LOCUS       NM_152547               3457 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens butyrophilin like 9 (BTNL9), transcript variant 1,
            mRNA.
ACCESSION   NM_152547
VERSION     NM_152547.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3457)
  AUTHORS   Zhang,H., Wang,S.Q., Zhu,J.B., Wang,L.N., Lin,H., Li,L.F.,
            Cheng,Y.D., Duan,C.J. and Zhang,C.F.
  TITLE     LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9
            methylation to drive non-small-cell lung cancer progression
  JOURNAL   Cancer Gene Ther 30 (12), 1649-1662 (2023)
   PUBMED   37884580
  REMARK    GeneRIF: LncRNA CALML3-AS1 modulated by m[6]A modification induces
            BTNL9 methylation to drive non-small-cell lung cancer progression.
REFERENCE   2  (bases 1 to 3457)
  AUTHORS   Carlson,J.C., Krishnan,M., Rosenthal,S.L., Russell,E.M.,
            Zhang,J.Z., Hawley,N.L., Moors,J., Cheng,H., Dalbeth,N., de
            Zoysa,J.R., Watson,H., Qasim,M., Murphy,R., Naseri,T.,
            Reupena,M.S., Viali,S., Stamp,L.K., Tuitele,J., Kershaw,E.E.,
            Deka,R., McGarvey,S.T., Merriman,T.R., Weeks,D.E. and Minster,R.L.
  TITLE     A stop-gain variant in BTNL9 is associated with atherogenic lipid
            profiles
  JOURNAL   HGG Adv 4 (1), 100155 (2022)
   PUBMED   36340932
  REMARK    GeneRIF: A stop-gain variant in BTNL9 is associated with
            atherogenic lipid profiles.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3457)
  AUTHORS   Zheng,P., Sun,S., Wang,J., Cheng,Z.J., Lei,K.C., Xue,M., Zhang,T.,
            Huang,H., Zhang,X.D. and Sun,B.
  TITLE     Integrative omics analysis identifies biomarkers of idiopathic
            pulmonary fibrosis
  JOURNAL   Cell Mol Life Sci 79 (1), 66 (2022)
   PUBMED   35015148
  REMARK    GeneRIF: Integrative omics analysis identifies biomarkers of
            idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3457)
  AUTHORS   Mo,Q., Xu,K., Luo,C., Zhang,Q., Wang,L. and Ren,G.
  TITLE     BTNL9 is frequently downregulated and inhibits proliferation and
            metastasis via the P53/CDC25C and P53/GADD45 pathways in breast
            cancer
  JOURNAL   Biochem Biophys Res Commun 553, 17-24 (2021)
   PUBMED   33756341
  REMARK    GeneRIF: BTNL9 is frequently downregulated and inhibits
            proliferation and metastasis via the P53/CDC25C and P53/GADD45
            pathways in breast cancer.
REFERENCE   5  (bases 1 to 3457)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3457)
  AUTHORS   Jiang,Z. and Liu,F.
  TITLE     Butyrophilin-Like 9 (BTNL9) Suppresses Invasion and Correlates with
            Favorable Prognosis of Uveal Melanoma
  JOURNAL   Med Sci Monit 25, 3190-3198 (2019)
   PUBMED   31039142
  REMARK    GeneRIF: Authors investigated the function of BTNL9 in UM
            proliferation and invasion. BTNL9 mRNAs in adjacent tissues were
            remarkably higher than in UM tissues. The percentages of BTNL9 low
            expression and high expression were 56.45% and 43.55%,
            respectively.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3457)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC379841.1, AY358358.1 and BC042112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152547.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358358.1, DRR138524.1133286.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327705.14/ ENSP00000330200.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               DC379841.1         42-255
            215-2302            AY358358.1         242-2329
            2303-3457           BC042112.1         1246-2400
FEATURES             Location/Qualifiers
     source          1..3457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3457
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /note="butyrophilin like 9"
                     /db_xref="GeneID:153579"
                     /db_xref="HGNC:HGNC:24176"
                     /db_xref="MIM:620648"
     exon            1..167
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            168..299
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1798
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; butyrophilin 3; butyrophilin-like protein 9"
                     /codon_start=1
                     /product="butyrophilin-like protein 9 isoform a precursor"
                     /protein_id="NP_689760.2"
                     /db_xref="CCDS:CCDS4460.2"
                     /db_xref="GeneID:153579"
                     /db_xref="HGNC:HGNC:24176"
                     /db_xref="MIM:620648"
                     /translation="MVDLSVSPDSLKPVSLTSSLVFLMHLLLLQPGEPSSEVKVLGPE
                     YPILALVGEEVEFPCHLWPQLDAQQMEIRWFRSQTFNVVHLYQEQQELPGRQMPAFRN
                     RTKLVKDDIAYGSVVLQLHSIIPSDKGTYGCRFHSDNFSGEALWELEVAGLGSDPHLS
                     LEGFKEGGIQLRLRSSGWYPKPKVQWRDHQGQCLPPEFEAIVWDAQDLFSLETSVVVR
                     AGALSNVSVSIQNLLLSQKKELVVQIADVFVPGASAWKSAFVATLPLLLVLAALALGV
                     LRKQRRSREKLRKQAEKRQEKLTAELEKLQTELDWRRAEGQAEWRAAQKYAVDVTLDP
                     ASAHPSLEVSEDGKSVSSRGAPPGPAPGHPQRFSEQTCALSLERFSAGRHYWEVHVGR
                     RSRWFLGACLAAVPRAGPARLSPAAGYWVLGLWNGCEYFVLAPHRVALTLRVPPRRLG
                     VFLDYEAGELSFFNVSDGSHIFTFHDTFSGALCAYFRPRAHDGGEHPDPLTICPLPVR
                     GTGVPEENDSDTWLQPYEPADPALDWW"
     exon            300..644
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            645..926
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1043
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1076
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1097
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1118
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1145
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1172
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..3457
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3431..3436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /note="hexamer: AATAAA"
     polyA_site      3457
                     /gene="BTNL9"
                     /gene_synonym="BTN3; BTN8; VDLS1900"
                     /note="major polyA site"
ORIGIN      
        1 aattctgtca cacgtgccct ggcctctgga gctcagctgc cagtccacgt ctagggaatc
       61 ttagcatctg ggaccaagac actttacagc aatcatcacc ctttgcagag gaggtgagct
      121 caccaggact catctgccat ttcagacctt ttgctgctac ctgccaggtg gcccccactg
      181 ctgacgagag atggtggacc tctcagtctc cccagactcc ttgaagccag tatcgctgac
      241 cagcagtctt gtcttcctca tgcacctcct cctccttcag cctggggagc cgagctcaga
      301 ggtcaaggtg ctaggccctg agtatcccat cctggccctc gtcggggagg aggtggagtt
      361 cccgtgccac ctatggccac agctggatgc ccagcaaatg gagatccgct ggttccggag
      421 tcagaccttc aatgtggtac acctgtacca ggagcagcag gagctccctg gcaggcagat
      481 gccggcgttc cggaacagga ccaagttggt caaggacgac atcgcctatg gcagcgtggt
      541 cctgcagctt cacagcatca tcccctctga caagggcaca tatggctgcc gcttccactc
      601 cgacaacttc tctggcgaag ctctctggga actggaggta gcagggctgg gctcagaccc
      661 tcacctctcc cttgagggct tcaaggaagg aggcattcag ctgaggctca gatccagtgg
      721 ctggtacccc aagcctaagg ttcagtggag agaccaccag ggacagtgcc tgcctccaga
      781 gtttgaagcc atcgtctggg atgcccagga cctgttcagt ctggaaacat ctgtggttgt
      841 ccgagcggga gccctcagca atgtgtccgt ctccatccag aatctcctct tgagccagaa
      901 gaaagagttg gtggtccaga tagcagacgt gttcgtaccc ggagcctctg cgtggaagag
      961 cgcgttcgtc gcgaccctgc cgctgctgtt ggtcctcgcg gcgctggcgc tgggcgtcct
     1021 ccggaagcag cggagaagcc gagaaaagct gaggaagcag gcggagaaga gacaagagaa
     1081 actcactgca gagctggaaa agcttcagac agagcttgac tggagacggg ctgaaggcca
     1141 ggctgagtgg agagcagccc aaaaatatgc agtggatgtg acgctggacc cggcctcggc
     1201 gcaccccagc ctggaggtgt cggaggatgg caagagcgtg tcttcccgcg gggcgccgcc
     1261 aggcccggcg cctggccacc cgcagcggtt ctcggagcag acgtgcgcgc tgagcctgga
     1321 gcggttctcc gccggccgcc actactggga ggtgcacgtg ggccgccgca gccgctggtt
     1381 cctgggcgcc tgcctggccg cggtgccgcg cgcggggcct gcgcgcctga gccctgcggc
     1441 cggctactgg gtgctggggc tgtggaacgg ctgcgagtac ttcgtcctgg ccccgcaccg
     1501 cgtcgcgctc accctgcgcg tgcccccgcg gcgcctgggc gtcttcctgg actacgaggc
     1561 cggagagctg tccttcttca acgtgtccga cggctcccac atcttcacct tccacgacac
     1621 cttctcgggc gcgctctgtg cgtacttcag gcccagggcc cacgacggcg gcgaacatcc
     1681 ggatcccctg accatctgcc cgctgccggt tagagggacg ggcgtccccg aagagaacga
     1741 cagtgacacc tggctacagc cctatgagcc cgcggacccc gccctggact ggtggtgagg
     1801 cgccctcgtg gccgcgggac tggccccggg gggccccctg gatcccaggc cagcgctttg
     1861 ctctcctgct ccgtctgaag ggagcaggtg caccagccaa aatgtcagcg agggggacaa
     1921 agagagggac ctttgcctac gtagatgtgt atgtgtagtg cgattttctt caaggaaagg
     1981 agacaagtcc aaagctcgtt tgtggattgt gggactgagc gaaggagtac aaatatatcc
     2041 acgtcgctca gagctggggt gctcacggtg ggcggtgggc aagaagccag catggaagaa
     2101 agaagggaga aaactttggt gactgcctta gagggatcag ttaatttgta tagttttata
     2161 ttttttgtat atgtttgcta gctctaaaaa ggtcgagatg caataacact tcgtaagcaa
     2221 cgagttcacc taagtaaggc tcagatccta gttttaaaaa ccatttccca ttaaaatgaa
     2281 gttggaggaa cagctgcttc tggagccggg gcaaaaattt caaggtgagc ctggagcatt
     2341 gtgtgtggtg aagtaaaata aaggctcaaa acgtgacggc aacccggcaa aagggtaggg
     2401 agccaggccg aaggggcctc actgaccaat tgtgggacaa tttgaacatc aggatgaata
     2461 atgacaggag agattataac acactgaata aaaacataat ccatgagttc atgctgatac
     2521 tcaaatttct ttttaaaaag gagaaacagg aaggtttctt ttggaggtga aatctaatta
     2581 ttggtgagag tcttggagaa caggctgttt ccagtctcaa agcagtaacc ttatacacta
     2641 cttataagtt tgaaagggga aaggttacct ttacaatgga gacatctacc agatcatcca
     2701 agtgattaaa tttaacatca tcaatgatgg gaccaaggac attattagtt tgacaactgg
     2761 ggaaagaagt gttcttcacc ccctaccccc aagacattgt ctctgtcggc caggctggag
     2821 tgcagcctca acctcctggg tccaagtgat cctcccacct cagcacacaa caccatgccc
     2881 aattttaagt gcgttataga gacgggggtc tcactttgtt acccaggctg gtctcaaact
     2941 cctgcgctca agcaatcctc ccacctgggc ctcccaaaat gctgggtgta caggcatgag
     3001 ccgctgtgcc tggcttcatt ttcagagtga gacatttgta ctgtggctat gtaggagaac
     3061 attcttgttc ttagcaaaca tactgaagtt tttagatatt aattaccaca gtgtctgcca
     3121 ctgaatttcc agtgactaag tggaaaaata taaaacatat gaatataaag aaagaaagag
     3181 acaagtcaaa tgtagtaaaa tgacaacact tggtgactct aggtgactgg tcgacagatg
     3241 ttcattgtac tatcaatgtg gctttgctgt gggtttgaaa ttttgcaaac taagagttgg
     3301 gtggcgggga gaaggataca ccaaaaaact aagtgattat ctttggatgg gaaaatgttt
     3361 ggtaattgca ttcttaaaat gtcttctttg tattttttaa tgttcaataa tgtatatgta
     3421 tcagttctgt aataaagggg aaaacacttt ttttaaa
//
