LOCUS       NM_003910               1052 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens BUD31 homolog (BUD31), transcript variant 1, mRNA.
ACCESSION   NM_003910
VERSION     NM_003910.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Wu,X., Fan,R., Zhang,Y., Duan,C., Yao,X., Liu,K., Lin,D. and
            Chen,Z.
  TITLE     The role of BUD31 in clear cell renal cell carcinoma: prognostic
            significance, alternative splicing, and tumor immune environment
  JOURNAL   Clin Exp Med 24 (1), 191 (2024)
   PUBMED   39136845
  REMARK    GeneRIF: The role of BUD31 in clear cell renal cell carcinoma:
            prognostic significance, alternative splicing, and tumor immune
            environment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Choudhry,M., Gamallat,Y., Khosh Kish,E., Seyedi,S., Gotto,G.,
            Ghosh,S. and Bismar,T.A.
  TITLE     Downregulation of BUD31 Promotes Prostate Cancer Cell Proliferation
            and Migration via Activation of p-AKT and Vimentin In Vitro
  JOURNAL   Int J Mol Sci 24 (7), 6055 (2023)
   PUBMED   37047027
  REMARK    GeneRIF: Downregulation of BUD31 Promotes Prostate Cancer Cell
            Proliferation and Migration via Activation of p-AKT and Vimentin In
            Vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Xu,W., Huang,H., Yu,L. and Cao,L.
  TITLE     Meta-analysis of gene expression profiles indicates genes in
            spliceosome pathway are up-regulated in hepatocellular carcinoma
            (HCC)
  JOURNAL   Med Oncol 32 (4), 96 (2015)
   PUBMED   25731616
  REMARK    GeneRIF: High BUD31 expression is associated with hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Hsu,C.L., Liu,J.S., Wu,P.L., Guan,H.H., Chen,Y.L., Lin,A.C.,
            Ting,H.J., Pang,S.T., Yeh,S.D., Ma,W.L., Chen,C.J., Wu,W.G. and
            Chang,C.
  TITLE     Identification of a new androgen receptor (AR) co-regulator BUD31
            and related peptides to suppress wild-type and mutated AR-mediated
            prostate cancer growth via peptide screening and X-ray structure
            analysis
  JOURNAL   Mol Oncol 8 (8), 1575-1587 (2014)
   PUBMED   25091737
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Hla,T., Jackson,A.Q., Appleby,S.B. and Maciag,T.
  TITLE     Characterization of edg-2, a human homologue of the Xenopus
            maternal transcript G10 from endothelial cells
  JOURNAL   Biochim Biophys Acta 1260 (2), 227-229 (1995)
   PUBMED   7841202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004922.2 and BC022821.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003910.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.677472.1,
                                           SRR1163658.123835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222969.10/ ENSP00000222969.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC004922.2         22790-22809         c
            21-171              BC022821.1         1-151
            172-172             AC004922.2         22638-22638         c
            173-1052            BC022821.1         153-1032
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1052
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /note="BUD31 homolog"
                     /db_xref="GeneID:8896"
                     /db_xref="HGNC:HGNC:29629"
                     /db_xref="MIM:603477"
     exon            1..277
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     exon            278..413
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     exon            414..536
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..877
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /note="maternal G10 transcript; functional
                     spliceosome-associated protein 17; protein EDG-2; protein
                     G10 homolog; G10 maternal transcript homolog"
                     /codon_start=1
                     /product="protein BUD31 homolog"
                     /protein_id="NP_003901.2"
                     /db_xref="CCDS:CCDS5663.1"
                     /db_xref="GeneID:8896"
                     /db_xref="HGNC:HGNC:29629"
                     /db_xref="MIM:603477"
                     /translation="MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVE
                     SLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCC
                     LRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG"
     exon            537..659
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     exon            660..826
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1052
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1030..1035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /note="hexamer: AATAAA"
     polyA_site      1052
                     /gene="BUD31"
                     /gene_synonym="Cwc14; EDG-2; EDG2; fSAP17; G10; YCR063W"
                     /note="major polyA site"
ORIGIN      
        1 gtcgagaagc agctacccaa gctccaggag cttccggtat gtgttttccc tctgttctcg
       61 attaccttgg caacggctga ggcgggagac cggtggtctg caccgtcctg gagggagata
      121 tgagtggctg gactctcagc cagccactgg gatgtgttcg ggctttggac cttgaggccg
      181 gagagagctc ccgagaggag gcggcgccac gttcgttctt ctgaggggac ggtagatttg
      241 ggggttttcc tctaggattc tcgcgccgtt tcctctgaag aaacaggacc agagagggaa
      301 ggtgacctga aagtcacaga ataatttttt agagctgaac aagaatccaa gcctgcaact
      361 gcagagacga gagatctttc tgctgtctat actcttggaa agcacatcct aagatctttg
      421 cagattatcc tgtggaagga aaatgcctaa agtcaaaaga agccggaaag cacccccaga
      481 tggctgggag ttgattgagc caacactgga tgaattagat caaaagatga gagaagctga
      541 aacagaaccg catgagggaa agaggaaagt ggaatctctg tggcccatct tcaggatcca
      601 ccaccagaaa acccgctaca tcttcgacct cttttacaag cggaaagcca tcagcagaga
      661 actctatgaa tattgtatta aagaaggcta tgcagacaaa aacctgattg caaaatggaa
      721 aaagcaagga tatgagaact tgtgctgcct gcggtgcatt cagacacggg acaccaactt
      781 cgggacgaac tgcatctgcc gcgtgcccaa aagcaagctg gaagtgggcc gcatcatcga
      841 gtgcacacac tgtggctgtc gtggctgctc tggctgaggc tggcgcgctc caccctggac
      901 tctggacttc gcaggttcct gcctgtcacg ccaccccctt cctgggagca gcgagcagtg
      961 ccccaggccc gagttggagc acggtctcta tggggaaggc ttcgctgtct atcagctgtg
     1021 atttgtaaaa ataaaatctt taaatctctc ga
//
