LOCUS       NM_001304561            1564 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens butyrophilin like 2 (BTNL2), mRNA.
ACCESSION   NM_001304561
VERSION     NM_001304561.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Du,Y., Peng,Q., Cheng,D., Pan,T., Sun,W., Wang,H., Ma,X., He,R.,
            Zhang,H., Cui,Z., Feng,X., Liu,Z., Zhao,T., Hu,W., Shen,L.,
            Jiang,W., Gao,N., Martin,B.N., Zhang,C.J., Zhang,Z. and Wang,C.
  TITLE     Cancer cell-expressed BTNL2 facilitates tumour immune escape via
            engagement with IL-17A-producing gammadelta T cells
  JOURNAL   Nat Commun 13 (1), 231 (2022)
   PUBMED   35017553
  REMARK    GeneRIF: Cancer cell-expressed BTNL2 facilitates tumour immune
            escape via engagement with IL-17A-producing gammadelta T cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Kim,S.Y., Kim,E.G., Kim,M., Hong,J.Y., Kim,G.E., Jung,J.H.,
            Park,M., Kim,M.J., Kim,Y.H., Sohn,M.H. and Kim,K.W.
  TITLE     Genome-wide association study identifies BTNL2 associated with
            atopic asthma in children
  JOURNAL   Medicine (Baltimore) 100 (44), e27626 (2021)
   PUBMED   34871226
  REMARK    GeneRIF: Genome-wide association study identifies BTNL2 associated
            with atopic asthma in children.
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Hoh,B.P., Zhang,X., Deng,L., Yuan,K., Yew,C.W., Saw,W.Y.,
            Hoque,M.Z., Aghakhanian,F., Phipps,M.E., Teo,Y.Y., Subbiah,V.K. and
            Xu,S.
  TITLE     Shared Signature of Recent Positive Selection on the
            TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North
            Borneo
  JOURNAL   Genome Biol Evol 12 (12), 2245-2257 (2020)
   PUBMED   33022050
  REMARK    GeneRIF: Shared Signature of Recent Positive Selection on the
            TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North
            Borneo.
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Arnett,H.A., Escobar,S.S., Gonzalez-Suarez,E., Budelsky,A.L.,
            Steffen,L.A., Boiani,N., Zhang,M., Siu,G., Brewer,A.W. and
            Viney,J.L.
  TITLE     BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory
            molecule modulated in intestinal inflammation
  JOURNAL   J Immunol 178 (3), 1523-1533 (2007)
   PUBMED   17237401
  REMARK    GeneRIF: Structural analysis of BTNL2 shows a molecule with an
            extracellular region containing two sets of two Ig domains, a
            transmembrane region, and a previously unreported cytoplasmic tail
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Traherne,J.A., Barcellos,L.F., Sawcer,S.J., Compston,A.,
            Ramsay,P.P., Hauser,S.L., Oksenberg,J.R. and Trowsdale,J.
  TITLE     Association of the truncating splice site mutation in BTNL2 with
            multiple sclerosis is secondary to HLA-DRB1*15
  JOURNAL   Hum Mol Genet 15 (1), 155-161 (2006)
   PUBMED   16321988
  REMARK    GeneRIF: Association of the truncating splice site mutation in
            BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Orozco,G., Eerligh,P., Sanchez,E., Zhernakova,S., Roep,B.O.,
            Gonzalez-Gay,M.A., Lopez-Nevot,M.A., Callejas,J.L., Hidalgo,C.,
            Pascual-Salcedo,D., Balsa,A., Gonzalez-Escribano,M.F.,
            Koeleman,B.P. and Martin,J.
  TITLE     Analysis of a functional BTNL2 polymorphism in type 1 diabetes,
            rheumatoid arthritis, and systemic lupus erythematosus
  JOURNAL   Hum Immunol 66 (12), 1235-1241 (2005)
   PUBMED   16690410
  REMARK    GeneRIF: resiults show that BTNL2 rs2076530 polymorphism is
            associated with type 1 diabetes, rheumatoid arthritis, and systemic
            lupus erythematosus because of its strong linkage disequalibrium
            with predisposing HLA DQB1-DRB1 haplotypes in Caucasian populations
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Rybicki,B.A., Walewski,J.L., Maliarik,M.J., Kian,H. and
            Iannuzzi,M.C.
  CONSRTM   ACCESS Research Group
  TITLE     The BTNL2 gene and sarcoidosis susceptibility in African Americans
            and Whites
  JOURNAL   Am J Hum Genet 77 (3), 491-499 (2005)
   PUBMED   16080124
  REMARK    GeneRIF: BNTL2 associates with sarcoidosis in both White Americans
            and African-Americans, with risk effects in Whites independent of
            HLA-DRB1 associations, and negative interactions between BRNL2 and
            HLA classII in African-Americans.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Valentonyte,R., Hampe,J., Huse,K., Rosenstiel,P., Albrecht,M.,
            Stenzel,A., Nagy,M., Gaede,K.I., Franke,A., Haesler,R., Koch,A.,
            Lengauer,T., Seegert,D., Reiling,N., Ehlers,S., Schwinger,E.,
            Platzer,M., Krawczak,M., Muller-Quernheim,J., Schurmann,M. and
            Schreiber,S.
  TITLE     Sarcoidosis is associated with a truncating splice site mutation in
            BTNL2
  JOURNAL   Nat Genet 37 (4), 357-364 (2005)
   PUBMED   15735647
  REMARK    GeneRIF: Sarcoidosis is associated with a truncating splice site
            mutation in BTNL2
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2005 Jun;37(6):652]
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Stammers,M., Rowen,L., Rhodes,D., Trowsdale,J. and Beck,S.
  TITLE     BTL-II: a polymorphic locus with homology to the butyrophilin gene
            family, located at the border of the major histocompatibility
            complex class II and class III regions in human and mouse
  JOURNAL   Immunogenetics 51 (4-5), 373-382 (2000)
   PUBMED   10803852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662796.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2021 this sequence version replaced NM_001304561.1.
            
            Summary: This gene encodes a major histocompatibility complex,
            class II associated, type I transmembrane protein which belongs to
            the butyrophilin-like B7 family of immunoregulators. It is thought
            to be involved in immune surveillance, serving as a negative T-cell
            regulator by decreasing T-cell proliferation and cytokine release.
            The encoded protein contains an N-terminal signal peptide, two
            pairs of immunoglobulin-like domains, separated by a heptad peptide
            sequence, and a C-terminal transmembrane domain. Naturally
            occurring mutations in this gene are associated with sarcoidosis,
            rheumatoid arthritis, ulcerative colitis, inflammatory bowel
            disease, myositis, type 1 diabetes, systemic lupus erythematosus,
            acute coronary syndrome, and prostate cancer. [provided by RefSeq,
            May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2152474 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000454136.8/ ENSP00000390613.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL662796.6         82415-82551         c
            138-485             AL662796.6         80309-80656         c
            486-767             AL662796.6         78305-78586         c
            768-788             AL662796.6         77155-77175         c
            789-1136            AL662796.6         71409-71756         c
            1137-1418           AL662796.6         70114-70395         c
            1419-1513           AL662796.6         69333-69427         c
            1514-1564           AL662796.6         68709-68759         c
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1564
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /note="butyrophilin like 2"
                     /db_xref="GeneID:56244"
                     /db_xref="HGNC:HGNC:1142"
                     /db_xref="MIM:606000"
     exon            1..137
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1507
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /note="butyrophilin-like protein 2; butyrophilin-like 2
                     (MHC class II associated)"
                     /codon_start=1
                     /product="butyrophilin-like protein 2 precursor"
                     /protein_id="NP_001291490.1"
                     /db_xref="CCDS:CCDS78126.1"
                     /db_xref="GeneID:56244"
                     /db_xref="HGNC:HGNC:1142"
                     /db_xref="MIM:606000"
                     /translation="MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGE
                     DALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGI
                     AKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGV
                     QLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSC
                     LVHNPVLTEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQ
                     SMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPS
                     DDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHV
                     PWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISAVDVTCSISIPFLGEEKIATF
                     SLSESRMTFLWKTLLVWGLLLAVAVGLPRKRS"
     exon            138..485
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..767
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..788
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1136
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1418
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1513
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1564
                     /gene="BTNL2"
                     /gene_synonym="BTL-II; BTN7; HSBLMHC1; SS2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggtgtgt cacagcctca cttaggcaca gcgtttcctt gtctttgttc cagggaggat
       61 ggtggatttt ccaggctaca atctgtctgg tgcagtcgcc tccttcctat tcatcctgct
      121 gacaatgaag cagtcagaag actttagagt cattggccct gctcatccta tcctggccgg
      181 ggttggggaa gatgccctgt taacctgcca gctactcccc aagaggacca caatgcacgt
      241 ggaggtgagg tggtaccgct cagagcccag cacacctgtg tttgtgcaca gggatggagt
      301 ggaggtgact gagatgcaga tggaggagta cagaggctgg gtagagtgga tagagaatgg
      361 cattgcaaag ggaaatgtgg cactgaagat acacaacatc cagccctccg acaatggaca
      421 atactggtgc catttccagg atgggaacta ctgtggagaa acaagcttgc tgctcaaagt
      481 agcaggtctg gggtctgccc ctagcatcca catggaggga cctggggaga gtggagtcca
      541 gcttgtgtgc actgcaaggg gctggttccc agagccccag gtgtattggg aagacatccg
      601 gggagagaag ctgctggccg tgtctgagca tcgcatccaa gataaagatg gcctgttcta
      661 tgcggaagcc accctggtgg tcaggaacgc ctctgcagag tctgtgtcct gcttggtcca
      721 caaccccgtc ctcactgagg agaaggggtc ggtcatcagc ctcccagaga aactccagac
      781 tgagctggct tctttaaaag tgaatggacc ttcccagccc atcctcgtca gagtgggaga
      841 agatatacag ctaacctgtt acctgtcccc caaggcgaat gcacagagca tggaggtgag
      901 gtgggaccga tcccaccgtt accctgctgt gcatgtgtat atggatgggg accatgtggc
      961 tggagagcag atggcagagt acagagggag gactgtactg gtgagtgacg ccattgacga
     1021 gggcagactg accctgcaga tactcagtgc cagaccttcg gacgacgggc agtaccgctg
     1081 cctttttgaa aaagatgatg tctaccagga ggccagtttg gatctgaagg tggtaagtct
     1141 gggttcttcc ccactgatca ctgtggaggg gcaagaagat ggagaaatgc agccgatgtg
     1201 ctcttcagat gggtggttcc cacagcccca cgtgccatgg agggacatgg aaggaaagac
     1261 gataccatca tcttcccagg ccctgactca aggcagccac gggctgttcc acgtgcagac
     1321 attgctaagg gtcacaaaca tctccgctgt ggacgtcact tgttccatca gcatcccctt
     1381 tttgggcgag gagaaaatcg caactttttc tctctcagag tccaggatga cgtttttgtg
     1441 gaaaacactg cttgtttggg gattgcttct tgctgtggct gtaggcctgc ccaggaagag
     1501 gagctgaaaa gagtgaatgt gacattggct tcaaacacag ctcacctgag actgatttct
     1561 tctg
//
