgtt
     2401 tctgagtatt agaaaaatca gtgttattac ctgcaggata ttaaaaaaca tttgaaaaag
     2461 agaaaaagaa aaatcagtgt ttagaaatgt tgatagttat tgaatctttg aattgaattt
     2521 taaaaatcca ttctagtaat cagagtatac tttttttata gaacaaggtg gcaggtgggg
     2581 agccctttac ccttctggtg aagttaaacc atagaagttt acaatttgcc tttcacaaac
     2641 attagcagtc cgggcatggt ggctgaagcc tgtgatccca gcatgttggg aggccgagtg
     2701 ggaggattgc ctgagcctag gagtttaaac cagcctgggc accatggtga gaccccatct
     2761 ctattattta aaatgtttct taaataaaaa aaacacaaac attagcaact agttggctag
     2821 ccataattcc tcccttgttt cgattgccag ttagaagcaa tttttatttc actggttatt
     2881 tgcaagagaa ggggtaaaaa aacagcatca gagtgcaaca ctgaagtgag cttactttaa
     2941 tttgtaagtg aagctgttgc tgaacatgac cactatcgtt gctgaaatat aaaattatac
     3001 tcactgattg taatggttga aattttcctg aataatcatt agccaaagat caactctcta
     3061 atggtgctaa tggcaatcta gctaatgtgc aaatttagga agtcttcagt actaagtaca
     3121 taattttcaa ataatatttt ttaattgtct actttggatg ttagctatgt cttgtgagta
     3181 taaattccaa ttttaagcac tattttgatg caaaaaaatg aataaaaaat ttaatttatg
     3241 atatgtttgt aatatcttac ctccagacaa aataatatta atagtctatc atttaacaaa
     3301 tatgtattga acacctaccc ttctctctgg agtgtacact tcatgtgggc aagggccttg
     3361 ttcacgactg tagcactagt gcctttaact gctagcaaag tagccactcg gatgattata
     3421 ccaaacactt tactaaagct ggggatctgt ctagtgggga agacaaacaa taaatatata
     3481 atatgtcagg tggtattaaa tgctatgaaa agaaaggagt agatggactg taaaggagga
     3541 tgctattttt ttgtggccat cccgcactga gacaggatgc attccacact caaaatttgg
     3601 ttcacatgtc cagactgata gccaagttca gtggctcacg cctgtaatcc tagtacttag
     3661 ggagaccaag gcaggaggat cacttgaggc caggagttca aggccagcct gggcaacaga
     3721 gagagacccc catctctgca aaaaaagaaa aaaaattttt taattatctg ggcatggttg
     3781 tgcacacctg ttgtcccagc tgctcaggag gctgaggcac gagaatcact tgagcccaga
     3841 agttggaggc tacagtgagc tatgattgtt tcattgcact gtagcctggg caacacagtg
     3901 agaccctgtc tcaaaaagaa aaaaaaaatg actgatgaag ccacacacac accaacagag
     3961 tatgaaaggg ttgttactca cataatgaag ctttctgggg aaagcagggc agctcctaag
     4021 caggatttga caacagggaa ggagactgac ttggagtttt ttggtggtta gggagtaggg
     4081 ccagagtgat gtttcttgca tgtggtttga atttcccact ggtatcaaag aaggaaacac
     4141 ccaggcttgc ttgctttatt tttttaaaga gatggtgtct cactatgttg cccaggctgg
     4201 gctcaagtca tcttcctgcc tcggcctccc aaagtgctgg gattacaggc atgggccacc
     4261 atgtctggcg agcacccagg ctttcttagc ttgccagagg tgtagggcat aaggggacga
     4321 ggggtgggat aaggcttaaa agccaccagc agtcaaacat aaattaagtc agattcttaa
     4381 ttacagattt cagatctgat ttcagatcag agcttatttc aggtcagatt ccaggtgtag
     4441 agatcatctg aagcagtcct gggcctcttc acactacaga taccaacact gcctttactc
     4501 ttccattagt gtcctccaaa atggggtgca tggacagcag gtacacatga ccttccaagg
     4561 ggtgtgggaa tattagaaca tctatttata tattttattt cgtcctttta agtttctgtg
     4621 gttttgtgta catttcttac gttagggatt tcagttcaaa attgtattgc tgatagacac
     4681 aattcaaaaa gcttggagac caggtacatt cacaccatct aatagagatg ggggaaaaga
     4741 tcaaaatgct tttcttttta aattttttct tagttttctt tctttataga gacagagttt
     4801 cgccgtgttg gccaggctgt tctcgaactc ctggcctcaa gtgatctgcc cgtctcagcc
     4861 tctcaaattg ctgggattac aggcatgagg cactgcacct caccca
//
