LOCUS       NM_004053               1718 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens bystin like (BYSL), mRNA.
ACCESSION   NM_004053
VERSION     NM_004053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Wang,Z.Z., Yao,G.T., Wang,L.Z., Zhu,Y.J. and Chen,J.H.
  TITLE     Increased Expression and Prognostic Significance of BYSL in
            Melanoma
  JOURNAL   J Immunother 47 (8), 279-302 (2024)
   PUBMED   38980088
  REMARK    GeneRIF: Increased Expression and Prognostic Significance of BYSL
            in Melanoma.
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Quan,X., Zhao,C., Gao,Z., Zhang,Y., Zhao,R., Wang,J. and Zhang,Q.
  TITLE     DDX10 and BYSL as the potential targets of chondrosarcoma and
            glioma
  JOURNAL   Medicine (Baltimore) 100 (46), e27669 (2021)
   PUBMED   34797290
  REMARK    GeneRIF: DDX10 and BYSL as the potential targets of chondrosarcoma
            and glioma.
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Nakayama,J., Aoki,D., Suga,T., Akama,T.O., Ishizone,S.,
            Yamaguchi,H., Imakawa,K., Nadano,D., Fazleabas,A.T., Katsuyama,T.,
            Nozawa,S. and Fukuda,M.N.
  TITLE     Implantation-dependent expression of trophinin by maternal
            fallopian tube epithelia during tubal pregnancies: possible role of
            human chorionic gonadotrophin on ectopic pregnancy
  JOURNAL   Am J Pathol 163 (6), 2211-2219 (2003)
   PUBMED   14633596
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Suzuki,N., Nakayama,J., Shih,I.M., Aoki,D., Nozawa,S. and
            Fukuda,M.N.
  TITLE     Expression of trophinin, tastin, and bystin by trophoblast and
            endometrial cells in human placenta
  JOURNAL   Biol Reprod 60 (3), 621-627 (1999)
   PUBMED   10026108
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Suzuki,N., Zara,J., Sato,T., Ong,E., Bakhiet,N., Oshima,R.G.,
            Watson,K.L. and Fukuda,M.N.
  TITLE     A cytoplasmic protein, bystin, interacts with trophinin, tastin,
            and cytokeratin and may be involved in trophinin-mediated cell
            adhesion between trophoblast and endometrial epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5027-5032 (1998)
   PUBMED   9560222
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Pack,S.D., Pak,E., Tanigami,A., Ledbetter,D.H. and Fukuda,M.N.
  TITLE     Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1
            by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 76-77 (1998)
   PUBMED   9925933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC062627.1, BC007340.2 and
            BC050645.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004053.3.
            
            Summary: Bystin is expressed as a 2-kb major transcript and a
            3.6-kb minor transcript in SNG-M cells and in human trophoblastic
            teratocarcinoma HT-H cells. Protein binding assays determined that
            bystin binds directly to trophinin and tastin, and that binding is
            enhanced when cytokeratins 8 and 18 are present.
            Immunocytochemistry of HT-H cells showed that bystin colocalizes
            with trophinin, tastin, and the cytokeratins, suggesting that these
            molecules form a complex in trophectoderm cells at the time of
            implantation. Using immunohistochemistry it was determined that
            trophinin and bystin are found in the placenta from the sixth week
            of pregnancy. Both proteins were localized in the cytoplasm of the
            syncytiotrophoblast in the chorionic villi and in endometrial
            decidual cells at the uteroplacental interface. After week 10, the
            levels of trophinin, tastin, and bystin decreased and then
            disappeared from placental villi. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007340.2, SRR3476690.380103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230340.9/ ENSP00000230340.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               BC062627.1         244-415
            173-705             BC007340.2         181-713
            706-1718            BC050645.1         978-1990
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1718
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /note="bystin like"
                     /db_xref="GeneID:705"
                     /db_xref="HGNC:HGNC:1157"
                     /db_xref="MIM:603871"
     exon            1..332
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1378
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /note="by the ribosomal protein s6 gene, drosophila,
                     homolog-like"
                     /codon_start=1
                     /product="bystin"
                     /protein_id="NP_004044.3"
                     /db_xref="CCDS:CCDS34450.1"
                     /db_xref="GeneID:705"
                     /db_xref="HGNC:HGNC:1157"
                     /db_xref="MIM:603871"
                     /translation="MPKFKAARGVGGQEKHAPLADQILAGNAVRAGVREKRRGRGTGE
                     AEEEYVGPRLSRRILQQARQQQEELEAEHGTGDKPAAPRERTTRLGPRMPQDGSDDED
                     EEWPTLEKAATMTAAGHHAEVVVDPEDERAIEMFMNKNPPARRTLADIIMEKLTEKQT
                     EVETVMSEVSGFPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILY
                     VTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDVAEYKRLNFHLYMAL
                     KKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEY
                     SGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKAD
                     LATDQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPITVE"
     exon            333..495
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..634
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..768
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..929
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1032
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1718
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /note="hexamer: GATAAA"
     polyA_site      1718
                     /gene="BYSL"
                     /gene_synonym="BYSTIN; Enp1"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcatcc tggcctttct tcagtcccca cgtgcgatcc ttcccggcaa ctttttcgag
       61 aaaaatgccc aaattcaagg cggcccgtgg ggtggggggt caggaaaaac atgcgcccct
      121 ggccgatcag atcctggctg ggaatgcggt gcgggcgggg gtccgggaga agcggcgggg
      181 tcgcgggaca ggagaagcgg aggaagagta tgtggggccc cggctgagcc gacggatttt
      241 gcagcaagca cggcagcaac aggaggaact cgaggccgag catgggactg gggacaagcc
      301 cgcggcgccg cgggaacgca ccacgcggct gggtccaaga atgcctcagg atggatcaga
      361 tgacgaggac gaggagtggc ccaccctgga gaaggctgcc acaatgacag cagcgggcca
      421 tcatgcagag gtggttgtgg accctgagga tgagcgtgcc atagagatgt tcatgaacaa
      481 gaaccctcct gccaggcgca ccctggctga catcatcatg gagaagctga ctgagaagca
      541 gacagaggtt gagacagtca tgtcagaggt gtcgggcttc cctatgcccc agctggaccc
      601 ccgggtccta gaagtgtaca ggggggtccg ggaggtatta tctaagtacc gcagtggaaa
      661 actgcccaag gcatttaaga tcatccctgc actctccaac tgggagcaaa tcctctacgt
      721 cacagagccg gaggcctgga ctgcagctgc catgtaccag gccaccagga tttttgcctc
      781 taacctgaag gaacgcatgg cccagcgctt ctacaacctt gtcctgctcc ctcgagtacg
      841 agatgacgtt gctgaataca aacgactcaa cttccatctc tacatggctc tcaagaaggc
      901 ccttttcaaa cctggagcct ggttcaaagg gatcctgatt ccactgtgcg agtctggcac
      961 ttgtaccctc cgggaagcca tcattgtggg tagcatcatc accaagtgct ccatccctgt
     1021 gttgcactcc agtgcggcca tgctgaaaat tgctgagatg gaatacagcg gtgccaacag
     1081 catcttcctg cgactgctgc tggataagaa gtatgcactg ccttaccggg tgctggatgc
     1141 cctagtcttc cacttcctgg ggttccggac agagaagcgt gaactgcctg tgctgtggca
     1201 ccagtgcctc ctgactttgg tccagcgcta caaggccgac ttggccacag accagaaaga
     1261 ggccctctta gaactgctcc ggctgcagcc ccatccacag ctatcgcccg aaatcaggcg
     1321 tgagcttcag agtgcagtcc cccgcgatgt ggaagatgtt cccatcaccg tggagtgagg
     1381 aaaacagtca gctgtcctgg ccaaaggggt ttggaaggac accaagaccc ccgttggtga
     1441 ctgaagatga cactgagctt taatggctga agacccagat cagggcagtg acagatcaca
     1501 gggacatctg tggctcccag tccaggacag gaaggactga gggtctggct ggttccctct
     1561 tccattctag gcccttatcc ctgtttagtt ctgagagcca acttgagata ccatatgcta
     1621 gcattcccag tccccagctg gggcttggtg tgagtacttt ttctatggct attgtgtcag
     1681 gtcactgtgg ataaaggcaa agacagatat ttattgaa
//
