LOCUS       NM_001211               3669 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase B
            (BUB1B), mRNA.
ACCESSION   NM_001211
VERSION     NM_001211.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3669)
  AUTHORS   Zhang,H., Li,Y. and Lu,H.
  TITLE     Correlation of BUB1 and BUB1B with the development and prognosis of
            endometrial cancer
  JOURNAL   Sci Rep 14 (1), 17084 (2024)
   PUBMED   39048649
  REMARK    GeneRIF: Correlation of BUB1 and BUB1B with the development and
            prognosis of endometrial cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3669)
  AUTHORS   Ding,Y., Gao,J., Chen,J., Ren,J., Jiang,J., Zhang,Z., Tong,X. and
            Zhao,J.
  TITLE     BUB1b impairs chemotherapy sensitivity via resistance to
            ferroptosis in lung adenocarcinoma
  JOURNAL   Cell Death Dis 15 (7), 525 (2024)
   PUBMED   39043653
  REMARK    GeneRIF: BUB1b impairs chemotherapy sensitivity via resistance to
            ferroptosis in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3669)
  AUTHORS   Cavalcante,I.L., Silva Barros,C.C.D., Colares,D.F., Cruz,V.M.S., de
            Andrade,B.A.B., Nonaka,C.F.W., Rabenhorst,S.H.B. and
            Cavalcante,R.B.
  TITLE     BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and
            polymorphous adenocarcinoma of minor salivary glands
  JOURNAL   Pathol Res Pract 253, 154961 (2024)
   PUBMED   38043194
  REMARK    GeneRIF: BubR1 and cyclin B1 immunoexpression in pleomorphic
            adenoma and polymorphous adenocarcinoma of minor salivary glands.
REFERENCE   4  (bases 1 to 3669)
  AUTHORS   Park,S.E., Chung,K.S., Heo,S.W., Kim,S.Y., Lee,J.H., Hassan,A.H.E.,
            Lee,Y.S., Lee,J.Y. and Lee,K.T.
  TITLE     Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting
            microtubule dynamics and Wnt/beta-catenin/EMT signaling in human
            colorectal cancer cells
  JOURNAL   Life Sci 334, 122227 (2023)
   PUBMED   37926298
REFERENCE   5  (bases 1 to 3669)
  AUTHORS   Nair,V.M., Sabu,A.S., Hussain,A., Kombarakkaran,D.P., Lakshmi,R.B.
            and Manna,T.K.
  TITLE     E3-ubiquitin ligase, FBXW7 regulates mitotic progression by
            targeting BubR1 for ubiquitin-mediated degradation
  JOURNAL   Cell Mol Life Sci 80 (12), 374 (2023)
   PUBMED   38008853
  REMARK    GeneRIF: E3-ubiquitin ligase, FBXW7 regulates mitotic progression
            by targeting BubR1 for ubiquitin-mediated degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3669)
  AUTHORS   Davenport,J.W., Fernandes,E.R., Harris,L.D., Neale,G.A. and
            Goorha,R.
  TITLE     The mouse mitotic checkpoint gene bub1b, a novel bub1 family
            member, is expressed in a cell cycle-dependent manner
  JOURNAL   Genomics 55 (1), 113-117 (1999)
   PUBMED   9889005
REFERENCE   7  (bases 1 to 3669)
  AUTHORS   Chan,G.K., Schaar,B.T. and Yen,T.J.
  TITLE     Characterization of the kinetochore binding domain of CENP-E
            reveals interactions with the kinetochore proteins CENP-F and
            hBUBR1
  JOURNAL   J Cell Biol 143 (1), 49-63 (1998)
   PUBMED   9763420
REFERENCE   8  (bases 1 to 3669)
  AUTHORS   Taylor,S.S., Ha,E. and McKeon,F.
  TITLE     The human homologue of Bub3 is required for kinetochore
            localization of Bub1 and a Mad3/Bub1-related protein kinase
  JOURNAL   J Cell Biol 142 (1), 1-11 (1998)
   PUBMED   9660858
REFERENCE   9  (bases 1 to 3669)
  AUTHORS   Donadelli,R., Benatti,L., Remuzzi,A., Morigi,M., Gullans,S.R.,
            Benigni,A., Remuzzi,G. and Noris,M.
  TITLE     Identification of a novel gene--SSK1--in human endothelial cells
            exposed to shear stress
  JOURNAL   Biochem Biophys Res Commun 246 (3), 881-887 (1998)
   PUBMED   9618306
REFERENCE   10 (bases 1 to 3669)
  AUTHORS   Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K.,
            Markowitz,S.D., Kinzler,K.W. and Vogelstein,B.
  TITLE     Mutations of mitotic checkpoint genes in human cancers
  JOURNAL   Nature 392 (6673), 300-303 (1998)
   PUBMED   9521327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025429.6.
            
            On Nov 30, 2019 this sequence version replaced NM_001211.5.
            
            Summary: This gene encodes a kinase involved in spindle checkpoint
            function. The protein has been localized to the kinetochore and
            plays a role in the inhibition of the anaphase-promoting
            complex/cyclosome (APC/C), delaying the onset of anaphase and
            ensuring proper chromosome segregation. Impaired spindle checkpoint
            function has been found in many forms of cancer. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF107297.1, AF068760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287598.11/ ENSP00000287598.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC025429.6         79609-79795
            188-331             AC025429.6         83593-83736
            332-391             AC025429.6         88602-88661
            392-536             AC025429.6         89077-89221
            537-733             AC025429.6         95017-95213
            734-903             AC025429.6         102254-102423
            904-1118            AC025429.6         103705-103919
            1119-1210           AC025429.6         104091-104182
            1211-1440           AC025429.6         115085-115314
            1441-1553           AC025429.6         118155-118267
            1554-1669           AC025429.6         118784-118899
            1670-1719           AC025429.6         119471-119520
            1720-1780           AC025429.6         120945-121005
            1781-1886           AC025429.6         121129-121234
            1887-2161           AC025429.6         124724-124998
            2162-2295           AC025429.6         127177-127310
            2296-2436           AC025429.6         128175-128315
            2437-2537           AC025429.6         128650-128750
            2538-2687           AC025429.6         131039-131188
            2688-2830           AC025429.6         131872-132014
            2831-3002           AC025429.6         136036-136207
            3003-3109           AC025429.6         136996-137102
            3110-3669           AC025429.6         139104-139663
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3669
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /note="BUB1 mitotic checkpoint serine/threonine kinase B"
                     /db_xref="GeneID:701"
                     /db_xref="HGNC:HGNC:1149"
                     /db_xref="MIM:602860"
     exon            1..187
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..3305
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /EC_number="2.7.11.1"
                     /note="MAD3/BUB1-related protein kinase; mitotic
                     checkpoint kinase MAD3L; budding uninhibited by
                     benzimidazoles 1 homolog beta; BUB1B, mitotic checkpoint
                     serine/threonine kinase"
                     /codon_start=1
                     /product="mitotic checkpoint serine/threonine-protein
                     kinase BUB1 beta"
                     /protein_id="NP_001202.5"
                     /db_xref="CCDS:CCDS10053.1"
                     /db_xref="GeneID:701"
                     /db_xref="HGNC:HGNC:1149"
                     /db_xref="MIM:602860"
                     /translation="MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGA
                     LAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLL
                     ERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAE
                     EYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFE
                     SSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFD
                     ENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVP
                     AVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEK
                     KEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEME
                     KKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARET
                     SLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSES
                     ITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHE
                     IMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHS
                     SGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS
                     AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSS
                     QPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITH
                     EITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSY
                     SVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVF
                     WDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSH
                     LNKALWKVGKLTSPGALLFQ"
     exon            188..331
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..391
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..536
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..733
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..903
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1118
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1210
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1440
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1553
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1669
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1719
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1780
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1886
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2161
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2295
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2436
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2537
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2687
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2830
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3002
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3109
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3669
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3649..3654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /note="hexamer: AATAAA"
     polyA_site      3669
                     /gene="BUB1B"
                     /gene_synonym="Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L;
                     MVA1; SSK1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcttga ggtggccggt ttgttaggga gtcgtgtacg tgccttggtc gcttctgtag
       61 ctccgagggc aggttgcgga agaaagccca ggcggtctgt ggcccagagg aaaggcctgc
      121 agcaggacga ggacctgagc caggaatgca ggatggcggc ggtgaagaag gaagggggtg
      181 ctctgagtga agccatgtcc ctggagggag atgaatggga actgagtaaa gaaaatgtac
      241 aacctttaag gcaagggcgg atcatgtcca cgcttcaggg agcactggca caagaatctg
      301 cctgtaacaa tactcttcag cagcagaaac gggcatttga atatgaaatt cgattttaca
      361 ctggaaatga ccctctggat gtttgggata ggtatatcag ctggacagag cagaactatc
      421 ctcaaggtgg gaaggagagt aatatgtcaa cgttattaga aagagctgta gaagcactac
      481 aaggagaaaa acgatattat agtgatcctc gatttctcaa tctctggctt aaattagggc
      541 gtttatgcaa tgagcctttg gatatgtaca gttacttgca caaccaaggg attggtgttt
      601 cacttgctca gttctatatc tcatgggcag aagaatatga agctagagaa aactttagga
      661 aagcagatgc gatatttcag gaagggattc aacagaaggc tgaaccacta gaaagactac
      721 agtcccagca ccgacaattc caagctcgag tgtctcggca aactctgttg gcacttgaga
      781 aagaagaaga ggaggaagtt tttgagtctt ctgtaccaca acgaagcaca ctagctgaac
      841 taaagagcaa agggaaaaag acagcaagag ctccaatcat ccgtgtagga ggtgctctca
      901 aggctccaag ccagaacaga ggactccaaa atccatttcc tcaacagatg caaaataata
      961 gtagaattac tgtttttgat gaaaatgctg atgaggcttc tacagcagag ttgtctaagc
     1021 ctacagtcca gccatggata gcacccccca tgcccagggc caaagagaat gagctgcaag
     1081 caggcccttg gaacacaggc aggtccttgg aacacaggcc tcgtggcaat acagcttcac
     1141 tgatagctgt acccgctgtg cttcccagtt tcactccata tgtggaagag actgcacgac
     1201 agccagttat gacaccatgt aaaattgaac ctagtataaa ccacatccta agcaccagaa
     1261 agcctggaaa ggaagaagga gatcctctac aaagggttca gagccatcag caagcgtctg
     1321 aggagaagaa agagaagatg atgtattgta aggagaagat ttatgcagga gtaggggaat
     1381 tctcctttga agaaattcgg gctgaagttt tccggaagaa attaaaagag caaagggaag
     1441 ccgagctatt gaccagtgca gagaagagag cagaaatgca gaaacagatt gaagagatgg
     1501 agaagaagct aaaagaaatc caaactactc agcaagaaag aacaggtgat cagcaagaag
     1561 agacgatgcc tacaaaggag acaactaaac tgcaaattgc ttccgagtct cagaaaatac
     1621 caggaatgac tctatccagt tctgtttgtc aagtaaactg ttgtgccaga gaaacttcac
     1681 ttgcggagaa catttggcag gaacaacctc attctaaagg tcccagtgta cctttctcca
     1741 tttttgatga gtttcttctt tcagaaaaga agaataaaag tcctcctgca gatcccccac
     1801 gagttttagc tcaacgaaga ccccttgcag ttctcaaaac ctcagaaagc atcacctcaa
     1861 atgaagatgt gtctccagat gtttgtgatg aatttacagg aattgaaccc ttgagcgagg
     1921 atgccattat cacaggcttc agaaatgtaa caatttgtcc taacccagaa gacacttgtg
     1981 actttgccag agcagctcgt tttgtatcca ctccttttca tgagataatg tccttgaagg
     2041 atctcccttc tgatcctgag agactgttac cggaagaaga tctagatgta aagacctctg
     2101 aggaccagca gacagcttgt ggcactatct acagtcagac tctcagcatc aagaagctga
     2161 gcccaattat tgaagacagt cgtgaagcca cacactcctc tggcttctct ggttcttctg
     2221 cctcggttgc aagcacctcc tccatcaaat gtcttcaaat tcctgagaaa ctagaactta
     2281 ctaatgagac ttcagaaaac cctactcagt caccatggtg ttcacagtat cgcagacagc
     2341 tactgaagtc cctaccagag ttaagtgcct ctgcagagtt gtgtatagaa gacagaccaa
     2401 tgcctaagtt ggaaattgag aaggaaattg aattaggtaa tgaggattac tgcattaaac
     2461 gagaatacct aatatgtgaa gattacaagt tattctgggt ggcgccaaga aactctgcag
     2521 aattaacagt aataaaggta tcttctcaac ctgtcccatg ggacttttat atcaacctca
     2581 agttaaagga acgtttaaat gaagattttg atcatttttg cagctgttat caatatcaag
     2641 atggctgtat tgtttggcac caatatataa actgcttcac ccttcaggat cttctccaac
     2701 acagtgaata tattacccat gaaataacag tgttgattat ttataacctt ttgacaatag
     2761 tggagatgct acacaaagca gaaatagtcc atggtgactt gagtccaagg tgtctgattc
     2821 tcagaaacag aatccacgat ccctatgatt gtaacaagaa caatcaagct ttgaagatag
     2881 tggacttttc ctacagtgtt gaccttaggg tgcagctgga tgtttttacc ctcagcggct
     2941 ttcggactgt acagatcctg gaaggacaaa agatcctggc taactgttct tctccctacc
     3001 aggtagacct gtttggtata gcagatttag cacatttact attgttcaag gaacacctac
     3061 aggtcttctg ggatgggtcc ttctggaaac ttagccaaaa tatttctgag ctaaaagatg
     3121 gtgaattgtg gaataaattc tttgtgcgga ttctgaatgc caatgatgag gccacagtgt
     3181 ctgttcttgg ggagcttgca gcagaaatga atggggtttt tgacactaca ttccaaagtc
     3241 acctgaacaa agccttatgg aaggtaggga agttaactag tcctggggct ttgctctttc
     3301 agtgagctag gcaatcaagt ctcacagatt gctgcctcag agcaatggtt gtattgtgga
     3361 acactgaaac tgtatgtgct gtaatttaat ttaggacaca tttagatgca ctaccattgc
     3421 tgttctactt tttggtacag gtatattttg acgtcactga tattttttat acagtgatat
     3481 acttactcat ggccttgtct aacttttgtg aagaactatt ttattctaaa cagactcatt
     3541 acaaatggtt accttgttat ttaacccatt tgtctctact tttccctgta cttttcccat
     3601 ttgtaatttg taaaatgttc tcttatgatc accatgtatt ttgtaaataa taaaatagta
     3661 tctgttaaa
//
