LOCUS       NM_001367975            1242 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BTG anti-proliferation factor 4 (BTG4), transcript
            variant 3, mRNA.
ACCESSION   NM_001367975 XM_024448593
VERSION     NM_001367975.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Wang,Y., Qin,Q., Yang,Y., Dong,S., Liu,Y., Wang,M., Zou,Y.,
            Gong,Y., Zhou,H. and Jiang,B.
  TITLE     A novel homozygous C-terminal deletion in BTG4 causes zygotic
            cleavage failure and female infertility
  JOURNAL   J Assist Reprod Genet 40 (1), 75-81 (2023)
   PUBMED   36471203
  REMARK    GeneRIF: A novel homozygous C-terminal deletion in BTG4 causes
            zygotic cleavage failure and female infertility.
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Liu,R., Zhou,Y., Li,Q., Chen,B., Zhou,Z., Wang,L., Wang,L., Sang,Q.
            and Jin,L.
  TITLE     A novel homozygous missense variant in BTG4 causes zygotic cleavage
            failure and female infertility
  JOURNAL   J Assist Reprod Genet 38 (12), 3261-3266 (2021)
   PUBMED   34647228
  REMARK    GeneRIF: A novel homozygous missense variant in BTG4 causes zygotic
            cleavage failure and female infertility.
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Zheng,W., Zhou,Z., Sha,Q., Niu,X., Sun,X., Shi,J., Zhao,L.,
            Zhang,S., Dai,J., Cai,S., Meng,F., Hu,L., Gong,F., Li,X., Fu,J.,
            Shi,R., Lu,G., Chen,B., Fan,H., Wang,L., Lin,G. and Sang,Q.
  TITLE     Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and
            Female Infertility
  JOURNAL   Am J Hum Genet 107 (1), 24-33 (2020)
   PUBMED   32502391
  REMARK    GeneRIF: Homozygous Mutations in BTG4 Cause Zygotic Cleavage
            Failure and Female Infertility.
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Zhang,N., Jiang,T., Wang,Y., Wang,S., Hu,L. and Bu,Y.
  TITLE     BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and
            Induces Apoptosis
  JOURNAL   Genes (Basel) 11 (2), 217 (2020)
   PUBMED   32093041
  REMARK    GeneRIF: BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth
            and Induces Apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1242)
  AUTHORS   Xu,Y., Liu,L., Liu,J., Zhang,Y., Zhu,J., Chen,J., Liu,S., Liu,Z.,
            Shi,H., Shen,H. and Hu,Z.
  TITLE     A potentially functional polymorphism in the promoter region of
            miR-34b/c is associated with an increased risk for primary
            hepatocellular carcinoma
  JOURNAL   Int J Cancer 128 (2), 412-417 (2011)
   PUBMED   20309940
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1242)
  AUTHORS   Toyota,M., Suzuki,H., Sasaki,Y., Maruyama,R., Imai,K., Shinomura,Y.
            and Tokino,T.
  TITLE     Epigenetic silencing of microRNA-34b/c and B-cell translocation
            gene 4 is associated with CpG island methylation in colorectal
            cancer
  JOURNAL   Cancer Res 68 (11), 4123-4132 (2008)
   PUBMED   18519671
  REMARK    GeneRIF: miR-34b/c and BTG4 are novel tumor suppressors in
            colorectal cancer (CRC) and that the miR-34b/c CpG island, which
            bidirectionally regulates miR-34b/c and BTG4, is a frequent target
            of epigenetic silencing in CRC
REFERENCE   7  (bases 1 to 1242)
  AUTHORS   Auer,R.L., Starczynski,J., McElwaine,S., Bertoni,F., Newland,A.C.,
            Fegan,C.D. and Cotter,F.E.
  TITLE     Identification of a potential role for POU2AF1 and BTG4 in the
            deletion of 11q23 in chronic lymphocytic leukemia
  JOURNAL   Genes Chromosomes Cancer 43 (1), 1-10 (2005)
   PUBMED   15672409
  REMARK    GeneRIF: BTG4 could contribute to chronic lymphocytic leykemia
            pathogenesis following inactivation by haploinsufficiency.
REFERENCE   8  (bases 1 to 1242)
  AUTHORS   Yoshida,Y., Hosoda,E., Nakamura,T. and Yamamoto,T.
  TITLE     Association of ANA, a member of the antiproliferative Tob family
            proteins, with a Caf1 component of the CCR4 transcriptional
            regulatory complex
  JOURNAL   Jpn J Cancer Res 92 (6), 592-596 (2001)
   PUBMED   11429045
REFERENCE   9  (bases 1 to 1242)
  AUTHORS   Tirone,F.
  TITLE     The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB
            family: regulator in control of cell growth, differentiation, and
            DNA repair?
  JOURNAL   J Cell Physiol 187 (2), 155-165 (2001)
   PUBMED   11267995
  REMARK    Review article
REFERENCE   10 (bases 1 to 1242)
  AUTHORS   Buanne,P., Corrente,G., Micheli,L., Palena,A., Lavia,P.,
            Spadafora,C., Lakshmana,M.K., Rinaldi,A., Banfi,S., Quarto,M.,
            Bulfone,A. and Tirone,F.
  TITLE     Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth
            inhibitory genes, highly expressed in the olfactory epithelium
  JOURNAL   Genomics 68 (3), 253-263 (2000)
   PUBMED   10995567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002008.5.
            
            On Jan 4, 2019 this sequence version replaced XM_024448593.1.
            
            Summary: The protein encoded by this gene is a member of the
            BTG/Tob family. This family has structurally related proteins that
            appear to have antiproliferative properties. This encoded protein
            can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.243772.1,
                                           SRR5189667.264636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692032.1/ ENSP00000509850.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AP002008.5         123425-123630       c
            207-405             AP002008.5         109848-110046       c
            406-543             AP002008.5         109242-109379       c
            544-742             AP002008.5         108455-108653       c
            743-1242            AP002008.5         106059-106558       c
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..1242
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /note="BTG anti-proliferation factor 4"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
     exon            1..206
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            207..405
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..922
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /note="isoform 2 is encoded by transcript variant 3;
                     protein BTG4; protein PC3b; B-cell translocation gene 4;
                     BTG family member 4"
                     /codon_start=1
                     /product="protein BTG4 isoform 2"
                     /protein_id="NP_001354904.1"
                     /db_xref="CCDS:CCDS91586.1"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
                     /translation="MRDEIATTVFFVTRLVKKHDKLSKQQIEDFAEKLMTILFETYRS
                     HWHSDCPSKGQAFRCIRINNNQNKDPILERACVESNVDFSHLGLPKEMTIWVDPFEVC
                     CRYGEKNHPFTVASFKGRWEEWELYQQISYAVSRASSDVSSGTSCDEESCSKEPRVIP
                     KVSNPKSIYQVENLKQPFQSWLQIPRKKNVVDGRVGLLGNTYHGSQKHPKCYRPAMHR
                     LDRYHWVNTHR"
     exon            406..543
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            544..742
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1242
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1219..1224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /note="hexamer: AATAAA"
     polyA_site      1242
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggctg agagaaagcg ctgtgggcgg tccctgaagg gcctccaagg gagacgccta
       61 gaagatggag gcccagattc ttgagacgtt tctctttctg atctagcagg agggacaaag
      121 agctcctcca ctccctcatt ccccaagaag gcccccagcc tacccagttt ccgtgaccat
      181 tccgccctgg gaaagcggct tcccagacct ccttatctat ttttcttgaa tcatgagaga
      241 tgaaattgca acaacagttt tctttgtcac aagattggtg aaaaaacatg ataaactaag
      301 taaacagcaa atagaagact ttgcagaaaa gctgatgacg atcttgtttg aaacatacag
      361 aagtcactgg cactctgatt gcccttctaa agggcaagcc ttcaggtgca tcaggataaa
      421 caacaatcag aataaagatc ccattctaga aagggcatgt gtggaaagta atgtagattt
      481 ttctcacctg ggacttccga aggagatgac catatgggta gatccctttg aagtatgctg
      541 taggtatggt gagaaaaacc atccatttac agttgcttct tttaaaggca gatgggagga
      601 atgggaacta tatcaacaaa tcagttatgc cgttagtaga gcctcatcag acgtttcctc
      661 tggcacttcc tgcgatgaag aaagttgtag caaggaacct cgtgtcattc ctaaagtcag
      721 caatccgaag agtatttatc aggttgaaaa cttgaaacag ccctttcaat cttggttaca
      781 aatcccccgc aaaaagaatg tggtggacgg ccgtgttggc ctcctgggaa acacttacca
      841 tggctcgcag aagcatccta agtgttacag gcctgctatg caccggctgg acaggtacca
      901 ctgggtcaac acacaccgat gacgcagcga ctgggcacgt ggtgggcaag agctcagagg
      961 agtgccttta ttctctctaa aataaaaatg aatttaaggt tgagaggccc atgaaacaaa
     1021 aaatgaccat attagggact agggtacaca atggtaaatc ctctcataca gatcatcact
     1081 gttcttagct gtacttttaa ttcttattta attttacatg aagttttatg taacatcagt
     1141 gaatgtaccc agtaaggtaa cagaatgaag atgttgacct ctaataagac tcaatgaatt
     1201 atgaaaagta atggtttaaa taaacgtaca gtgtttttaa ta
//
