LOCUS       NM_001164375            4794 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens chromosome 10 open reading frame 105 (C10orf105),
            transcript variant 1, mRNA.
ACCESSION   NM_001164375 XM_001715769
VERSION     NM_001164375.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4794)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC071608.1 and AL731541.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001164375.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071608.1, SRR1803616.5470.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441508.4/ ENSP00000403151.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1061              BC071608.1         44-1104
            1062-4794           AL731541.6         56472-60204         c
FEATURES             Location/Qualifiers
     source          1..4794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..4794
                     /gene="C10orf105"
                     /note="chromosome 10 open reading frame 105"
                     /db_xref="GeneID:414152"
                     /db_xref="HGNC:HGNC:20304"
     exon            1..152
                     /gene="C10orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            153..4794
                     /gene="C10orf105"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..559
                     /gene="C10orf105"
                     /codon_start=1
                     /product="uncharacterized protein C10orf105"
                     /protein_id="NP_001157847.1"
                     /db_xref="CCDS:CCDS44430.1"
                     /db_xref="GeneID:414152"
                     /db_xref="HGNC:HGNC:20304"
                     /translation="MSTEGPSLASSPAISPLAFLSAPVTPGTLAEATDPLPMLIALAC
                     IFLLLATCLLFMTLCKPAALDPSRRRAHECMPHHPGSPSEPQLRLWKRLGSLRLSLHS
                     FRHGRPTVPRQPLPGPEDNRSHCDYMESTKM"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C10orf105"
                     /note="hexamer: AATAAA"
     polyA_site      4794
                     /gene="C10orf105"
                     /note="major polyA site"
ORIGIN      
        1 actctgctgg ccaggctgac cgagggctgc agggcacagc agagcctggc agggctgggg
       61 tcacaggcac tgcccagggc tccttgggcc tcccttccac agctgagaag acctctccac
      121 ggagctccgg acggctgggg tctggctctg aggagccatg agcacagagg gccccagcct
      181 cgccagctcc ccagccatca gccccctcgc ctttctctca gctcccgtca ctcccgggac
      241 ccttgcagag gcaactgacc ccctccccat gctcatcgcc ctggcctgca tcttcctcct
      301 gctggccacc tgtctgctgt tcatgacgct ctgcaagccg gccgcgctgg acccgagccg
      361 ccgcagggct cacgagtgca tgccccacca ccctgggagc cccagtgagc cccagctccg
      421 gctctggaag cgcctgggct ccttgcgcct ctccctgcac agcttccgcc atggccggcc
      481 caccgtccct cgacagcccc tgccgggccc cgaggacaac cgcagccact gtgactacat
      541 ggaatctacc aagatgtaat ggggtgtcca caaacatgcc cccacatccc cctaggtcta
      601 cctgtagatc ctcctgcttc agagaccggt gctgcaggct gcaggaagac agtggcccaa
      661 gcagtctggg acacacactc accccccgaa gctccttgca tgcccaggcc agcgcccttt
      721 cccaaagatg atcctcagaa gagcaccttc ctctctgcag accccctcgc tgctgcttga
      781 tgaaagactt ctggtcaaga gatgtgcact cgtggtcatc tgggcctttg gcctgaggct
      841 ccacagggta caacctgggg ctcgtaacca cctcctagaa gcagcaccct cgctcgccac
      901 agaagccttg ccctccaggt gccaaagccc agcatggaga agttgccaaa tggcaaaggt
      961 tccctttagt caagtgaaat gctcagccta caccggggcc aagacactgt cctggcatct
     1021 gtgctggccc agtgctgggg caaaacctcg gggctctctt ccttgggttt cccgggtgct
     1081 gccagcatct gcctggtgcc ctgtgggagc agctgcctcc ctcctggtgg aacagatgcc
     1141 tgggtgccag ctgggaggag gagcaaacag ggctctccaa gcatggtctt ggcagccgtc
     1201 ttggtggccc ctcttcaggg cacccacgtt gggatcaatc aggaagggat tgaagatgat
     1261 cgaggaggct cccttcagag gccagggcgg gtgctgtgac agagtggcaa gaggcagggc
     1321 atttccagca gctggaggtg atgccacctg gactcggagg aggacagctc acagcagctc
     1381 cacacctcac ccagggaaag cggcagcctc cccgagggtg ggatggtctg gacctctcca
     1441 ggacagctgt ggggtcccaa gtcctgccca cactagggat gctatctgtg gttttggtga
     1501 gtgctttgct gatgacccgt caaagcagtc ccaccccagg atgggcttct cagaatccca
     1561 aacccttgac ctctcctcac aacgcgaggg ttaaacactt tggtcaggtc ccaaatttga
     1621 agggtgggca gagggaggac ctgggctgcc cagctcctgt cccagtcagc tggccaggat
     1681 cccaccacaa agctgcccca cccccatcct gctgtgaccc acagtgcagc cagccacgtc
     1741 tccccaagga gtgagctctg gcttgccact ccccagctcc aaaaccttca ctggctccct
     1801 aatgccaaat ggatatagcc aaagctcctc agcgcagtgt gcagtgccct ctgggagctg
     1861 gctccaatta atctttctag cctcatcttg atccaaaact ccaggaaaac tgaaagacct
     1921 gtcacccact aactgtggct tatgcttcac acacacccac tctgtgaagc cctcctgcct
     1981 ggagccgccc ctactgtctc ctacctctct tggggaggaa aaggaacatt ctcttggcag
     2041 catgggtcct ttttgtctat gtcttctctt tcctaccagc ttgggagctt gcagagagcc
     2101 agacattgtc cagcccctca ctttgactcc ccagttctgt gcacagaagt atgaggcttc
     2161 tgtgtacaga gtgaagcgtg gcccagcctg ggtgtgtccc caccctctga ggcaggagtc
     2221 ttggtggaag ctggcataac acagagcctc atcttccctc agatgactct agaaagattt
     2281 ctctccaagc aggctctatt ggagaagccc actgtccctt ccttccaagt caatctgatc
     2341 tcaaaaagtg agtccggctt cacaagaaac ttaccaagag gaccttggag aagtcatcct
     2401 gagacgctgc atttctccct gagaaatggg agaactcagg gctgccctat attaactcgc
     2461 tggctctagg atttcagtaa gagtagtatt gtgtaaatag aaaccaagtc tttgggttta
     2521 gaaagtgggg caggcctcct ccctaagggt tttgttcctt cctcccttcc tgctcagtaa
     2581 cctcttcctg gtttgcttcc cctggggcct ccctgcaaat cctaggctgg attcagcctg
     2641 tagccatcca cctcaccagc aggccctgct ggccactagg cactgtcttc ctggaggttg
     2701 gggtgggggt tgaggctgcc ctgaggcctg aagaaggaaa agtccaggag ggggagggct
     2761 ctcaattggg tttcaggcac caggccaggg gggtatgctc caagtcctca caagctgagg
     2821 ccctgatcga gagaaccctc tacttcctcc ttctggagct agccaccaca ctctcgcaaa
     2881 tcctcagggc tttctgggct ctctgtgttt ctgggagtca gctccctgct ccccagccct
     2941 ttcctgcccg cctcctggtc ccgatgcagg gaggggagca ttgccagcct cccacgcttc
     3001 tgtccctccc aagcccggga gcctgcccca gtgggcaggc ccagattccc tgtttggctc
     3061 agcctccgag tcggaaaccc catagttggt aaagagactc attcactccg ggcctccctc
     3121 cccacccagc aactgaggcc tctgggcaga ggtgtgggtg cacacccaaa ttgttttcag
     3181 ggtcctccct tctctccctc tgagccttgg agctgttgcg cctgctccct gggcaaagga
     3241 gccctttctt cttgtgcctg tttacttccc aagaggggag cctcggccaa gggctctgtg
     3301 aaagcagctc tgttctgggc cttgctgggc cctggctctc ttctcaactc ctttccggga
     3361 aattgtgacg tctctttctc cccgctactc tgaaaggccc ttctgggtgg ggcgggagat
     3421 atgcaggggg aggccaagtc ttcctcctgt ttgtggggag ccagagccct atcctcagct
     3481 ctgcaacctg ggggcccaca ctccctggga tgggagaggg cctgggtccc cctttcccca
     3541 cagcaccttc cagagcagcg gacccaccct gggcccccac ctgcttccgc ctctggtgcc
     3601 actgagcatg tgccctcagg gccgtgtgtg gctccgcctc ccccagccca ccacctgccc
     3661 cagaggccac gggccacctg cctgcaagat gctgtggcct tcagggatgt cctcagggac
     3721 gctggcctca tagctgctct gcagaaagat gggccggttg tcattcacat ccaggacagt
     3781 gacgaacacg gtggctgtgc ccgtgtgtcg cttccctaca gggccgttgt ctgtgggagt
     3841 tgaaggaaga caggtgttag cagctgcctg agagaggggc acacttcctg tgactttgca
     3901 cactcccggg caccggccag agaggtgccc tgttccgccc catctgccct agcctttgca
     3961 aggggtgact tcctttttag cttaggaata acactaacag tatcaaatac ttagataaca
     4021 ccatgtgcca gccattcttc taacccattc agtcctcaca gcaaccccat gaagcagaca
     4081 ctttactgtc atccccattt tacagaggag gtaactgagg cactcaagtg gattgaatga
     4141 tggctcccaa aaaaaacaga cccatgttaa acccctggga acctgtgaag attaatttat
     4201 ttgggaaaag ggcctttgaa aatgtaatta cgttaaggat cttgagaagt gatcatcctg
     4261 ggtgagctgg gtggcccata aacccaatgg caagtgtcct tacaagagaa aggcagaggg
     4321 acatttgaga cagagaggag gaggccacat gcagatggag gcagaggctg gagttatgct
     4381 gccacaagcc accgaatgcc tagcgactcc agaaactggg acggtcaagg actgattctc
     4441 tctagagcct ttggaggaag cgtgaccctg ccgacacctt aatttctaac ttctggcctt
     4501 gagaaccagg agagaataca cttctgctgt tttaagtttg tggtagtttg tcgtggcaaa
     4561 tttaggatgc agatacaggt actaagagca aaaagccaac tgctgtcagg gactggcggg
     4621 tatagcacct gggtcaaaca cctggatggg ccccgctgga agggcagctg tcctccactc
     4681 cagtccacag cggacaggca gaatgtgggc ccagagacac cagatcttct gatttctcat
     4741 gagaaattga acatctgagc ttttaaataa aatctcctga tctttaaact ttca
//
