LOCUS       NM_006806               1410 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens BTG anti-proliferation factor 3 (BTG3), transcript
            variant 2, mRNA.
ACCESSION   NM_006806
VERSION     NM_006806.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Cheng,Y.C., Acedera,J.D., Li,Y.J. and Shieh,S.Y.
  TITLE     A keratinocyte-adipocyte signaling loop is reprogrammed by loss of
            BTG3 to augment skin carcinogenesis
  JOURNAL   Cell Death Differ 31 (8), 970-982 (2024)
   PUBMED   38714880
  REMARK    GeneRIF: A keratinocyte-adipocyte signaling loop is reprogrammed by
            loss of BTG3 to augment skin carcinogenesis.
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Zhang,X.Y., Zhuang,H.W., Wang,J., Shen,Y., Bu,Y.Z., Guan,B.G.,
            Xu,F. and Dou,J.
  TITLE     Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and
            invasion by sponging miR-93-5p and targeting BTG3
  JOURNAL   Gene Ther 29 (9), 566-574 (2022)
   PUBMED   33051589
  REMARK    GeneRIF: Long noncoding RNA CA3-AS1 suppresses gastric cancer
            migration and invasion by sponging miR-93-5p and targeting BTG3.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Zhang,F., Fan,G. and Wang,X.
  TITLE     Correlation between BTG3, CASP9 and LRP4 single-nucleotide
            polymorphisms and susceptibility to papillary thyroid carcinoma
  JOURNAL   Biomark Med 16 (7), 537-547 (2022)
   PUBMED   35362324
  REMARK    GeneRIF: Correlation between BTG3, CASP9 and LRP4 single-nucleotide
            polymorphisms and susceptibility to papillary thyroid carcinoma.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Ye,Z., Wei,L., Yin,X., Li,H., Qin,G., Li,S., Peng,T., Liu,B.,
            Zhao,S. and Zhuo,Q.
  TITLE     Long non-coding RNA cancer susceptibility candidate 2 regulates the
            function of human fibroblast-like synoviocytes via the
            microRNA-18a-5p/B-cell translocation gene 3 signaling axis in
            rheumatoid arthritis
  JOURNAL   Bioengineered 13 (2), 3240-3250 (2022)
   PUBMED   35045800
  REMARK    GeneRIF: Long non-coding RNA cancer susceptibility candidate 2
            regulates the function of human fibroblast-like synoviocytes via
            the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in
            rheumatoid arthritis.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Cheng,Y.C., Chiang,H.Y., Cheng,S.J., Chang,H.W., Li,Y.J. and
            Shieh,S.Y.
  TITLE     Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor
            microenvironment through HIF-1 activation
  JOURNAL   Cell Death Dis 11 (12), 1046 (2020)
   PUBMED   33311481
  REMARK    GeneRIF: Loss of the tumor suppressor BTG3 drives a pro-angiogenic
            tumor microenvironment through HIF-1 activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Yoshida,Y., Hosoda,E., Nakamura,T. and Yamamoto,T.
  TITLE     Association of ANA, a member of the antiproliferative Tob family
            proteins, with a Caf1 component of the CCR4 transcriptional
            regulatory complex
  JOURNAL   Jpn J Cancer Res 92 (6), 592-596 (2001)
   PUBMED   11429045
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Matsuda,S., Rouault,J., Magaud,J. and Berthet,C.
  TITLE     In search of a function for the TIS21/PC3/BTG1/TOB family
  JOURNAL   FEBS Lett 497 (2-3), 67-72 (2001)
   PUBMED   11377414
  REMARK    Review article
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Yoshida,Y., Matsuda,S., Ikematsu,N., Kawamura-Tsuzuku,J.,
            Inazawa,J., Umemori,H. and Yamamoto,T.
  TITLE     ANA, a novel member of Tob/BTG1 family, is expressed in the
            ventricular zone of the developing central nervous system
  JOURNAL   Oncogene 16 (20), 2687-2693 (1998)
   PUBMED   9632145
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Guehenneux,F., Duret,L., Callanan,M.B., Bouhas,R., Hayette,S.,
            Berthet,C., Samarut,C., Rimokh,R., Birot,A.M., Wang,Q., Magaud,J.P.
            and Rouault,J.P.
  TITLE     Cloning of the mouse BTG3 gene and definition of a new gene family
            (the BTG family) involved in the negative control of the cell cycle
  JOURNAL   Leukemia 11 (3), 370-375 (1997)
   PUBMED   9067576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA381239.1, DR155504.1,
            AK289408.1 and BF110486.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006806.4.
            
            Summary: The protein encoded by this gene is a member of the
            BTG/Tob family. This family has structurally related proteins that
            appear to have antiproliferative properties. This encoded protein
            might play a role in neurogenesis in the central nervous system.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289408.1, BI668105.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348354.7/ ENSP00000284879.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA381239.1         50-86
            38-824              DR155504.1         3-789
            825-1408            AK289408.1         822-1405
            1409-1410           BF110486.1         6-7                 c
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..1410
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /note="BTG anti-proliferation factor 3"
                     /db_xref="GeneID:10950"
                     /db_xref="HGNC:HGNC:1132"
                     /db_xref="MIM:605674"
     exon            1..203
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /inference="alignment:Splign:2.1.0"
     exon            204..384
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..970
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /note="isoform b is encoded by transcript variant 2;
                     B-cell translocation gene 3; protein BTG3; protein Tob5;
                     abundant in neuroepithelium area protein; BTG family
                     member 3"
                     /codon_start=1
                     /product="protein BTG3 isoform b"
                     /protein_id="NP_006797.3"
                     /db_xref="CCDS:CCDS13569.1"
                     /db_xref="GeneID:10950"
                     /db_xref="HGNC:HGNC:1132"
                     /db_xref="MIM:605674"
                     /translation="MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTLILQEKYKN
                     HWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVC
                     CRYGEKNNAFIVASFENKDENKDEISRKVTRALDKVTSDYHSGSSSSDEETSKEMEVK
                     PSSVTAAASPVYQISELIFPPLPMWHPLPRKKPGMYRGNGHQNHYPPPVPFGYPNQGR
                     KNKPYRPIPVTWVPPPGMHCDRNHWINPHMLAPH"
     exon            385..522
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /inference="alignment:Splign:2.1.0"
     exon            523..730
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1410
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /note="hexamer: AATAAA"
     polyA_site      1410
                     /gene="BTG3"
                     /gene_synonym="ANA; ANA/BTG3; APRO4; TOB5; TOB55; TOFA"
                     /note="major polyA site"
ORIGIN      
        1 actcgtgtgc gcgctcgtcc gcccgccagt cctctcaacg cgcgcttggc cgcccgacga
       61 cgcgggagcc gcacgcgccg gacgaggctc gctgcgctcc ctgttgccca gcgcgggccc
      121 gttgaggcgg agccctcagt tcccggccag gacacggtct gggccgccga atctccggcc
      181 gaagagcggc ggcggcagcg gcgggaaaaa aatgaagaat gaaattgctg ccgttgtctt
      241 ctttttcaca aggctagttc gaaaacatga taagttgaaa aaagaggcag ttgagaggtt
      301 tgctgagaaa ttgaccctaa tacttcaaga aaaatataaa aatcactggt atccagaaaa
      361 accatcgaaa ggacaggcct acagatgtat tcgtgtcaat aaatttcaga gagttgatcc
      421 tgatgtcctg aaagcctgtg aaaacagctg catcttgtat agtgacctgg gcttgccaaa
      481 ggagctcact ctctgggtgg acccatgtga ggtgtgctgt cggtatggag agaaaaacaa
      541 tgcattcatt gttgccagct ttgaaaataa agatgagaac aaggatgaga tctccaggaa
      601 agttaccagg gcccttgata aggttacctc tgattatcat tcaggatcct cttcttcaga
      661 tgaagaaaca agtaaggaaa tggaagtgaa acccagttcg gtgactgcag ccgcaagtcc
      721 tgtgtaccag atttcagaac ttatatttcc acctcttcca atgtggcacc ctttgcccag
      781 aaaaaagcca ggaatgtatc gagggaatgg ccatcagaat cactatcctc ctcctgttcc
      841 atttggttat ccaaatcagg gaagaaaaaa taaaccatat cgcccaattc cagtgacatg
      901 ggtacctcct cctggaatgc attgtgaccg gaatcactgg attaatcctc acatgttagc
      961 acctcactaa cttcgttttt gattgtgttg gtgtcatgtt gagaaaaagg tagaataaac
     1021 cttactacac attaaaagtt aaaagttctt actaatagta gtgaagttag atgggccaaa
     1081 ccatcaaact tatttttata gaagttattg agaataatct ttcttaaaaa atatatgcac
     1141 tttagatatt gatatagttt gagaaatttt attaaagtta gtcaagtgcc taagttttta
     1201 atattggact tgagtattta tatattgtgc atcaactctg ttggatacga gaacactgta
     1261 gaagtggacg atttgttcta gcacctttga gaatttactt tatggagcgt atgtaagtta
     1321 tttatataca aggaaatcta ttttatgtcg ttgtttaaga gaattgtgtg aaatcatgta
     1381 gttgcaaata aaaaatagtt tgaggcatga
//
