LOCUS       NP_001337850             796 aa            linear   PRI 30-APR-2025
DEFINITION  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1
            [Homo sapiens].
ACCESSION   NP_001337850 XP_011537518
VERSION     NP_001337850.1
DBSOURCE    REFSEQ: accession NM_001350921.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 796)
  AUTHORS   Zhang,T.M., Zhang,J., Zhou,D.J. and Wang,C.L.
  TITLE     [Expression of FATS in non-small cell lung cancer and its
            relationship with prognosis]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 41 (11), 826-830 (2019)
   PUBMED   31770849
  REMARK    GeneRIF: The expression of FATS protein is associated with the
            development and is an independent prognostic factor of non-small
            cell lung cancer patients.
REFERENCE   2  (residues 1 to 796)
  AUTHORS   Zhang,J., Wu,N., Zhang,T., Sun,T., Su,Y., Zhao,J., Mu,K., Jin,Z.,
            Gao,M., Liu,J. and Gu,L.
  TITLE     The value of FATS expression in predicting sensitivity to
            radiotherapy in breast cancer
  JOURNAL   Oncotarget 8 (24), 38491-38500 (2017)
   PUBMED   28402275
  REMARK    GeneRIF: FATS status is a biomarker in breast cancer to identify
            individuals likely to benefit from radiotherapy
REFERENCE   3  (residues 1 to 796)
  AUTHORS   Song,F., Zhang,J., Qiu,L., Zhao,Y., Xing,P., Lu,J., Chen,K. and
            Li,Z.
  TITLE     A functional genetic variant in fragile-site gene FATS modulates
            the risk of breast cancer in triparous women
  JOURNAL   BMC Cancer 15, 559 (2015)
   PUBMED   26223354
  REMARK    GeneRIF: Data identified a genetic variant in the FATS gene (905C >
            T, 262D/N) that is associated with susceptibility to breast cancer
            in a parity-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 796)
  AUTHORS   Yan,S., Qiu,L., Ma,K., Zhang,X., Zhao,Y., Zhang,J., Li,X., Hao,X.
            and Li,Z.
  TITLE     FATS is an E2-independent ubiquitin ligase that stabilizes p53 and
            promotes its activation in response to DNA damage
  JOURNAL   Oncogene 33 (47), 5424-5433 (2014)
   PUBMED   24240685
  REMARK    GeneRIF: FATS is an E2-independent ubiquitin ligase that stabilizes
            p53 and promotes its activation in response to DNA damage.
REFERENCE   5  (residues 1 to 796)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   6  (residues 1 to 796)
  AUTHORS   Zhang,J., Gu,L., Zhao,L.J., Zhang,X.F., Qiu,L. and Li,Z.
  TITLE     Expression level of novel tumor suppressor gene FATS is associated
            with the outcome of node positive breast cancer
  JOURNAL   Chin Med J (Engl) 124 (18), 2894-2898 (2011)
   PUBMED   22040499
  REMARK    GeneRIF: FATS is involved in the carcinogenesis and development of
            breast cancer and could be a potential biomarker and prognostic
            factor for breast cancer therapy.
REFERENCE   7  (residues 1 to 796)
  AUTHORS   Knorz,V.J., Spalluto,C., Lessard,M., Purvis,T.L., Adigun,F.F.,
            Collin,G.B., Hanley,N.A., Wilson,D.I. and Hearn,T.
  TITLE     Centriolar association of ALMS1 and likely centrosomal functions of
            the ALMS motif-containing proteins C10orf90 and KIAA1731
  JOURNAL   Mol Biol Cell 21 (21), 3617-3629 (2010)
   PUBMED   20844083
  REMARK    GeneRIF: data suggest centrosomal functions for C10orf90 and
            KIAA1731 and new centriole-related functions for ALMS1
REFERENCE   8  (residues 1 to 796)
  AUTHORS   Zhang,X., Zhang,Q., Zhang,J., Qiu,L., Yan,S.S., Feng,J., Sun,Y.,
            Huang,X., Lu,K.H. and Li,Z.
  TITLE     FATS is a transcriptional target of p53 and associated with
            antitumor activity
  JOURNAL   Mol Cancer 9, 244 (2010)
   PUBMED   20843368
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 796)
  AUTHORS   Li,Z., Zhang,Q., Mao,J.H., Weise,A., Mrasek,K., Fan,X., Zhang,X.,
            Liehr,T., Lu,K.H., Balmain,A. and Cai,W.W.
  TITLE     An HDAC1-binding domain within FATS bridges p21 turnover to
            radiation-induced tumorigenesis
  JOURNAL   Oncogene 29 (18), 2659-2671 (2010)
   PUBMED   20154723
REFERENCE   10 (residues 1 to 796)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL392108.4, AL583860.7 and AL589787.16.
            
            On Apr 27, 2017 this sequence version replaced XP_011537518.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297577.1, SRR1803613.248705.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488181.3/ ENSP00000474558.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     Protein         1..796
                     /product="(E2-independent) E3 ubiquitin-conjugating enzyme
                     FATS isoform 1"
                     /note="fragile-site associated tumor suppressor homolog;
                     centrosomal protein C10orf90; E2/E3 hybrid
                     ubiquitin-protein ligase FATS; (E2-independent) E3
                     ubiquitin-conjugating enzyme FATS"
                     /calculated_mol_wt=89040
     Region          149..660
                     /region_name="Centro_C10orf90"
                     /note="Centrosomal C10orf90; pfam17730"
                     /db_xref="CDD:465473"
     Region          666..794
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..796
                     /gene="C10orf90"
                     /gene_synonym="bA422P15.2; FATS"
                     /coded_by="NM_001350921.2:214..2604"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS91374.1"
                     /db_xref="GeneID:118611"
                     /db_xref="HGNC:HGNC:26563"
                     /db_xref="MIM:617735"
ORIGIN      
        1 mqhsgiptkt hpqgyaaryt etavhrtfqi ktfstelknh vmvmdfvksn wfpsqrrakv
       61 ciihmcqglk taeqtasrye ihsrlfsspk dhsawernes lsnaglrdsy hsrrdqialk
      121 nlqsdvteak sdftketlas qntkmissiv isqmidenks renraslplp caiaqsrahh
      181 akqslanrsg vnihrafall pgrlgipaps dergpeaelp pkeerpcggp rrgfasitit
      241 arrvgppara lvwgtagdsl cpkcraedtl fqappalang ahpgrhqrsf actefsrnss
      301 vvrlkvpeah tglcerrkyw vthaddkets fspdtplsgk splvfsscvh lrvsqqcpds
      361 iyyvdkslsv pieppqiasp kmhrsvlsln lncsshrlta dgvdglvnre pisealkqel
      421 legdqdlvgq rwnpglqesh lketpslrrv hlgtgacpws gsfplentel anvganqvtv
      481 rkgekdhtth chasdhanql sihipgwsyr avhtkvfsgs skrqqgevcm tvsappveqk
      541 ptrhflpigd sspsddclsr dlsepterrh qsflkprilf pgflcplqdv caslqedngv
      601 qieskfpkgd ytccdlvvki keckksedpt tpepspaaps paprdgagsp glsedcsesq
      661 qtparsltlq ealevrkpqf isrsqerlkk lehmvqqrka qrkedlrqkq sllpirtskk
      721 qftiphplsd nlfkpkerci sekemhmrsk riydnlpevk kkkeeqrkrv ilqsnrlrae
      781 vfkkqlldql lqrnav
//
