LOCUS       NM_181780               3126 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens B and T lymphocyte associated (BTLA), transcript
            variant 1, mRNA.
ACCESSION   NM_181780
VERSION     NM_181780.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3126)
  AUTHORS   Ries,J., Trumet,L., Hahn,A., Kunater,L., Lutz,R., Geppert,C.,
            Kesting,M. and Weber,M.
  TITLE     The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and
            Its Correlation to Other Immune Modulators
  JOURNAL   Int J Mol Sci 25 (12), 6601 (2024)
   PUBMED   38928307
  REMARK    GeneRIF: The Immune Checkpoint BTLA in Oral Cancer: Expression
            Analysis and Its Correlation to Other Immune Modulators.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3126)
  AUTHORS   Guruprasad,P., Carturan,A., Zhang,Y., Cho,J.H., Kumashie,K.G.,
            Patel,R.P., Kim,K.H., Lee,J.S., Lee,Y., Kim,J.H., Chung,J.,
            Joshi,A., Cohen,I., Shestov,M., Ghilardi,G., Harris,J.,
            Pajarillo,R., Angelos,M., Lee,Y.G., Liu,S., Rodriguez,J., Wang,M.,
            Ballard,H.J., Gupta,A., Ugwuanyi,O.H., Hong,S.J.A.,
            Bochi-Layec,A.C., Sauter,C.T., Chen,L., Paruzzo,L., Kammerman,S.,
            Shestova,O., Liu,D., Vella,L.A., Schuster,S.J., Svoboda,J.,
            Porazzi,P. and Ruella,M.
  TITLE     The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
  JOURNAL   Nat Immunol 25 (6), 1020-1032 (2024)
   PUBMED   38831106
  REMARK    GeneRIF: The BTLA-HVEM axis restricts CAR T cell efficacy in
            cancer.
REFERENCE   3  (bases 1 to 3126)
  AUTHORS   Yu,X., Yang,F., Shen,Z., Zhang,Y., Sun,J., Qiu,C., Zheng,Y.,
            Zhao,W., Yuan,S., Zeng,D., Zhang,S., Long,J., Zhu,M., Zhang,X.,
            Wu,J., Ma,Z., Zhu,H., Su,M., Xu,J., Li,B., Mao,R., Su,Z. and
            Zhang,J.
  TITLE     BTLA contributes to acute-on-chronic liver failure infection and
            mortality through CD4+ T-cell exhaustion
  JOURNAL   Nat Commun 15 (1), 1835 (2024)
   PUBMED   38418488
  REMARK    GeneRIF: BTLA contributes to acute-on-chronic liver failure
            infection and mortality through CD4[+] T-cell exhaustion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3126)
  AUTHORS   Dolade,N., Rayego-Mateos,S., Garcia-Carrasco,A., Guerin,M.,
            Martin-Ventura,J.L., Ruiz-Ortega,M., Tharaux,P.L. and
            Valdivielso,J.M.
  TITLE     B- and T-lymphocyte attenuator could be a new player in accelerated
            atherosclerosis associated with chronic kidney disease
  JOURNAL   Clin Sci (Lond) 137 (17), 1409-1429 (2023)
   PUBMED   37655751
  REMARK    GeneRIF: B- and T-lymphocyte attenuator could be a new player in
            accelerated atherosclerosis associated with chronic kidney disease.
REFERENCE   5  (bases 1 to 3126)
  AUTHORS   Sordo-Bahamonde,C., Lorenzo-Herrero,S., Martinez-Perez,A.,
            Gonzalez-Rodriguez,A.P., Payer,A.R., Gonzalez-Garcia,E.,
            Aguilar-Garcia,C., Gonzalez-Rodriguez,S., Lopez-Soto,A.,
            Garcia-Torre,A. and Gonzalez,S.
  TITLE     BTLA dysregulation correlates with poor outcome and diminished T
            cell-mediated antitumor responses in chronic lymphocytic leukemia
  JOURNAL   Cancer Immunol Immunother 72 (7), 2529-2539 (2023)
   PUBMED   37041226
  REMARK    GeneRIF: BTLA dysregulation correlates with poor outcome and
            diminished T cell-mediated antitumor responses in chronic
            lymphocytic leukemia.
REFERENCE   6  (bases 1 to 3126)
  AUTHORS   Cheung,T.C., Humphreys,I.R., Potter,K.G., Norris,P.S.,
            Shumway,H.M., Tran,B.R., Patterson,G., Jean-Jacques,R., Yoon,M.,
            Spear,P.G., Murphy,K.M., Lurain,N.S., Benedict,C.A. and Ware,C.F.
  TITLE     Evolutionarily divergent herpesviruses modulate T cell activation
            by targeting the herpesvirus entry mediator cosignaling pathway
  JOURNAL   Proc Natl Acad Sci U S A 102 (37), 13218-13223 (2005)
   PUBMED   16131544
  REMARK    GeneRIF: distinct herpesviruses target the HVEM-BTLA cosignaling
            pathway, suggesting the importance of this pathway in regulating T
            cell activation during host defenses.
REFERENCE   7  (bases 1 to 3126)
  AUTHORS   Gonzalez,L.C., Loyet,K.M., Calemine-Fenaux,J., Chauhan,V.,
            Wranik,B., Ouyang,W. and Eaton,D.L.
  TITLE     A coreceptor interaction between the CD28 and TNF receptor family
            members B and T lymphocyte attenuator and herpesvirus entry
            mediator
  JOURNAL   Proc Natl Acad Sci U S A 102 (4), 1116-1121 (2005)
   PUBMED   15647361
  REMARK    GeneRIF: Binding of HVEM to BTLA attenuates T cell activation,
            identifying HVEM/BTLA as a coinhibitory receptor pair.
REFERENCE   8  (bases 1 to 3126)
  AUTHORS   Sedy,J.R., Gavrieli,M., Potter,K.G., Hurchla,M.A., Lindsley,R.C.,
            Hildner,K., Scheu,S., Pfeffer,K., Ware,C.F., Murphy,T.L. and
            Murphy,K.M.
  TITLE     B and T lymphocyte attenuator regulates T cell activation through
            interaction with herpesvirus entry mediator
  JOURNAL   Nat Immunol 6 (1), 90-98 (2005)
   PUBMED   15568026
  REMARK    GeneRIF: HVEM binds to B T lymphocyte attenuator (BTLA), an Ig
            family member, which inhibits T cell proliferation.
REFERENCE   9  (bases 1 to 3126)
  AUTHORS   Gavrieli,M., Watanabe,N., Loftin,S.K., Murphy,T.L. and Murphy,K.M.
  TITLE     Characterization of phosphotyrosine binding motifs in the
            cytoplasmic domain of B and T lymphocyte attenuator required for
            association with protein tyrosine phosphatases SHP-1 and SHP-2
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1236-1243 (2003)
   PUBMED   14652006
REFERENCE   10 (bases 1 to 3126)
  AUTHORS   Watanabe,N., Gavrieli,M., Sedy,J.R., Yang,J., Fallarino,F.,
            Loftin,S.K., Hurchla,M.A., Zimmerman,N., Sim,J., Zang,X.,
            Murphy,T.L., Russell,J.H., Allison,J.P. and Murphy,K.M.
  TITLE     BTLA is a lymphocyte inhibitory receptor with similarities to
            CTLA-4 and PD-1
  JOURNAL   Nat Immunol 4 (7), 670-679 (2003)
   PUBMED   12796776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092894.6.
            
            On Nov 23, 2018 this sequence version replaced NM_181780.3.
            
            Summary: This gene encodes a member of the immunoglobulin
            superfamily. The encoded protein contains a single immunoglobulin
            (Ig) domain and is a receptor that relays inhibitory signals to
            suppress the immune response. Alternative splicing results in
            multiple transcript variants. Polymorphisms in this gene have been
            associated with an increased risk of rheumatoid arthritis.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.147623.1,
                                           SRR1163658.109994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334529.10/ ENSP00000333919.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC092894.6         120808-121009       c
            203-517             AC092894.6         100992-101306       c
            518-661             AC092894.6         92749-92892         c
            662-708             AC092894.6         91295-91341         c
            709-3126            AC092894.6         85503-87920         c
FEATURES             Location/Qualifiers
     source          1..3126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..3126
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /note="B and T lymphocyte associated"
                     /db_xref="GeneID:151888"
                     /db_xref="HGNC:HGNC:21087"
                     /db_xref="MIM:607925"
     exon            1..202
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..984
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B- and T-lymphocyte attenuator; B- and
                     T-lymphocyte-associated protein"
                     /codon_start=1
                     /product="B- and T-lymphocyte attenuator isoform 1
                     precursor"
                     /protein_id="NP_861445.4"
                     /db_xref="CCDS:CCDS33819.1"
                     /db_xref="GeneID:151888"
                     /db_xref="HGNC:HGNC:21087"
                     /db_xref="MIM:607925"
                     /translation="MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQS
                     EHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHF
                     EPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLP
                     LGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQV
                     LLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVK
                     EAPTEYASICVRS"
     exon            203..517
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /inference="alignment:Splign:2.1.0"
     exon            518..661
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /inference="alignment:Splign:2.1.0"
     exon            662..708
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /inference="alignment:Splign:2.1.0"
     exon            709..3126
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /note="hexamer: ATTAAA"
     polyA_site      1166
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /note="hexamer: ATTAAA"
     polyA_site      3126
                     /gene="BTLA"
                     /gene_synonym="BTLA1; CD272"
                     /note="major polyA site"
ORIGIN      
        1 agttatttca cagatgccac tggggtaggt aaactgaccc aactctgcag cactcagaag
       61 acgaagcaaa gccttctact tgagcagttt ttccatcact gatatgtgca ggaaatgaag
      121 acattgcctg ccatgcttgg aactgggaaa ttattttggg tcttcttctt aatcccatat
      181 ctggacatct ggaacatcca tgggaaagaa tcatgtgatg tacagcttta tataaagaga
      241 caatctgaac actccatctt agcaggagat ccctttgaac tagaatgccc tgtgaaatac
      301 tgtgctaaca ggcctcatgt gacttggtgc aagctcaatg gaacaacatg tgtaaaactt
      361 gaagatagac aaacaagttg gaaggaagag aagaacattt catttttcat tctacatttt
      421 gaaccagtgc ttcctaatga caatgggtca taccgctgtt ctgcaaattt tcagtctaat
      481 ctcattgaaa gccactcaac aactctttat gtgacagatg taaaaagtgc ctcagaacga
      541 ccctccaagg acgaaatggc aagcagaccc tggctcctgt atcgtttact tcctttgggg
      601 ggattgcctc tactcatcac tacctgtttc tgcctgttct gctgcctgag aaggcaccaa
      661 ggaaagcaaa atgaactctc tgacacagca ggaagggaaa ttaacctggt tgatgctcac
      721 cttaagagtg agcaaacaga agcaagcacc aggcaaaatt cccaagtact gctatcagaa
      781 actggaattt atgataatga ccctgacctt tgtttcagga tgcaggaagg gtctgaagtt
      841 tattctaatc catgcctgga agaaaacaaa ccaggcattg tttatgcttc cctgaaccat
      901 tctgtcattg gaccgaactc aagactggca agaaatgtaa aagaagcacc aacagaatat
      961 gcatccatat gtgtgaggag ttaagtctgt ttctgactcc aacagggacc attgaatgat
     1021 cagcatgttg acatcattgt ctgggctcaa caggatgtca aataatattt ctcaatttga
     1081 gaatttttac tttagaaatg ttcatgttag tgcttgggtc ttaagggtcc ataggataaa
     1141 tgattaaaat ttctctcaga aacttatttg ggagcttttt atattatagc cttgaataac
     1201 aaaatctctc caaaactggt tgacatcatg agtagcagaa tagtagaacg tttaaactta
     1261 gctacatttt acccaatata caaactcgat cttgcctttg aagctattgg aaagacttgt
     1321 agggaaaaga ggtttgtgtt acctgcatca gttcactaca cactcttgaa aacaaaatgt
     1381 cccaatttga ctaaccaacc ataaatacag taatgattgt atatttcaag tcagtcttcc
     1441 aaaataagaa atttttgctg tgtcagtcta agaatggtgt ttcttaaatg caaaggagaa
     1501 atcattttag gcttgatgta agaaaatgaa aataataaat ggtgcaataa aaatatagaa
     1561 tataccaatt ggatataggg tagatgttcc acatacctgg caaacaaatg cttatatcta
     1621 ctctgttaga ttgataagca aatataggta ttaatggagc agtcaacgta tagcacattt
     1681 atgaggaaag tagagactca ctgggtcaca tagactaatg gataggaatg tgacataatg
     1741 ctgctgaatt aatatactta tgggcatctg aatagtttaa aagttagtca gaataggtat
     1801 cactgggcaa gtgaagatag cttaaactgc ttcatgcttg acttgatagc aagttaaagt
     1861 gcaattaatg gaatggagga aaacccagaa tatttaattg gtctgtaggg gtcaatttgc
     1921 tttcattcac cacatctgca tcttgctgtt cttcttacta aggaatcagg gcaaatcatc
     1981 tgtagtgaca tattttagtt tgctaatcat ttattttaaa atactgaggt tgcagccact
     2041 taagagtata gcaaaagatg gattcagatt tttggacttt ccaaagtact tgagttaaac
     2101 tatttcaaaa atagcctata attttattca acagtttgag gctattcgaa ttctcaggtg
     2161 ctgctactga ataatgtaat agtcttcata caaagtggat agcaaaggtt aaaatccatt
     2221 tcaacaaata tgtgagctga gctgctgcac aaaggaatgt gatgtgtgtg tgtgtgtgtg
     2281 tgtgtgtgtg tgttaggtgg ggtgggtgac aacagaaatg gtgcacgaga aactgatcaa
     2341 attgacatta tattttcagt ttgcttatga agctcaaaat actagagtaa atgggtcatt
     2401 aaagaaaata atatgtgaaa ttatggagtt tagaatacaa gtggggtata tatacaaaaa
     2461 gacaaaactg aggttttgtg gtggagagat tttcttaagt aacactggca ttaagtttta
     2521 gctccttaga tttgggggtg caaatattct tttgagtcac tgttattttg ccaattacac
     2581 ctagaatttc aagcaaccaa ttcgagatag gctgttttag ccaggctgca tttgtggaca
     2641 acttatgtaa gaaagacatg ttagaatagc tgcttgtggt attcttaaaa atagaaacag
     2701 gaaatatggg gaggatacat ttagctgtcc tcttatcaga tgaacacacg aaattgaaca
     2761 gttccttcat gattctctca aacttaaaag caaaatattt ctgtcttatt taaaatatcc
     2821 ttagtatgtc ttatagtaaa gataatgctg ataatgattt catctctaag atgtattaat
     2881 atatttgtac tgtttgccaa aatcacaaat catttatgtt tttattcctt ttcaaaatgg
     2941 tgtcagagac atacatgcat tttcccaaat gactctactt cactattatt tacatggctt
     3001 atttcattag tttatagagg gtttgagaaa aagaatatgt agataattta atggtttttc
     3061 acaaatttta agcttgtgat tgtgctcaat gagaaggtaa agttattaaa acttatttga
     3121 aatcaa
//
