LOCUS       XM_047425985            6047 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens beta-transducin repeat containing E3
            ubiquitin protein ligase (BTRC), transcript variant X9, mRNA.
ACCESSION   XM_047425985
VERSION     XM_047425985.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000010.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
     gene            1..6047
                     /gene="BTRC"
                     /gene_synonym="BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A;
                     FBXW1; FBXW1A; FWD1"
                     /note="beta-transducin repeat containing E3 ubiquitin
                     protein ligase; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 27 ESTs, 927
                     long SRA reads, 8 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     5 samples with support for all annotated introns"
                     /db_xref="GeneID:8945"
                     /db_xref="HGNC:HGNC:1144"
                     /db_xref="MIM:603482"
     CDS             337..1857
                     /gene="BTRC"
                     /gene_synonym="BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A;
                     FBXW1; FBXW1A; FWD1"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 1A isoform
                     X7"
                     /protein_id="XP_047281941.1"
                     /db_xref="GeneID:8945"
                     /db_xref="HGNC:HGNC:1144"
                     /db_xref="MIM:603482"
                     /translation="MKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQ
                     WSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLD
                     AKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPD
                     GNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV
                     SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEM
                     LNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVD
                     FDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW
                     DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLR
                     TLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR"
ORIGIN      
        1 acattaacag cccatgtcac tgtaataggt agtacagccg agttgttcag ttttctatta
       61 ttttagcttt gaaataactg ttagtgctgc cccaaaatct tcgtgtataa aattgtatat
      121 tggctgcccc ccaggactcg ttcaggctct gttgcaccat ccaaccttga gcaagatgct
      181 tactcaaaga ttattaattc ctcagagaga gaagactgta ataatggcga accccctagg
      241 aagataatac cagagaagaa ttcacttaga cagacataca acagctgtgc cagactctgc
      301 ttaaaccaag aaacagtatg tttagcaagc actgctatga agactgagaa ttgtgtggcc
      361 aaaacaaaac ttgccaatgg cacttccagt atgattgtgc ccaagcaacg gaaactctca
      421 gcaagctatg aaaaggaaaa ggaactgtgt gtcaaatact ttgagcagtg gtcagagtca
      481 gatcaagtgg aatttgtgga acatcttata tcccaaatgt gtcattacca acatgggcac
      541 ataaactcgt atcttaaacc tatgttgcag agagatttca taactgctct gccagctcgg
      601 ggattggatc atattgctga gaacattctg tcatacctgg atgccaaatc actatgtgct
      661 gctgaacttg tgtgcaagga atggtaccga gtgacctctg atggcatgct gtggaagaag
      721 cttatcgaga gaatggtcag gacagattct ctgtggagag gcctggcaga acgaagagga
      781 tggggacagt atttattcaa aaacaaacct cctgacggga atgctcctcc caactctttt
      841 tatagagcac tttatcctaa aattatacaa gacattgaga caatagaatc taattggaga
      901 tgtggaagac atagtttaca gagaattcac tgccgaagtg aaacaagcaa aggagtttac
      961 tgtttacagt atgatgatca gaaaatagta agcggccttc gagacaacac aatcaagatc
     1021 tgggataaaa acacattgga atgcaagcga attctcacag gccatacagg ttcagtcctc
     1081 tgtctccagt atgatgagag agtgatcata acaggatcat cggattccac ggtcagagtg
     1141 tgggatgtaa atacaggtga aatgctaaac acgttgattc accattgtga agcagttctg
     1201 cacttgcgtt tcaataatgg catgatggtg acctgctcca aagatcgttc cattgctgta
     1261 tgggatatgg cctccccaac tgacattacc ctccggaggg tgctggtcgg acaccgagct
     1321 gctgtcaatg ttgtagactt tgatgacaag tacattgttt ctgcatctgg ggatagaact
     1381 ataaaggtat ggaacacaag tacttgtgaa tttgtaagga ccttaaatgg acacaaacga
     1441 ggcattgcct gtttgcagta cagggacagg ctggtagtga gtggctcatc tgacaacact
     1501 atcagattat gggacataga atgtggtgca tgtttacgag tgttagaagg ccatgaggaa
     1561 ttggtgcgtt gtattcgatt tgataacaag aggatagtca gtggggccta tgatggaaaa
     1621 attaaagtgt gggatcttgt ggctgctttg gacccccgtg ctcctgcagg gacactctgt
     1681 ctacggaccc ttgtggagca ttccggaaga gtttttcgac tacagtttga tgaattccag
     1741 attgtcagta gttcacatga tgacacaatc ctcatctggg acttcctaaa tgatccagct
     1801 gcccaagctg aacccccccg ttccccttct cgaacataca cctacatctc cagataaata
     1861 accatacact gacctcatac ttgcccagga cccattaaag ttgcggtatt taacgtatct
     1921 gccaatacca ggatgagcaa caacagtaac aatcaaacta ctgcccagtt tccctggact
     1981 agccgaggag cagggctttg agactcctgt tgggacacag ttggtctgca gtcggcccag
     2041 gacggtctac tcagcacaac tgactgcttc agtgctgcta tcagaagatg tcttctatct
     2101 tttgtgaatg attggaactt ttaaacctcc cctcctctcc tcctttcacc tctgcaccta
     2161 gttttttccc attggttcca gacaaaggtg acttataaat atatttagtg ttttgccaga
     2221 atctctcttg ctttgccatt aagcagaaga actagtttcc ctgtatagcc tgctgggaga
     2281 gacccacttc tagggtatgg gggatgcagc ttcaagccca gtgcccagtg tctccctgtt
     2341 aactgcagga atgccaagca cctggccaga gcagcccagc cccaatatgc ttaggaggag
     2401 acagagttcc ctctgtatag cctctgggac aagaaaaaga aaacacaaga atgtatacac
     2461 tggaagattt gggcctcctg cctgccttct ctttgtttct gttcctcttc ccatctactc
     2521 ccctacgccc cttcaacctt ttttctctgt ctgcttcacc tgagaagaaa gtgtacgaag
     2581 agagtgtcct cctctcacat gagccagatc agccagaaaa tgcaacactt ggaagagtta
     2641 aatgctgttc agtgaagatt tcagccccag gcctttgctg caagtgaccc tgtggcaaca
     2701 gtggattctc agacatgata ctctcatcat atttgcaact cttctctctc tttcttcccc
     2761 acacccaaga ggaggattgg tggtaggggg caggcagagg gggtggggag aagtttcctg
     2821 ggctccatca atggctgcat cttttctgga ctcagcagtc tccttgattc catgtagagt
     2881 gtggaaagga gttgctgatt gcatttcctc tcattaacaa ttgggtgtgt aataaaaagc
     2941 attgtacttc atcttaaatc actggtaagg ctcagcctac agaaagattt gaaatggcca
     3001 gagccaatcg cttggtgcat tctgcgtaat ggtttccatc tccgatttcc tcatcagggc
     3061 ctgtgaatac ccaggtgcct gtatctttgc caagaccgtg atcaaggtag cttaagagag
     3121 atggtcagga gaaaacactg tttttgtttt ttttgttgtt ttgttttgtt ttggccagtt
     3181 aaatatcatc tctcaaatat tgatctcacc gtgtcaacct tgcactgcac aaccttcctt
     3241 ctgcttctcc cacacccagt atttgcagaa gggcaaagct gcttaagaga gaggatcagg
     3301 gtgaagtttg gcacacaggg tttattaatg gggcaaaaac tgccttttct tcctcctcct
     3361 gaccttattt tgctcttcac tctccccagc caataaagcg tctgtggcga ttggtgaaca
     3421 gcataaacag ctggacctca gcaagggtca ggcaaaccca gtcactcgga aggcagctgt
     3481 gtgagctgcc aagctagtgg gcttcaggtg caagggtacc tgtgccacac caacctggga
     3541 gcacacagaa tactattaat gtgcacccag ctggtctccc caggcaagaa ggtatcctct
     3601 tcccaaggtg tacccactga atgttgttac tacatattga gagtcatttt atgcatatgc
     3661 attctacctt tcctgcttta tgagtatttt taagctttta gttcaaggtt atattcagaa
     3721 aatatttccc agtataatga tacatcgtag cctaagaaat attttctcaa tgtaattccc
     3781 ttcccagcta cccaaatgct acagagaaat gttttctact tggccactat cagggttcgt
     3841 catctattgt gttgactatt aatggctttt tgattgggta aggattttgc tatagatgaa
     3901 ggtagagggc tgtcagccct gaaaaacaca caggtcagac atttaaaagg catgggtttc
     3961 gagctgtctc aaaatattgc ccaatagcca taattttacc agcctttctg tcatatgctg
     4021 ctattacaaa gtggaagctg ttgaatgttt attggtgccc agggttttgc tctccaatct
     4081 aggttcagtt gaaggaatat tgtttctaag actgttttga gacatgtcca gtacatcaca
     4141 aaggagatcg gggcgacccc tgcagatgtg gagccattag cccagttgag gatattctcc
     4201 aagttgtcct ctctcctgct gatggaaatg ggaatgaagt taagtggtct gaaaaacttg
     4261 aatcgttcac atttctcagc tctgggggtc atttaccagt ttgttgtaga agaaataatc
     4321 aggtaagtta aaagttcatt tccagagaag gtaaacccca cttaccatct ctgcatgatt
     4381 tcagtgggaa ttgattatca ctaatcccca actgggctag aataaatgta aagtttgacc
     4441 tttttaaaac gaaaagagag acaaagtctc agcacattcc aaggagtggt agaaacagag
     4501 ctgaaggtgt ccccattgta gattagtctc ttctcactaa aatttacttt ccaacgtagg
     4561 gcctaaagga aacctttctt aaagacaggc tgaaacccct tcaaaggcag atgaggaggt
     4621 acagacacgt gaccttttgg tgcacactgg agctacttgg acaagaccag catgccttgc
     4681 tgcacgtgtg tgtatttcac tgctgagaac atcctttaac ttggtgtgca atttgaaagg
     4741 atgtgaatca tggatggaag gccatttgta catgtccctt ggcaaaattc tttctggtgt
     4801 ctcctaactt cagagacagg gactcttttt ggatctctat tgacaagtaa taaaagtctg
     4861 gccctcataa cttgtttccg aactagaaaa gtctgtgaga cccctacatc attctggttt
     4921 ttttgcttga gtaagaacaa tcctttttta tttttcttct gtacagtcta aagctacaga
     4981 gaaaaaaaaa tgcactcttc ccttgccggc tcctggtacc attggtctga acagctgtag
     5041 ttggtctact ccttacttag cacttgattg tgtggggaaa caaaggtggg aggggtgggg
     5101 aatactggaa ataatcaggg caattttttt ctttcccata attggactag ataccttggt
     5161 actgttgacc ttctcagcat ctcccttttg ccttagatgg caacaccctc cagtctgtag
     5221 cagagcagtc caacccagat tagtgcagcc cggaggctta gggtgcagcc tccctggtct
     5281 tcctccacac agttgttcac caacagacca gacctccttt aaccacagtg tcaacatagt
     5341 atcggaaaga gagccatttc ttaggggaat aaaacagttt cgcttcttta gctcatctgt
     5401 ggtgtcagaa tccttggagc tgaagagaga aatcaaaaga gcatgatgat ggctgcctgg
     5461 tttcaggtgg aacttaatgc attgatcttt agaagctcct tctgttggaa gttgagtacc
     5521 tgtgatctaa aatgtcctgg aggcagatga catctaaaat atgtgctttc caaccagcac
     5581 agctggcgct cttagctcct gattggttgt gtgttttatt aaggatcagt gcagttaagt
     5641 cgtattttaa agtgttacct cccctcctaa cccttcccct tcttggacac tgaaggaaaa
     5701 ggccaactag ggtgttagcc ctctgggcac caaggaaact aacagctttc tcaaagcggt
     5761 gaccactcag gccagcccag acaaatctga gggatggcca gtgcactcca atgatgggac
     5821 aggcctaaca acacatgtaa gcttccccga gagctttcag ctggttcacc tctttgttct
     5881 ctagactctt aagtactgac tgctttgact tttgtgatta tgttatggtg atgtgtagtc
     5941 agtgtaccaa tatgttcaca acctaggatc atgataatgg agtgtgtttt gggttttttt
     6001 taactgttca gaaaaaaagt aaattacaaa tataagatta aagtgaa
//
