LOCUS       NM_007047               3776 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens butyrophilin subfamily 3 member A2 (BTN3A2),
            transcript variant 1, mRNA.
ACCESSION   NM_007047
VERSION     NM_007047.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Vantourout,P., Laing,A., Woodward,M.J., Zlatareva,I., Apolonia,L.,
            Jones,A.W., Snijders,A.P., Malim,M.H. and Hayday,A.C.
  TITLE     Heteromeric interactions regulate butyrophilin (BTN) and BTN-like
            molecules governing gammadelta T cell biology
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), 1039-1044 (2018)
   PUBMED   29339503
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Horsburgh,S., Ciechomska,M. and O'Reilly,S.
  TITLE     CpG-specific methylation at rheumatoid arthritis diagnosis as a
            marker of treatment response
  JOURNAL   Epigenomics 9 (5), 595-597 (2017)
   PUBMED   28447857
  REMARK    GeneRIF: CpG-specific DNA methylation of ADAMTSL2 and BTN3A2 at
            rheumatoid arthritis diagnosis can serve as a marker of treatment
            response.
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Viken,M.K., Blomhoff,A., Olsson,M., Akselsen,H.E., Pociot,F.,
            Nerup,J., Kockum,I., Cambon-Thomsen,A., Thorsby,E., Undlien,D.E.
            and Lie,B.A.
  TITLE     Reproducible association with type 1 diabetes in the extended class
            I region of the major histocompatibility complex
  JOURNAL   Genes Immun 10 (4), 323-333 (2009)
   PUBMED   19295542
  REMARK    GeneRIF: our results identify PRSS16 and BTN3A2, two genes thought
            to play important roles in regulating the immune response, as
            potentially novel susceptibility genes for Type I Deabetes.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Cavaletto,M., Giuffrida,M.G., Fortunato,D., Gardano,L.,
            Dellavalle,G., Napolitano,L., Giunta,C., Bertino,E., Fabris,C. and
            Conti,A.
  TITLE     A proteomic approach to evaluate the butyrophilin gene family
            expression in human milk fat globule membrane
  JOURNAL   Proteomics 2 (7), 850-856 (2002)
   PUBMED   12124930
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Rhodes,D.A., Stammers,M., Malcherek,G., Beck,S. and Trowsdale,J.
  TITLE     The cluster of BTN genes in the extended major histocompatibility
            complex
  JOURNAL   Genomics 71 (3), 351-362 (2001)
   PUBMED   11170752
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
REFERENCE   10 (bases 1 to 3776)
  AUTHORS   Tazi-Ahnini,R., Henry,J., Offer,C., Bouissou-Bouchouata,C.,
            Mather,I.H. and Pontarotti,P.
  TITLE     Cloning, localization, and structure of new members of the
            butyrophilin gene family in the juxta-telomeric region of the major
            histocompatibility complex
  JOURNAL   Immunogenetics 47 (1), 55-63 (1997)
   PUBMED   9382921
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD705662.1, AK290880.1,
            BC020214.1 and AL021917.4.
            
            On Nov 22, 2018 this sequence version replaced NM_007047.4.
            
            Summary: This gene encodes a member of the immunoglobulin
            superfamily, which resides in the juxta-telomeric region of the
            major histocompatability class 1 locus and is clustered with the
            other family members on chromosome 6. The encoded protein may be
            involved in the adaptive immune response. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1-3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90546.1, SRR1803614.239473.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377708.7/ ENSP00000366937.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CD705662.1         72-107
            37-70               AK290880.1         4-37
            71-1511             BC020214.1         1-1441
            1512-3776           AL021917.4         92229-94493
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..3776
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /note="butyrophilin subfamily 3 member A2"
                     /db_xref="GeneID:11118"
                     /db_xref="HGNC:HGNC:1139"
                     /db_xref="MIM:613594"
     exon            1..155
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            156..216
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            217..306
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1226
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; butyrophilin protein"
                     /codon_start=1
                     /product="butyrophilin subfamily 3 member A2 isoform a
                     precursor"
                     /protein_id="NP_008978.2"
                     /db_xref="CCDS:CCDS4605.1"
                     /db_xref="GeneID:11118"
                     /db_xref="HGNC:HGNC:1139"
                     /db_xref="MIM:613594"
                     /translation="MKMASSLAFLLLNFHVSLLLVQLLTPCSAQFSVLGPSGPILAMV
                     GEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRD
                     GITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSNLHVEVKGYEDG
                     GIHLECRSTGWYPQPQIQWSNAKGENIPAVEAPVVADGVGLYEVAASVIMRGGSGEGV
                     SCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPILLLLLAGASYFLWRQQKE
                     ITALSSEIESEQEMKEMGYAATEREISLRESLQEELKRKKIQYLTRGEESSSDTNKSA
                     "
     exon            307..654
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            655..936
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1137
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1158
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1185
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1232
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1260
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3776
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /note="hexamer: AATAAA"
     polyA_site      3776
                     /gene="BTN3A2"
                     /gene_synonym="BT3.2; BTF4; BTN3.2; CD277"
                     /note="major polyA site"
ORIGIN      
        1 gactcttact gtttctcatg gtgagaagac aatatttgct ttctcttttt cctttcttcc
       61 ggatgagagg ctaagccata atagaaagaa tggagaatta ttgattgacc gtctttattc
      121 tgtgggctct gattctccaa tgggaatacc aagggatggt tttccatact ggaacccaaa
      181 ggtaaagaca ctcaaggaca gacatttttg gcagagcata gatgaaaatg gcaagttccc
      241 tggctttcct tctgctcaac tttcatgtct ccctcctctt ggtccagctg ctcactcctt
      301 gctcagctca gttttctgtg cttggaccct ctgggcccat cctggccatg gtgggtgaag
      361 acgctgatct gccctgtcac ctgttcccga ccatgagtgc agagaccatg gagctgaagt
      421 gggtaagttc cagcctaagg caggtggtga acgtgtatgc agatggaaag gaagtggaag
      481 acaggcagag tgcaccgtat cgagggagaa cttcgattct gcgggatggc atcactgcag
      541 ggaaggctgc tctccgaata cacaacgtca cagcctctga cagtggaaag tacttgtgtt
      601 atttccaaga tggtgacttc tatgaaaaag ccctggtgga gctgaaggtt gcagcactgg
      661 gttctaatct tcacgtcgaa gtgaagggtt atgaggatgg agggatccat ctggagtgca
      721 ggtccaccgg ctggtacccc caaccccaaa tacagtggag caacgccaag ggagagaaca
      781 tcccagctgt ggaagcacct gtggttgcag atggagtggg cctatatgaa gtagcagcat
      841 ctgtgatcat gagaggcggc tccggggagg gtgtatcctg catcatcaga aattccctcc
      901 tcggcctgga aaagacagcc agcatttcca tcgcagaccc cttcttcagg agcgcccagc
      961 cctggatcgc agccctggca gggaccctgc ctatcttgct gctgcttctc gccggagcca
     1021 gttacttctt gtggagacaa cagaaggaaa taactgctct gtccagtgag atagaaagtg
     1081 agcaagagat gaaagaaatg ggatatgctg caacagagcg ggaaataagc ctaagagaga
     1141 gcctccagga ggaactcaag aggaaaaaaa tccagtactt gactcgtgga gaggagtctt
     1201 cgtccgatac caataagtca gcctgatgct ctaatggaaa aatggccctc ttcaagcctg
     1261 gtgaggaaat gcttcagatg aggctccacc ttgttaaata aattggatgt atggaaaaat
     1321 agactgcaga aaaggggaac tcatttagct cacgagtggt cgagtgaaga ttgaaaatta
     1381 acctctgagg gccagcacag cagctcatgc ctgtaatcct agcactttgg aaggctgagg
     1441 agggcggatc acaaggtcag gagatcaaga ccatcctggc taacacggtg aaaccccgtc
     1501 tctactaaaa atacaaaaaa taaaaaatta gccgggcatg gtgacgggca cctgtagtcc
     1561 cagctactcg ggaggctgag gcaggagaat ggcatgaacc cggaaggcag agcttgcagt
     1621 gagccgagat cacgccactg cactccagcc tgggagacag agcgagactc tgtctcaaga
     1681 aaaaaaaaaa aaaaaaaaaa gaaaagaaaa ttaacctctg agtataaagc atcagtgggc
     1741 agaatcaatg tggggaggga aacaacaaaa atgtagaaag aggatccttg ttgcttcttg
     1801 gggccgcatc agggtattgg gttaggcaga tactgacctt actttcattt cccctctggt
     1861 cactagaccc ctggggcttt caccaatgac attgatgaga gaatcacatt cagggcaggc
     1921 tagggacacg gggttctgga aggacctcct cagcatggcc caagccttgc atgctgtggc
     1981 tcttaaatcc aggaaaaatg gctgacccca tggacacctc ctcaaactct ctgcagcaga
     2041 tgtaattctg tatccagaca tggcaaatgc catcctcctt gtttctgagg accagaggag
     2101 tgtacagcgt gctgaggagc cccatgacct accagacaac cctgagagat ttgaatggcg
     2161 ttactgtgtg cttggctgtg aaagcttcat gtcagagaga cactactggg aggtggaagt
     2221 gggggacaga aaagagtggc atattggggt atgtagtaag aacgtggaga ggaaaaaagt
     2281 ttgggtcaaa atgacaccgg agaacggata ctggactatg ggcctgactg atgggaataa
     2341 gtatcgggct ctcactgagc ccagaaccaa cctgaaactt cctgagcctc ctaggaaagt
     2401 gggggtcatc ctggactatg agactggaca tatctcgttc tacaatgcca cggatggatc
     2461 tcatatctac acatttctgc acgcctcttc ctctgagcct ctgtatcctg tattcagaat
     2521 tttgaccttg gagcccactg ccctgaccgt ttgcccaata ccaaaagtag agagttcccc
     2581 cgatcccgac ctagtgcctg atcattccct ggagatacca ctgaccccag gcttagctaa
     2641 tgaaagtggg gagcctcagg ctgaagtaac atctctgctt ctccctgccc agcctggagc
     2701 taagggtctc accctccaca acagccagtc agaaccataa agctacaggc acacactgaa
     2761 gcactttact gatattcatt caattattcc ataggacagt tgtttgagtt tggtgccacc
     2821 ttattggccc ctttatacag ataaggaaac tggggtgtag aaaagtgtat tgactttaca
     2881 aagcagacag gaatagtgaa caacagagct gggatctgaa caacaatgac taacattaat
     2941 ggagaattta aaacgttctg agtgctgtgt tatgagcttt ggtgggtgtc actcctttaa
     3001 tcctcacaac accctgtcag gtagtctcat ttggcaagta tggaagcaga ggcagggcaa
     3061 cattaagtag cttacataac tcacacggta atttgtgcag ttgggagatg ttcagcttca
     3121 gtccctggcc aattgcccgt tcttttccag cctgattttt cctgcatggg aagagcccac
     3181 atgtagccct gaggttccct tcccaggaca gctccaggat cgagatcact gtgagtggtt
     3241 gtggagttaa gacccctatg gactccttcc cagctgatta tcagagcctt agacccagca
     3301 ctccttggat tggctctgca gagtgtcttg gttgagagaa taacgttgca gttcccacag
     3361 ggcatgtgac tttgaaagag actagaggcc acactcagtt aataatgggg cacagatgtg
     3421 ttcccaccca acaaatgtga taagtgatcg tgcagccaga gccagccttc cttcagtcaa
     3481 ggtttccagg cagagcaaat accctagaga ttctctgtaa tattggtaat ttggatgaag
     3541 gaagctagaa gaattacagg gatgttttta atcccactat ggactcagtc tcctggaaaa
     3601 ggatctgtcc actcctggtc attggtggat gttaaaccca tattcctttc aactgctgcc
     3661 tgctagggaa aactgctcct cattatcatc actattattg ctcaccactg tatcccctct
     3721 actgggcaag tgcttgtcaa gttctagttg ttcaataaat ttgttaataa tgctga
//
