LOCUS       NM_024942               2913 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 10 open reading frame 88 (C10orf88), mRNA.
ACCESSION   NM_024942
VERSION     NM_024942.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Yang,X., Yang,J., Li,L., Sun,L., Yi,X., Han,X., Si,W., Yan,R.,
            Chen,Z., Xie,G., Li,W., Shang,Y. and Liang,J.
  TITLE     PAAT, a novel ATPase and trans-regulator of mitochondrial ABC
            transporters, is critically involved in the maintenance of
            mitochondrial homeostasis
  JOURNAL   FASEB J 28 (11), 4821-4834 (2014)
   PUBMED   25063848
  REMARK    GeneRIF: Regulates iron transport into the mitochondria
REFERENCE   8  (bases 1 to 2913)
  AUTHORS   Kitanaka,S., Isojima,T., Takaki,M., Numakura,C., Hayasaka,K. and
            Igarashi,T.
  TITLE     Association of vitamin D-related gene polymorphisms with
            manifestation of vitamin D deficiency in children
  JOURNAL   Endocr J 59 (11), 1007-1014 (2012)
   PUBMED   22785457
REFERENCE   9  (bases 1 to 2913)
  AUTHORS   Ahn,J., Yu,K., Stolzenberg-Solomon,R., Simon,K.C., McCullough,M.L.,
            Gallicchio,L., Jacobs,E.J., Ascherio,A., Helzlsouer,K.,
            Jacobs,K.B., Li,Q., Weinstein,S.J., Purdue,M., Virtamo,J.,
            Horst,R., Wheeler,W., Chanock,S., Hunter,D.J., Hayes,R.B., Kraft,P.
            and Albanes,D.
  TITLE     Genome-wide association study of circulating vitamin D levels
  JOURNAL   Hum Mol Genet 19 (13), 2739-2745 (2010)
   PUBMED   20418485
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 2913)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032645.1, CB044034.1 and AC073585.8.
            
            On Nov 23, 2018 this sequence version replaced NM_024942.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.230873.1,
                                           SRR1803617.22055.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142348,
                                           SAMEA2146411 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481909.2/ ENSP00000419126.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2306              BC032645.1         17-2322
            2307-2911           CB044034.1         17-621              c
            2912-2913           AC073585.8         107484-107485
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..2913
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /note="chromosome 10 open reading frame 88"
                     /db_xref="GeneID:80007"
                     /db_xref="HGNC:HGNC:25822"
                     /db_xref="MIM:620661"
     exon            1..213
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1387
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /EC_number="3.6.1.3"
                     /note="uncharacterized protein C10orf88; protein
                     associated with ABC transporters"
                     /codon_start=1
                     /product="ATPase PAAT"
                     /protein_id="NP_079218.2"
                     /db_xref="CCDS:CCDS7632.1"
                     /db_xref="GeneID:80007"
                     /db_xref="HGNC:HGNC:25822"
                     /db_xref="MIM:620661"
                     /translation="METRTEDGGLTRRPTLASSWDVAGGALTHSLLLTRAGLGPGDFD
                     WEELLAPPAPGQDLVILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVY
                     LGEEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKLESSTHACKIKLLSFGERQCVFIS
                     KVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGSKLSPGAQQLMDMVRCQQRNC
                     IPIGEQLQSVLGNSGYKHMIGLQSSSTLGTLNKSSSTPFPFRTGLTSGNVTENLQTYI
                     DKSTQLPGGENSTKLDECKVMPQNHSFLENDLKNAMASFLPKKVSDNSNIPNSELLPF
                     LQNLCSQVNHLHVGNKTECQENITKHGERILGVGMEEQSICSYLEKILSKNMELMEKK
                     LMDYIDQRIHELQEHIDDKIALLLDLLQNPNSPPTGIPLRHYDSGERLSNGER"
     exon            214..417
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            418..490
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            491..697
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1152
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..2913
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /note="major polyA site"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
                     /note="hexamer: AATAAA"
     polyA_site      2913
                     /gene="C10orf88"
                     /gene_synonym="PAAT"
ORIGIN      
        1 actggaagag aggttccggg gctgggctgg cctgactgaa ggcggcggaa tggagacgcg
       61 gaccgaggac gggggcctca cccgccgccc cacgctggcc tcttcttggg atgttgcagg
      121 cggggccctg acccacagcc tcctcctcac ccgggccggt ctcggccccg gtgacttcga
      181 ctgggaggag ctgctggcac cgcctgctcc aggtcaggat ctggtgattt tgaagagaaa
      241 ccacaacaac aaagatgaaa acccctgctt cctttacctg aggtgtggcc ctgatggagg
      301 tgaagaaatc gcttctattg gcattttaag ttcagcaaga aatatggaag tgtacttagg
      361 agaggagtac tgtggaacca gtaggggcaa gaatgtttgt actgtcctgg atgacagtga
      421 acatgaaaag atcattttgt ataaaaaaaa tctaaaattg gagtcctcca cacatgcttg
      481 taaaataaag ttgctctcct ttggcgaaag gcagtgtgtg ttcatcagta aagttgtggt
      541 acacatgaga tcagtttttg caaattcttc aacaagctct cctgctctag gatcaaggat
      601 agaccttgac aaggtccaaa ccataatgga gtccatgggg tcaaagttat ctcctggagc
      661 tcagcagttg atggatatgg ttaggtgtca gcagcggaat tgtattccca ttggagagca
      721 gcttcagtcg gtgttgggca attctggata caagcatatg attggactac aatcctcatc
      781 taccttagga accttaaaca agtcgtcctc cacacctttt ccttttagaa ctggattgac
      841 atctgggaac gtgactgaaa acttacaaac ttacattgat aaaagtacac aactgcctgg
      901 tggagagaat tctaccaagc ttgatgagtg taaagttatg cctcaaaacc attcctttct
      961 tgaaaatgat cttaaaaatg caatggcctc tttcttacca aagaaagtaa gtgacaactc
     1021 aaatataccc aactccgagt tgctgccttt tctccagaat ttatgtagtc aagttaatca
     1081 tctccatgtg ggaaataaga ccgagtgtca ggaaaacatc accaagcatg gtgaacgcat
     1141 tcttggtgtt ggaatggaag agcaatctat ttgctcctac ttggaaaaga ttctttctaa
     1201 aaatatggaa ctgatggaaa agaaacttat ggattacatt gatcagcgaa tacatgaact
     1261 ccaggagcac attgatgata agattgcttt gttactggat ttgctgcaaa atcctaactc
     1321 cccgcccact gggatacctc taagacatta tgactctgga gaaagacttt caaatggaga
     1381 aagataagct ctcaacataa acagtgtact gcagatattt attacatatt tattacaaag
     1441 ccaaaaccca aaaatattta taaaaagcaa gtatttaatg tcctttgagg gatcattgtc
     1501 ttacacaaag tgacctcagt tttcgttttt actacacttg ttattttaaa tccagtactg
     1561 tacactgagt taatatgata cagtcaaatt atttttgctc acgatatttt tcagtcttac
     1621 agaaatgtat gtatatttgt gttaagagtt taaaatgctt gaggatttct aatacagttc
     1681 attagtttgt attgtatatg tgtttaagta taatttttat ttatacaaag atcttatagt
     1741 cttagaagta tgaaaaataa tgcttaagag tatttgattt ttttcttttt ctaattatct
     1801 tggaaaattg gatacttaag acttggagcc tttacttcag attaccagtt tacattttgt
     1861 attgcttgtg tgagataatg aataagatgt gatatttggc atgtgtaaac ttagttcact
     1921 ctggggttgt taatattatt tgtttcatta cagagtagct gtaggtagga aagtaaacat
     1981 cagaactagc ctagtccttg ttacgattag tactttggat ttgatttttc ctgtaaaaca
     2041 gatgcagtca tcttgtttga cctcagtaac cccagacagt ttaagaaaac ctctcctttt
     2101 gagctgatac aggttttttc cccagaatcc ttttctggca tgtttattgt atgaaataat
     2161 gaggctctcc atggaaggat gaacacatat gagtcaaggg attgcaattc tctctgatag
     2221 acttagtttt cagaccttat aactattgta tatgcattga agggtgatat atttgcatat
     2281 aaaaataaat gcacctgctc tgggaactac ttgtctttag ttagtagaac tgttttattt
     2341 caactaatct ttacttcaaa tgtcttattt tttagaaaaa gggtatctca tactcattta
     2401 atattttggc aaatttcttc tttaaaaatg ttacctgatg taattcctgc gtgacatagc
     2461 tgaattttta ccctgcccta actctgctta tctttaagaa acaggatgcc tgtgatgaaa
     2521 agttcctttt gtaaccagtc cagaggagac tggttacaac cacgatagct gaccaaacga
     2581 ctttaaaaag acctcagcct ttttataatc ttatttctgt gctaaataac gctcctgcta
     2641 gctccatgac agttgacaat cgccatgaca gtgaccagaa gaagccatga aaggacaaaa
     2701 aggaaggcag cactctggtt ttaggaagtt cactgcccat ttctgaaaaa tccaggaata
     2761 ttcctccctt tgcttgaatg tgaaacacct ttattagaaa aattatattt taaccccctc
     2821 actcctcatt agttgaaaag ttgatttgtg agccatactc ctgcttctca attcagtggc
     2881 gattgaataa aacctgcagt gtttgtcact ctt
//
