LOCUS       NM_001350921            3471 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chromosome 10 open reading frame 90 (C10orf90),
            transcript variant 1, mRNA.
ACCESSION   NM_001350921 XM_011539216
VERSION     NM_001350921.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3471)
  AUTHORS   Zhang,T.M., Zhang,J., Zhou,D.J. and Wang,C.L.
  TITLE     [Expression of FATS in non-small cell lung cancer and its
            relationship with prognosis]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 41 (11), 826-830 (2019)
   PUBMED   31770849
  REMARK    GeneRIF: The expression of FATS protein is associated with the
            development and is an independent prognostic factor of non-small
            cell lung cancer patients.
REFERENCE   2  (bases 1 to 3471)
  AUTHORS   Zhang,J., Wu,N., Zhang,T., Sun,T., Su,Y., Zhao,J., Mu,K., Jin,Z.,
            Gao,M., Liu,J. and Gu,L.
  TITLE     The value of FATS expression in predicting sensitivity to
            radiotherapy in breast cancer
  JOURNAL   Oncotarget 8 (24), 38491-38500 (2017)
   PUBMED   28402275
  REMARK    GeneRIF: FATS status is a biomarker in breast cancer to identify
            individuals likely to benefit from radiotherapy
REFERENCE   3  (bases 1 to 3471)
  AUTHORS   Song,F., Zhang,J., Qiu,L., Zhao,Y., Xing,P., Lu,J., Chen,K. and
            Li,Z.
  TITLE     A functional genetic variant in fragile-site gene FATS modulates
            the risk of breast cancer in triparous women
  JOURNAL   BMC Cancer 15, 559 (2015)
   PUBMED   26223354
  REMARK    GeneRIF: Data identified a genetic variant in the FATS gene (905C >
            T, 262D/N) that is associated with susceptibility to breast cancer
            in a parity-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3471)
  AUTHORS   Yan,S., Qiu,L., Ma,K., Zhang,X., Zhao,Y., Zhang,J., Li,X., Hao,X.
            and Li,Z.
  TITLE     FATS is an E2-independent ubiquitin ligase that stabilizes p53 and
            promotes its activation in response to DNA damage
  JOURNAL   Oncogene 33 (47), 5424-5433 (2014)
   PUBMED   24240685
  REMARK    GeneRIF: FATS is an E2-independent ubiquitin ligase that stabilizes
            p53 and promotes its activation in response to DNA damage.
REFERENCE   5  (bases 1 to 3471)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   6  (bases 1 to 3471)
  AUTHORS   Zhang,J., Gu,L., Zhao,L.J., Zhang,X.F., Qiu,L. and Li,Z.
  TITLE     Expression level of novel tumor suppressor gene FATS is associated
            with the outcome of node positive breast cancer
  JOURNAL   Chin Med J (Engl) 124 (18), 2894-2898 (2011)
   PUBMED   22040499
  REMARK    GeneRIF: FATS is involved in the carcinogenesis and development of
            breast cancer and could be a potential biomarker and prognostic
            factor for breast cancer therapy.
REFERENCE   7  (bases 1 to 3471)
  AUTHORS   Knorz,V.J., Spalluto,C., Lessard,M., Purvis,T.L., Adigun,F.F.,
            Collin,G.B., Hanley,N.A., Wilson,D.I. and Hearn,T.
  TITLE     Centriolar association of ALMS1 and likely centrosomal functions of
            the ALMS motif-containing proteins C10orf90 and KIAA1731
  JOURNAL   Mol Biol Cell 21 (21), 3617-3629 (2010)
   PUBMED   20844083
  REMARK    GeneRIF: data suggest centrosomal functions for C10orf90 and
            KIAA1731 and new centriole-related functions for ALMS1
REFERENCE   8  (bases 1 to 3471)
  AUTHORS   Zhang,X., Zhang,Q., Zhang,J., Qiu,L., Yan,S.S., Feng,J., Sun,Y.,
            Huang,X., Lu,K.H. and Li,Z.
  TITLE     FATS is a transcriptional target of p53 and associated with
            antitumor activity
  JOURNAL   Mol Cancer 9, 244 (2010)
   PUBMED   20843368
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3471)
  AUTHORS   Li,Z., Zhang,Q., Mao,J.H., Weise,A., Mrasek,K., Fan,X., Zhang,X.,
            Liehr,T., Lu,K.H., Balmain,A. and Cai,W.W.
  TITLE     An HDAC1-binding domain within FATS bridges p21 turnover to
            radiation-induced tumorigenesis
  JOURNAL   Oncogene 29 (18), 2659-2671 (2010)
   PUBMED   20154723
REFERENCE   10 (bases 1 to 3471)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL392108.4, AL583860.7 and AL589787.16.
            
            On Jun 23, 2020 this sequence version replaced NM_001350921.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297577.1, SRR1803613.248705.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488181.3/ ENSP00000474558.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               AL392108.4         82206-82658         c
            454-526             AL392108.4         58530-58602         c
            527-618             AL583860.7         11658-11749         c
            619-1513            AL583860.7         2001-2895           c
            1514-1747           AL589787.16        146054-146287       c
            1748-2038           AL589787.16        106793-107083       c
            2039-2223           AL589787.16        103498-103682       c
            2224-2401           AL589787.16        101137-101314       c
            2402-2465           AL589787.16        71884-71947         c
            2466-2565           AL589787.16        68088-68187         c
            2566-3471           AL589787.16        67094-67999         c
FEATURES             Location/Qualifiers
     source          1..3471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..3471
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /note="chromosome 10 open reading frame 90"
                     /db_xref="GeneID:118611"
                     /db_xref="HGNC:HGNC:26563"
                     /db_xref="MIM:617735"
     exon            1..453
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2604
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fragile-site associated tumor suppressor homolog;
                     centrosomal protein C10orf90; E2/E3 hybrid
                     ubiquitin-protein ligase FATS; (E2-independent) E3
                     ubiquitin-conjugating enzyme FATS"
                     /codon_start=1
                     /product="(E2-independent) E3 ubiquitin-conjugating enzyme
                     FATS isoform 1"
                     /protein_id="NP_001337850.1"
                     /db_xref="CCDS:CCDS91374.1"
                     /db_xref="GeneID:118611"
                     /db_xref="HGNC:HGNC:26563"
                     /db_xref="MIM:617735"
                     /translation="MQHSGIPTKTHPQGYAARYTETAVHRTFQIKTFSTELKNHVMVM
                     DFVKSNWFPSQRRAKVCIIHMCQGLKTAEQTASRYEIHSRLFSSPKDHSAWERNESLS
                     NAGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKS
                     RENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAE
                     LPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPA
                     LANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPD
                     TPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLN
                     CSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRV
                     HLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWS
                     YRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPT
                     ERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECK
                     KSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFIS
                     RSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCI
                     SEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQLLQRNAV"
     exon            454..526
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            527..618
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1747
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..2038
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2223
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2401
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2465
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2565
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..3471
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3444..3449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /note="hexamer: AATAAA"
     polyA_site      3471
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /note="major polyA site"
ORIGIN      
        1 gcacgtaaag gtcacccctg aggttcccac atccacatcc ttcacaaatg tagctgggat
       61 attgagacaa ctagctctgg agttggaaaa cactgggaca ggtccgagct ggggcactgc
      121 ccaagtccct cctgttgcac tcaatacctg ggttaaacaa agaaaattgt gtttgccagt
      181 ctcactagct aaagtcacaa gatactgagt ctcatgcagc actctggaat tcctacaaaa
      241 actcatccgc aggggtatgc tgcccgctac acagaaacgg ccgtgcatcg gactttccag
      301 ataaaaacat ttagtacaga gttgaaaaac catgtgatgg tcatggattt tgtgaagagt
      361 aactggtttc cctcccagag aagagccaaa gtttgtatca tccatatgtg tcaaggcttg
      421 aagacggctg agcagacagc cagcagatat gagatccaca gtcgactctt ctcatccccc
      481 aaagatcatt ctgcctggga aagaaatgaa agtctttcca atgcaggatt acgggacagc
      541 taccacagta gaagagatca aattgccctt aaaaatctcc agtctgatgt cacagaggca
      601 aaatctgact tcaccaagga gaccctggca tcacaaaaca caaaaatgat ttcatccata
      661 gtcatctccc agatgattga tgagaataag tcaagagaaa acagggcctc cttgccccta
      721 ccgtgtgcca ttgctcagtc tcgtgcacat cacgccaagc aatctctggc taaccgcagc
      781 ggagtcaaca ttcacagagc atttgcgtta cttccgggca gattaggaat cccggcaccg
      841 tcagatgagc gaggacctga ggcagagctg ccgcccaaag aggagagacc ctgtgggggc
      901 ccccgcagag ggtttgcatc catcaccatc acggccagac gcgtgggccc cccagcccgc
      961 gccctggtgt gggggactgc tggggactct ctgtgcccca agtgcagggc tgaggacaca
     1021 ctgttccagg cgcccccggc tctggccaat ggcgcccatc caggtcggca tcagagatct
     1081 tttgcctgca cagagttctc cagaaacagc tccgtggtgc ggctgaaggt tcccgaggcc
     1141 cacactgggt tgtgtgagag acgcaagtac tgggtcaccc atgcagacga caaagagacc
     1201 agtttttctc cagacacccc actgtcagga aagagcccgc tggtgttcag ttcctgtgtc
     1261 cacctcaggg tgtctcagca gtgtccagat tcaatctatt acgtagacaa gtctctctcc
     1321 gtccccattg agccacctca aattgccagc cccaaaatgc acagatccgt cctgtcgctc
     1381 aacctcaatt gtagttccca cagattaaca gcagatggag tagatggcct agtgaacaga
     1441 gagccaataa gcgaagccct gaagcaggag ctcctggagg gagaccagga cctcgtaggc
     1501 cagcgctgga acccaggttt acaagaaagt cacttgaagg aaaccccatc gttgaggcgg
     1561 gtgcatttgg ggaccggcgc ttgtccttgg agtggttctt ttccattgga aaacacagaa
     1621 ttggcaaatg tgggagctaa ccaagtcact gtaagaaaag gggaaaagga ccatacaact
     1681 cattgtcacg ccagcgatca tgccaaccaa ctgtccattc acattcctgg ctggagttac
     1741 agggcagtac acacaaaagt attttctgga agcagcaaga ggcaacaagg agaagtatgt
     1801 atgactgtgt ctgctcctcc agtggaacag aagcccacta gacatttcct tcccattggg
     1861 gatagctctc caagcgatga ctgtctgtct agagaccttt ctgagcccac agagagacga
     1921 catcaaagct tcctgaaacc cagaatcctt tttcctgggt ttctttgccc cttacaagat
     1981 gtatgtgcat ctctgcagga agacaatggt gttcagatag aaagcaagtt ccccaaagga
     2041 gattacacat gctgtgactt ggttgtaaaa ataaaggaat gtaagaagag tgaggacccc
     2101 accacacctg agccctcccc agcagcaccc tcgccagcac cccgcgatgg agcagggagc
     2161 cctggcctgt ccgaagactg ttctgagtct cagcaaacgc ctgcaagatc tttgaccttg
     2221 caagaagcac tggaagttcg taagcctcag ttcatttctc gctcacaaga acggctgaag
     2281 aagcttgaac acatggtcca gcagaggaaa gcccagcgga aggaggacct gaggcagaag
     2341 cagagcctcc ttcccatccg caccagcaag aagcagttca cgattcccca tcctctgagt
     2401 gataacttgt tcaaacccaa agaacggtgc atttcagaga aggagatgca tatgcgatct
     2461 aagagaatct atgataactt gccggaagtt aaaaagaaaa aagaagaaca aaggaaaagg
     2521 gtgatcttac aaagtaacag actccgtgcc gaagtcttca aaaagcaatt actggaccag
     2581 ctccttcaaa ggaatgcggt ctaaccacag gctgccctgc tgaccacact acctggacct
     2641 gggaggactt cgaatgctgg ataagccatt aaacttagca ttatcttcat catgggaaaa
     2701 cacttatttt actttcgatt ttttttttcc ataaaggaaa acatcacttc ctgaattact
     2761 gacccaagcc aaacagaaac aataaccctc gagaaaatag gtcaacaatc tgttgtgggg
     2821 aaaccacctc catgtaaccc actggataca gtccccttaa tgtttttgct tctaaattgt
     2881 accttttgct tctgatttct tctcccctgc tgtttcctgc ccatcagaga ggcctgatac
     2941 aagcaagttt gtttacatcc ctggggaatc ttttacatca aacttttggg atccaaatcc
     3001 atctcctttt aaatttcaat ctcagcacct gccagttatg caaatgccaa aatgtgggtc
     3061 atcatatagt atatttgaaa cctttctgaa catgtacacc acccaatgct agaggctgac
     3121 ttggaaaccg gtgggtgcaa tgcccgaggc tgtggaacaa tcagcccatc tctttgtgac
     3181 ctggagcagt cagagggccc tcagtcaccc cgccccattc ctcaccagag aaaagaatcc
     3241 atttctatgg aagctctgac gtaacttcag tgttttctac aatactcctc ctgccccgcc
     3301 ccattaaaac agttcttttg ttaagaaata gcctaatggt ccaactttgc tgtctgttct
     3361 tccaaatgtt tataatacac attatttata aatatgtctg tttgggaagc taagaacaag
     3421 ctagttttta caacacaaat ggaaataaat gcaattatta taaaaattca a
//
