LOCUS       NM_001371909            3153 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 10 open reading frame 67 (C10orf67),
            transcript variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001371909
VERSION     NM_001371909.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3153)
  AUTHORS   Wu,D.D., Yang,C.P., Wang,M.S., Dong,K.Z., Yan,D.W., Hao,Z.Q.,
            Fan,S.Q., Chu,S.Z., Shen,Q.S., Jiang,L.P., Li,Y., Zeng,L.,
            Liu,H.Q., Xie,H.B., Ma,Y.F., Kong,X.Y., Yang,S.L., Dong,X.X.,
            Esmailizadeh,A., Irwin,D.M., Xiao,X., Li,M., Dong,Y., Wang,W.,
            Shi,P., Li,H.P., Ma,Y.H., Gou,X., Chen,Y.B. and Zhang,Y.P.
  TITLE     Convergent genomic signatures of high-altitude adaptation among
            domestic mammals
  JOURNAL   Natl Sci Rev 7 (6), 952-963 (2020)
   PUBMED   34692117
REFERENCE   2  (bases 1 to 3153)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3153)
  AUTHORS   Thiebaut,R., Esmiol,S., Lecine,P., Mahfouz,B., Hermant,A.,
            Nicoletti,C., Parnis,S., Perroy,J., Borg,J.P., Pascoe,L.,
            Hugot,J.P. and Ollendorff,V.
  TITLE     Characterization and Genetic Analyses of New Genes Coding for NOD2
            Interacting Proteins
  JOURNAL   PLoS One 11 (11), e0165420 (2016)
   PUBMED   27812135
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3153)
  AUTHORS   Franke,A., Fischer,A., Nothnagel,M., Becker,C., Grabe,N., Till,A.,
            Lu,T., Muller-Quernheim,J., Wittig,M., Hermann,A., Balschun,T.,
            Hofmann,S., Niemiec,R., Schulz,S., Hampe,J., Nikolaus,S.,
            Nurnberg,P., Krawczak,M., Schurmann,M., Rosenstiel,P., Nebel,A. and
            Schreiber,S.
  TITLE     Genome-wide association analysis in sarcoidosis and Crohn's disease
            unravels a common susceptibility locus on 10p12.2
  JOURNAL   Gastroenterology 135 (4), 1207-1215 (2008)
   PUBMED   18723019
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606469.8, AL592296.16 and AL139281.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.1786809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000636213.3/
                                                ENSP00000490528.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AL606469.8         12844-13072         c
            230-350             AL592296.16        76425-76545         c
            351-494             AL592296.16        65757-65900         c
            495-569             AL592296.16        64104-64178         c
            570-725             AL592296.16        46667-46822         c
            726-873             AL592296.16        34495-34642         c
            874-932             AL592296.16        33263-33321         c
            933-998             AL592296.16        25376-25441         c
            999-1058            AL592296.16        10558-10617         c
            1059-1223           AL592296.16        9625-9789           c
            1224-1303           AL139281.7         168758-168837       c
            1304-1369           AL139281.7         168601-168666       c
            1370-1457           AL139281.7         157875-157962       c
            1458-1532           AL139281.7         141890-141964       c
            1533-1593           AL139281.7         141744-141804       c
            1594-3153           AL139281.7         120842-122401       c
FEATURES             Location/Qualifiers
     source          1..3153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3153
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="chromosome 10 open reading frame 67"
                     /db_xref="GeneID:256815"
                     /db_xref="HGNC:HGNC:28716"
     exon            1..229
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1676
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="isoform 4 is encoded by transcript variant 4; long
                     intergenic non-protein coding RNA 1552; uncharacterized
                     protein C10orf67, mitochondrial"
                     /codon_start=1
                     /product="uncharacterized protein C10orf67, mitochondrial
                     isoform 4"
                     /protein_id="NP_001358838.1"
                     /db_xref="CCDS:CCDS91221.1"
                     /db_xref="GeneID:256815"
                     /db_xref="HGNC:HGNC:28716"
                     /translation="MALVRDRRAHYVMSIVIRWVHCFSSSLRGTFGTRWEAMKAKATE
                     LRVCCARRKREAREFKPPQMRGSTRLNISDDLKIGFFSTDHATQTDSSEILSVKELSS
                     STQKLAQMMKSLQVDFGFLKQLLQLKFEDRLKEESLSLFTILHDRILEIEKHYQQNED
                     KMRKSFNQQLADAIAVIKGMYQQFFEVEEENVSLQDASTVKTNILLRKLKEKEEVIKE
                     LKEELDQYKDFGFHKMESFAKETSSPKSNLEKENLEYKVENERLLQIISELEEEIQIN
                     LKENSGLEDELISMKEMAEKDHKTIQKLMDSRDRLREELHYEKSLVQDVINKQKEDKE
                     MRKKYGSLSVKVARSAKGREASLSPWPKSPPSTTALRPHSATMSVSSAGAQKAKMPKK
                     ALKEDQAVVEDKHGLESQIEALKANLENEKKKVERFRKEADRLNKSWEKRFFILRNSF
                     HVLKNEMFTRHTLFRQFAVLADTSFNYIKVKPLLVQSRTTMTAISSSSHCTSSIDGKH
                     VDVVSDQAALQLSPKGKLSESPKEESLEEPSMRQSSPAETVD"
     exon            230..350
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            351..494
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            495..569
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            570..725
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            726..873
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            874..932
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            933..998
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1058
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1223
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1303
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1369
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1457
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1532
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1593
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..3153
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2008..2013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="hexamer: ATTAAA"
     polyA_site      2033
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="major polyA site"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="hexamer: CATAAA"
     polyA_site      2498
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="major polyA site"
     regulatory      3135..3140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
                     /note="hexamer: AATAAA"
     polyA_site      3153
                     /gene="C10orf67"
                     /gene_synonym="C10orf115; LINC01552"
ORIGIN      
        1 aggcagcctg ctctcctctt atgatggcct tggtccggga tcgcagggct cattatgtca
       61 tgagcatagt tattagatgg gttcactgct tttcctcctc cttgaggggg acctttggca
      121 cacgctggga ggccatgaaa gccaaggcca ccgagctgcg ggtctgctgc gcgcgtagga
      181 agcgagaagc tcgggaattc aagcccccgc aaatgcgcgg gtccacgaga cttaacattt
      241 cagatgattt aaagattggc tttttcagca cagaccatgc cactcaaact gattccagtg
      301 aaatactgtc agtaaaagaa ttgagttcat ctacgcaaaa gttagcacag atgatgaaat
      361 ccctccaggt agattttggg ttcctcaaac aattgcttca gttgaagttt gaggaccgac
      421 tgaaagagga atctttgagt ctcttcacca ttctgcatga caggatccta gaaattgaaa
      481 agcattatca acagaatgag gataagatga gaaaatcctt caatcagcag ttagctgatg
      541 ccatagctgt tatcaaagga atgtaccagc aattctttga ggtagaagaa gagaatgttt
      601 ctttgcaaga tgcgagtact gtcaaaacaa atattttgtt aagaaaactg aaagagaaag
      661 aagaagttat taaagaatta aaagaagaac tagaccaata taaagatttt ggatttcaca
      721 aaatggaatc ttttgccaaa gaaaccagct ctccaaaatc aaacctagaa aaggaaaatt
      781 tggagtacaa agtggaaaat gagaggctgc ttcagatcat ttcagagctt gaagaagaaa
      841 tccagatcaa tctaaaagaa aattcaggat tagaagatga acttataagt atgaaagaga
      901 tggcagaaaa ggatcacaaa actattcaaa agttaatgga tagtagagac agattaagag
      961 aagagcttca ttatgaaaaa tcattagttc aggatgtgat taataaacag aaagaggaca
     1021 aggaaatgag aaaaaagtat ggcagcttaa gtgtaaaggt tgcaagatca gccaagggga
     1081 gagaagcctc tttgtcccca tggcccaagt ctccacccag caccacagct ttgaggccac
     1141 attctgcgac catgagtgta tcatctgctg gggcccagaa agctaaaatg ccaaagaagg
     1201 ctttaaagga agaccaagct gtggttgaag acaaacatgg tttggagtct caaatagaag
     1261 cattaaaggc aaatttagag aatgagaaaa agaaggtgga aaggtttagg aaggaagctg
     1321 atcgactaaa taaaagctgg gaaaagagat tctttattct caggaacagc tttcatgtcc
     1381 ttaagaatga gatgtttaca aggcacacac tgtttcgtca gtttgcagtg cttgctgaca
     1441 catccttcaa ttatattaaa gtaaaaccct tattagtgca gtctagaacg accatgacag
     1501 ctatatcctc ttcaagtcat tgtacatctt caatagacgg taagcatgtg gatgtagtca
     1561 gtgatcaggc agcccttcaa ctttcaccaa aagggaagtt gtcggaatcc ccaaaagaag
     1621 agtccttgga ggagccctcc atgcgccaga gcagccccgc agagactgtt gattaaccca
     1681 gcagaagcct gggctgcgca gacggggcct cagaaagagt ggcctcgccg tcctggtgta
     1741 aggtgcctcc ctcggaaagg atactatctc caaggatttt ctaaactaat tgtttaatct
     1801 ctccagatta tgtatattaa ccagcactgc gctcgaatag acctcaatgc gcgccttgtg
     1861 cgcgctcctt tccacgcctt taaggaaagc cctggctggt gctgggtgag cggggcgcac
     1921 tgaacctccg gggcaaccac atccattcag gagctccggg gactcagaag agcccaggcg
     1981 tctaagagtg ggaagggacg gactttaatt aaaaagtttg actccctctc taatccagtc
     2041 tttctatacc aaaagcatca acctgttttg ctgtctcctc acccaataac tagtccccat
     2101 gaaggtaggt catgaagact acagggagat cgtacatttc ctcaagcaag attcattctt
     2161 atcttacccc ggcacagggc acctagccgc atcttaaagg ctgtcagaaa ttctttagta
     2221 agtagggaaa ctctttggag ttttgcttcc tggtaaggat gcaaaccaag attctgctgg
     2281 aatgccagac accgtttacc aaaaggcggg tttgcttttc ttccatgcgt aatgtccaac
     2341 ttggttcttt ctattcccct aactacaagt aaggccttgt taagagcctg tatctgaatc
     2401 gtaggctctg gattacagaa ttctacagtt atttattaag tctcaggaaa tatatttgtg
     2461 gtagttgtca cataaagctg atatacttta gttcaaaaga aagctgcaga ggtgatttat
     2521 ttgtgcgtaa aaggaacaag atttaattgg agagagacgt gttcttttca acgcaagtac
     2581 atgggatggt atagcgctgt ggagcgttat tcgagcttca tctactatgc actatatgcc
     2641 gctgtctcca aaggagtgtt gccctagaaa cttgttttaa atctgctgct atatatcaac
     2701 accttgtttt agcagtcctt ggctgaatta cagttacaca gtttggcgct tctttcaaat
     2761 ttcctcccat cagtttggct aaagaaagga atttttctcc tttagaaatg aattggctta
     2821 attagtaagt agattaatgg caattgctgg tgagttggtt tccagcagag tttcaccaga
     2881 gagggttaat cggagtcagg tctggaatct ttcccagaac tggctgccag ccatttccac
     2941 caaccaatca accctacaag aaacagagga aatgaaataa aatttgtatt ctctgtgcca
     3001 tcgtcctgga cagaaattcc ttggaagcag cctcctggtt gggtgtgata tcaaactgct
     3061 tcatttcaga actttaatag aaacttgaac cttcaagatt tatctgggta ccaaagcaaa
     3121 gtttcaaatg gcacaataaa ggtctccaca gaa
//
