LOCUS       NM_001042427            3259 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 10 open reading frame 53 (C10orf53),
            transcript variant 2, mRNA.
ACCESSION   NM_001042427
VERSION     NM_001042427.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R.
  TITLE     Personalized smoking cessation: interactions between nicotine dose,
            dependence and quit-success genotype score
  JOURNAL   Mol Med 16 (7-8), 247-253 (2010)
   PUBMED   20379614
  REMARK    GeneRIF: Clinical trial of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
            Erratum:[Mol Med. 2012;18(1):729]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073366.4.
            
            On May 17, 2019 this sequence version replaced NM_001042427.2.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform b, which
            is shorter and has a distinct C-terminus, compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB043416.1, AI990484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374111.8/ ENSP00000363225.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC073366.4         23606-23749         c
            145-264             AC073366.4         9507-9626           c
            265-3259            AC073366.4         5868-8862           c
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..3259
                     /gene="C10orf53"
                     /note="chromosome 10 open reading frame 53"
                     /db_xref="GeneID:282966"
                     /db_xref="HGNC:HGNC:27421"
     exon            1..144
                     /gene="C10orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..329
                     /gene="C10orf53"
                     /note="isoform b is encoded by transcript variant 2;
                     UPF0728 protein C10orf53"
                     /codon_start=1
                     /product="UPF0728 protein C10orf53 isoform b"
                     /protein_id="NP_001035892.1"
                     /db_xref="CCDS:CCDS41521.1"
                     /db_xref="GeneID:282966"
                     /db_xref="HGNC:HGNC:27421"
                     /translation="MPKNAVVILRYGPYSAAGLPVEHHTFRLQGLQAVLAIDGHEVIL
                     EKIEDWNVVELMVNEEVIFHCNIKDLEFGGDGKLDPLCEKARIAVLNAY"
     exon            145..264
                     /gene="C10orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            265..3259
                     /gene="C10orf53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      610..615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf53"
                     /note="hexamer: AATAAA"
     polyA_site      629
                     /gene="C10orf53"
                     /note="major polyA site"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf53"
                     /note="hexamer: AATAAA"
     polyA_site      865
                     /gene="C10orf53"
     regulatory      1744..1749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf53"
                     /note="hexamer: AATAAA"
     polyA_site      1766
                     /gene="C10orf53"
ORIGIN      
        1 agcagcgtgt gtttctccct tgcctctgcg gcggcggagg cctggcgatg cccaagaacg
       61 cagtggtcat cctgcgctat gggccctaca gcgcggcagg cctaccggtg gagcaccaca
      121 ccttccgcct gcagggcctg caagctgtgt tggccataga tggacatgag gtcatcctag
      181 agaagataga agactggaat gtggtggaac tcatggtgaa tgaagaagtc atcttccact
      241 gcaacattaa ggacttggag ttcggaggcg atggtaaact agacccactg tgtgaaaagg
      301 ccaggatagc cgtgctgaat gcctactgat ctcctcatgg aacaggcatc tcaagtcggc
      361 acaacagcag ctgccccagc cattctatga tgcaggcaga agtggctgtg ccacggtgtg
      421 gacactgggc tctgctagtc agaacagggc aactcgggcc tgacctccag cttacgcagc
      481 ctcaggattg tcacctggct gcacaggagc ccacagaaat aataaaaacc acatcattta
      541 taacatgtct caatctcaac ccatagggag agccctccaa tatcaggtac acattgagct
      601 gaaggaaaca ataaaatgca atcaaataac aaggtgccat tcctgactaa taacacatag
      661 ttgccagaag catctgagat tccattgttt agtactcaaa gtgctcagaa caggtgaaat
      721 taaagagagg ttgggggaag agtgggaata aaggcttttg aaagtctgaa ccaaaagcaa
      781 atgttaatat ttggaaacct tgctattcct acagatttat ttctgactcc tgagggaata
      841 aatattttaa attgctatta taaaattagc caaaatcaaa tcttcaattt ctctcatcta
      901 aaacaagaaa atgacctgcc ttcttttgca ttaatatcgt ctgaggaggg cgcaaaagag
      961 tcctcagcag aatgtgagat ggttccctgg tccctctgga gtagaacaca gccccataga
     1021 gttaaagagg gttttcacta tgttcagtgt gaaaatcagt catgtcgaaa tgatattttt
     1081 actttccact cttacgcacc aatgtgtagt atatattctt aactatagag taacagagag
     1141 ggggaaatgc agatattgat ctaatgacgt caaatgggag gtcatggtaa gaaggcctca
     1201 cacctacggg gagaaaacca gattccctaa cagaaaactc tggacccggg gcacctgtgc
     1261 tgaaggagca gggctttcag gatcgctcag agacctgcgg cttcacctgc tctgagagca
     1321 gtcctaacca tcgccccagg cagcctcaaa ccctcctgca ccccagaact tcaaagacca
     1381 ctggggacca tgaaactgct tgcacaagtt ccttctcaca caggacaaag taggggatat
     1441 aatttttaaa accccagccc aagcttcact tgtcagagtt gattcaggga ttgtgaatca
     1501 cttagaactc tatggaacta tttaagcatc tccttactga gaaactgagg ctcaaaagag
     1561 attcttcctc ccagtgtctg gtgctggttt tcacatatct tttgtaaccc tacatttagt
     1621 cccttttttt caaaacccag tttaagttac tatagatgta gcattcaatc tttgtttcaa
     1681 tataacattt tactacaaga gaaatccatt ctcattaaag aaaaatggaa aaatacaggt
     1741 aaaaataaag tacaacttta gtaacatttt tatatatttc aatttgggtt tcttctgttt
     1801 atgtctgaat attcataaag agatagacat atagaaattg acttcatcca tttgagattt
     1861 atgcacaatt ttgtaagttt ttaaaaattt ttcaactttt attttagata cagggggtac
     1921 atgggcaggt atgttgaatc tttttttaaa cgtaacattt tacatagagc ctcttcccgc
     1981 atgatttgtt gactgtctga gcattttatc ttgaatcagg aaatctctcc cttgagctgt
     2041 gatttctact ttcatggcca aaactttttc aatgctgaga actgaaattg ctagcttccc
     2101 ctgtctgcat ttggagtggg aacttcatct ccaaacacag tggaatcctg tctcctctag
     2161 ccctgcaacc ccggcattaa actggtaaca agtgcttccc tcggcagccc catgccctcc
     2221 tccagcatcc gcctcaaccc cgcaggttgt atttgtgcct tcagagtagc actacaagtg
     2281 aagaagacct gccctccttg gcttcatgac cagagctgaa gggcaggtaa ggcgagacag
     2341 tacacggatt ctaagaaata ccggagaagc ttctgggaga tgcctgtgcc cagagcccta
     2401 tgtttcagtt tggatcagag gcaaatgatg tctgaatcag cattgctggg aaaaatcacc
     2461 gaggtttcct ctgagcagtg ggattggggg gtgtgggggg caggtgaggt agagggagga
     2521 agtttgcagg gctattctgc cttccgtatt gtaaatgttt ttagtggtgg aattgatttt
     2581 cactttgtat gtaagtgtgt gttaggggta cttttcagat aaaaacttaa aatcagggcc
     2641 gggcactatg gcttttgcct gtaatcccag cactttggga atccaaggtg ggtggatttg
     2701 tttgaacaca ggagttcgag agcagcctgg ccaacatggt gaagcctcat ctctacaaaa
     2761 aatacaaaaa ttagccaggc ctggtggcat gcacctgtag tcccagctac ttgaggggct
     2821 gaggcaggag gatcacctga gcccaggagc tagaggctgc agcgaaccta gatcacgcca
     2881 ctgcactcca gcctgggtga caaagtgaga ccctgtctca gaaaataaaa taaagatttt
     2941 gacatagaag ccacctgtct atggccttat cctcctctgt cactgattaa gaggaacttt
     3001 ctctatggaa atctctgaag aatgtgctgt catcctcctc ctttgcctcc ctctctcgag
     3061 cacgcacctc cctgcccaga agcaagagac acagcttgct ccccatcaaa ggcaaaagtg
     3121 ccctgtgctt caacgtgcta gacattcggg cgccttcatg cttttaaaat accactgatt
     3181 aaatcacatt ttaagtttta taagatgtca agtcaatgtc gttatgatta acatgtaaag
     3241 aaagtgtatt ttaaaataa
//
