LOCUS       NM_001040462            2017 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens butyrophilin like 8 (BTNL8), transcript variant 2,
            mRNA.
ACCESSION   NM_001040462
VERSION     NM_001040462.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Bobyn,A., Zarrei,M., Zhu,Y., Hoffman,M., Brenner,D., Resnick,A.C.,
            Scherer,S.W. and Gallo,M.
  TITLE     Ancestry and frequency of genetic variants in the general
            population are confounders in the characterization of germline
            variants linked to cancer
  JOURNAL   BMC Med Genet 21 (1), 92 (2020)
   PUBMED   32375678
  REMARK    GeneRIF: analysis of genomic information from multiple non-cancer
            cohorts showed that both the NEGR1 promoter deletion and the
            BTNL3-8 deletion were CNVs occurring at high frequencies in the
            general population. Intriguingly, the upstream NEGR1 CNV deletion
            was homozygous in ~ 40% of individuals in the non-cancer
            population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Vantourout,P., Laing,A., Woodward,M.J., Zlatareva,I., Apolonia,L.,
            Jones,A.W., Snijders,A.P., Malim,M.H. and Hayday,A.C.
  TITLE     Heteromeric interactions regulate butyrophilin (BTN) and BTN-like
            molecules governing gammadelta T cell biology
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), 1039-1044 (2018)
   PUBMED   29339503
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Chapoval,A.I., Smithson,G., Brunick,L., Mesri,M., Boldog,F.L.,
            Andrew,D., Khramtsov,N.V., Feshchenko,E.A., Starling,G.C. and
            Mezes,P.S.
  TITLE     BTNL8, a butyrophilin-like molecule that costimulates the primary
            immune response
  JOURNAL   Mol Immunol 56 (4), 819-828 (2013)
   PUBMED   24036152
  REMARK    GeneRIF: Data suggest that butyrophilin-like molecule BTNL8 may
            play an essential role in priming of naive T lymphocytes.
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Ramani,S.R., Tom,I., Lewin-Koh,N., Wranik,B., Depalatis,L.,
            Zhang,J., Eaton,D. and Gonzalez,L.C.
  TITLE     A secreted protein microarray platform for extracellular protein
            interaction discovery
  JOURNAL   Anal Biochem 420 (2), 127-138 (2012)
   PUBMED   21982860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358523.1 and AK025111.1.
            
            On May 17, 2019 this sequence version replaced NM_001040462.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the middle portion of the coding region compared to variant 1,
            that results in a frameshift. It encodes isoform 2, previously
            known as the long form, which is longer and has a distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358523.1, ERR279826.3309.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340184.9/ ENSP00000342197.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2016              AY358523.1         31-2046
            2017-2017           AK025111.1         2147-2147
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2017
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /note="butyrophilin like 8"
                     /db_xref="GeneID:79908"
                     /db_xref="HGNC:HGNC:26131"
                     /db_xref="MIM:615606"
     exon            1..201
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1655
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; butyrophilin-like protein 8; B7-H5
                     costimulatory molecule"
                     /codon_start=1
                     /product="butyrophilin-like protein 8 isoform 2 precursor"
                     /protein_id="NP_001035552.1"
                     /db_xref="CCDS:CCDS43413.1"
                     /db_xref="GeneID:79908"
                     /db_xref="HGNC:HGNC:26131"
                     /db_xref="MIM:615606"
                     /translation="MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSP
                     KTNAEAMEVRFFRGQFSSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLE
                     NITVLDAGLYGCRISSQSYYQKAIWELQVSALGSVPLISITGYVDRDIQLLCQSSGWF
                     PRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSISCSMRHAHLSREVE
                     SRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQWKIQAELDWRRKHG
                     QAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQ
                     SFQAGKHYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLN
                     PRFISVFPRTPPTKIGVFLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYN
                     EQNGTPIVICPVTQESEKEASWQRASAIPETSNSESSSQATTPFLPRGEM"
     exon            202..549
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..825
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..939
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..960
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..987
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1014
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..2017
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /note="hexamer: ATTATA"
     polyA_site      2017
                     /gene="BTNL8"
                     /gene_synonym="BTN9.2"
                     /note="major polyA site"
ORIGIN      
        1 agaacagcgc agtttgccct ccgctcacgc agagcctctc cgtggcttcc gcaccttgag
       61 cattaggcca gttctcctct tctctctaat ccatccgtca cctctcctgt catccgtttc
      121 catgccgtga ggtccattca cagaacacat ccatggctct catgctcagt ttggttctga
      181 gtctcctcaa gctgggatca gggcagtggc aggtgtttgg gccagacaag cctgtccagg
      241 ccttggtggg ggaggacgca gcattctcct gtttcctgtc tcctaagacc aatgcagagg
      301 ccatggaagt gcggttcttc aggggccagt tctctagcgt ggtccacctc tacagggacg
      361 ggaaggacca gccatttatg cagatgccac agtatcaagg caggacaaaa ctggtgaagg
      421 attctattgc ggaggggcgc atctctctga ggctggaaaa cattactgtg ttggatgctg
      481 gcctctatgg gtgcaggatt agttcccagt cttactacca gaaggccatc tgggagctac
      541 aggtgtcagc actgggctca gttcctctca tttccatcac gggatatgtt gatagagaca
      601 tccagctact ctgtcagtcc tcgggctggt tcccccggcc cacagcgaag tggaaaggtc
      661 cacaaggaca ggatttgtcc acagactcca ggacaaacag agacatgcat ggcctgtttg
      721 atgtggagat ctctctgacc gtccaagaga acgccgggag catatcctgt tccatgcggc
      781 atgctcatct gagccgagag gtggaatcca gggtacagat aggagatacc tttttcgagc
      841 ctatatcgtg gcacctggct accaaagtac tgggaatact ctgctgtggc ctattttttg
      901 gcattgttgg actgaagatt ttcttctcca aattccagtg gaaaatccag gcggaactgg
      961 actggagaag aaagcacgga caggcagaat tgagagacgc ccggaaacac gcagtggagg
     1021 tgactctgga tccagagacg gctcacccga agctctgcgt ttctgatctg aaaactgtaa
     1081 cccatagaaa agctccccag gaggtgcctc actctgagaa gagatttaca aggaagagtg
     1141 tggtggcttc tcagagtttc caagcaggga aacattactg ggaggtggac ggaggacaca
     1201 ataaaaggtg gcgcgtggga gtgtgccggg atgatgtgga caggaggaag gagtacgtga
     1261 ctttgtctcc cgatcatggg tactgggtcc tcagactgaa tggagaacat ttgtatttca
     1321 cattaaatcc ccgttttatc agcgtcttcc ccaggacccc acctacaaaa ataggggtct
     1381 tcctggacta tgagtgtggg accatctcct tcttcaacat aaatgaccag tcccttattt
     1441 ataccctgac atgtcggttt gaaggcttat tgaggcccta cattgagtat ccgtcctata
     1501 atgagcaaaa tggaactccc atagtcatct gcccagtcac ccaggaatca gagaaagagg
     1561 cctcttggca aagggcctct gcaatcccag agacaagcaa cagtgagtcc tcctcacagg
     1621 caaccacgcc cttcctcccc aggggtgaaa tgtaggatga atcacatccc acattcttct
     1681 ttagggatat taaggtctct ctcccagatc caaagtcccg cagcagccgg ccaaggtggc
     1741 ttccagatga agggggactg gcctgtccac atgggagtca ggtgtcatgg ctgccctgag
     1801 ctgggaggga agaaggctga cattacattt agtttgctct cactccatct ggctaagtga
     1861 tcttgaaata ccacctctca ggtgaagaac cgtcaggaat tcccatctca caggctgtgg
     1921 tgtagattaa gtagacaagg aatgtgaata atgcttagat cttattgatg acagagtgta
     1981 tcctaatggt ttgttcatta tattacactt tcagtaa
//
