LOCUS       NM_001329958            2831 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens chromosome 11 open reading frame 21 (C11orf21),
            transcript variant 2, mRNA.
ACCESSION   NM_001329958 NR_024621
VERSION     NM_001329958.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Yu,X., Li,Y., Yang,P., Wang,Y., Liu,X., Cai,L., Lai,J., Zhang,Y.,
            Zha,X., Przybylski,G.K., Xu,L. and Li,Y.
  TITLE     BCL11B promotes T-cell acute lymphoblastic leukaemia cell survival
            via the XRCC5/C11ORF21 axis
  JOURNAL   Clin Transl Med 14 (2), e1580 (2024)
   PUBMED   38317587
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Zhu,X., Higashimoto,K., Soejima,H., Yatsuki,H., Sugihara,H.,
            Mukai,T. and Joh,K.
  TITLE     C11orf21, a novel gene within the Beckwith-Wiedemann syndrome
            region in human chromosome 11p15.5
  JOURNAL   Gene 256 (1-2), 311-317 (2000)
   PUBMED   11054561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129929.5 and AB029488.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001329958.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon
            compared to variant 1. The resulting isoform (2) has a shorter and
            distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029488.1, DA675136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381153.8/ ENSP00000370545.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC129929.5         85179-85183
            6-1682              AB029488.1         154-1830
            1683-2831           AC129929.5         90321-91469
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2831
                     /gene="C11orf21"
                     /note="chromosome 11 open reading frame 21"
                     /db_xref="GeneID:29125"
                     /db_xref="HGNC:HGNC:13231"
                     /db_xref="MIM:611033"
     exon            1..163
                     /gene="C11orf21"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..509
                     /gene="C11orf21"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C11orf21"
                     /codon_start=1
                     /product="uncharacterized protein C11orf21 isoform 2"
                     /protein_id="NP_001316887.1"
                     /db_xref="CCDS:CCDS86168.1"
                     /db_xref="GeneID:29125"
                     /db_xref="HGNC:HGNC:13231"
                     /db_xref="MIM:611033"
                     /translation="MGRTWCGMWRRRRPGRRSAVPRWPHLSSQSGVEPPDRWTGTPGW
                     PSRDQEAPGSMMPPAAAQPSAHGALVPPATAHEPVDHPALHWLACCCCLSLPGQLPLA
                     IRLGWDLDLEAGPSSGKLCPRARRWQPLPS"
     exon            164..257
                     /gene="C11orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            258..537
                     /gene="C11orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            538..2831
                     /gene="C11orf21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf21"
                     /note="hexamer: AATAAG"
     polyA_site      683
                     /gene="C11orf21"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C11orf21"
                     /note="hexamer: ATTACA"
     polyA_site      2831
                     /gene="C11orf21"
                     /note="major polyA site"
ORIGIN      
        1 agcccagccc aagacaccag ggcatttgct gacatctgag gcccttccca ggaagacatg
       61 gcctcgttct tggtgtggcc actgaggacg gcgctgagag ggggaaagtc atgggcagga
      121 cctggtgtgg gatgtggagg agacggcgcc cggggaggag gagcgctgtg cccaggtggc
      181 ctcacttgtc atctcaaagt ggcgtcgaac cccctgacag gtggacggga acccccggct
      241 ggccctccag agaccaggag gcccctggct caatgatgcc acctgcagct gcccaaccct
      301 ccgcccatgg tgcccttgtt ccacctgcca ccgctcatga acctgtggat cacccagctc
      361 tgcactggct tgcctgctgc tgctgtctca gtttacctgg gcagttgccc ctggctatcc
      421 ggctgggatg ggacttggac ttagaagcag gcccctcctc tggaaagctg tgtcctcggg
      481 ccaggaggtg gcagcctcta ccttcctgag acagggaccc ttttctgtcc atcagaggac
      541 agctgtatga agacacagag agaaggcagc catctgtaag ccaggaagag agccctcacc
      601 aagactggaa tcagcagcac cttgatattg gacttccagc ctccagaact gcaagaaata
      661 agcacctgct gtttacatgc ccagcctgca gtgcttcctt atggcagatt ggagctaact
      721 gagacagctc ccagcactca ttcattcatt cattcattca ctcacctcat gtctactaaa
      781 cagctctggg ctggctctgg gaagcagtga gtcacacaca ctgcccccag caacgtgtga
      841 aatatgttta gagacagtgg gctacagcgg aaagggtaga tgccctgaga accccagcgg
      901 tgctggtcag aagcacaggc cttgttgggc tgaggctggc atggggtgaa cctggggagc
      961 ctcgggggca gaggtgatag atgtggggtg tttcaaggca gtgagacaaa gaagggagat
     1021 gggtggtgcc ccccaatgcc aggcttcacc agcctcccaa cacacgagtg ttcacccgcc
     1081 tggatgagac acctctgtgg acttgggagt gaaggcagtg aatttgggca atgctggagg
     1141 ccgtgcaggt gggaggtggg acaggggcaa gaggccgggg cccaggcagg agctgacagc
     1201 ccaccagtgg tgctcccctg agaagcaacc tcagtgggtg gcttggggtc tgctgggctg
     1261 tccccacact gacaccctgg ctgcagggcc cccctgtgtc cccagtgagg ggtctcggga
     1321 gctgtgtgtc ctactcaggg ccatccctgc agcccatgct ctctgggtga ccagttgcca
     1381 gcagtgtccc ccctgccttg ggcggaggct gaggacccca gggtgggagg gaaggtgcgg
     1441 tgggggctca gccaatgctg cccagcctga gggtccctca catgtgggcc gcacccctgc
     1501 gtcagccgga gtgatctctg cttagggtgg tttgaggtga gttctgatat ctcaaacacc
     1561 agcatcaggg ccagggcaga caaaataaga gtgagctggt caggggtgtc ccagttggga
     1621 gctcgctcac agtctttaag gaggcagggc acagcccagt gggggtggcc acgaggcccc
     1681 gggcctgtgg ctgagatggc aactggcacc ggcagtgatt ggaacagtcc agcccatgga
     1741 gccctgtggc cttggccggt ggctcacggt gccacgggag ctggagcaat gggtggcctc
     1801 ccttgcctgg tgcctgagtg aaggaggact gggtgcccct gaggaaggac cttgccatac
     1861 tcctacaaat ttacattatt cttctttccc cagtctcccc tcagggacct gcagccattt
     1921 gctggggtgg ctagtggaaa gggggatcat cagactcagg gggattactg gactctaact
     1981 ctaacctgac acccactcct ggggacacaa acacccatcg gatctaatag tcagaggagg
     2041 ggcgtatgga ggtcagtggg ctcacggagt tctagctcag gtccaaccct cggtgggtgc
     2101 agaggtcact tccctagcct cagatgggtg agtaaacaga cgtatgtggc agccagcaga
     2161 gcccccacat ttgttccctg acctgagggt gggggctact atgctgggaa aggccaggtg
     2221 gaagccattg gggtgaactc tgcctaggaa aattgtcagt caaaagcaac ctgcagccct
     2281 ggagggactg caaaggtcag tgccgccatc gaggacttgg aagatgcagg gtggtgaccc
     2341 ccactgcagc ctcgttccac tcgtctaatt ggcttgtgtg gaagacaggg gggtcccgga
     2401 gaaagaagga cagtgaatcc tggtaaactt aaccaggact ccaattgcaa ctgctgttcc
     2461 agatatgact actgatcact ggggcaaatc aaagcatccc cggacacctg gtctacagcc
     2521 attgatctgg tgaaagcttt aatttttaat atagatttta ttttttagag cagtttcatg
     2581 tttacagaga aattgagcat atttgagagt cctcatatag catctctccc tacacacagt
     2641 ttcccttatt attcatatct tgaattactg tgatacatct ttgcaattga tgaaccaata
     2701 ttgacctagt cattgatcag gttacatgag ggttcactct tcttgttgta catgctgtga
     2761 gttcgggcaa atgtgtaatg gcatatctcc actattacag tgtcacacag aattatttta
     2821 ctgccctaaa a
//
