LOCUS       NM_014038               1804 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens basic leucine zipper and W2 domains 2 (BZW2),
            transcript variant 2, mRNA.
ACCESSION   NM_014038
VERSION     NM_014038.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Li,C., Li,Q., Li,L., Sun,S. and Lei,X.
  TITLE     The Prognostic and Immune Significance of BZW2 in Pan-Cancer and
            its Relationship with Proliferation and Apoptosis of Cervical
            Cancer
  JOURNAL   Front Biosci (Landmark Ed) 29 (3), 97 (2024)
   PUBMED   38538258
  REMARK    GeneRIF: The Prognostic and Immune Significance of BZW2 in
            Pan-Cancer and its Relationship with Proliferation and Apoptosis of
            Cervical Cancer.
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Maio,G., Smith,M., Bhawal,R., Zhang,S., Baskin,J.M., Li,J. and
            Lin,H.
  TITLE     Interactome Analysis Identifies the Role of BZW2 in Promoting
            Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial
            Metabolism
  JOURNAL   Mol Cell Proteomics 23 (2), 100709 (2024)
   PUBMED   38154691
  REMARK    GeneRIF: Interactome Analysis Identifies the Role of BZW2 in
            Promoting Endoplasmic Reticulum-Mitochondria Contact and
            Mitochondrial Metabolism.
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Agarwal,S., Afaq,F., Bajpai,P., Behring,M., Kim,H.G.,
            Varambally,A., Chandrashekar,D.S., Peter,S., Diffalha,S.A.,
            Khushman,M., Seeber,A., Varambally,S. and Manne,U.
  TITLE     BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis
  JOURNAL   Mol Cancer Res 21 (7), 698-712 (2023)
   PUBMED   37067340
  REMARK    GeneRIF: BZW2 Inhibition Reduces Colorectal Cancer Growth and
            Metastasis.
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Huang,X., Yang,Z., Li,Y. and Long,X.
  TITLE     m6A methyltransferase METTL3 facilitates multiple myeloma cell
            growth through the m6A modification of BZW2
  JOURNAL   Ann Hematol 102 (7), 1801-1810 (2023)
   PUBMED   37222774
  REMARK    GeneRIF: m6A methyltransferase METTL3 facilitates multiple myeloma
            cell growth through the m6A modification of BZW2.
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Long,X., Li,J., Wen,F., Cao,Y., Luo,Z. and Luo,C.
  TITLE     miR-140-3p attenuated the tumorigenesis of multiple myeloma via
            attenuating BZW2
  JOURNAL   Hematology 27 (1), 173-180 (2022)
   PUBMED   35068373
  REMARK    GeneRIF: miR-140-3p attenuated the tumorigenesis of multiple
            myeloma via attenuating BZW2.
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Singh,C.R., Watanabe,R., Zhou,D., Jennings,M.D., Fukao,A., Lee,B.,
            Ikeda,Y., Chiorini,J.A., Campbell,S.G., Ashe,M.P., Fujiwara,T.,
            Wek,R.C., Pavitt,G.D. and Asano,K.
  TITLE     Mechanisms of translational regulation by a human eIF5-mimic
            protein
  JOURNAL   Nucleic Acids Res 39 (19), 8314-8328 (2011)
   PUBMED   21745818
  REMARK    GeneRIF: 5MP1 (BZW2) acts as a partial mimic and competitor of
            eIF5, interfering with the key steps by which eIF5 regulates eIF2
            function.
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF083246.1 and BC009597.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014038.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008453.1, SRR5189658.119037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258761.8/ ENSP00000258761.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AF083246.1         48-112
            66-1804             BC009597.1         97-1835
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..1804
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /note="basic leucine zipper and W2 domains 2"
                     /db_xref="GeneID:28969"
                     /db_xref="HGNC:HGNC:18808"
                     /db_xref="MIM:619275"
     exon            1..108
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            109..173
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1375
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /note="isoform 1 is encoded by transcript variant 2; basic
                     leucine zipper and W2 domain-containing protein 2;
                     eIF5-mimic protein 1"
                     /codon_start=1
                     /product="eIF5-mimic protein 1 isoform 1"
                     /protein_id="NP_054757.1"
                     /db_xref="CCDS:CCDS5362.1"
                     /db_xref="GeneID:28969"
                     /db_xref="HGNC:HGNC:18808"
                     /db_xref="MIM:619275"
                     /translation="MNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDD
                     LEAVAKFLDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSAN
                     EDHETIRNYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLG
                     NGTLPATILTSLFTDSLVKEGIAASFAVKLFKAWMAEKDANSVTSSLRKANLDKRLLE
                     LFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVV
                     LYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSS
                     QGQSELILLQKVQEYCYDNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHVAKGKS
                     VFLDQMKKFVEWLQNAEEESESEGEEN"
     exon            174..350
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            351..454
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            455..520
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            521..656
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            657..766
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            767..937
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1084
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1223
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1346
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1804
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="BZW2"
                     /gene_synonym="5MP1; HSPC028; MST017; MSTP017"
                     /note="major polyA site"
ORIGIN      
        1 actcctccat tgtctgccgc cactgctgct gctgctgctg ctgccgctgc tgctgcacga
       61 atcgccgcag cccccagcct tgcgcgtcgt cgctacctcc tcggacagaa attttatgaa
      121 taagcatcag aagccagtgc taacaggcca gcggttcaaa actcggaaaa gggatgaaaa
      181 agagaaattc gaacccacag tcttcaggga tacacttgtc caggggctta atgaggctgg
      241 tgatgacctt gaagctgtag ccaaatttct ggactctaca ggctcaagat tagattatcg
      301 tcgctatgca gacacactct tcgatatcct ggtggctggc agtatgcttg cccctggagg
      361 aacgcgcata gatgatggtg acaagaccaa gatgaccaac cactgtgtgt tttcagcaaa
      421 tgaagatcat gaaaccatcc gaaactatgc tcaggtcttc aataaactca tcaggagata
      481 taagtatttg gagaaggcat ttgaagatga aatgaaaaag cttctcctct tccttaaagc
      541 cttttccgaa acagagcaga caaagttggc gatgctgtcg gggattctgc tgggcaatgg
      601 caccctgccc gccaccatcc tcaccagtct cttcaccgac agcttagtca aagaaggcat
      661 tgcggcctca tttgctgtca agcttttcaa agcatggatg gcagaaaaag atgccaactc
      721 tgttacctcg tctttgagaa aagccaactt agacaagagg ctgcttgaac tctttccagt
      781 taacagacag agtgtggatc attttgctaa atacttcact gacgcaggtc ttaaggagct
      841 ttccgacttc ctccgagtcc agcagtccct gggcaccagg aaggaactgc agaaggagct
      901 ccaggagcgt ctttctcagg aatgcccgat caaggaggtg gtgctttatg tcaaagaaga
      961 aatgaagagg aatgatcttc cagaaacagc agtgattggt cttctgtgga catgtataat
     1021 gaacgctgtt gagtggaaca agaaggaaga acttgttgca gagcaggctc tgaagcacct
     1081 gaagcaatat gctcccctgc tggccgtgtt cagctcccaa ggccagtcag agctgatcct
     1141 cctccagaag gttcaggaat actgctacga caacatccat ttcatgaaag cctttcagaa
     1201 gattgtggtt ctcttttata aagctgatgt tctgagcgaa gaagcaatac tgaaatggta
     1261 taaggaagca catgttgcta aaggcaaaag tgtttttctt gaccagatga agaaatttgt
     1321 tgagtggtta caaaatgcag aagaagaatc cgaatcggaa ggtgaggaaa attaaatggc
     1381 tcaacaagca caatacctag gttaccacac accacttttt gattgggaat gctgaaccat
     1441 ttgagaagag aaacttggct tctgttttcg caaaggaaaa aaaaaatagg ataggcttcc
     1501 cttgtgcaga gggagaaatg gttttgtttt tgttttgttt ttaaatggag ccctgaggca
     1561 tcagctatta tacttgggac tctacctctc actcactata tgctaactta aagccattca
     1621 acaaggagtc aagtagatct gaaattaaat actcaacaga ctcctccttt tttagctgta
     1681 tttttcaggt actgtgtggt gaccgcccca ctggtgtcta ttacaggcca ctttggtagt
     1741 tgtgtatctg ctcatgtatg tgatttgaca aaccagtttt ttaaaataaa tggcttttta
     1801 aaaa
//
