LOCUS       NM_001128628            3879 bp    mRNA    linear   PRI 17-JUL-2023
DEFINITION  Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript
            variant 1, mRNA.
ACCESSION   NM_001128628
VERSION     NM_001128628.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Liu T, Li Y, Gu H, Zhu G, Li J, Cao L and Li F.
  TITLE     p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via
            phosphorylation of androgen receptor and tumorigenic E3 ligase
            murine double minute-2 (Mdm2)
  JOURNAL   J Biol Chem 288 (5), 3359-3369 (2013)
   PUBMED   23132866
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Shepelev MV and Korobko IV.
  TITLE     Pak6 protein kinase is a novel effector of an atypical Rho family
            GTPase Chp/RhoV
  JOURNAL   Biochemistry (Mosc) 77 (1), 26-32 (2012)
   PUBMED   22339630
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA
            and Butte NF.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   McCarty SK, Saji M, Zhang X, Jarjoura D, Fusco A, Vasko VV and
            Ringel MD.
  TITLE     Group I p21-activated kinases regulate thyroid cancer cell
            migration and are overexpressed and activated in thyroid cancer
            invasion
  JOURNAL   Endocr Relat Cancer 17 (4), 989-999 (2010)
   PUBMED   20817787
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Wells CM and Jones GE.
  TITLE     The emerging importance of group II PAKs
  JOURNAL   Biochem J 425 (3), 465-473 (2010)
   PUBMED   20070256
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   Wu X, Carr HS, Dan I, Ruvolo PP and Frost JA.
  TITLE     p21 activated kinase 5 activates Raf-1 and targets it to
            mitochondria
  JOURNAL   J Cell Biochem 105 (1), 167-175 (2008)
   PUBMED   18465753
REFERENCE   7  (bases 1 to 3879)
  AUTHORS   Kaur R, Liu X, Gjoerup O, Zhang A, Yuan X, Balk SP, Schneider MC
            and Lu ML.
  TITLE     Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38
            MAP kinase
  JOURNAL   J Biol Chem 280 (5), 3323-3330 (2005)
   PUBMED   15550393
REFERENCE   8  (bases 1 to 3879)
  AUTHORS   Schrantz N, da Silva Correia J, Fowler B, Ge Q, Sun Z and Bokoch
            GM.
  TITLE     Mechanism of p21-activated kinase 6-mediated inhibition of androgen
            receptor signaling
  JOURNAL   J Biol Chem 279 (3), 1922-1931 (2004)
   PUBMED   14573606
REFERENCE   9  (bases 1 to 3879)
  AUTHORS   Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML and Balk SP.
  TITLE     AR and ER interaction with a p21-activated kinase (PAK6)
  JOURNAL   Mol Endocrinol 16 (1), 85-99 (2002)
   PUBMED   11773441
REFERENCE   10 (bases 1 to 3879)
  AUTHORS   Yang F, Li X, Sharma M, Zarnegar M, Lim B and Sun Z.
  TITLE     Androgen receptor specifically interacts with a novel p21-activated
            kinase, PAK6
  JOURNAL   J Biol Chem 276 (18), 15345-15353 (2001)
   PUBMED   11278661
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025429.6 and AC020658.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001128628.2.
            
            Summary: This gene represents readthrough transcription between the
            genes BUB1B (mitotic checkpoint serine/threonine-protein kinase
            BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The
            protein encoded by the readthrough transcripts is the same as the
            product of the downstream gene (PAK6). Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315813.1, AK290227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 701, 56924
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC025429.6         135968-136207
            241-323             AC020658.6         78974-79056
            324-435             AC020658.6         91553-91664
            436-644             AC020658.6         103156-103364
            645-1298            AC020658.6         104217-104870
            1299-1796           AC020658.6         110599-111096
            1797-1930           AC020658.6         111241-111374
            1931-2057           AC020658.6         111721-111847
            2058-2183           AC020658.6         111926-112051
            2184-2318           AC020658.6         112517-112651
            2319-3879           AC020658.6         114302-115862
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3879
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /note="BUB1B-PAK6 readthrough"
                     /db_xref="GeneID:106821730"
                     /db_xref="HGNC:HGNC:52276"
     exon            1..240
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            241..323
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            324..435
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            436..644
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..2486
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /EC_number="2.7.11.1"
                     /note="p21-activated kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 6"
                     /protein_id="NP_001122100.1"
                     /db_xref="GeneID:106821730"
                     /db_xref="HGNC:HGNC:52276"
                     /translation="MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL
                     DTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRG
                     RSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPW
                     PEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMK
                     AAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSS
                     SKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLR
                     TAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKA
                     ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLF
                     NEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCE
                     AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY
                     WMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS
                     HKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC"
     exon            645..1298
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1796
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1930
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2057
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2183
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2318
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..3879
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3857..3862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /note="hexamer: ATTAAA"
     polyA_site      3879
                     /gene="BUB1B-PAK6"
                     /gene_synonym="PAK-5; PAK-6; PAK5; PAK6"
                     /note="major polyA site"
ORIGIN      
        1 aaagaccagc tatgcagctt ctttcatggc ctatttttat tatctccttc tcttaaatct
       61 gggctcagaa tccacgatcc ctatgattgt aacaagaaca atcaagcttt gaagatagtg
      121 gacttttcct acagtgttga ccttagggtg cagctggatg tttttaccct cagcggcttt
      181 cggactgtac agatcctgga aggacaaaag atcctggcta actgttcttc tccctaccag
      241 ggagtgccgc ttcctgggct agagacaagc accagcctgc agtggagaac gcaggacccc
      301 gctgcccaga aggagcagcc acggcctgcg gaggactggc ccagcaaggt cccaggtctt
      361 ccctctcctc agcgcctaag agagaggccc agtgcgggtg aggagtcgcg aggaagaggc
      421 ggaaggcgcc ggaaggcacc atgttccgca agaaaaagaa gaaacgccct gagatctcag
      481 cgccacagaa cttccagcac cgtgtccaca cctccttcga ccccaaagaa ggcaagtttg
      541 tgggcctccc cccacaatgg cagaacatcc tggacacact gcggcgcccc aagcccgtgg
      601 tggacccttc gcgaatcaca cgggtgcagc tccagcccat gaagacagtg gtgcggggca
      661 gcgcgatgcc tgtggatggc tacatctcgg ggctgctcaa cgacatccag aagttgtcag
      721 tcatcagctc caacaccctg cgtggccgca gccccaccag ccggcggcgg gcacagtccc
      781 tggggctgct gggggatgag cactgggcca ccgacccaga catgtacctc cagagccccc
      841 agtctgagcg cactgacccc cacggcctct acctcagctg caacgggggc acaccagcag
      901 gccacaagca gatgccgtgg cccgagccac agagcccacg ggtcctgccc aatgggctgg
      961 ctgcaaaggc acagtccctg ggccccgccg agtttcaggg tgcctcgcag cgctgtctgc
     1021 agctgggtgc ctgcctgcag agctccccac caggagcctc gccccccacg ggcaccaata
     1081 ggcatggaat gaaggctgcc aagcatggct ctgaggaggc ccggccacag tcctgcctgg
     1141 tgggctcagc cacaggcagg ccaggtgggg aaggcagccc tagccctaag acccgggaga
     1201 gcagcctgaa gcgcaggcta ttccgaagca tgttcctgtc cactgctgcc acagcccctc
     1261 caagcagcag caagccaggc cctccaccac agagcaagcc caactcctct ttccgaccgc
     1321 cgcagaaaga caacccccca agcctggtgg ccaaggccca gtccttgccc tcggaccagc
     1381 cggtggggac cttcagccct ctgaccactt cggataccag cagcccccag aagtccctcc
     1441 gcacagcccc ggccacaggc cagcttccag gccggtcttc cccagcggga tccccccgca
     1501 cctggcacgc ccagatcagc accagcaacc tgtacctgcc ccaggacccc acggttgcca
     1561 agggtgccct ggctggtgag gacacaggtg ttgtgacaca tgagcagttc aaggctgcgc
     1621 tcaggatggt ggtggaccag ggtgaccccc ggctgctgct ggacagctac gtgaagattg
     1681 gcgagggctc caccggcatc gtctgcttgg cccgggagaa gcactcgggc cgccaggtgg
     1741 ccgtcaagat gatggacctc aggaagcagc agcgcaggga gctgctcttc aacgaggtgg
     1801 tgatcatgcg ggactaccag cacttcaacg tggtggagat gtacaagagc tacctggtgg
     1861 gcgaggagct gtgggtgctc atggagttcc tgcagggagg agccctcaca gacatcgtct
     1921 cccaagtcag gctgaatgag gagcagattg ccactgtgtg tgaggctgtg ctgcaggccc
     1981 tggcctacct gcatgctcag ggtgtcatcc accgggacat caagagtgac tccatcctgc
     2041 tgaccctcga tggcagggtg aagctctcgg acttcggatt ctgtgctcag atcagcaaag
     2101 acgtccctaa gaggaagtcc ctggtgggaa ccccctactg gatggctcct gaagtgatct
     2161 ccaggtcttt gtatgccact gaggtggata tctggtctct gggcatcatg gtgattgaga
     2221 tggtagatgg ggagccaccg tacttcagtg actccccagt gcaagccatg aagaggctcc
     2281 gggacagccc cccacccaag ctgaaaaact ctcacaaggt ctccccagtg ctgcgagact
     2341 tcctggagcg gatgctggtg cgggaccccc aagagagagc cacagcccag gagctcctag
     2401 accacccctt cctgctgcag acagggctac ctgagtgcct ggtgcccctg atccagctct
     2461 accgaaagca gacctccacc tgctgagccc accccaagta tgcctgccac ctacgcccac
     2521 aggcagggca cactgggcag ccagcctgcc ggcaggactt gcctgcctcc tcctctcagt
     2581 attctctcca aagattgaaa tgtgaagccc cagccccacc ctctgccctt cagcctactg
     2641 ggccaggccg gacctgcccc ctcagtgtct ctccctcccg agtccccaga tggagacccc
     2701 tttctacagg atgacccctt gatatttgca cagggatatt tctaagaaac gcagaggcca
     2761 gcgttcctgg cctctgcagc caacacagta gaaaaggctg ctgtggtttt ttaaaggcag
     2821 ttgtccacta gtgtcctagg ccactgcaga gggcagactg ctggtctcca cagatacctg
     2881 ctgttctcag ctccagcttc aaacctcgag tctcgagagg gccacggggt ggtttttatg
     2941 accggaatcc cgcttcctcc ctcacgtctg atgtcctgaa ggtgcagtcc cacctgtaca
     3001 gcccctcccc gcccagaact gtgaatggcc tgctccaggc catggctggg ggcagggagt
     3061 gaggggacaa tttctgagtg aaagagaaag aatggggtcg gtggtgaagg tgctctcact
     3121 ttacagaatg gagagaacat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3181 taaggggagg aaagccacct tgacagccca ggtccctcca ggtcacccac agccagtttc
     3241 aggaaggctg cccctctctc ccactaagtt ctggcctgaa gggacctgct ttcttggcct
     3301 ggcttccacc tctccactcc tgtgtctacc tggccagtgg agtggtccat gctaagtcta
     3361 acactcctgg gagctcagga ggcttctgag cttctcctgt actgtgcatc gtgagggcca
     3421 gagacaggaa tgtaaggatt ggcaactgtg ttacctttca agtttatctc aataaccagg
     3481 tcatcaggga cccattgttc tcttcagaac cctatctggg agagaaggcg aaccacctcc
     3541 gggtttccat catgtcaagg tcacaggcat ccatgtgtgc aaaccatctg ccccagctgc
     3601 ctccacagac tgctgtctcc ttgtcctcct cggccctgcc ccacttcagg gctgctgtga
     3661 gatggaattc caggaaagaa cttcaggtgt ctggaccctt tctatctaga taatattttt
     3721 agattcttct gctccctagt gacctacctg ggggcaaaga aattgcaagg actttttttt
     3781 aagggtcaga gttttcaaaa caaaagcatc ttccctagaa atttttgtga attgtttgca
     3841 cttgtgcctg ttttaaatta aattgagtgt tcaaagcca
//
