LOCUS       NM_197975               2439 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens butyrophilin like 3 (BTNL3), mRNA.
ACCESSION   NM_197975 XR_017851
VERSION     NM_197975.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Kim,J.W., Rim,D., Ann,C.H. and Lee,S.H.
  TITLE     Frameshift mutations of immunomodulatory BTN2A1, BTN2A2, and BTNL3
            genes in colon cancers
  JOURNAL   Pathol Res Pract 249, 154769 (2023)
   PUBMED   37634314
  REMARK    GeneRIF: Frameshift mutations of immunomodulatory BTN2A1, BTN2A2,
            and BTNL3 genes in colon cancers.
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Bobyn,A., Zarrei,M., Zhu,Y., Hoffman,M., Brenner,D., Resnick,A.C.,
            Scherer,S.W. and Gallo,M.
  TITLE     Ancestry and frequency of genetic variants in the general
            population are confounders in the characterization of germline
            variants linked to cancer
  JOURNAL   BMC Med Genet 21 (1), 92 (2020)
   PUBMED   32375678
  REMARK    GeneRIF: analysis of genomic information from multiple non-cancer
            cohorts showed that both the NEGR1 promoter deletion and the
            BTNL3-8 deletion were CNVs occurring at high frequencies in the
            general population. Intriguingly, the upstream NEGR1 CNV deletion
            was homozygous in ~ 40% of individuals in the non-cancer
            population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Vantourout,P., Laing,A., Woodward,M.J., Zlatareva,I., Apolonia,L.,
            Jones,A.W., Snijders,A.P., Malim,M.H. and Hayday,A.C.
  TITLE     Heteromeric interactions regulate butyrophilin (BTN) and BTN-like
            molecules governing gammadelta T cell biology
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), 1039-1044 (2018)
   PUBMED   29339503
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2439)
  AUTHORS   Shibui,A., Tsunoda,T., Seki,N., Suzuki,Y., Sugano,S. and Sugane,K.
  TITLE     Cloning, expression analysis, and chromosomal localization of a
            novel butyrophilin-like receptor
  JOURNAL   J Hum Genet 44 (4), 249-252 (1999)
   PUBMED   10429365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA431389.1, AK025267.1 and AY358385.1.
            
            On May 17, 2019 this sequence version replaced NM_197975.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358385.1, AK025267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342868.7/ ENSP00000341787.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA431389.1         2-22
            22-2076             AK025267.1         1-2055
            2077-2439           AY358385.1         2027-2389
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2439
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /note="butyrophilin like 3"
                     /db_xref="GeneID:10917"
                     /db_xref="HGNC:HGNC:1143"
                     /db_xref="MIM:606192"
     exon            1..232
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1584
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /note="butyrophilin-like receptor; butyrophilin-like
                     protein 3"
                     /codon_start=1
                     /product="butyrophilin-like protein 3 precursor"
                     /protein_id="NP_932079.1"
                     /db_xref="CCDS:CCDS47358.1"
                     /db_xref="GeneID:10917"
                     /db_xref="HGNC:HGNC:1143"
                     /db_xref="MIM:606192"
                     /translation="MAFVLILVLSFYELVSGQWQVTGPGKFVQALVGEDAVFSCSLFP
                     ETSAEAMEVRFFRNQFHAVVHLYRDGEDWESKQMPQYRGRTEFVKDSIAGGRVSLRLK
                     NITPSDIGLYGCWFSSQIYDEEATWELRVAALGSLPLISIVGYVDGGIQLLCLSSGWF
                     PQPTAKWKGPQGQDLSSDSRANADGYSLYDVEISIIVQENAGSILCSIHLAEQSHEVE
                     SKVLIGETFFQPSPWRLASILLGLLCGALCGVVMGMIIVFFKSKGKIQAELDWRRKHG
                     QAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQ
                     GFQAGKHYWEVDVGQNVGWYVGVCRDDVDRGKNNVTLSPNNGYWVLRLTTEHLYFTFN
                     PHFISLPPSTPPTRVGVFLDYEGGTISFFNTNDQSLIYTLLTCQFEGLLRPYIQHAMY
                     DEEKGTPIFICPVSWG"
     exon            233..580
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            581..856
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            857..970
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            971..991
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1018
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1045
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..2439
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /note="hexamer: CATAAA"
     polyA_site      2076
                     /gene="BTNL3"
                     /gene_synonym="BTN9.1; BTNLR"
                     /note="major polyA site"
ORIGIN      
        1 atactcctca ttcatacagc catgtttagg gaggctctag ggagaaatgc acagtttgac
       61 atcgttcatg aagagcctct ccacggctcc tgcgcctgag acagctggcc tgacctccaa
      121 atcatccatc cacccctgct gtcatctgtt ttcatagtgt gagatcaacc cacaggaata
      181 tccatggctt ttgtgctcat tttggttctc agtttctacg agctggtgtc aggacagtgg
      241 caagtcactg gaccgggcaa gtttgtccag gccttggtgg gggaggacgc cgtgttctcc
      301 tgctccctct ttcctgagac cagtgcagag gctatggaag tgcggttctt caggaatcag
      361 ttccatgctg tggtccacct ctacagagat ggggaagact gggaatctaa gcagatgcca
      421 cagtatcgag ggagaactga gtttgtgaag gactccattg caggggggcg tgtctctcta
      481 aggctaaaaa acatcactcc ctcggacatc ggcctgtatg ggtgctggtt cagttcccag
      541 atttacgatg aggaggccac ctgggagctg cgggtggcag cactgggctc acttcctctc
      601 atttccatcg tgggatatgt tgacggaggt atccagttac tctgcctgtc ctcaggctgg
      661 ttcccccagc ccacagccaa gtggaaaggt ccacaaggac aggatttgtc ttcagactcc
      721 agagcaaatg cagatgggta cagcctgtat gatgtggaga tctccattat agtccaggaa
      781 aatgctggga gcatattgtg ttccatccac cttgctgagc agagtcatga ggtggaatcc
      841 aaggtattga taggagagac gtttttccag ccctcacctt ggcgcctggc ttctatttta
      901 ctcgggttac tctgtggtgc cctgtgtggt gttgtcatgg ggatgataat tgttttcttc
      961 aaatccaaag ggaaaatcca ggcggaactg gactggagaa gaaagcacgg acaggcagaa
     1021 ttgagagacg cccggaaaca cgcagtggag gtgactctgg atccagagac ggctcacccg
     1081 aagctctgcg tttctgatct gaaaactgta acccatagaa aagctcccca ggaggtgcct
     1141 cactctgaga agagatttac aaggaagagt gtggtggctt ctcagggttt ccaagcaggg
     1201 aaacattact gggaggtgga cgtgggacaa aatgtagggt ggtatgtggg agtgtgtcgg
     1261 gatgacgtag acagggggaa gaacaatgtg actttgtctc ccaacaatgg gtattgggtc
     1321 ctcagactga caacagaaca tttgtatttc acattcaatc cccattttat cagcctcccc
     1381 cccagcaccc ctcctacacg agtaggggtc ttcctggact atgagggtgg gaccatctcc
     1441 ttcttcaata caaatgacca gtcccttatt tataccctgc tgacatgtca gtttgaaggc
     1501 ttgttgagac cctatatcca gcatgcgatg tatgacgagg aaaaggggac tcccatattc
     1561 atatgtccag tgtcctgggg atgagacaga gaagaccctg cttaaagggc cccacaccac
     1621 agacccagac acagccaagg gagagtgctc ccgacaggtg gccccagctt cctctccgga
     1681 gcctgcgcac agagagtcac gccccccact ctcctttagg gagctgaggt tcttctgccc
     1741 tgagccctgc agcagcggca gtcacagctt ccagatgagg ggggattggc ctgaccctgt
     1801 gggagtcaga agccatggct gccctgaagt ggggacggaa tagactcaca ttaggtttag
     1861 tttgtgaaaa ctccatccag ctaagcgatc ttgaacaagt cacaacctcc caggctcctc
     1921 atttgctagt cacggacagt gattcctgcc tcacaggtga agattaaaga gacaacgaat
     1981 gtgaatcatg cttgcaggtt tgagggcaca gtgtttgcta atgatgtgtt tttatattat
     2041 acattttccc accataaact ctgtttgctt attccacatt aatttacttt tctctatacc
     2101 aaatcaccca tggaatagtt attgaacacc tgctttgtga ggctcaaaga ataaagagga
     2161 ggtaggattt ttcactgatt ctataagccc agcattacct gataccaaaa ccaggcaaag
     2221 aaaacagaag aagaggaagg aaaactacag gtccatatcc ctcattaaca cagacacaaa
     2281 aattctaaat aaaattttaa caaattaaac taaacaatat atttaaagat gatatataac
     2341 tactcagtgt ggtttgtccc acaaatgcag agttggttta atatttaaat atcaaccagt
     2401 gtaattcagc acattaataa agtaaaaaag aaaaccata
//
