LOCUS       NM_001286069            4163 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 54 (C11orf54),
            transcript variant 3, mRNA.
ACCESSION   NM_001286069 XM_005273934
VERSION     NM_001286069.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Tan,J., Wang,W., Liu,X., Xu,J., Che,Y., Liu,Y., Hu,J., Hu,L., Li,J.
            and Zhou,Q.
  TITLE     C11orf54 promotes DNA repair via blocking CMA-mediated degradation
            of HIF1A
  JOURNAL   Commun Biol 6 (1), 606 (2023)
   PUBMED   37277441
  REMARK    GeneRIF: C11orf54 promotes DNA repair via blocking CMA-mediated
            degradation of HIF1A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Manjasetty,B.A., Bussow,K., Fieber-Erdmann,M., Roske,Y., Gobom,J.,
            Scheich,C., Gotz,F., Niesen,F.H. and Heinemann,U.
  TITLE     Crystal structure of Homo sapiens PTD012 reveals a zinc-containing
            hydrolase fold
  JOURNAL   Protein Sci 15 (4), 914-920 (2006)
   PUBMED   16522806
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL708049.1, AK291833.1, BC012298.1, AA864999.1 and AP001273.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001286069.1.
            
            Transcript Variant: This variant (3) lacks an exon in the 5' UTR,
            compared to variant 1. Variants 1-3 and 7-11 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.170074.1,
                                           SRR1660803.104541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354421.8/ ENSP00000346403.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL708049.1         86-101
            17-997              AK291833.1         1-981
            998-2115            BC012298.1         893-2010
            2116-2516           AA864999.1         4-404               c
            2517-4163           AP001273.4         35431-37077
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4163
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="chromosome 11 open reading frame 54"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
     exon            1..57
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            58..209
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1102
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="isoform a is encoded by transcript variant 3; ester
                     hydrolase C11orf54; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="ester hydrolase C11orf54 isoform a"
                     /protein_id="NP_001272998.1"
                     /db_xref="CCDS:CCDS66204.1"
                     /db_xref="GeneID:28970"
                     /db_xref="HGNC:HGNC:30204"
                     /db_xref="MIM:615810"
                     /translation="MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKE
                     PFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPF
                     QTLGFNSEFMPVIQTESEHKPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANL
                     FASEGQPGKVIEVKAKRRTGPLNFVTCMRETLEKHYGNKPIGMGGTFIIQKGKVKSHI
                     MPAEFSSCPLNSDEEVNKWLHFYEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEG
                     GHYHYDTTPDIVEYLGYFLPAEFLYRIDQPKETHSIGRD"
     exon            210..308
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            309..382
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            383..484
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            485..661
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            662..811
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            812..928
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     exon            929..4163
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: ATTAAA"
     polyA_site      1127
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
                     /note="major polyA site"
     polyA_site      3868
                     /gene="C11orf54"
                     /gene_synonym="MEEP; PTD012; PTOD012"
ORIGIN      
        1 ggggttggcc taggcgaaga tccggactct gggtgttttg ctaccgtgac cgtttagaac
       61 agaaactgtt catacttggt gcgctgtgga ctcttgtgat aattaaccaa gagtagctct
      121 atttgtccaa cctcacacct aaagaagaaa gaaaatggct tgtgctgagt tttcttttca
      181 tgtaccaagt cttgaagagc ttgctggagt tatgcagaag gggttaaaag ataactttgc
      241 tgatgtccag gtctctgtag ttgattgccc tgatttgact aaggaaccct ttacctttcc
      301 tgtaaaaggc atctgtggga aaactagaat tgcagaagtt ggaggtgtgc cttacttatt
      361 gcctcttgta aaccaaaaaa aagtttatga tctgaataaa attgcaaaag aaatcaagct
      421 gcctggagcc tttattcttg gagcaggagc aggtccattt cagactctcg ggttcaattc
      481 tgagtttatg ccagttattc agacagaaag tgaacacaag cctcctgtaa atggaagtta
      541 ctttgcccat gtgaaccctg cagatggagg gtgcctactg gagaaataca gtgagaaatg
      601 tcatgatttt cagtgtgcat tactggctaa tctttttgcc agtgaaggcc aacctggcaa
      661 ggtaattgag gtgaaagcca aaagaagaac tggaccactt aactttgtga cttgtatgag
      721 agagaccctg gaaaaacatt atggaaataa gcctatagga atgggaggta ctttcataat
      781 tcagaaggga aaagtgaagt ctcacattat gcctgcagaa ttttcttcct gccccttgaa
      841 ctctgatgaa gaagtgaata aatggttgca tttttatgaa atgaaagctc ctttggtttg
      901 tctaccagtt tttgtctcca gagacccagg gtttgatttg cgactggagc acactcattt
      961 ttttagtcgt catggagaag gtggacacta ccattatgac actactccag atatagtgga
     1021 atatcttgga tacttcttac ctgcagagtt tctctatcgc attgatcaac caaaagagac
     1081 gcattcaatt gggcgagatt aaatcagctg atacttattt agaaaaagaa ataattaagg
     1141 ttaattaatt gattgactta ttaattaata ctgatataaa accaatagaa atgatcccac
     1201 aggccaggca caatggctca tgcctataat cccagcactt tgggaggctg aggcaggaag
     1261 cacactggag cccaggagtt tgagaccagc ttgggcaaca tagcaagacc ctgtctattt
     1321 ttttaaaaaa gtaaaaaata gaaattatct cactacttaa atcccatttt tttcacttca
     1381 tatgaaagaa catattgata gtatattcta tattatttca tagatctgtc tgaaagagat
     1441 tgggaacaaa aatatctaat tgagatattc tttaattttt tacatagcag ctttattttt
     1501 tttattctgt agtatcagcg aaatcagtca tgtttatacc ttgaatataa atatcaggaa
     1561 tcatgcaatt atttctacta tgtatttagt agtatcttat atttgtataa cattattaca
     1621 ttttgcaaat tagtatcaca actgctaagt agatgtttct gagtattaga aaaatcagtg
     1681 ttattacctg caggatatta aaaaacattt gaaaaagaga aaaagaaaaa tcagtgttta
     1741 gaaatgttga tagttattga atctttgaat tgaattttaa aaatccattc tagtaatcag
     1801 agtatacttt ttttatagaa caaggtggca ggtggggagc cctttaccct tctggtgaag
     1861 ttaaaccata gaagtttaca atttgccttt cacaaacatt agcagtccgg gcatggtggc
     1921 tgaagcctgt gatcccagca tgttgggagg ccgagtggga ggattgcctg agcctaggag
     1981 tttaaaccag cctgggcacc atggtgagac cccatctcta ttatttaaaa tgtttcttaa
     2041 ataaaaaaaa cacaaacatt agcaactagt tggctagcca taattcctcc cttgtttcga
     2101 ttgccagtta gaagcaattt ttatttcact ggttatttgc aagagaaggg gtaaaaaaac
     2161 agcatcagag tgcaacactg aagtgagctt actttaattt gtaagtgaag ctgttgctga
     2221 acatgaccac tatcgttgct gaaatataaa attatactca ctgattgtaa tggttgaaat
     2281 tttcctgaat aatcattagc caaagatcaa ctctctaatg gtgctaatgg caatctagct
     2341 aatgtgcaaa tttaggaagt cttcagtact aagtacataa ttttcaaata atatttttta
     2401 attgtctact ttggatgtta gctatgtctt gtgagtataa attccaattt taagcactat
     2461 tttgatgcaa aaaaatgaat aaaaaattta atttatgata tgtttgtaat atcttacctc
     2521 cagacaaaat aatattaata gtctatcatt taacaaatat gtattgaaca cctacccttc
     2581 tctctggagt gtacacttca tgtgggcaag ggccttgttc acgactgtag cactagtgcc
     2641 tttaactgct agcaaagtag ccactcggat gattatacca aacactttac taaagctggg
     2701 gatctgtcta gtggggaaga caaacaataa atatataata tgtcaggtgg tattaaatgc
     2761 tatgaaaaga aaggagtaga tggactgtaa aggaggatgc tatttttttg tggccatccc
     2821 gcactgagac aggatgcatt ccacactcaa aatttggttc acatgtccag actgatagcc
     2881 aagttcagtg gctcacgcct gtaatcctag tacttaggga gaccaaggca ggaggatcac
     2941 ttgaggccag gagttcaagg ccagcctggg caacagagag agacccccat ctctgcaaaa
     3001 aaagaaaaaa aattttttaa ttatctgggc atggttgtgc acacctgttg tcccagctgc
     3061 tcaggaggct gaggcacgag aatcacttga gcccagaagt tggaggctac agtgagctat
     3121 gattgtttca ttgcactgta gcctgggcaa cacagtgaga ccctgtctca aaaagaaaaa
     3181 aaaaatgact gatgaagcca cacacacacc aacagagtat gaaagggttg ttactcacat
     3241 aatgaagctt tctggggaaa gcagggcagc tcctaagcag gatttgacaa cagggaagga
     3301 gactgacttg gagttttttg gtggttaggg agtagggcca gagtgatgtt tcttgcatgt
     3361 ggtttgaatt tcccactggt atcaaagaag gaaacaccca ggcttgcttg ctttattttt
     3421 ttaaagagat ggtgtctcac tatgttgccc aggctgggct caagtcatct tcctgcctcg
     3481 gcctcccaaa gtgctgggat tacaggcatg ggccaccatg tctggcgagc acccaggctt
     3541 tcttagcttg ccagaggtgt agggcataag gggacgaggg gtgggataag gcttaaaagc
     3601 caccagcagt caaacataaa ttaagtcaga ttcttaatta cagatttcag atctgatttc
     3661 agatcagagc ttatttcagg tcagattcca ggtgtagaga tcatctgaag cagtcctggg
     3721 cctcttcaca ctacagatac caacactgcc tttactcttc cattagtgtc ctccaaaatg
     3781 gggtgcatgg acagcaggta cacatgacct tccaaggggt gtgggaatat tagaacatct
     3841 atttatatat tttatttcgt ccttttaagt ttctgtggtt ttgtgtacat ttcttacgtt
     3901 agggatttca gttcaaaatt gtattgctga tagacacaat tcaaaaagct tggagaccag
     3961 gtacattcac accatctaat agagatgggg gaaaagatca aaatgctttt ctttttaaat
     4021 tttttcttag ttttctttct ttatagagac agagtttcgc cgtgttggcc aggctgttct
     4081 cgaactcctg gcctcaagtg atctgcccgt ctcagcctct caaattgctg ggattacagg
     4141 catgaggcac tgcacctcac cca
//
