LOCUS       NM_004725               7703 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BUB3 mitotic checkpoint protein (BUB3), transcript
            variant 1, mRNA.
ACCESSION   NM_004725
VERSION     NM_004725.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7703)
  AUTHORS   Perlee,S., Kikuchi,S., Nakadai,T., Masuda,T., Ohtsuki,S.,
            Matsumoto,M., Rahmutulla,B., Fukuyo,M., Cifani,P., Kentsis,A.,
            Roeder,R.G., Kaneda,A. and Hoshii,T.
  TITLE     SETD1A function in leukemia is mediated through interaction with
            mitotic regulators BuGZ/BUB3
  JOURNAL   EMBO Rep 24 (10), e57108 (2023)
   PUBMED   37535603
  REMARK    GeneRIF: SETD1A function in leukemia is mediated through
            interaction with mitotic regulators BuGZ/BUB3.
REFERENCE   2  (bases 1 to 7703)
  AUTHORS   Wang,S., Liu,X., Yang,M., Yuan,D., Ye,K., Qu,X. and Wang,X.
  TITLE     BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting
            Prognosis in Breast Cancer
  JOURNAL   Dis Markers 2022, 2760432 (2022)
   PUBMED   35493295
  REMARK    GeneRIF: BUBs Are New Biomarkers of Promoting Tumorigenesis and
            Affecting Prognosis in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7703)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 7703)
  AUTHORS   Zhao,L.Y., Xin,G.J., Tang,Y.Y., Li,X.F., Li,Y.Z., Tang,N. and
            Ma,Y.H.
  TITLE     miR-664b-3p inhibits colon cell carcinoma via negatively regulating
            Budding uninhibited by benzimidazole 3
  JOURNAL   Bioengineered 13 (3), 4857-4868 (2022)
   PUBMED   35156516
  REMARK    GeneRIF: miR-664b-3p inhibits colon cell carcinoma via negatively
            regulating Budding uninhibited by benzimidazole 3.
REFERENCE   5  (bases 1 to 7703)
  AUTHORS   Xiao,M., Zhang,S., Liu,Z., Mo,Y., Wang,H., Zhao,X., Yang,X.,
            Boohaker,R.J., Chen,Y., Han,Y., Liu,H. and Xu,B.
  TITLE     Dual-functional significance of ATM-mediated phosphorylation of
            spindle assembly checkpoint component Bub3 in mitosis and the DNA
            damage response
  JOURNAL   J Biol Chem 298 (3), 101632 (2022)
   PUBMED   35085551
  REMARK    GeneRIF: Dual-functional significance of ATM-mediated
            phosphorylation of spindle assembly checkpoint component Bub3 in
            mitosis and the DNA damage response.
REFERENCE   6  (bases 1 to 7703)
  AUTHORS   Saffery,R., Irvine,D.V., Griffiths,B., Kalitsis,P. and Choo,K.H.
  TITLE     Components of the human spindle checkpoint control mechanism
            localize specifically to the active centromere on dicentric
            chromosomes
  JOURNAL   Hum Genet 107 (4), 376-384 (2000)
   PUBMED   11129339
REFERENCE   7  (bases 1 to 7703)
  AUTHORS   Kwon,T.K., Hawkins,A.L., Griffin,C.A. and Gabrielson,E.
  TITLE     Assignment of BUB3 to human chromosome band 10q26 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 202-203 (2000)
   PUBMED   10828586
REFERENCE   8  (bases 1 to 7703)
  AUTHORS   Cahill,D.P., da Costa,L.T., Carson-Walter,E.B., Kinzler,K.W.,
            Vogelstein,B. and Lengauer,C.
  TITLE     Characterization of MAD2B and other mitotic spindle checkpoint
            genes
  JOURNAL   Genomics 58 (2), 181-187 (1999)
   PUBMED   10366450
REFERENCE   9  (bases 1 to 7703)
  AUTHORS   Seeley,T.W., Wang,L. and Zhen,J.Y.
  TITLE     Phosphorylation of human MAD1 by the BUB1 kinase in vitro
  JOURNAL   Biochem Biophys Res Commun 257 (2), 589-595 (1999)
   PUBMED   10198256
REFERENCE   10 (bases 1 to 7703)
  AUTHORS   Taylor,S.S., Ha,E. and McKeon,F.
  TITLE     The human homologue of Bub3 is required for kinetochore
            localization of Bub1 and a Mad3/Bub1-related protein kinase
  JOURNAL   J Cell Biol 142 (1), 1-11 (1998)
   PUBMED   9660858
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP328027.1, AF047472.1,
            BM989334.1 and AC012391.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004725.3.
            
            Summary: This gene encodes a protein involved in spindle checkpoint
            function. The encoded protein contains four WD repeat domains and
            has sequence similarity with the yeast BUB3 protein. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.151310.1,
                                           SRR1803612.78959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368865.9/ ENSP00000357858.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BP328027.1         159-196
            39-2601             AF047472.1         25-2587
            2602-2606           BM989334.1         19-23               c
            2607-7703           AC012391.10        117909-123005
FEATURES             Location/Qualifiers
     source          1..7703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..7703
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /note="BUB3 mitotic checkpoint protein"
                     /db_xref="GeneID:9184"
                     /db_xref="HGNC:HGNC:1151"
                     /db_xref="MIM:603719"
     exon            1..84
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1071
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /note="isoform a is encoded by transcript variant 1;
                     mitotic checkpoint component; budding uninhibited by
                     benomyl; mitotic checkpoint protein BUB3; BUB3 budding
                     uninhibited by benzimidazoles 3 homolog; testicular tissue
                     protein Li 27"
                     /codon_start=1
                     /product="mitotic checkpoint protein BUB3 isoform a"
                     /protein_id="NP_004716.1"
                     /db_xref="CCDS:CCDS7635.1"
                     /db_xref="GeneID:9184"
                     /db_xref="HGNC:HGNC:1151"
                     /db_xref="MIM:603719"
                     /translation="MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDV
                     PANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCV
                     EYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVL
                     VWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKK
                     YAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYP
                     TSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT"
     exon            85..279
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            280..349
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..501
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..660
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..838
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1055
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..7703
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /note="major polyA site"
     regulatory      7686..7691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
                     /note="hexamer: AATAAA"
     polyA_site      7703
                     /gene="BUB3"
                     /gene_synonym="BUB3L; hBUB3"
ORIGIN      
        1 gagtgttctg agggaagcaa ggaggcggcg gcggccgcag cgagtggcga gtagtggaaa
       61 cgttgcttct gaggggagcc caagatgacc ggttctaacg agttcaagct gaaccagcca
      121 cccgaggatg gcatctcctc cgtgaagttc agccccaaca cctcccagtt cctgcttgtc
      181 tcctcctggg acacgtccgt gcgtctctac gatgtgccgg ccaactccat gcggctcaag
      241 taccagcaca ccggcgccgt cctggactgc gccttctacg atccaacgca tgcctggagt
      301 ggaggactag atcatcaatt gaaaatgcat gatttgaaca ctgatcaaga aaatcttgtt
      361 gggacccatg atgcccctat cagatgtgtt gaatactgtc cagaagtgaa tgtgatggtc
      421 actggaagtt gggatcagac agttaaactg tgggatccca gaactccttg taatgctggg
      481 accttctctc agcctgaaaa ggtatatacc ctctcagtgt ctggagaccg gctgattgtg
      541 ggaacagcag gccgcagagt gttggtgtgg gacttacgga acatgggtta cgtgcagcag
      601 cgcagggagt ccagcctgaa ataccagact cgctgcatac gagcgtttcc aaacaagcag
      661 ggttatgtat taagctctat tgaaggccga gtggcagttg agtatttgga cccaagccct
      721 gaggtacaga agaagaagta tgccttcaaa tgtcacagac taaaagaaaa taatattgag
      781 cagatttacc cagtcaatgc catttctttt cacaatatcc acaatacatt tgccacaggt
      841 ggttctgatg gctttgtaaa tatttgggat ccatttaaca aaaagcgact gtgccaattc
      901 catcggtacc ccacgagcat cgcatcactt gccttcagta atgatgggac tacgcttgca
      961 atagcgtcat catatatgta tgaaatggat gacacagaac atcctgaaga tggtatcttc
     1021 attcgccaag tgacagatgc agaaacaaaa cccaagtcac catgtacttg acaagatttc
     1081 atttacttaa gtgccatgtt gatgataata aaacaattcg tactccccaa tggtggattt
     1141 attactatta aagaaaccag ggaaaatatt aattttaata ttataacaac ctgaaaataa
     1201 tggaaaagag gtttttgaat tttttttttt aaataaacac cttcttaagt gcatgagatg
     1261 gtttgatggt ttgctgcatt aaaggtattt gggcaaacaa aattggaggg caagtgactg
     1321 cagttttgag aatcagtttt gaccttgatg attttttgtt tccactgtgg aaataaatgt
     1381 ttgtaaataa gtgtaataaa aatccctttg cattctttct ggaccttaaa tggtagagga
     1441 aaaggctcgt gagccatttg tttcttttgc tggttatagt tgctaattct aaagctgctt
     1501 cagactgctt catgaggagg ttaatctaca attaaacaat atttcctctt ggccgtccat
     1561 tattttctga agcagatggt tcatcatttc ctgggctgtt aaacaaagcg aggttaaggt
     1621 tagactcttg ggaatcagct agttttcaat cttattaggg tgcagaagga aaactaataa
     1681 gaaaacctcc taatatcatt ttgtgactgt aaacaattat ttattagcaa acaattgatc
     1741 ccagaagggc aaattgtttg agtcagtaat gagctgagaa aagacagagc atatctgtgt
     1801 atttggaaaa ataattgtaa cgtaattgca gtgcatttag acaggcatct atttggacct
     1861 gtttctatct ctaaatgaat ttttggaaac attaatgagg tttacatatt tctctgacat
     1921 ttatatagtt cttatgtcca tttcagttga ccagccgctg gtgattaaag ttaaaaagaa
     1981 aaaaattata gtgagaatga gattcatttc aatgtaatgc actaaagcag aacacgaact
     2041 tagcttggcc tattctaggt agttccaaat agtatttttg ttgtcaaact ttaaaattta
     2101 tattaatttg caaatgtatg tctctgagta ggacttggac ctttcctgag atttatttta
     2161 tccgtgatgt atttttttta attcttttga tacagagaag ggtctttttt tttttaagta
     2221 tttcagtgaa aacttggtgt aagtctgaac ccatcttttg aaatgtattt tcttcattgc
     2281 aggtccacct aatcatcctg tgaaagtggt ttctctatgg aaagctttgt ttgcttccta
     2341 caaatacatg cttattcctt aagggatgtg ttagagttac tgtggatttc tctgttttct
     2401 gtcttacaag aaacttgtct atgtacctta atactttgtt taggatgagg agtctttgtg
     2461 tccctgtaca gtagtctgac gtatttcccc ttctgtcccc tagtaagccc agttgctgta
     2521 tctgaacagt ttgagctctt tttgtaatat actctaaacc tgttatttct gtgctaataa
     2581 acgagatgca gaacccttga atgttggatg tttttgaatg ttggtaatta atataattta
     2641 cttaaaaagg cttgtgtaag gcaaaactcg tcatcacagg catgttgggg gatgacattt
     2701 tacctttaag tccactctcc ctcgtttaat tgtctcctct gatgtgtgtt ggggattcag
     2761 tcctgcataa agtgatttgt tggagttcag ccatttccct catgccccct tgtgccctct
     2821 cggtggatca gcagggcctt tgagccaagt gtgcagcttc actcaggatg ggcagagact
     2881 atgtggcagc ctctggggac cttttggctc agtgctttac tagtgccagc gcagtagtgc
     2941 ttaggtagct tgtgcatccc cgtgttgatg tagtcatagt ccacacagag ccaaataaca
     3001 gacccttctg tacttagcca tcaaatacta aatcacagtg aagcccttgg gaaggtaaat
     3061 aatgtaatag ccagggactg atggtattag ttctttagtg tgattatgtg cttctaaaag
     3121 tccctaacca cttggttgag gacagaccat aagtttaaaa cattgtataa gtgaaagaat
     3181 taatatagta ttgttatagg taaccaaatt atagtaatgt ggacttgttt ttgaggtggt
     3241 gagggagggc ttattttgtg gttccatctg gatgtcctct tgtctctgga aatcaagtgt
     3301 gcctccctgc catctctaca taccccttaa ccagctctcc acaatttact tgtttatggt
     3361 tatagctacc ttttccccaa gttacccagg tgtagttacc ttggccttct cattggtttc
     3421 cctcacccac attctttaag tgtctcttct gtttatcttt tcttcctact gctaccatcc
     3481 cagggccttt tgggtgaatg tggcagcctc caatttctgc cttaagtcct ccatctaata
     3541 gagtagtgac ttttgaacct tgtagttgtg acccaagtaa gaaatacatt ttgaactaca
     3601 gttcagaaca cagaggtcag tatattatac atgacagaag gatcctgaaa tatgacttgc
     3661 ccttcttgca tgcgatgtat ctggtgcatg tgtgcatttt tttctttgct ttttaagaaa
     3721 tcctggctat gtcaccttga attgatttta caacaaatgc ctgtcacctg taatttgcaa
     3781 aaactgcttg atcagattct aaaaaatttc taaaagattt ttaaaaaatg tattctgatg
     3841 tcatacttgg aatcctccac tgcttcctgt tgctcatagt cacccttcag tgatttcata
     3901 aggaggtgtg ctgcttccca agcttctaga tcatcaggaa ggggccgcgg actgtaaggt
     3961 gctctcagaa gatgggacta acctttgttg ggaatataaa taagtggatg ggatgggaag
     4021 tgacagcaat atctggttct gagttctgtt gtgtaaaaac ttaaaggtat attagcaggt
     4081 tagcctttgt tctgtgggag atccaggcct tgttagaagg accaaggcca gaatgcccag
     4141 tttagcctta gcattcaaac ccttcattgt ttttcctcca ttatctgtta aactcctgct
     4201 ttgccaaagg tatcttctat accctaataa cactagcttc cttccctcag tggggactca
     4261 acgcacatta gcctactgag agcttagatc actacaacga atccttgtaa atttgtttaa
     4321 ctcagttttc cccaaattca tttaagccgg ttctactttt tctggtcttg ttcccacaat
     4381 cattttacct tttaccactc ccccagaaaa cactggggtt cttctcttac gctgagagcc
     4441 aggttacttt cttcactatc actccgacgc ttgtgttgat tcccaaatct cagtctgccc
     4501 agggtcattc tctttctgaa ttgctctttc aggatttaat ttgaatcctg caaagtcctg
     4561 ttcaaggccc ccttttccat gaagcccttc ttccttgttg cagctcacaa ataagtgtgc
     4621 cctttctcaa aacacgtatg aaacacctcc tgcttgtata cctttagcag tagttcctca
     4681 tattgcctgg catttaaaca tttttgtatg cgtacatctt gctttcctac ttaaagcaag
     4741 agcaggacca catctttttg tatgctctgg cacatgactg ttggaccact ttgatattgc
     4801 tgaattatat agactccttt taaaataatt tgaaatataa ttttggagta tagacatctt
     4861 gtccagtgca ctagacaggt gacctttggc tttgttcatt aagcatttag tgtcttagaa
     4921 gtgatatgtt tactgcagaa aaatttggat agcatgcaaa aaatgaaaca tactatcaca
     4981 atcctatgat ataacttaaa aatttcttta tagcttcatg gaggtatttg atgaaaattg
     5041 tatatattta aggtatataa tgttttgata catgtataca ttgtgaaatg attaccacaa
     5101 ggaggttact aaacatctcc atcaccttgt taaattgagt taaacaaatt tacaagttga
     5161 caaattacat ttacaaattt atgtaatttt ttacgctttt tttttttctc ctttttctgg
     5221 agaacggggt ctcgctatac tgcccaggca ggtctcgaac tcctgggctc aagctatcct
     5281 cccgcctctt gcctccctaa gagctgggat tataggcgtg agccacccca cccggcctat
     5341 gtcatttttt tatgtggtga gaataaataa tctcagcaaa tttcaagtat acaattcatt
     5401 attactaaga tagccaccac actgtatgtc agggctccag aacttactca tctcatagga
     5461 ggcagctact tttaacattc ttggtgtata tccatccttc aggattttct gtatatttct
     5521 ctaacagcaa aagtttttgt tagctacatc atgtgaaatg cctgggtaga caaatttaaa
     5581 gatgttattt gggatggtgt gacttgcaca agccacacag cctgcatggt gtccactttg
     5641 agggggatgc ccatagctat acttagaagt catcctctag agcaagcttg tccaatttgt
     5701 tgtccatggg ccacatgctg cccaggatgg ctttgaaggt ggcccaaaac aaattcataa
     5761 acttttgtaa aacgtgagat tttttgtgat tttttttttt tcgagacaca gtctcgttct
     5821 gtcgcccagg ctggagtgca agtggcgcga tctccgctca ttgcaagctc cgcctctcgg
     5881 gttcaagcaa ttctcctgcc tcagccaccc gagtagttgg gattacaggc acccgccatc
     5941 acgcccggct aatttttgta tttcttttag tagagaccgg gtttcatcat gttggccagg
     6001 ttggtcttga actcctgact tcaggtaatc cgccctcctt ggtctcccaa agtgctggga
     6061 tacaggcatg agccactgca cccagctgtg actttttttt ttttaagctc atcagctatt
     6121 gtattagtgt attttatgtg tagctcaaga caattcttcc agtgtggacc aggaaagcca
     6181 aaagattgga cacccctgcc ctagagcatc tgacgcctgg atacaaaaga gcctgtggct
     6241 atgactatca ggattctggc catgaggaat tccatgacat ggagggaaaa tggcaacttc
     6301 aaatttgcac ccccaggtat catgtgggca ggtgctccat gtggctggtg atagttgtga
     6361 gtgagccttg cacgggcttt ccccctatcg gctgttccag agcgagaggc tgcaggtgtc
     6421 cacttacgta cctgtggcta agatgcgcct gagcaagtga gggccagtta gtatacataa
     6481 tttttacaaa atttggatca tattacataa atatcttgct tcatgcactt aatatgaaat
     6541 tttgcccatg atttattttt taccttattt ttaagggcca cctagttaga atttgattat
     6601 ttgagcaact atttagtgcc tgtgatgtgc cagccactgc taggttctgg ggctcaaaac
     6661 actgtgacag atgctgtgat accacaacgt ggccacattt tgttttcaag accttggcca
     6721 acctttggtc ttcacagcca ctgccctggt agtaagggac ttagttaagt ttggtgactg
     6781 cttgaagtct aagatcacca aagtggctaa tgcaggcact gtgacaatct gggcactagg
     6841 aaaagcaatg tgggcagaaa ttccttgttc gagagccttc tggttatact ttaaaaagaa
     6901 gggagcctag catcttgtca aatctttgag cccactcact cagagggcct gtcactcatc
     6961 cagaattgaa tctgctggtt taacaggtca ggcagtgtga tttgacagcg tgaatcttag
     7021 agtccagcct ttgaacctgg cgctgaatcc tgactttact gcttattcag ggggccacta
     7081 gctaagttaa tttgtgagcc tgggcaacat ggcgtgaccc atctctacaa aagatacaaa
     7141 aattaactgg atgtggtggt gcatgcctgt agttcatagc tactctggag gctgaggcgg
     7201 gaggataacc tgagtgcggg aggttgaggt tgcagtgagc tgaagttgca ccactgcact
     7261 ccagcctagg tgacagagtg agaccttatc ttaatctaaa aaataaaatt tctgagcctt
     7321 attttcctca tctgtaaaat gaagagaata cctagctcat ggagttagga acaagtatgt
     7381 taaatattta tcagagtgtg cctgacagtg agttgaaaat atctactctc tttggatgaa
     7441 aaatatttaa cacttcactc tcagatataa ttattagctg actttttaga ttcttttttc
     7501 ttttacatga tgtagttctc agatatatac gggatttcta gttcttaaat gccagtattt
     7561 tttttctgtt aaaatattta tgaactattt caaacattca gaaaaactca ggatcatacc
     7621 cataaaccca ctgtttagat tttaaaaagt tcaatgtttt tctgtatttt atctcttcat
     7681 tttaaaataa agttttgcac atg
//
