LOCUS       NM_022338               2071 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 24 (C11orf24),
            transcript variant 1, mRNA.
ACCESSION   NM_022338
VERSION     NM_022338.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2071)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2071)
  AUTHORS   Fraisier,V., Kasri,A., Miserey-Lenkei,S., Sibarita,J.B., Nair,D.,
            Mayeux,A., Bardin,S., Toyoda,Y., Poser,I., Poznyakovskiy,A.,
            Goud,B., Hyman,A.A. and Dimitrov,A.
  TITLE     C11ORF24 is a novel type I membrane protein that cycles between the
            Golgi apparatus and the plasma membrane in Rab6-positive vesicles
  JOURNAL   PLoS One 8 (12), e82223 (2013)
   PUBMED   24312644
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2071)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   4  (bases 1 to 2071)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2071)
  AUTHORS   Twells,R.C., Metzker,M.L., Brown,S.D., Cox,R., Garey,C.,
            Hammond,H., Hey,P.J., Levy,E., Nakagawa,Y., Philips,M.S., Todd,J.A.
            and Hess,J.F.
  TITLE     The sequence and gene characterization of a 400-kb candidate region
            for IDDM4 on chromosome 11q13
  JOURNAL   Genomics 72 (3), 231-242 (2001)
   PUBMED   11401438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG701401.1, AF264781.1 and BC011765.2.
            
            On Nov 22, 2018 this sequence version replaced NM_022338.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.607804.1,
                                           SRR3476690.1107725.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304271.11/ ENSP00000307264.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BG701401.1         34-53
            21-2070             AF264781.1         9-2058
            2071-2071           BC011765.2         1948-1948
FEATURES             Location/Qualifiers
     source          1..2071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2071
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /note="chromosome 11 open reading frame 24"
                     /db_xref="GeneID:53838"
                     /db_xref="HGNC:HGNC:1174"
                     /db_xref="MIM:610880"
     exon            1..117
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /inference="alignment:Splign:2.1.0"
     exon            118..315
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..490
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1764
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C11orf24"
                     /codon_start=1
                     /product="uncharacterized protein C11orf24 isoform 1
                     precursor"
                     /protein_id="NP_071733.1"
                     /db_xref="CCDS:CCDS8180.1"
                     /db_xref="GeneID:53838"
                     /db_xref="HGNC:HGNC:1174"
                     /db_xref="MIM:610880"
                     /translation="MWTALVLIWIFSLSLSESHAASNDPRNFVPNKMWKGLVKRNASV
                     ETVDNKTSEDVTMAAASPVTLTKGTSAAHLNSMEVTTEDTSRTDVSEPATSGGAADGV
                     TSIAPTAVASSTTAASITTAASSMTVASSAPTTAASSTTVASIAPTTAASSMTAASST
                     PMTLALPAPTSTSTGRTPSTTATGHPSLSTALAQVPKSSALPRTATLATLATRAQTVA
                     TTANTSSPMSTRPSPSKHMPSDTAASPVPPMRPQAQGPISQVSVDQPVVNTTNKSTPM
                     PSNTTPEPAPTPTVVTTTKAQAREPTASPVPVPHTSPIPEMEAMSPTTQPSPMPYTQR
                     AAGPGTSQAPEQVETEATPGTDSTGPTPRSSGGTKMPATDSCQPSTQGQYMVVTTEPL
                     TQAVVDKTLLLVVLLLGVTLFITVLVLFALQAYESYKKKDYTQVDYLINGMYADSEM"
     exon            491..2071
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /note="hexamer: ACTAAA"
     polyA_site      1946
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /note="major polyA site"
     regulatory      2049..2054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /note="hexamer: ATTAAA"
     polyA_site      2071
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
ORIGIN      
        1 agggcgcgct gcccggagct gcctgggttg cgctgccggc cacgtccccg cgccgggcct
       61 caggctcctt cctactgtcc gagggccacc aggccgccgg gggcctgctg cgcccggatg
      121 cgtctgttac tagagtggag agtctacctt cgtctcacat gtgccacaaa ggatggcatg
      181 gcccgggagt gccccaccac gtggctttca ccccctgcaa agccagactt cgcccagcga
      241 cacagtgtca agcccacagc tctccaagga ggaagatggt ccaggctggg agcatcccct
      301 tagcagcagc ctctgatccc ttggccaagc aggagggaac cattagcagc ctgaggagct
      361 ggctggctgg gagcctcggg gaccgcccag ccttgctccc agctcaccca caagatgtgg
      421 acagctcttg tgctcatttg gattttctcc ttgtccttat ctgaaagcca tgcggcatcc
      481 aacgatccac gcaactttgt ccctaacaaa atgtggaagg gattagtcaa gaggaatgca
      541 tctgtggaaa cagttgataa taaaacgtct gaggatgtaa ccatggcagc agcttctcct
      601 gtcacattga ccaaagggac ttcggcagcc cacctcaact ctatggaagt cacaacagag
      661 gacacaagca ggacagatgt gagtgaacca gcaacttcag gaggtgcagc tgatggtgtg
      721 acctccattg ctcccacggc tgtggcctcc agtacgactg cggcctccat tacgactgcg
      781 gcctccagta tgactgtggc ctccagtgct cccacgactg cagcctccag tacaactgtg
      841 gcctccattg ctcccacgac tgcagcctcc agtatgactg cggcctccag cactcccatg
      901 acacttgcac tccccgcgcc cacgtccact tccacagggc ggaccccgtc cactaccgcc
      961 actgggcatc catctctcag cacagccctc gcacaagtgc caaagagcag cgcgttgcca
     1021 agaacagcaa ccctggccac attggccaca cgtgctcaga ctgtagcgac cacagcaaac
     1081 acaagcagcc ccatgagcac tcgtccaagt ccttccaagc acatgcccag tgacaccgcg
     1141 gcaagccctg taccccctat gcgtccccaa gcacaaggtc ccattagcca ggtgtcagtg
     1201 gaccagcctg tggttaacac aacaaataaa tccacaccca tgccctcaaa cacaacccca
     1261 gagcccgccc ccacccccac agtggtgacc accaccaagg cacaagccag ggagccaact
     1321 gccagcccag tgccagtacc tcacaccagc ccaatccctg agatggaggc catgtccccc
     1381 acgacacagc caagccccat gccatatacc cagagggccg ctgggccagg cacatcccag
     1441 gcaccggagc aggtagagac tgaagccaca ccaggtactg attccactgg gccaacaccc
     1501 aggagctcag ggggcactaa gatgccagcc acggactcgt gccagcccag cacccaaggc
     1561 cagtacatgg tggtcaccac tgagcccctc acccaggccg tggtagacaa aactctcctt
     1621 ctggtggtgc tgttactcgg ggtgaccctt ttcatcacag tcttggtttt gtttgccctg
     1681 caggcctatg agagctacaa gaagaaggac tacacccagg tggactactt aatcaacggg
     1741 atgtatgcgg actcagaaat gtgagggggg cgggggcctg gcgggaggcc tggccccttc
     1801 ctcgtccttt ccttttgcct ttgagaccaa accaagtgct tccaaattct tttggtgcaa
     1861 ttgaggagat atgccagatg cttaaacaca tttaattgct gtcagattaa ttccatgatc
     1921 actaaagagt tgctgctttt ttcatattta tttttgtaaa tgattctgtg cccaggagca
     1981 gctgggggtt ccacctcagg gtggggcggg caggaccccg tctccccagg tgtcggagcc
     2041 tgacctgaat taaagtactg actgctcgcc a
//
