LOCUS       NM_006994               2970 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens butyrophilin subfamily 3 member A3 (BTN3A3),
            transcript variant 1, mRNA.
ACCESSION   NM_006994
VERSION     NM_006994.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Zhang,Q., Shi,P., Wang,Z., Sun,L., Li,W., Zhao,Q., Liu,T., Pan,Q.,
            Sun,Y., Jia,F., Chen,W., Fu,X., Yu,G., Bao,F., Mi,Z., Wang,C.,
            Sun,Y., Li,B., Liu,J., Liu,H., Gu,H. and Zhang,F.
  TITLE     Identification of the BTN3A3 Gene as a Molecule Implicated in
            Generalized Pustular Psoriasis in a Chinese Population
  JOURNAL   J Invest Dermatol 143 (8), 1439-1448 (2023)
   PUBMED   36804966
  REMARK    GeneRIF: Identification of the BTN3A3 Gene as a Molecule Implicated
            in Generalized Pustular Psoriasis in a Chinese Population.
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Pinto,R.M., Bakshi,S., Lytras,S., Zakaria,M.K., Swingler,S.,
            Worrell,J.C., Herder,V., Hargrave,K.E., Varjak,M., Cameron-Ruiz,N.,
            Collados Rodriguez,M., Varela,M., Wickenhagen,A., Loney,C., Pei,Y.,
            Hughes,J., Valette,E., Turnbull,M.L., Furnon,W., Gu,Q., Orr,L.,
            Taggart,A., Diebold,O., Davis,C., Boutell,C., Grey,F.,
            Hutchinson,E., Digard,P., Monne,I., Wootton,S.K., MacLeod,M.K.L.,
            Wilson,S.J. and Palmarini,M.
  TITLE     BTN3A3 evasion promotes the zoonotic potential of influenza A
            viruses
  JOURNAL   Nature 619 (7969), 338-347 (2023)
   PUBMED   37380775
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Liu,D., Lu,Q., Wang,X., Wang,J., Lu,N., Jiang,Z., Hao,X., Li,J.,
            Liu,J., Cao,P., Peng,G., Tao,Y., Zhao,D., He,F. and Tang,L.
  TITLE     LSECtin on tumor-associated macrophages enhances breast cancer
            stemness via interaction with its receptor BTN3A3
  JOURNAL   Cell Res 29 (5), 365-378 (2019)
   PUBMED   30858559
  REMARK    GeneRIF: Macrophage-specific silencing of BTN3A3 in breast cancer
            cells decreased cancer stem cell frequency and tumor growth.
            Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3
            monoclonal antibodies has a therapeutic effect on breast cancer.
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Vantourout,P., Laing,A., Woodward,M.J., Zlatareva,I., Apolonia,L.,
            Jones,A.W., Snijders,A.P., Malim,M.H. and Hayday,A.C.
  TITLE     Heteromeric interactions regulate butyrophilin (BTN) and BTN-like
            molecules governing gammadelta T cell biology
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), 1039-1044 (2018)
   PUBMED   29339503
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Rhodes,D.A., Stammers,M., Malcherek,G., Beck,S. and Trowsdale,J.
  TITLE     The cluster of BTN genes in the extended major histocompatibility
            complex
  JOURNAL   Genomics 71 (3), 351-362 (2001)
   PUBMED   11170752
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Henry,J., Miller,M.M. and Pontarotti,P.
  TITLE     Structure and evolution of the extended B7 family
  JOURNAL   Immunol Today 20 (6), 285-288 (1999)
   PUBMED   10354554
  REMARK    Review article
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC410234.1 and BC015815.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006994.4.
            
            Summary: The butyrophilin (BTN) genes are a group of major
            histocompatibility complex (MHC)-associated genes that encode type
            I membrane proteins with 2 extracellular immunoglobulin (Ig)
            domains and an intracellular B30.2 (PRYSPRY) domain. Three
            subfamilies of human BTN genes are located in the MHC class I
            region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2
            (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which
            have undergone tandem duplication, resulting in 3 copies of each
            (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by
            OMIM, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.148684.1,
                                           SRR1803614.212336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244519.7/ ENSP00000244519.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DC410234.1         33-63
            32-2970             BC015815.2         1-2939
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..2970
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /note="butyrophilin subfamily 3 member A3"
                     /db_xref="GeneID:10384"
                     /db_xref="HGNC:HGNC:1140"
                     /db_xref="MIM:613595"
     exon            1..145
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            146..206
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            207..296
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1966
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; butyrophilin 3"
                     /codon_start=1
                     /product="butyrophilin subfamily 3 member A3 isoform a
                     precursor"
                     /protein_id="NP_008925.1"
                     /db_xref="CCDS:CCDS4611.1"
                     /db_xref="GeneID:10384"
                     /db_xref="HGNC:HGNC:1140"
                     /db_xref="MIM:613595"
                     /translation="MKMASSLAFLLLNFHVSLFLVQLLTPCSAQFSVLGPSGPILAMV
                     GEDADLPCHLFPTMSAETMELRWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRD
                     GITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHIEVKGYEDG
                     GIHLECRSTGWYPQPQIKWSDTKGENIPAVEAPVVADGVGLYAVAASVIMRGSSGGGV
                     SCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPISLLLLAGASYFLWRQQKE
                     KIALSRETEREREMKEMGYAATEQEISLREKLQEELKWRKIQYMARGEKSLAYHEWKM
                     ALFKPADVILDPDTANAILLVSEDQRSVQRAEEPRDLPDNPERFEWRYCVLGCENFTS
                     GRHYWEVEVGDRKEWHIGVCSKNVERKKGWVKMTPENGYWTMGLTDGNKYRALTEPRT
                     NLKLPEPPRKVGIFLDYETGEISFYNATDGSHIYTFPHASFSEPLYPVFRILTLEPTA
                     LTICPIPKEVESSPDPDLVPDHSLETPLTPGLANESGEPQAEVTSLLLPAHPGAEVSP
                     SATTNQNHKLQARTEALY"
     exon            297..644
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            645..926
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1127
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1148
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1175
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1202
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1229
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2970
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2948..2953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /note="hexamer: AATAAA"
     polyA_site      2970
                     /gene="BTN3A3"
                     /gene_synonym="BTF3; BTN3.3"
                     /note="major polyA site"
ORIGIN      
        1 gttattattc ctcacaataa ccagatagcc tctgctttct ttttcctttc ttcggaatga
       61 gagactcaac cataatagaa agaatggaga actattaacc accattcttc agtgggctgt
      121 gattttcaga ggggaatact aagaaatggt tttccatact ggaacccaaa ggtaaagaca
      181 ctcaaggaca gacatttttg gcagagcata gatgaaaatg gcaagttccc tggctttcct
      241 tctgctcaac tttcatgtct ccctcttctt ggtccagctg ctcactcctt gctcagctca
      301 gttttctgtg cttggaccct ctgggcccat cctggccatg gtgggtgaag acgctgatct
      361 gccctgtcac ctgttcccga ccatgagtgc agagaccatg gagctgaggt gggtgagttc
      421 cagcctaagg caggtggtga acgtgtatgc agatggaaag gaagtggaag acaggcagag
      481 tgcaccgtat cgagggagaa cttcgattct gcgggatggc atcactgcag ggaaggctgc
      541 tctccgaata cacaacgtca cagcctctga cagtggaaag tacttgtgtt atttccaaga
      601 tggtgacttc tacgaaaaag ccctggtgga gctgaaggtt gcagcattgg gttctgatct
      661 tcacattgaa gtgaagggtt atgaggatgg agggatccat ctggagtgca ggtccactgg
      721 ctggtacccc caaccccaaa taaagtggag cgacaccaag ggagagaaca tcccggctgt
      781 ggaagcacct gtggttgcag atggagtggg cctgtatgca gtagcagcat ctgtgatcat
      841 gagaggcagc tctggtgggg gtgtatcctg catcatcaga aattccctcc tcggcctgga
      901 aaagacagcc agcatatcca tcgcagaccc cttcttcagg agcgcccagc cctggatcgc
      961 ggccctggca gggaccctgc ctatctcgtt gctgcttctc gcaggagcca gttacttctt
     1021 gtggagacaa cagaaggaaa aaattgctct gtccagggag acagaaagag agcgagagat
     1081 gaaagaaatg ggatacgctg caacagagca agaaataagc ctaagagaga agctccagga
     1141 ggaactcaag tggaggaaaa tccagtacat ggctcgtgga gagaagtctt tggcctatca
     1201 tgaatggaaa atggccctct tcaaacctgc ggatgtgatt ctggatccag acacggcaaa
     1261 cgccatcctc cttgtttctg aggaccagag gagtgtgcag cgtgctgaag agccgcggga
     1321 tctgccagac aaccctgaga gatttgaatg gcgttactgt gtccttggct gtgaaaactt
     1381 cacatcaggg agacattact gggaggtgga agtgggggac agaaaagagt ggcatattgg
     1441 ggtatgtagt aagaacgtgg agaggaaaaa aggttgggtc aaaatgacac cggagaacgg
     1501 atactggact atgggcctga ctgatgggaa taagtatcgg gctctcactg agcccagaac
     1561 caacctgaaa cttcctgagc ctcctaggaa agtggggatc ttcctggact atgagactgg
     1621 agagatctcg ttctataatg ccacagatgg atctcatatc tacacctttc cgcacgcctc
     1681 tttctctgag cctctatatc ctgttttcag aattttgacc ttggagccca ctgccctgac
     1741 catttgccca ataccaaaag aagtagagag ttcccccgat cctgacctag tgcctgatca
     1801 ttccctggag acaccactga ccccgggctt agctaatgaa agtggggagc ctcaggctga
     1861 agtaacatct ctgcttctcc ctgcccaccc tggagctgag gtctcccctt ctgcaacaac
     1921 caatcagaac cataagctac aggcacgcac tgaagcactt tactgatatt cattccatta
     1981 ttccatatga cagttgtttt gagtttcgta ccaccttatt gtccccttat acagataagg
     2041 aaactggggt gcagaaaggt gaattaactt tacaaagtag acatgacaag tgaacagcag
     2101 agctgggatc taaacagcaa taactaacat taacagagaa tttaaaatgt tcttagtgct
     2161 gtgttataag ctttggtgga tgtcactcct ttaatcctca caacaccctg tcgggtagtc
     2221 atattttgca agtatggaag ctgaggcagg gcaacatgaa gtaacttaca taactcatac
     2281 agtaatttgt gcagttggga gatgttcagc cttagtccct ggctaattgc ctgttctttt
     2341 ccagcctgat tttttttccc acaggaagag cccacatgta gccctgaggt ttccttccca
     2401 ggacagctgc agggtagaga tcattttaag tgcttgtgga gttgacatcc ctattgactc
     2461 tttcccagct gatatcagag acttagaccc agcactcctt ggattagctc tgcagagtgt
     2521 cttggttgag agaataacct catagtacca acatgacatg tgacttggaa agagactaga
     2581 ggccacactt gataaatcat ggggcacaga tatgttccca cccaacaaat gtgataagtg
     2641 attgtgcagc cagagccagc cttccttcaa tcaaggtttc caggcagagc aaatacccta
     2701 gagattctct gtgatatagg aaatttggat caaggaagct aaaagaatta cagggatgtt
     2761 tttaatccca ctatggactc agtctcctgg aaataggtct gtccactcct ggtcattggt
     2821 ggatgttaaa cccatattcc tttcaactgc tgcctgctag ggaaaactgc tcctcattat
     2881 catcactatt attgctcacc actgtatccc ctctacttgg caagtggttg tcaagttcta
     2941 gttgttcaat aaatgtgtta ataatgctta
//
